iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000179698.13	ENST00000534167.5	ENSP00000435391.1
ENSG00000179698.13	ENST00000323662.8	ENSP00000320648.8

Annotation

Cancer Mutation
ICGC	COSMIC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	InWeb_IM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.60e-16	59.9	331	363

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           gHt++vt++   ++ tl++s+s Dgt++ WDl 
   Q: 331  GHTGPVTAMTVlPNtTLVLSASQDGTLRTWDLQ 363
           8********978666****************85 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MEAEVWEAEG YNLVLDSDLY DADGYDVPDP GLLTEKNELT FTEPSQVLPF LTSSQQWQSL 60
TPRARARRLW LLLRTSLHEV VEKEKRAELR AARLTHGLEP LRRLEVAAGL RSVAQDPVGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCTCTGGG ACCGCAGTTG CTGAAATGGA GGCAGAGGTG TGGGAGGCAG AAGGCTACAA 60
CCTAGTTCTG GACTCGGACC TGTATGATGC GGATGGCTAT GATGTCCCAG ACCCTGGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm

KEGG

hsa:340390

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001634	Ailuropoda melanoleuca	67.52	0.00e+00	1608.00
IUUC-Aca-004338	Anolis carolinensis	33.26	8.00e-49	188.00
IUUC-Ame-011119	Astyanax mexicanus	30.71	1.00e-16	80.10
IUUC-Bta-013156	Bos taurus	70.06	0.00e+00	1194.00
IUUC-Cja-019751	Callithrix jacchus	79.88	0.00e+00	1155.00
IUUC-Cfa-020762	Canis familiaris	68.60	0.00e+00	1097.00
IUUC-Cpo-021294	Cavia porcellus	74.78	0.00e+00	1097.00
IUUC-Csa-023056	Chlorocebus sabaeus	91.49	0.00e+00	2394.00
IUUC-Dre-027485	Danio rerio	28.71	7.00e-52	199.00
IUUC-Dno-029124	Dasypus novemcinctus	68.32	0.00e+00	1028.00
IUUC-Dor-031028	Dipodomys ordii	71.52	0.00e+00	872.00
IUUC-Eca-033731	Equus caballus	78.88	0.00e+00	1050.00
IUUC-Eeu-035238	Erinaceus europaeus	64.13	3.00e-122	432.00
IUUC-Fca-035830	Felis catus	79.25	0.00e+00	1199.00
IUUC-Ggo-045403	Gorilla gorilla	97.23	0.00e+00	2676.00
IUUC-Itr-048146	Ictidomys tridecemlineatus	68.83	0.00e+00	1779.00
IUUC-Lch-050064	Latimeria chalumnae	34.29	2.00e-99	356.00
IUUC-Loc-051877	Lepisosteus oculatus	31.76	8.00e-79	289.00
IUUC-Mcc-055043	Macaca mulatta	90.51	0.00e+00	2275.00
IUUC-Meu-056016	Macropus eugenii	55.94	0.00e+00	692.00
IUUC-Mmr-061379	Microcebus murinus	68.64	0.00e+00	1798.00
IUUC-Mmu-064193	Mus musculus	56.14	0.00e+00	1460.00
IUUC-Mlu-067080	Myotis lucifugus	63.05	0.00e+00	1544.00
IUUC-Nle-069838	Nomascus leucogenys	92.50	0.00e+00	2488.00
IUUC-Opr-071152	Ochotona princeps	77.30	4.00e-127	448.00
IUUC-Oga-088927	Otolemur garnettii	68.06	0.00e+00	1767.00
IUUC-Oar-089930	Ovis aries	58.33	0.00e+00	1050.00
IUUC-Ptr-091677	Pan troglodytes	95.24	0.00e+00	1365.00
IUUC-Pan-092861	Papio anubis	91.24	0.00e+00	2336.00
IUUC-Pfo-097158	Poecilia formosa	25.99	3.00e-52	200.00
IUUC-Pab-097743	Pongo abelii	97.65	0.00e+00	1389.00
IUUC-Pca-100520	Procavia capensis	80.40	0.00e+00	792.00
IUUC-Pva-102814	Pteropus vampyrus	78.59	0.00e+00	1049.00
IUUC-Rno-105018	Rattus norvegicus	58.17	0.00e+00	1496.00
IUUC-Sar-113385	Sorex araneus	64.53	0.00e+00	783.00
IUUC-Ssc-115745	Sus scrofa	67.03	0.00e+00	1641.00
IUUC-Tbe-127804	Tupaia belangeri	78.30	3.00e-175	608.00
IUUC-Ttr-128208	Tursiops truncatus	78.02	0.00e+00	1076.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence