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Tag Content
iUUCD ID IUUC-Pab-098501
Ensembl Protein ID ENSPPYP00000018899.2
UniProt Accession Q5R792; ATG5_PONAB
Genbank Protein ID CAH92368.1
Protein Name Autophagy protein 5; APG5-like
Genbank Nucleotide ID CR860226
Gene Name ATG5; APG5L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000016880.2 ENSPPYT00000019645.2 ENSPPYP00000018899.2
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/Other 24.72 2.00e-09 57.40 IUUC-Sce-106216
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Pongo abelii
Functional Description
(View)

Functional Description



     May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD (By similarity).
May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD (By similarity).
Protein Sequence
(Fasta)
MTDDKDVLRD VWFGRIPTCF TLCQDEITER EAEPYYLLLP RVSYLTLVTD KVKKHFQKVM 60
RQEDISEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNI TVHFKSFPEK DLLHCPSKDA 120
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Protein Fasta Sequence



>IUUC-Pab-098501|E3,Cullin RING/Other|Pongo abelii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AACACCGAGG GCGGAGTTCG GGCCACGTGG GGTCTCGTGA CGTCATCTCC GGGCGCCGAG 60
GGTGACTGGA CTTGTGGTGC GCTTCCAGGG CTCCGCAGCG TTGCCGGTTG TGTTCGCTGG 120
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Nucleotide Fasta Sequence



>IUUC-Pab-098501|E3,Cullin RING/Other|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0053--Apoptosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0005776--C:autophagosome
GO:0005930--C:axoneme
GO:0044233--C:ER-mitochondrion membrane contact site
GO:0034045--C:pre-autophagosomal structure membrane
GO:0035973--P:aggrephagy
GO:0019883--P:antigen processing and presentation of endogenous antigen
GO:0006915--P:apoptotic process
GO:0001974--P:blood vessel remodeling
GO:0019725--P:cellular homeostasis
GO:0071500--P:cellular response to nitrosative stress
GO:0009267--P:cellular response to starvation
GO:0060047--P:heart contraction
GO:0045087--P:innate immune response
GO:0000422--P:mitophagy
GO:0043066--P:negative regulation of apoptotic process
GO:2000619--P:negative regulation of histone H4-K16 acetylation
GO:0050765--P:negative regulation of phagocytosis
GO:0031397--P:negative regulation of protein ubiquitination
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0039689--P:negative stranded viral RNA replication
GO:0045060--P:negative thymic T cell selection
GO:0048840--P:otolith development
GO:0070257--P:positive regulation of mucus secretion
GO:0061739--P:protein lipidation involved in autophagosome assembly
GO:1902017--P:regulation of cilium assembly
GO:0002739--P:regulation of cytokine secretion involved in immune response
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0042493--P:response to drug
GO:0009620--P:response to fungus
GO:0042311--P:vasodilation
GO:0055015--P:ventricular cardiac muscle cell development

KEGG pon:100173376
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000583 Aegilops tauschii 32.35 1.00e-24 108.00
IUUC-Aml-002403 Ailuropoda melanoleuca 97.83 5.00e-156 543.00
IUUC-Atr-002645 Amborella trichopoda 26.41 3.00e-23 102.00
IUUC-Apl-003611 Anas platyrhynchos 89.82 5.00e-152 529.00
IUUC-Aca-004411 Anolis carolinensis 89.57 1.00e-149 521.00
IUUC-Aly-005636 Arabidopsis lyrata 26.97 9.00e-27 114.00
IUUC-Ath-006959 Arabidopsis thaliana 27.58 4.00e-27 115.00
IUUC-Ago-007978 Ashbya gossypii 25.49 3.00e-07 48.90
IUUC-Acl-008328 Aspergillus clavatus 25.70 2.00e-19 89.40
IUUC-Afl-008638 Aspergillus flavus 24.60 2.00e-24 106.00
IUUC-Afu-009042 Aspergillus fumigatus 25.96 3.00e-26 112.00
IUUC-Ani-009364 Aspergillus nidulans 29.11 2.00e-23 102.00
IUUC-Aor-009889 Aspergillus oryzae 24.60 2.00e-24 106.00
IUUC-Ate-010511 Aspergillus terreus 31.18 4.00e-10 56.20
IUUC-Ame-011644 Astyanax mexicanus 84.81 7.00e-37 144.00
IUUC-Bgr-012153 Blumeria graminis 27.78 5.00e-18 84.70
IUUC-Bta-012360 Bos taurus 98.11 4.00e-86 309.00
IUUC-Bci-013723 Botrytis cinerea 26.99 3.00e-16 78.60
IUUC-Bdi-014520 Brachypodium distachyon 22.92 8.00e-22 97.80
IUUC-Bol-016053 Brassica oleracea 26.57 4.00e-29 122.00
IUUC-Bra-017072 Brassica rapa 26.95 2.00e-29 123.00
IUUC-Cel-018529 Caenorhabditis elegans 35.64 6.00e-38 150.00
IUUC-Cja-019569 Callithrix jacchus 99.27 1.00e-158 551.00
IUUC-Cfa-020473 Canis familiaris 98.55 5.00e-158 549.00
IUUC-Cpo-021421 Cavia porcellus 96.73 2.00e-155 541.00
IUUC-Cre-022862 Chlamydomonas reinhardtii 29.31 3.00e-18 85.10
IUUC-Csa-024197 Chlorocebus sabaeus 99.27 6.00e-159 552.00
IUUC-Cho-024521 Choloepus hoffmanni 96.65 2.00e-132 464.00
IUUC-Cin-025119 Ciona intestinalis 45.28 4.00e-64 237.00
IUUC-Csv-026192 Ciona savignyi 46.27 5.00e-66 243.00
IUUC-Cgl-026686 Colletotrichum gloeosporioides 23.47 1.00e-08 53.10
IUUC-Dre-028466 Danio rerio 81.09 2.00e-135 474.00
IUUC-Dse-031228 Dothistroma septosporum 26.80 3.00e-31 129.00
IUUC-Dme-031703 Drosophila melanogaster 48.34 4.00e-73 267.00
IUUC-Ete-032482 Echinops telfairi 97.49 1.00e-133 468.00
IUUC-Eca-034036 Equus caballus 97.82 2.00e-157 547.00
IUUC-Eeu-035235 Erinaceus europaeus 97.48 1.00e-85 309.00
IUUC-Fca-036263 Felis catus 98.55 9.00e-158 548.00
IUUC-Fal-037064 Ficedula albicollis 89.82 2.00e-152 530.00
IUUC-Fox-037813 Fusarium oxysporum 25.80 3.00e-16 78.60
IUUC-Fso-038139 Fusarium solani 26.67 1.00e-17 83.60
IUUC-Gmo-039509 Gadus morhua 81.08 9.00e-111 392.00
IUUC-Ggr-040111 Gaeumannomyces graminis 25.39 7.00e-14 71.20
IUUC-Gga-040517 Gallus gallus 89.09 1.00e-150 525.00
IUUC-Gac-042270 Gasterosteus aculeatus 76.92 1.00e-116 412.00
IUUC-Gma-044400 Glycine max 35.54 2.00e-23 102.00
IUUC-Ggo-045048 Gorilla gorilla 99.27 8.00e-160 555.00
IUUC-Hsa-046744 Homo sapiens 99.27 4.00e-159 553.00
IUUC-Kpa-049174 Komagataella pastoris 25.00 8.00e-15 74.30
IUUC-Lch-049475 Latimeria chalumnae 88.00 1.00e-146 511.00
IUUC-Lpe-051283 Leersia perrieri 35.46 5.00e-24 106.00
IUUC-Loc-052446 Lepisosteus oculatus 83.64 2.00e-141 494.00
IUUC-Lma-053278 Leptosphaeria maculans 27.22 2.00e-29 122.00
IUUC-Laf-054020 Loxodonta africana 98.19 6.00e-157 546.00
IUUC-Mcc-055176 Macaca mulatta 99.27 4.00e-159 553.00
IUUC-Mor-057164 Magnaporthe oryzae 27.34 2.00e-16 79.70
IUUC-Mpo-057428 Magnaporthe poae 26.27 3.00e-13 68.90
IUUC-Mtr-058424 Medicago truncatula 35.37 3.00e-23 101.00
IUUC-Mla-058872 Melampsora laricipopulina 29.41 3.00e-29 122.00
IUUC-Mga-059859 Meleagris gallopavo 89.09 1.00e-150 525.00
IUUC-Mmr-061482 Microcebus murinus 98.55 6.00e-158 549.00
IUUC-Mdo-062371 Monodelphis domestica 94.91 1.00e-158 551.00
IUUC-Mmu-063139 Mus musculus 96.73 2.00e-156 543.00
IUUC-Mac-065332 Musa acuminata 34.48 7.00e-26 111.00
IUUC-Mpu-066783 Mustela putorius furo 98.18 4.00e-157 546.00
IUUC-Mlu-068165 Myotis lucifugus 95.31 1.00e-152 531.00
IUUC-Nfi-068578 Neosartorya fischeri 27.07 1.00e-27 117.00
IUUC-Ncr-068636 Neurospora crassa 24.24 4.00e-12 65.50
IUUC-Nle-069740 Nomascus leucogenys 99.64 2.00e-159 554.00
IUUC-Opr-070802 Ochotona princeps 99.37 1.00e-86 312.00
IUUC-Ont-072222 Oreochromis niloticus 78.91 4.00e-135 473.00
IUUC-Oan-072760 Ornithorhynchus anatinus 94.42 8.00e-112 395.00
IUUC-Ocu-074844 Oryctolagus cuniculus 95.93 1.00e-97 348.00
IUUC-Oba-075834 Oryza barthii 33.33 1.00e-24 107.00
IUUC-Obr-076230 Oryza brachyantha 32.69 7.00e-15 74.30
IUUC-Ogl-077554 Oryza glaberrima 33.33 1.00e-24 107.00
IUUC-Ogu-078687 Oryza glumaepatula 33.33 8.00e-25 107.00
IUUC-Oin-079677 Oryza indica 26.10 3.00e-26 112.00
IUUC-Olo-081078 Oryza longistaminata 36.11 2.00e-25 110.00
IUUC-Ome-081548 Oryza meridionalis 33.90 2.00e-27 117.00
IUUC-Oni-082050 Oryza nivara 33.90 3.00e-25 109.00
IUUC-Opu-083609 Oryza punctata 33.71 2.00e-25 109.00
IUUC-Oru-085057 Oryza rufipogon 33.90 4.00e-25 108.00
IUUC-Osa-085917 Oryza sativa 33.90 5.00e-25 108.00
IUUC-Ola-087032 Oryzias latipes 78.91 3.00e-133 467.00
IUUC-Olu-087877 Ostreococcus lucimarinus 25.88 2.20e-02 31.60
IUUC-Oga-088468 Otolemur garnettii 97.11 2.00e-160 557.00
IUUC-Oar-089751 Ovis aries 97.82 7.00e-157 545.00
IUUC-Ptr-091064 Pan troglodytes 99.27 4.00e-159 553.00
IUUC-Pan-092505 Papio anubis 98.92 7.00e-158 549.00
IUUC-Psi-093086 Pelodiscus sinensis 90.94 5.00e-153 533.00
IUUC-Pno-094825 Phaeosphaeria nodorum 28.07 9.00e-27 113.00
IUUC-Ppa-095419 Physcomitrella patens 33.13 3.00e-25 109.00
IUUC-Pfo-096224 Poecilia formosa 78.18 1.00e-132 465.00
IUUC-Pop-099243 Populus trichocarpa 27.96 4.00e-25 108.00
IUUC-Ppe-101255 Prunus persica 26.76 1.00e-27 117.00
IUUC-Pva-102828 Pteropus vampyrus 97.45 8.00e-156 542.00
IUUC-Pgr-103672 Puccinia graminis 29.28 3.00e-25 108.00
IUUC-Ptt-104013 Puccinia triticina 27.05 2.00e-21 96.70
IUUC-Pyt-104615 Pyrenophora triticirepentis 27.69 1.00e-27 117.00
IUUC-Rno-106089 Rattus norvegicus 93.88 6.00e-134 469.00
IUUC-Sce-106216 Saccharomyces cerevisiae 24.72 2.00e-12 66.20
IUUC-Sha-106484 Sarcophilus harrisii 94.91 2.00e-158 551.00
IUUC-Sja-107699 Schizosaccharomyces japonicus 27.44 3.00e-26 112.00
IUUC-Spo-108177 Schizosaccharomyces pombe 28.11 1.00e-22 99.40
IUUC-Ssl-108475 Sclerotinia sclerotiorum 27.34 4.00e-16 78.20
IUUC-Smo-109473 Selaginella moellendorffii 27.74 1.00e-23 103.00
IUUC-Sit-110736 Setaria italica 25.22 5.00e-29 121.00
IUUC-Sly-111657 Solanum lycopersicum 36.59 4.00e-27 115.00
IUUC-Sar-113050 Sorex araneus 82.43 2.00e-107 381.00
IUUC-Sbi-114258 Sorghum bicolor 33.33 1.00e-25 110.00
IUUC-Sre-114902 Sporisorium reilianum 31.19 6.00e-23 102.00
IUUC-Ssc-116166 Sus scrofa 91.27 2.00e-146 511.00
IUUC-Tgu-116814 Taeniopygia guttata 89.09 5.00e-151 526.00
IUUC-Tru-118172 Takifugu rubripes 79.35 2.00e-133 468.00
IUUC-Tsy-119010 Tarsius syrichta 84.36 3.00e-134 470.00
IUUC-Tni-120397 Tetraodon nigroviridis 79.52 2.00e-101 360.00
IUUC-Tca-121283 Theobroma cacao 28.49 5.00e-29 121.00
IUUC-Tvi-122545 Trichoderma virens 24.05 3.00e-14 72.00
IUUC-Tae-122685 Triticum aestivum 31.58 2.00e-24 105.00
IUUC-Tur-126407 Triticum urartu 34.00 4.00e-25 108.00
IUUC-Tme-126913 Tuber melanosporum 30.88 1.00e-39 156.00
IUUC-Tbe-127738 Tupaia belangeri 90.82 2.00e-105 374.00
IUUC-Ttr-128528 Tursiops truncatus 97.82 3.00e-156 543.00
IUUC-Uma-129625 Ustilago maydis 28.11 1.00e-20 94.40
IUUC-Vda-129906 Verticillium dahliae 23.11 2.00e-10 58.90
IUUC-Vpa-130223 Vicugna pacos 96.73 7.00e-151 526.00
IUUC-Vvi-131617 Vitis vinifera 33.53 1.00e-24 107.00
IUUC-Xtr-132288 Xenopus tropicalis 86.18 6.00e-143 499.00
IUUC-Xma-134214 Xiphophorus maculatus 81.87 9.00e-97 345.00
IUUC-Yli-134377 Yarrowia lipolytica 24.88 1.00e-12 66.20
IUUC-Zma-135108 Zea mays 34.03 6.00e-24 104.00
Created Date 25-Jun-2017

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