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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Spo-108380
UUCD1 version UUC-ScP-00139
Ensembl Protein ID SPAC6F12.14.1:pep
UniProt Accession O94556; APC8_SCHPO
Genbank Protein ID CAB11101.2
Protein Name Anaphase-promoting complex subunit 8; 20S cyclosome/APC complex protein apc8; Cell untimely torn protein 23
Genbank Nucleotide ID CU329670
Gene Name cut23; apc8; SPAC6F12.14
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC6F12.14 SPAC6F12.14.1 SPAC6F12.14.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Protein Expression/Proteomics
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 42.09 5.00e-97 353.00 IUUC-Hsa-045713
E3 adaptor/Cullin RING/APC_C/APC_C 45.06 3.00e-92 333.00 IUUC-Sce-106199
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.
 Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.
Protein Sequence
(Fasta)
MTVSLNTMMG VDGLEDQEQL REIRNCLLKC ISECSERGLV YAVRWAAEML NGMNPIEMEH 60
IPFSSTPTGE FDLDPDMANE KLLEVEEKNI YLLAKSYFDC KEFERAAYTL QNCKSSKSIF 120
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Protein Fasta Sequence


>IUUC-Spo-108380|E3,APC_C|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGTAAACAAG TAGCTAGACA CACAAAAGCA TTTGAAAATA ATTCTCCTTT AATGCCTAAT 60
TCTTTATGTT AATCAACCTC CAAAACATTT AAATTTTTCT AATTTTTTTC TGCTTGTTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108380|E3,APC_C|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR007192--APC8
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
Pfam

PF04049--ANAPC8
PF13181--TPR_8
SMART

SM00028--TPR
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0044732--C:mitotic spindle pole body
GO:0005634--C:nucleus
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
KEGG spo:SPAC6F12.14
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000540 Aegilops tauschii 39.87 5.00e-85 306.00
IUUC-Aml-002139 Ailuropoda melanoleuca 40.11 3.00e-100 357.00
IUUC-Atr-002658 Amborella trichopoda 40.92 3.00e-103 367.00
IUUC-Apl-004020 Anas platyrhynchos 43.42 4.00e-96 343.00
IUUC-Aca-005101 Anolis carolinensis 41.20 1.00e-98 352.00
IUUC-Aly-006437 Arabidopsis lyrata 41.67 9.00e-102 362.00
IUUC-Ath-006712 Arabidopsis thaliana 41.67 4.00e-101 360.00
IUUC-Ago-007953 Ashbya gossypii 37.79 2.00e-106 377.00
IUUC-Acl-008166 Aspergillus clavatus 40.32 9.00e-132 462.00
IUUC-Afl-008420 Aspergillus flavus 41.06 5.00e-132 462.00
IUUC-Afu-009028 Aspergillus fumigatus 39.94 6.00e-130 456.00
IUUC-Ani-009390 Aspergillus nidulans 40.66 5.00e-132 462.00
IUUC-Ang-009704 Aspergillus niger 47.39 8.00e-133 465.00
IUUC-Aor-009990 Aspergillus oryzae 41.21 4.00e-132 462.00
IUUC-Ate-010510 Aspergillus terreus 40.15 4.00e-129 453.00
IUUC-Ame-011724 Astyanax mexicanus 34.70 2.00e-75 274.00
IUUC-Bgr-012007 Blumeria graminis 37.63 7.00e-118 416.00
IUUC-Bta-013310 Bos taurus 40.48 1.00e-102 365.00
IUUC-Bci-013833 Botrytis cinerea 38.33 5.00e-121 426.00
IUUC-Bdi-014957 Brachypodium distachyon 41.50 2.00e-95 341.00
IUUC-Bol-016105 Brassica oleracea 41.00 8.00e-107 379.00
IUUC-Bra-017168 Brassica rapa 41.00 4.00e-97 346.00
IUUC-Cel-018142 Caenorhabditis elegans 29.63 9.00e-57 213.00
IUUC-Cja-019339 Callithrix jacchus 39.93 1.00e-99 355.00
IUUC-Cfa-020690 Canis familiaris 40.11 3.00e-100 357.00
IUUC-Cpo-021859 Cavia porcellus 39.78 1.00e-100 358.00
IUUC-Cre-022698 Chlamydomonas reinhardtii 38.41 2.00e-72 264.00
IUUC-Csa-024176 Chlorocebus sabaeus 40.66 5.00e-103 366.00
IUUC-Cho-024903 Choloepus hoffmanni 41.27 3.00e-96 343.00
IUUC-Cin-025468 Ciona intestinalis 36.82 2.00e-79 287.00
IUUC-Csv-026223 Ciona savignyi 36.98 4.00e-90 323.00
IUUC-Cgl-026453 Colletotrichum gloeosporioides 39.37 7.00e-110 389.00
IUUC-Cne-027038 Cryptococcus neoformans 38.53 4.00e-103 366.00
IUUC-Cme-027161 Cyanidioschyzon merolae 32.81 6.00e-73 266.00
IUUC-Dre-027972 Danio rerio 38.86 2.00e-101 360.00
IUUC-Dno-029164 Dasypus novemcinctus 39.93 1.00e-99 355.00
IUUC-Dor-030344 Dipodomys ordii 45.18 1.00e-73 268.00
IUUC-Dse-031277 Dothistroma septosporum 44.94 8.00e-86 308.00
IUUC-Dme-031895 Drosophila melanogaster 40.26 1.00e-103 368.00
IUUC-Ete-032942 Echinops telfairi 41.54 1.00e-92 331.00
IUUC-Eca-034355 Equus caballus 40.29 3.00e-100 357.00
IUUC-Eeu-035313 Erinaceus europaeus 33.14 3.00e-43 167.00
IUUC-Fca-035799 Felis catus 40.04 8.00e-99 352.00
IUUC-Fal-037373 Ficedula albicollis 41.74 1.00e-98 351.00
IUUC-Fox-037722 Fusarium oxysporum 37.23 6.00e-113 399.00
IUUC-Fso-038295 Fusarium solani 36.12 1.00e-104 372.00
IUUC-Gmo-039241 Gadus morhua 40.73 2.00e-101 361.00
IUUC-Ggr-039994 Gaeumannomyces graminis 47.91 4.00e-96 343.00
IUUC-Gga-040280 Gallus gallus 41.38 1.00e-98 352.00
IUUC-Gac-042265 Gasterosteus aculeatus 39.85 8.00e-99 352.00
IUUC-Gma-043161 Glycine max 39.54 1.00e-104 371.00
IUUC-Ggo-044898 Gorilla gorilla 37.70 4.00e-86 310.00
IUUC-Hsa-045713 Homo sapiens 40.11 5.00e-100 356.00
IUUC-Hvu-047296 Hordeum vulgare 42.21 5.00e-83 299.00
IUUC-Itr-048205 Ictidomys tridecemlineatus 39.86 3.00e-100 357.00
IUUC-Kpa-049344 Komagataella pastoris 47.28 7.00e-112 395.00
IUUC-Lch-049878 Latimeria chalumnae 41.62 2.00e-104 370.00
IUUC-Lpe-050917 Leersia perrieri 41.14 1.00e-97 348.00
IUUC-Loc-052893 Lepisosteus oculatus 46.15 1.00e-62 232.00
IUUC-Lma-053031 Leptosphaeria maculans 41.59 5.00e-133 466.00
IUUC-Laf-053888 Loxodonta africana 40.48 2.00e-100 357.00
IUUC-Mcc-055617 Macaca mulatta 37.55 9.00e-88 315.00
IUUC-Meu-056377 Macropus eugenii 39.31 9.00e-96 342.00
IUUC-Mor-057030 Magnaporthe oryzae 37.16 2.00e-113 400.00
IUUC-Mpo-057558 Magnaporthe poae 49.04 1.00e-97 348.00
IUUC-Mtr-058778 Medicago truncatula 39.58 1.00e-105 375.00
IUUC-Mla-058861 Melampsora laricipopulina 42.47 4.00e-92 329.00
IUUC-Mga-059809 Meleagris gallopavo 43.51 7.00e-98 348.00
IUUC-Mvi-060381 Microbotryum violaceum 41.50 8.00e-97 345.00
IUUC-Mmr-060669 Microcebus murinus 39.24 3.00e-91 327.00
IUUC-Mdo-062293 Monodelphis domestica 40.26 6.00e-99 352.00
IUUC-Mmu-064261 Mus musculus 40.00 5.00e-100 356.00
IUUC-Mac-065082 Musa acuminata 44.30 1.00e-98 351.00
IUUC-Mpu-066465 Mustela putorius furo 32.24 6.00e-59 219.00
IUUC-Mlu-067770 Myotis lucifugus 40.66 7.00e-103 365.00
IUUC-Nfi-068311 Neosartorya fischeri 40.09 8.00e-130 455.00
IUUC-Ncr-068653 Neurospora crassa 37.99 7.00e-112 395.00
IUUC-Nle-069036 Nomascus leucogenys 40.11 5.00e-100 356.00
IUUC-Opr-070229 Ochotona princeps 41.67 2.00e-85 307.00
IUUC-Ont-072218 Oreochromis niloticus 40.81 7.00e-107 379.00
IUUC-Ocu-073869 Oryctolagus cuniculus 40.11 4.00e-100 356.00
IUUC-Oba-075863 Oryza barthii 38.05 4.00e-97 346.00
IUUC-Obr-076071 Oryza brachyantha 36.67 3.00e-95 340.00
IUUC-Ogl-077026 Oryza glaberrima 40.29 5.00e-92 329.00
IUUC-Ogu-078601 Oryza glumaepatula 37.82 1.00e-97 348.00
IUUC-Oin-079443 Oryza indica 37.91 5.00e-97 346.00
IUUC-Olo-080836 Oryza longistaminata 42.11 7.00e-96 342.00
IUUC-Ome-081640 Oryza meridionalis 42.32 7.00e-97 345.00
IUUC-Oni-083014 Oryza nivara 38.05 3.00e-97 347.00
IUUC-Opu-083788 Oryza punctata 37.76 2.00e-97 347.00
IUUC-Oru-085205 Oryza rufipogon 38.05 4.00e-97 346.00
IUUC-Osa-085809 Oryza sativa 38.05 2.00e-97 347.00
IUUC-Ola-087272 Oryzias latipes 39.96 9.00e-99 352.00
IUUC-Olu-087775 Ostreococcus lucimarinus 40.36 7.00e-90 322.00
IUUC-Oga-088234 Otolemur garnettii 40.11 4.00e-100 357.00
IUUC-Oar-089533 Ovis aries 40.48 1.00e-102 365.00
IUUC-Ptr-090956 Pan troglodytes 40.11 4.00e-100 356.00
IUUC-Pan-091781 Papio anubis 40.11 5.00e-100 356.00
IUUC-Psi-093533 Pelodiscus sinensis 41.56 6.00e-105 373.00
IUUC-Pma-094153 Petromyzon marinus 39.89 3.00e-104 370.00
IUUC-Pno-095099 Phaeosphaeria nodorum 37.81 5.00e-115 406.00
IUUC-Ppa-095917 Physcomitrella patens 41.58 4.00e-105 373.00
IUUC-Pfo-096378 Poecilia formosa 40.44 1.00e-104 371.00
IUUC-Pab-098457 Pongo abelii 40.48 1.00e-102 365.00
IUUC-Pop-099359 Populus trichocarpa 41.11 1.00e-101 361.00
IUUC-Pca-100406 Procavia capensis 49.54 1.00e-50 192.00
IUUC-Ppe-101636 Prunus persica 41.27 1.00e-104 371.00
IUUC-Pva-103102 Pteropus vampyrus 39.39 3.00e-100 357.00
IUUC-Pgr-103324 Puccinia graminis 39.52 8.00e-107 379.00
IUUC-Ptt-103755 Puccinia triticina 38.75 2.00e-107 380.00
IUUC-Pte-104290 Pyrenophora teres 40.78 2.00e-132 464.00
IUUC-Pyt-104739 Pyrenophora triticirepentis 40.80 2.00e-133 468.00
IUUC-Rno-105205 Rattus norvegicus 40.18 9.00e-101 358.00
IUUC-Sce-106199 Saccharomyces cerevisiae 40.11 1.00e-96 345.00
IUUC-Sha-107218 Sarcophilus harrisii 40.26 4.00e-99 353.00
IUUC-Sja-107667 Schizosaccharomyces japonicus 70.67 0.00e+00 802.00
IUUC-Smo-109350 Selaginella moellendorffii 42.80 5.00e-101 359.00
IUUC-Sit-110418 Setaria italica 42.74 2.00e-97 347.00
IUUC-Sly-111724 Solanum lycopersicum 39.68 6.00e-103 365.00
IUUC-Stu-112247 Solanum tuberosum 38.27 7.00e-96 342.00
IUUC-Sar-113502 Sorex araneus 36.69 1.00e-83 301.00
IUUC-Sbi-113784 Sorghum bicolor 42.95 1.00e-98 351.00
IUUC-Sre-115116 Sporisorium reilianum 36.14 6.00e-73 266.00
IUUC-Ssc-115914 Sus scrofa 40.48 1.00e-102 365.00
IUUC-Tgu-117390 Taeniopygia guttata 41.74 2.00e-98 351.00
IUUC-Tru-118703 Takifugu rubripes 40.62 6.00e-100 356.00
IUUC-Tsy-118972 Tarsius syrichta 40.95 2.00e-80 290.00
IUUC-Tni-119710 Tetraodon nigroviridis 39.71 9.00e-98 348.00
IUUC-Tca-121327 Theobroma cacao 42.10 7.00e-106 375.00
IUUC-Tre-121974 Trichoderma reesei 35.72 2.00e-102 364.00
IUUC-Tvi-122260 Trichoderma virens 35.05 9.00e-104 369.00
IUUC-Tae-124866 Triticum aestivum 39.78 1.00e-48 185.00
IUUC-Tme-127161 Tuber melanosporum 50.90 1.00e-159 554.00
IUUC-Tbe-127932 Tupaia belangeri 42.51 7.00e-95 339.00
IUUC-Ttr-129091 Tursiops truncatus 40.48 1.00e-102 365.00
IUUC-Uma-129376 Ustilago maydis 35.48 7.00e-76 276.00
IUUC-Vda-129821 Verticillium dahliae 37.38 2.00e-110 391.00
IUUC-Vpa-130644 Vicugna pacos 40.48 1.00e-102 365.00
IUUC-Vvi-130971 Vitis vinifera 40.53 1.00e-102 364.00
IUUC-Xtr-132050 Xenopus tropicalis 41.04 7.00e-103 365.00
IUUC-Xma-133078 Xiphophorus maculatus 40.07 5.00e-100 356.00
IUUC-Yli-134413 Yarrowia lipolytica 46.49 5.00e-136 476.00
IUUC-Zma-135224 Zea mays 42.53 4.00e-96 343.00
Created Date 25-Jun-2017

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