iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091551

Ensembl Protein ID

ENSPTRP00000048521.2

UniProt Accession

H2R5W0; H2R5W0_PANTR

Protein Name

Tyrosine-protein kinase

Gene Name

BLK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000019991.4	ENSPTRT00000037044.4	ENSPTRP00000048521.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.50e-14	53.0	59	117

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +k+ v +lydy+a nd +L++ kG++++v+   +  ++W+ + +  +g++G +P+nFv+++e
   Q: 59   DKHFVVALYDYTAMNDRDLQMLKGEKLQVL---KGTGDWWLARSLVTGREGYVPSNFVARVE 117
           57899*************************...999************************97 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP LPDEHLDEDK 60
HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLARSL VTGREGYVPS NFVARVESLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGCTGG TAAGCAGCAA AAAGCCGGAC AAGGAAAAGC CGATCAAGGA GAAGGACAAG 60
GGCCAATGGA GCCCCCTGAA GGTCAGCGCC CAAGACAAGG ATGCCCCGCC ACTGCCACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0032024--P:positive regulation of insulin secretion
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	88.41	0.00e+00	880.00
IUUC-Apl-003307	Anas platyrhynchos	74.65	0.00e+00	697.00
IUUC-Aca-004357	Anolis carolinensis	68.94	0.00e+00	639.00
IUUC-Ame-010642	Astyanax mexicanus	70.07	0.00e+00	655.00
IUUC-Bta-012400	Bos taurus	86.04	0.00e+00	870.00
IUUC-Cja-019717	Callithrix jacchus	88.21	0.00e+00	739.00
IUUC-Cfa-021056	Canis familiaris	86.83	0.00e+00	894.00
IUUC-Cpo-021779	Cavia porcellus	84.36	0.00e+00	822.00
IUUC-Csa-023557	Chlorocebus sabaeus	95.88	0.00e+00	920.00
IUUC-Dre-027517	Danio rerio	68.62	0.00e+00	662.00
IUUC-Eca-034218	Equus caballus	87.93	0.00e+00	870.00
IUUC-Eeu-035095	Erinaceus europaeus	66.67	0.00e+00	649.00
IUUC-Fca-036015	Felis catus	86.01	0.00e+00	883.00
IUUC-Fal-036946	Ficedula albicollis	74.88	0.00e+00	695.00
IUUC-Gga-040822	Gallus gallus	73.72	0.00e+00	699.00
IUUC-Ggo-044608	Gorilla gorilla	97.37	0.00e+00	1013.00
IUUC-Hsa-046719	Homo sapiens	97.94	0.00e+00	955.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	87.24	0.00e+00	870.00
IUUC-Laf-053387	Loxodonta africana	84.98	0.00e+00	873.00
IUUC-Mcc-055026	Macaca mulatta	96.30	0.00e+00	923.00
IUUC-Mga-059427	Meleagris gallopavo	73.26	0.00e+00	688.00
IUUC-Mmr-061660	Microcebus murinus	88.07	0.00e+00	874.00
IUUC-Mdo-062318	Monodelphis domestica	72.95	0.00e+00	746.00
IUUC-Mmu-063325	Mus musculus	84.77	0.00e+00	868.00
IUUC-Mpu-066582	Mustela putorius furo	87.98	0.00e+00	875.00
IUUC-Nle-069624	Nomascus leucogenys	95.47	0.00e+00	892.00
IUUC-Opr-070656	Ochotona princeps	80.04	0.00e+00	762.00
IUUC-Ont-072266	Oreochromis niloticus	68.82	0.00e+00	642.00
IUUC-Ocu-073907	Oryctolagus cuniculus	84.16	0.00e+00	827.00
IUUC-Oga-088057	Otolemur garnettii	87.06	0.00e+00	872.00
IUUC-Oar-089332	Ovis aries	81.31	0.00e+00	825.00
IUUC-Pan-092173	Papio anubis	95.68	0.00e+00	897.00
IUUC-Psi-093895	Pelodiscus sinensis	73.03	0.00e+00	704.00
IUUC-Pab-097598	Pongo abelii	96.30	0.00e+00	903.00
IUUC-Pva-102135	Pteropus vampyrus	88.09	0.00e+00	837.00
IUUC-Rno-104891	Rattus norvegicus	85.60	0.00e+00	839.00
IUUC-Sha-107192	Sarcophilus harrisii	75.46	0.00e+00	764.00
IUUC-Ssc-115696	Sus scrofa	85.83	0.00e+00	879.00
IUUC-Tgu-117056	Taeniopygia guttata	74.12	0.00e+00	689.00
IUUC-Tbe-127520	Tupaia belangeri	87.30	0.00e+00	697.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence