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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063841
UUCD1 version UUC-MuM-00673
Ensembl Protein ID ENSMUSP00000030841.5
UniProt Accession Q8BUL5; Q9CZP4; KLHL7_MOUSE
Genbank Protein ID BAB28163.1; BAC38883.1
Protein Name Kelch-like protein 7
Genbank Nucleotide ID AK012326; AK083358
Gene Name Klhl7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028986.12 ENSMUST00000030841.9 ENSMUSP00000030841.5
ENSMUSG00000028986.12 ENSMUST00000200116.4 ENSMUSP00000143000.1
ENSMUSG00000028986.12 ENSMUST00000163409.4 ENSMUSP00000129461.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 3.30e-18 66.9 44 110
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 3.80e-14 51.6 144 174
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dvil v++++++ah++vLaa+S++F+ +f++++ esk + +ve+kd +p+  ++l++F Yt +++ n
   Q: 44   CDVILTVQERKIPAHRVVLAAASHFFNLMFTTNMLESK-SFEVELKDAEPDIIEQLVEFAYTARISVN 110
           9*************************************.*************************9876 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhFk 32
           +Nclgi  +A+++dcp+Lk  a+dfi++hF+
   Q: 144  SNCLGISVLAECLDCPELKATADDFIHQHFT 174
           8*****************************7 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination (By similarity).
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination (By similarity).
Protein Sequence
(Fasta)
MATSGVEKSS KKKTEKKLAA REEAKLLAGF MGVMNNMRKQ RTLCDVILTV QERKIPAHRV 60
VLAAASHFFN LMFTTNMLES KSFEVELKDA EPDIIEQLVE FAYTARISVN SNNVQSLLDA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063841|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCTTCGCTTG CAACCGTGGC CGAGTTGGCT TCGTCTCGTC CTCCTTCGGC TTTCCCGCAG 60
TTCTCCGAGC TCCGCCGCCG AAGCCGTGCT CCAGACTGCC GCGTGTGGCG GGCAAACTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063841|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030599--KLHL7
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0042802--F:identical protein binding
GO:0042803--F:protein homodimerization activity
GO:0016567--P:protein ubiquitination
KEGG mmu:52323
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001981 Ailuropoda melanoleuca 97.78 0.00e+00 1157.00
IUUC-Apl-003183 Anas platyrhynchos 97.31 0.00e+00 1144.00
IUUC-Aca-004273 Anolis carolinensis 97.12 0.00e+00 1145.00
IUUC-Ame-011343 Astyanax mexicanus 83.36 0.00e+00 967.00
IUUC-Bta-012785 Bos taurus 97.61 0.00e+00 1154.00
IUUC-Cja-019038 Callithrix jacchus 97.61 0.00e+00 1178.00
IUUC-Cfa-020774 Canis familiaris 97.80 0.00e+00 1127.00
IUUC-Cpo-021716 Cavia porcellus 97.78 0.00e+00 1150.00
IUUC-Csa-023029 Chlorocebus sabaeus 97.78 0.00e+00 1157.00
IUUC-Cho-024947 Choloepus hoffmanni 75.43 0.00e+00 833.00
IUUC-Dre-028014 Danio rerio 83.59 0.00e+00 877.00
IUUC-Dno-029946 Dasypus novemcinctus 97.95 0.00e+00 1157.00
IUUC-Dor-030916 Dipodomys ordii 82.09 9.00e-175 606.00
IUUC-Dse-031294 Dothistroma septosporum 32.95 3.00e-06 44.30
IUUC-Ete-032454 Echinops telfairi 92.74 0.00e+00 630.00
IUUC-Eca-034041 Equus caballus 97.95 0.00e+00 1157.00
IUUC-Eeu-034627 Erinaceus europaeus 97.56 0.00e+00 958.00
IUUC-Fca-035854 Felis catus 97.78 0.00e+00 1157.00
IUUC-Fal-036883 Ficedula albicollis 96.94 0.00e+00 1141.00
IUUC-Gmo-038902 Gadus morhua 78.56 0.00e+00 896.00
IUUC-Gga-040866 Gallus gallus 97.31 0.00e+00 1149.00
IUUC-Gac-041428 Gasterosteus aculeatus 78.49 0.00e+00 942.00
IUUC-Ggo-044846 Gorilla gorilla 92.06 0.00e+00 1067.00
IUUC-Hsa-047034 Homo sapiens 97.78 0.00e+00 1157.00
IUUC-Itr-048807 Ictidomys tridecemlineatus 98.11 4.00e-139 486.00
IUUC-Lch-049815 Latimeria chalumnae 89.13 0.00e+00 1044.00
IUUC-Loc-052232 Lepisosteus oculatus 83.62 0.00e+00 904.00
IUUC-Laf-053520 Loxodonta africana 97.44 0.00e+00 1154.00
IUUC-Mcc-055237 Macaca mulatta 97.61 0.00e+00 1157.00
IUUC-Meu-056095 Macropus eugenii 90.65 4.00e-172 596.00
IUUC-Mor-057181 Magnaporthe oryzae 29.01 7.00e-11 61.60
IUUC-Mga-059927 Meleagris gallopavo 97.31 0.00e+00 1149.00
IUUC-Mmr-060974 Microcebus murinus 96.43 0.00e+00 1137.00
IUUC-Mdo-062729 Monodelphis domestica 90.62 0.00e+00 1100.00
IUUC-Mpu-066524 Mustela putorius furo 95.02 0.00e+00 1146.00
IUUC-Mlu-067215 Myotis lucifugus 97.85 0.00e+00 1154.00
IUUC-Nle-069341 Nomascus leucogenys 97.78 0.00e+00 1157.00
IUUC-Opr-070269 Ochotona princeps 97.95 0.00e+00 1157.00
IUUC-Ont-071551 Oreochromis niloticus 79.43 0.00e+00 939.00
IUUC-Oan-072718 Ornithorhynchus anatinus 97.45 0.00e+00 1131.00
IUUC-Ocu-074287 Oryctolagus cuniculus 97.78 0.00e+00 1157.00
IUUC-Ola-086718 Oryzias latipes 78.37 0.00e+00 952.00
IUUC-Oga-088757 Otolemur garnettii 97.27 0.00e+00 1155.00
IUUC-Oar-090309 Ovis aries 97.61 0.00e+00 1154.00
IUUC-Ptr-090509 Pan troglodytes 97.78 0.00e+00 1157.00
IUUC-Pan-092929 Papio anubis 97.78 0.00e+00 1157.00
IUUC-Psi-092941 Pelodiscus sinensis 97.13 0.00e+00 1144.00
IUUC-Pfo-097421 Poecilia formosa 79.21 0.00e+00 927.00
IUUC-Pab-097792 Pongo abelii 97.78 0.00e+00 1157.00
IUUC-Pca-101033 Procavia capensis 88.62 0.00e+00 843.00
IUUC-Pva-102364 Pteropus vampyrus 87.71 0.00e+00 1011.00
IUUC-Rno-105596 Rattus norvegicus 99.49 0.00e+00 1173.00
IUUC-Sha-106815 Sarcophilus harrisii 97.95 0.00e+00 1109.00
IUUC-Smo-109320 Selaginella moellendorffii 26.72 9.00e-16 79.00
IUUC-Sar-113305 Sorex araneus 98.12 0.00e+00 1157.00
IUUC-Ssc-115871 Sus scrofa 94.14 8.00e-166 575.00
IUUC-Tgu-116940 Taeniopygia guttata 96.58 0.00e+00 1137.00
IUUC-Tru-118682 Takifugu rubripes 78.69 0.00e+00 956.00
IUUC-Tsy-118787 Tarsius syrichta 97.37 0.00e+00 790.00
IUUC-Tni-120224 Tetraodon nigroviridis 79.43 0.00e+00 959.00
IUUC-Tbe-127633 Tupaia belangeri 57.05 4.00e-88 317.00
IUUC-Ttr-128500 Tursiops truncatus 97.13 0.00e+00 1142.00
IUUC-Vpa-130512 Vicugna pacos 95.26 0.00e+00 1101.00
IUUC-Xtr-131983 Xenopus tropicalis 96.05 0.00e+00 1132.00
Created Date 25-Jun-2017

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