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Tag Content
UUCD2 ID IUUC-Oan-073621
UUCD1 version UUC-OrA-00158
Ensembl Protein ID ENSOANP00000012296.1
UniProt Accession F6TJ28; F6TJ28_ORNAN
Genbank Protein ID ENSOANP00000012296
Protein Name Uncharacterized protein
Genbank Nucleotide ID AAPN01301399
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOANG00000007719.2 ENSOANT00000012298.1 ENSOANP00000012296.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.50e-128 429.1 426 758
Active Site
Position(s) Description Evidence
727 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ +tlq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 426  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 513
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 514  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 598
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 599  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CTADSNIVKWFWQAVETFDEERRARLLQFV 686
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+    prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 687  TGSTRVPLQGFKALQgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 758
           ***************************99999**************************************76 PP
   
Organism Ornithorhynchus anatinus
Protein Sequence
(Fasta)
GRKRGEVQLK IAVLCAKNLA KKDFFRLPDP FAKIVVDGSG QCHSTDTVKN TLDPKWNQHY 60
DLYVGKTDSI TISVWNHKKI HKKQGAGFLG CVRLLSNAIS RLKDTGYQRL DLCKLNPTDT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Oan-073621|E3,HECT|Ornithorhynchus anatinus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGAGAAAAA GAGGGGAAGT ACAGTTAATT TCTGAACCTC CGAAATGCTC TTCTGTGTGT 60
GTTCTTGAAG TCATCAGATA TATCTGAACT GTGAAAGTCC TGGTGGTGTC TTAATCGCAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Oan-073621|E3,HECT|Ornithorhynchus anatinus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001459 Ailuropoda melanoleuca 92.18 0.00e+00 1427.00
IUUC-Apl-004155 Anas platyrhynchos 90.12 0.00e+00 1425.00
IUUC-Aca-005238 Anolis carolinensis 91.27 0.00e+00 1428.00
IUUC-Ame-010901 Astyanax mexicanus 85.56 0.00e+00 1347.00
IUUC-Bta-013221 Bos taurus 92.42 0.00e+00 1360.00
IUUC-Cja-018985 Callithrix jacchus 88.45 0.00e+00 1424.00
IUUC-Cfa-020568 Canis familiaris 88.20 0.00e+00 1401.00
IUUC-Cpo-022531 Cavia porcellus 87.94 0.00e+00 1416.00
IUUC-Csa-024145 Chlorocebus sabaeus 91.83 0.00e+00 1445.00
IUUC-Cho-024963 Choloepus hoffmanni 76.03 0.00e+00 750.00
IUUC-Dre-028341 Danio rerio 85.85 0.00e+00 1357.00
IUUC-Dno-029705 Dasypus novemcinctus 88.67 0.00e+00 1386.00
IUUC-Dme-031740 Drosophila melanogaster 70.85 1.00e-173 603.00
IUUC-Eca-034125 Equus caballus 89.32 0.00e+00 1414.00
IUUC-Fca-035905 Felis catus 91.63 0.00e+00 1410.00
IUUC-Fal-037336 Ficedula albicollis 92.41 0.00e+00 1417.00
IUUC-Gmo-039486 Gadus morhua 80.11 0.00e+00 868.00
IUUC-Gga-040218 Gallus gallus 90.43 0.00e+00 1432.00
IUUC-Gac-041707 Gasterosteus aculeatus 79.45 0.00e+00 1243.00
IUUC-Ggo-045408 Gorilla gorilla 84.17 0.00e+00 1312.00
IUUC-Hsa-045878 Homo sapiens 88.58 0.00e+00 1426.00
IUUC-Itr-048317 Ictidomys tridecemlineatus 89.30 0.00e+00 1415.00
IUUC-Loc-052628 Lepisosteus oculatus 84.64 0.00e+00 1363.00
IUUC-Laf-053644 Loxodonta africana 92.38 0.00e+00 1394.00
IUUC-Mcc-055479 Macaca mulatta 83.60 0.00e+00 1278.00
IUUC-Mga-059723 Meleagris gallopavo 92.55 0.00e+00 1419.00
IUUC-Mdo-063005 Monodelphis domestica 92.51 0.00e+00 1453.00
IUUC-Mmu-063634 Mus musculus 90.81 0.00e+00 1407.00
IUUC-Mpu-065898 Mustela putorius furo 91.16 0.00e+00 1414.00
IUUC-Mlu-067584 Myotis lucifugus 89.19 0.00e+00 1412.00
IUUC-Nle-069033 Nomascus leucogenys 89.70 0.00e+00 1419.00
IUUC-Ont-072265 Oreochromis niloticus 78.26 0.00e+00 1257.00
IUUC-Ocu-073960 Oryctolagus cuniculus 88.06 0.00e+00 1382.00
IUUC-Oga-088579 Otolemur garnettii 88.58 0.00e+00 1425.00
IUUC-Oar-090396 Ovis aries 87.29 0.00e+00 1319.00
IUUC-Ptr-091624 Pan troglodytes 88.58 0.00e+00 1426.00
IUUC-Pan-092479 Papio anubis 89.58 0.00e+00 1419.00
IUUC-Pfo-097203 Poecilia formosa 80.05 0.00e+00 1271.00
IUUC-Pab-097540 Pongo abelii 87.95 0.00e+00 1354.00
IUUC-Pca-100379 Procavia capensis 72.08 0.00e+00 632.00
IUUC-Rno-105396 Rattus norvegicus 90.81 0.00e+00 1409.00
IUUC-Sha-107216 Sarcophilus harrisii 90.13 0.00e+00 1436.00
IUUC-Ssc-116413 Sus scrofa 90.55 0.00e+00 1387.00
IUUC-Tgu-116723 Taeniopygia guttata 88.96 0.00e+00 1393.00
IUUC-Tru-117843 Takifugu rubripes 80.76 0.00e+00 1272.00
IUUC-Tsy-119455 Tarsius syrichta 88.44 0.00e+00 1321.00
IUUC-Tni-120829 Tetraodon nigroviridis 79.55 0.00e+00 1205.00
IUUC-Tbe-127879 Tupaia belangeri 76.60 0.00e+00 1156.00
IUUC-Ttr-128423 Tursiops truncatus 87.89 0.00e+00 1335.00
IUUC-Xtr-132237 Xenopus tropicalis 82.95 0.00e+00 1343.00
Created Date 25-Jun-2017

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