iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-087965

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03137108

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000013436.2	ENSOGAT00000013443.2	ENSOGAP00000012039.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-122	408.8	1241	1573

Active Site

Position(s)	Description	Evidence
1541	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1241 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1326
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1327 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1409
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1410 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1496
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1497 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1573
           ************************999***********************************************985 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MASPSRNSQS RRRCKEPLRY SYHPDQFPTM DIGGGPHGGV TIPRSTSDTD LVTSDSRSTL 60
MVSSSYYSIG HSQDLVIHWD IKEEVDAGDW IGMYLIGDID EVLSENFLDY KNRGVNGSHR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTTCTC CATCCAGAAA CTCCCAGAGC CGACGCCGGT GCAAGGAGCC GCTGCGCTAC 60
AGCTACCACC CTGACCAGTT CCCCACCATG GACATCGGGG GTGGCCCCCA CGGCGGTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	86.22	0.00e+00	2147.00
IUUC-Apl-003299	Anas platyrhynchos	80.29	0.00e+00	2375.00
IUUC-Aca-005024	Anolis carolinensis	78.64	0.00e+00	2331.00
IUUC-Bta-012604	Bos taurus	89.10	0.00e+00	2572.00
IUUC-Cja-019880	Callithrix jacchus	86.16	0.00e+00	2237.00
IUUC-Cfa-021216	Canis familiaris	91.24	0.00e+00	1801.00
IUUC-Cpo-021466	Cavia porcellus	97.10	0.00e+00	1722.00
IUUC-Csa-023080	Chlorocebus sabaeus	91.64	0.00e+00	2667.00
IUUC-Cho-024740	Choloepus hoffmanni	92.76	0.00e+00	1137.00
IUUC-Dre-028750	Danio rerio	73.43	0.00e+00	1544.00
IUUC-Dno-030019	Dasypus novemcinctus	89.35	0.00e+00	2605.00
IUUC-Dor-031030	Dipodomys ordii	73.33	0.00e+00	1133.00
IUUC-Ete-032352	Echinops telfairi	94.29	0.00e+00	1261.00
IUUC-Eca-033948	Equus caballus	87.81	0.00e+00	2505.00
IUUC-Eeu-034474	Erinaceus europaeus	71.18	0.00e+00	1571.00
IUUC-Fca-036148	Felis catus	90.19	0.00e+00	2549.00
IUUC-Fal-036957	Ficedula albicollis	79.71	0.00e+00	2344.00
IUUC-Gmo-038714	Gadus morhua	68.88	0.00e+00	1015.00
IUUC-Gga-041194	Gallus gallus	79.54	0.00e+00	2351.00
IUUC-Gac-041366	Gasterosteus aculeatus	77.90	0.00e+00	1369.00
IUUC-Ggo-045442	Gorilla gorilla	77.20	0.00e+00	2022.00
IUUC-Hsa-045730	Homo sapiens	91.77	0.00e+00	2667.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	90.81	0.00e+00	2658.00
IUUC-Lch-050185	Latimeria chalumnae	73.01	0.00e+00	1389.00
IUUC-Loc-052744	Lepisosteus oculatus	73.52	0.00e+00	2154.00
IUUC-Laf-054368	Loxodonta africana	98.32	0.00e+00	1503.00
IUUC-Mcc-055487	Macaca mulatta	91.25	0.00e+00	2667.00
IUUC-Meu-056751	Macropus eugenii	91.60	0.00e+00	729.00
IUUC-Mga-059545	Meleagris gallopavo	80.40	0.00e+00	2353.00
IUUC-Mmr-061078	Microcebus murinus	90.98	0.00e+00	2537.00
IUUC-Mdo-062176	Monodelphis domestica	84.78	0.00e+00	1694.00
IUUC-Mmu-063513	Mus musculus	86.43	0.00e+00	2457.00
IUUC-Mpu-065786	Mustela putorius furo	88.44	0.00e+00	2542.00
IUUC-Mlu-067780	Myotis lucifugus	83.20	0.00e+00	2295.00
IUUC-Nle-069213	Nomascus leucogenys	91.13	0.00e+00	2619.00
IUUC-Opr-070208	Ochotona princeps	97.05	0.00e+00	1493.00
IUUC-Ont-072132	Oreochromis niloticus	81.49	0.00e+00	1365.00
IUUC-Oan-072807	Ornithorhynchus anatinus	85.03	0.00e+00	1786.00
IUUC-Ocu-074745	Oryctolagus cuniculus	85.88	0.00e+00	2500.00
IUUC-Ola-086981	Oryzias latipes	73.10	0.00e+00	1482.00
IUUC-Oar-089749	Ovis aries	92.94	0.00e+00	1872.00
IUUC-Ptr-091243	Pan troglodytes	91.64	0.00e+00	2664.00
IUUC-Pan-092201	Papio anubis	90.74	0.00e+00	2680.00
IUUC-Psi-093511	Pelodiscus sinensis	78.73	0.00e+00	2319.00
IUUC-Pfo-097001	Poecilia formosa	65.55	0.00e+00	1581.00
IUUC-Pab-098728	Pongo abelii	88.95	0.00e+00	2550.00
IUUC-Pca-100129	Procavia capensis	82.32	0.00e+00	1255.00
IUUC-Pva-102250	Pteropus vampyrus	78.38	0.00e+00	2126.00
IUUC-Rno-105031	Rattus norvegicus	86.34	0.00e+00	2496.00
IUUC-Tgu-117515	Taeniopygia guttata	78.71	0.00e+00	2341.00
IUUC-Tru-117914	Takifugu rubripes	76.34	0.00e+00	1382.00
IUUC-Tsy-119379	Tarsius syrichta	81.66	0.00e+00	1384.00
IUUC-Tni-120178	Tetraodon nigroviridis	77.02	0.00e+00	1392.00
IUUC-Tbe-127762	Tupaia belangeri	82.94	0.00e+00	1954.00
IUUC-Ttr-128806	Tursiops truncatus	93.49	0.00e+00	1745.00
IUUC-Xtr-132903	Xenopus tropicalis	73.95	0.00e+00	1870.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence