iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007033

Ensembl Protein ID

AT4G03240.1

UniProt Accession

Q9ZR07; Q6GKV0; FRDA_ARATH

Genbank Protein ID

AAU11485.1; AAD14452.1; CAB77809.1; AEE82296.1; AAT47815.1; BAD44211.1; BAD44594.1

Protein Name

Frataxin, mitochondrial

Genbank Nucleotide ID

AY649366; AC005275; AL161496; CP002687; BT014964; AK176448; AK176831

Gene Name

FH; At4g03240; F4C21.17

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G03240	AT4G03240.1	AT4G03240.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Other/Other	44.79	6.00e-18	88.20	IUUC-Hsa-046921

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Arabidopsis thaliana

Functional Description
(View)

Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways (PubMed:17092311). May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+) (PubMed:17092311). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (PubMed:17092311). Binds to the mitochondrial cysteine desulfurase NIFS1 and increases its activity (PubMed:22511606).

Protein Sequence
(Fasta)

MATASRFLLR KLPRFLKLSP TLLRSNGVRV SSNLIQDSIE PLDSFWRIGS RIRHDSLTTR 60
SFSSQGPASV DYSSVLQEEE FHKLANFTIN HLLEKIEDYG DNVQIDGFDI DYGNEVLTLK 120

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Nucleotide Sequence
(Fasta)

GTGACAGAAC CGCCATGGCT ACAGCTTCAA GGTTTCTTCT ACGGAAATTG CCGAGGTTTC 60
TCAAGCTGTC TCCAACTCTT CTCCGTAGCA ATGGCGTAAG AGTTTCAAGC AATCTGATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0350--Heme biosynthesis
KW-0406--Ion transport
KW-0408--Iron
KW-0409--Iron storage
KW-0410--Iron transport
KW-0496--Mitochondrion
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0813--Transport

Interpro

IPR017789--Frataxin
IPR002908--Frataxin/CyaY
IPR020895--Frataxin_CS

PROSITE

PS01344--FRATAXIN_1
PS50810--FRATAXIN_2

Pfam

PF01491--Frataxin_Cyay

SMART

SM01219--Frataxin_Cyay

Gene Ontology

GO:0009507--C:chloroplast
GO:0005739--C:mitochondrion
GO:0051537--F:2 iron, 2 sulfur cluster binding
GO:0008199--F:ferric iron binding
GO:0008198--F:ferrous iron binding
GO:0004322--F:ferroxidase activity
GO:0034986--F:iron chaperone activity
GO:0009060--P:aerobic respiration
GO:0006879--P:cellular iron ion homeostasis
GO:0034599--P:cellular response to oxidative stress
GO:0006783--P:heme biosynthetic process
GO:0006811--P:ion transport
GO:0018283--P:iron incorporation into metallo-sulfur cluster
GO:0007005--P:mitochondrion organization
GO:1903329--P:regulation of iron-sulfur cluster assembly
GO:0042542--P:response to hydrogen peroxide
GO:0006979--P:response to oxidative stress

KEGG

ath:AT4G03240

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002122	Ailuropoda melanoleuca	46.39	4.00e-20	90.50
IUUC-Apl-003853	Anas platyrhynchos	46.46	5.00e-20	89.00
IUUC-Aca-005026	Anolis carolinensis	44.66	6.00e-20	89.40
IUUC-Aly-006200	Arabidopsis lyrata	96.26	2.00e-93	333.00
IUUC-Ago-007707	Ashbya gossypii	50.00	2.00e-17	80.10
IUUC-Acl-008146	Aspergillus clavatus	47.13	4.00e-17	80.50
IUUC-Afl-008501	Aspergillus flavus	48.24	9.00e-17	79.30
IUUC-Afu-008851	Aspergillus fumigatus	42.35	6.00e-15	73.60
IUUC-Ani-009129	Aspergillus nidulans	36.36	3.00e-11	61.20
IUUC-Ang-009557	Aspergillus niger	42.35	2.00e-14	72.00
IUUC-Ate-010486	Aspergillus terreus	44.71	2.00e-16	77.80
IUUC-Bgr-012108	Blumeria graminis	45.33	2.00e-15	74.30
IUUC-Bta-013437	Bos taurus	46.74	1.00e-19	89.00
IUUC-Bci-013810	Botrytis cinerea	27.27	1.00e-11	62.00
IUUC-Bdi-014226	Brachypodium distachyon	68.07	2.00e-45	174.00
IUUC-Bol-015092	Brassica oleracea	83.51	7.00e-77	278.00
IUUC-Bra-017945	Brassica rapa	94.74	4.00e-53	199.00
IUUC-Cel-018466	Caenorhabditis elegans	44.00	9.00e-14	68.60
IUUC-Cja-019306	Callithrix jacchus	43.27	4.00e-20	90.50
IUUC-Cfa-020063	Canis familiaris	43.81	1.00e-20	92.40
IUUC-Cpo-021325	Cavia porcellus	45.00	5.00e-21	93.20
IUUC-Cre-022889	Chlamydomonas reinhardtii	50.55	2.00e-24	104.00
IUUC-Csa-023739	Chlorocebus sabaeus	41.90	5.00e-20	90.10
IUUC-Cho-024324	Choloepus hoffmanni	45.83	3.00e-18	84.30
IUUC-Cgl-026402	Colletotrichum gloeosporioides	39.42	4.00e-18	83.60
IUUC-Cne-027094	Cryptococcus neoformans	42.35	1.00e-14	72.40
IUUC-Cme-027112	Cyanidioschyzon merolae	38.06	3.00e-13	67.00
IUUC-Dre-028813	Danio rerio	46.88	3.00e-19	87.40
IUUC-Dno-029949	Dasypus novemcinctus	47.92	5.00e-21	92.40
IUUC-Dse-031482	Dothistroma septosporum	36.54	1.00e-15	75.50
IUUC-Dme-031608	Drosophila melanogaster	39.13	2.00e-18	84.70
IUUC-Ete-032937	Echinops telfairi	79.31	3.00e-08	50.40
IUUC-Eca-033899	Equus caballus	45.83	5.00e-20	89.70
IUUC-Fca-036579	Felis catus	48.86	9.00e-20	89.40
IUUC-Fox-037940	Fusarium oxysporum	36.79	5.00e-17	80.10
IUUC-Fso-038465	Fusarium solani	36.79	1.00e-16	79.30
IUUC-Ggr-040089	Gaeumannomyces graminis	38.60	1.00e-17	82.40
IUUC-Gga-040910	Gallus gallus	46.46	4.00e-20	90.10
IUUC-Gma-044349	Glycine max	74.19	6.00e-51	192.00
IUUC-Ggo-044854	Gorilla gorilla	34.32	2.00e-20	92.00
IUUC-Hsa-046921	Homo sapiens	34.88	3.00e-20	90.90
IUUC-Hvu-047142	Hordeum vulgare	58.45	1.00e-43	168.00
IUUC-Kpa-049187	Komagataella pastoris	38.66	8.00e-18	82.40
IUUC-Lch-050614	Latimeria chalumnae	41.80	5.00e-20	90.10
IUUC-Lpe-051184	Leersia perrieri	67.21	3.00e-47	180.00
IUUC-Loc-052083	Lepisosteus oculatus	46.00	3.00e-20	89.70
IUUC-Lma-053209	Leptosphaeria maculans	46.75	1.00e-15	75.50
IUUC-Laf-054090	Loxodonta africana	46.46	7.00e-21	92.80
IUUC-Meu-056814	Macropus eugenii	45.36	6.00e-19	85.90
IUUC-Mor-057169	Magnaporthe oryzae	49.35	9.00e-19	85.90
IUUC-Mpo-057483	Magnaporthe poae	37.72	1.00e-17	82.00
IUUC-Mtr-058166	Medicago truncatula	69.35	4.00e-35	140.00
IUUC-Mla-059015	Melampsora laricipopulina	41.05	4.00e-21	93.20
IUUC-Mvi-060356	Microbotryum violaceum	55.36	1.00e-15	75.90
IUUC-Mdo-062658	Monodelphis domestica	47.42	6.00e-20	90.10
IUUC-Mmu-063470	Mus musculus	44.76	3.00e-21	94.00
IUUC-Mac-065327	Musa acuminata	69.67	5.00e-46	176.00
IUUC-Mpu-065761	Mustela putorius furo	43.10	2.00e-20	90.90
IUUC-Mlu-067175	Myotis lucifugus	46.39	2.00e-20	92.00
IUUC-Nfi-068535	Neosartorya fischeri	42.35	3.00e-15	74.30
IUUC-Ncr-068966	Neurospora crassa	32.09	2.00e-16	78.60
IUUC-Opr-070533	Ochotona princeps	48.21	9.00e-10	55.50
IUUC-Oan-073024	Ornithorhynchus anatinus	50.00	5.00e-19	86.70
IUUC-Ocu-074451	Oryctolagus cuniculus	45.36	7.00e-20	90.50
IUUC-Oba-075540	Oryza barthii	59.86	1.00e-43	168.00
IUUC-Obr-076285	Oryza brachyantha	64.08	1.00e-47	182.00
IUUC-Ogl-077827	Oryza glaberrima	59.86	1.00e-43	168.00
IUUC-Ogu-078491	Oryza glumaepatula	68.97	1.00e-43	168.00
IUUC-Oin-080149	Oryza indica	70.18	2.00e-43	167.00
IUUC-Olo-080318	Oryza longistaminata	65.83	6.00e-41	158.00
IUUC-Oni-083037	Oryza nivara	68.97	2.00e-43	167.00
IUUC-Opu-083448	Oryza punctata	66.93	2.00e-45	174.00
IUUC-Oru-084793	Oryza rufipogon	68.97	2.00e-43	167.00
IUUC-Osa-086032	Oryza sativa	68.97	2.00e-43	167.00
IUUC-Ola-086956	Oryzias latipes	43.09	2.00e-19	87.80
IUUC-Olu-087806	Ostreococcus lucimarinus	41.94	1.00e-15	75.10
IUUC-Oga-089029	Otolemur garnettii	45.83	9.00e-20	89.40
IUUC-Oar-089471	Ovis aries	46.74	3.00e-19	87.80
IUUC-Pan-092091	Papio anubis	41.90	5.00e-20	90.10
IUUC-Psi-093193	Pelodiscus sinensis	46.46	3.00e-20	90.50
IUUC-Pma-094540	Petromyzon marinus	46.39	9.00e-20	88.20
IUUC-Pno-094873	Phaeosphaeria nodorum	40.00	3.00e-16	77.40
IUUC-Ppa-095343	Physcomitrella patens	53.15	1.00e-36	145.00
IUUC-Pfo-097093	Poecilia formosa	45.36	4.00e-18	84.00
IUUC-Pab-098781	Pongo abelii	55.93	3.00e-14	70.10
IUUC-Pop-098983	Populus trichocarpa	55.78	1.00e-49	188.00
IUUC-Pca-100872	Procavia capensis	46.67	3.00e-17	80.90
IUUC-Ppe-101711	Prunus persica	70.50	3.00e-49	186.00
IUUC-Pva-102256	Pteropus vampyrus	46.39	2.00e-19	87.80
IUUC-Pgr-103607	Puccinia graminis	40.35	2.00e-22	98.20
IUUC-Pte-104220	Pyrenophora teres	45.95	1.00e-14	71.20
IUUC-Pyt-104562	Pyrenophora triticirepentis	45.95	5.00e-15	73.20
IUUC-Rno-105021	Rattus norvegicus	40.40	3.00e-15	74.30
IUUC-Sce-106182	Saccharomyces cerevisiae	46.67	3.00e-12	64.30
IUUC-Sha-107279	Sarcophilus harrisii	48.45	4.00e-20	90.50
IUUC-Sja-107819	Schizosaccharomyces japonicus	38.05	1.00e-20	91.30
IUUC-Spo-108197	Schizosaccharomyces pombe	40.59	5.00e-19	86.30
IUUC-Smo-108810	Selaginella moellendorffii	61.80	1.00e-30	123.00
IUUC-Sit-110256	Setaria italica	63.08	2.00e-45	174.00
IUUC-Sly-111448	Solanum lycopersicum	73.60	6.00e-51	192.00
IUUC-Stu-112702	Solanum tuberosum	73.60	9.00e-51	192.00
IUUC-Sbi-113956	Sorghum bicolor	65.08	9.00e-47	178.00
IUUC-Sre-115024	Sporisorium reilianum	35.16	2.00e-16	78.20
IUUC-Ssc-116034	Sus scrofa	45.36	4.00e-20	90.50
IUUC-Tgu-117503	Taeniopygia guttata	47.83	4.00e-19	86.30
IUUC-Tni-120703	Tetraodon nigroviridis	30.43	8.00e-06	43.10
IUUC-Tca-121473	Theobroma cacao	76.61	1.00e-49	187.00
IUUC-Tre-122241	Trichoderma reesei	41.51	3.00e-18	83.20
IUUC-Tvi-122347	Trichoderma virens	38.46	3.00e-16	77.40
IUUC-Tae-124560	Triticum aestivum	65.71	4.00e-41	160.00
IUUC-Tur-126452	Triticum urartu	65.52	5.00e-41	159.00
IUUC-Tme-127205	Tuber melanosporum	40.66	2.00e-13	66.20
IUUC-Ttr-128186	Tursiops truncatus	40.00	2.00e-17	81.30
IUUC-Uma-129523	Ustilago maydis	34.21	1.00e-15	75.50
IUUC-Vda-129793	Verticillium dahliae	40.38	2.00e-18	84.30
IUUC-Vpa-130040	Vicugna pacos	44.33	1.00e-18	84.70
IUUC-Vvi-131588	Vitis vinifera	69.33	5.00e-51	192.00
IUUC-Yli-134631	Yarrowia lipolytica	38.64	1.00e-16	78.20
IUUC-Zma-135478	Zea mays	63.57	2.00e-46	177.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence