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Tag Content
iUUCD ID IUUC-Sja-107727
Ensembl Protein ID EEB08461
UniProt Accession B6K4Q4; B6K4Q4_SCHJY
Genbank Protein ID EEB08461.1
Protein Name Ubiquitin-related modifier 1
Genbank Nucleotide ID KE651167
Gene Name URM1; SJAG_03616
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SJAG_03616 EEB08461 EEB08461
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 43.30 2.00e-17 82.00 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Schizosaccharomyces japonicus
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MSIRVELCGG LDLLFNKQKE LTVQLTDIGQ NATVGDLIQY MTNKIEDESK CELFVMDGSV 60
RPGIIILVND QDWELLDKED YVLETKDNVV FVSTLHDHLG NISVQHSHRS VHLQ 114
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Protein Fasta Sequence


>IUUC-Sja-107727|ULD,UBQ_Other|Schizosaccharomyces japonicus
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Nucleotide Sequence
(Fasta)
ATGTCCATTC GGGTGGAACT GTGGTATGTG AATAAAAACG TTCATTACAA AAGTTTACTA 60
ATTAAATGTG CCCAGTGGCG GATTAGATCT GCTTTTTAAC AAGCAGAAAG AACTGACTGT 120
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Nucleotide Fasta Sequence


>IUUC-Sja-107727|ULD,UBQ_Other|Schizosaccharomyces japonicus
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Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 42.71 3.00e-17 77.80
IUUC-Atr-003089 Amborella trichopoda 39.80 3.00e-16 74.70
IUUC-Apl-003382 Anas platyrhynchos 42.05 4.00e-16 73.90
IUUC-Aca-004981 Anolis carolinensis 43.75 1.00e-17 79.30
IUUC-Aly-005517 Arabidopsis lyrata 38.89 1.00e-12 62.40
IUUC-Ath-006718 Arabidopsis thaliana 47.69 2.00e-11 58.50
IUUC-Ago-007917 Ashbya gossypii 44.33 2.00e-20 88.20
IUUC-Acl-008054 Aspergillus clavatus 57.14 7.00e-14 65.90
IUUC-Afl-008704 Aspergillus flavus 39.77 8.00e-17 75.90
IUUC-Aor-009890 Aspergillus oryzae 41.00 1.00e-20 89.70
IUUC-Bta-012448 Bos taurus 42.71 3.00e-17 77.80
IUUC-Bci-013865 Botrytis cinerea 47.47 9.00e-22 93.20
IUUC-Bdi-014980 Brachypodium distachyon 45.59 2.00e-12 61.60
IUUC-Bol-016055 Brassica oleracea 37.50 4.00e-11 57.40
IUUC-Bra-016845 Brassica rapa 37.50 4.00e-11 57.40
IUUC-Cel-018485 Caenorhabditis elegans 32.32 1.00e-07 46.20
IUUC-Cja-019587 Callithrix jacchus 41.67 3.00e-17 77.40
IUUC-Cfa-020653 Canis familiaris 41.67 4.00e-17 77.00
IUUC-Cpo-021622 Cavia porcellus 41.67 3.00e-17 77.40
IUUC-Cre-023015 Chlamydomonas reinhardtii 40.21 2.00e-15 71.60
IUUC-Csa-023756 Chlorocebus sabaeus 32.23 1.00e-11 59.70
IUUC-Cgl-026518 Colletotrichum gloeosporioides 40.40 7.00e-20 87.00
IUUC-Cne-026953 Cryptococcus neoformans 36.27 2.00e-14 69.30
IUUC-Cme-027314 Cyanidioschyzon merolae 41.05 5.00e-13 63.50
IUUC-Dre-027884 Danio rerio 41.67 2.00e-17 78.20
IUUC-Dno-029262 Dasypus novemcinctus 39.47 4.00e-10 55.50
IUUC-Dor-030601 Dipodomys ordii 46.94 2.00e-06 42.00
IUUC-Dme-031893 Drosophila melanogaster 43.88 2.00e-17 78.60
IUUC-Ete-032773 Echinops telfairi 41.24 1.00e-14 68.90
IUUC-Eca-034187 Equus caballus 40.62 5.00e-17 77.00
IUUC-Eeu-034808 Erinaceus europaeus 41.67 2.00e-17 78.20
IUUC-Fca-036107 Felis catus 42.71 1.00e-17 79.30
IUUC-Fal-036607 Ficedula albicollis 40.91 3.00e-15 70.90
IUUC-Fox-037698 Fusarium oxysporum 42.42 9.00e-20 86.30
IUUC-Gmo-039492 Gadus morhua 41.67 6.00e-17 76.60
IUUC-Ggr-039965 Gaeumannomyces graminis 44.44 3.00e-21 92.40
IUUC-Gga-041268 Gallus gallus 41.67 5.00e-18 80.10
IUUC-Gac-042111 Gasterosteus aculeatus 44.79 2.00e-18 81.30
IUUC-Gma-043240 Glycine max 48.39 2.00e-10 55.50
IUUC-Ggo-045176 Gorilla gorilla 39.47 3.00e-09 52.00
IUUC-Hsa-046077 Homo sapiens 41.67 3.00e-15 71.20
IUUC-Itr-048111 Ictidomys tridecemlineatus 42.05 4.00e-13 63.50
IUUC-Kpa-049157 Komagataella pastoris 41.24 9.00e-18 79.30
IUUC-Lch-049889 Latimeria chalumnae 42.71 6.00e-18 80.10
IUUC-Lpe-050783 Leersia perrieri 40.00 2.00e-11 58.90
IUUC-Loc-052400 Lepisosteus oculatus 40.62 3.00e-17 77.80
IUUC-Lma-053259 Leptosphaeria maculans 39.39 2.00e-20 88.60
IUUC-Laf-053596 Loxodonta africana 42.86 3.00e-17 77.80
IUUC-Mcc-054845 Macaca mulatta 41.38 2.00e-14 68.20
IUUC-Meu-055968 Macropus eugenii 40.62 7.00e-17 76.60
IUUC-Mor-057126 Magnaporthe oryzae 41.41 2.00e-19 85.90
IUUC-Mpo-057311 Magnaporthe poae 44.44 3.00e-21 92.00
IUUC-Mtr-058266 Medicago truncatula 41.98 2.00e-10 55.10
IUUC-Mla-058847 Melampsora laricipopulina 36.36 5.00e-14 67.40
IUUC-Mga-059468 Meleagris gallopavo 42.05 4.00e-16 73.90
IUUC-Mvi-060235 Microbotryum violaceum 50.82 2.00e-13 65.90
IUUC-Mdo-061948 Monodelphis domestica 40.62 2.00e-16 75.50
IUUC-Mmu-063946 Mus musculus 39.58 9.00e-17 76.30
IUUC-Mac-064812 Musa acuminata 48.44 3.00e-12 61.20
IUUC-Mpu-066763 Mustela putorius furo 41.67 9.00e-18 79.30
IUUC-Mlu-066970 Myotis lucifugus 39.47 4.00e-11 57.00
IUUC-Ncr-068824 Neurospora crassa 44.44 1.00e-20 89.00
IUUC-Nle-069849 Nomascus leucogenys 39.47 6.00e-11 57.80
IUUC-Opr-070227 Ochotona princeps 41.67 3.00e-17 77.40
IUUC-Ont-072530 Oreochromis niloticus 43.75 2.00e-18 81.30
IUUC-Oan-073191 Ornithorhynchus anatinus 39.58 2.00e-16 75.10
IUUC-Ocu-074460 Oryctolagus cuniculus 42.71 1.00e-17 79.30
IUUC-Oba-075499 Oryza barthii 45.59 1.00e-10 57.00
IUUC-Obr-076896 Oryza brachyantha 53.06 7.00e-11 58.50
IUUC-Ogl-077834 Oryza glaberrima 45.59 8.00e-11 56.60
IUUC-Ogu-078622 Oryza glumaepatula 45.59 8.00e-11 56.60
IUUC-Oin-079358 Oryza indica 45.59 2.00e-10 57.00
IUUC-Olo-081035 Oryza longistaminata 40.66 2.00e-12 63.50
IUUC-Oni-082425 Oryza nivara 45.59 8.00e-11 56.60
IUUC-Opu-083461 Oryza punctata 39.51 1.00e-10 57.00
IUUC-Oru-084875 Oryza rufipogon 50.00 5.00e-09 50.10
IUUC-Oga-089128 Otolemur garnettii 40.62 7.00e-17 76.60
IUUC-Oar-089896 Ovis aries 42.71 3.00e-17 77.80
IUUC-Ptr-091618 Pan troglodytes 39.47 3.00e-09 52.00
IUUC-Pan-092238 Papio anubis 32.23 1.00e-11 60.10
IUUC-Psi-093879 Pelodiscus sinensis 42.71 6.00e-18 80.10
IUUC-Pma-094484 Petromyzon marinus 55.10 4.00e-12 60.80
IUUC-Ppa-095801 Physcomitrella patens 40.00 2.00e-13 65.10
IUUC-Pfo-097192 Poecilia formosa 40.62 1.00e-16 75.50
IUUC-Pab-098203 Pongo abelii 41.67 4.00e-15 70.50
IUUC-Pop-099614 Populus trichocarpa 50.00 4.00e-12 60.80
IUUC-Pca-100507 Procavia capensis 40.79 2.00e-11 57.40
IUUC-Ppe-101174 Prunus persica 44.44 1.00e-15 72.40
IUUC-Pva-102735 Pteropus vampyrus 41.84 6.00e-15 70.10
IUUC-Pgr-103510 Puccinia graminis 38.38 4.00e-15 71.20
IUUC-Ptt-103918 Puccinia triticina 39.39 1.00e-15 72.80
IUUC-Pte-104173 Pyrenophora teres 41.41 2.00e-20 88.20
IUUC-Pyt-104806 Pyrenophora triticirepentis 41.41 3.00e-20 87.80
IUUC-Rno-105820 Rattus norvegicus 39.58 2.00e-16 74.70
IUUC-Sce-106366 Saccharomyces cerevisiae 43.30 1.00e-18 82.00
IUUC-Spo-108074 Schizosaccharomyces pombe 62.50 7.00e-25 103.00
IUUC-Smo-108944 Selaginella moellendorffii 40.91 5.00e-13 63.20
IUUC-Sit-110277 Setaria italica 48.53 2.00e-11 58.90
IUUC-Sly-111505 Solanum lycopersicum 42.50 3.00e-13 64.30
IUUC-Stu-112076 Solanum tuberosum 42.50 3.00e-13 64.70
IUUC-Sbi-114274 Sorghum bicolor 47.83 2.00e-11 58.90
IUUC-Sre-114953 Sporisorium reilianum 44.55 3.00e-16 74.70
IUUC-Ssc-115418 Sus scrofa 41.67 3.00e-17 77.80
IUUC-Tgu-117311 Taeniopygia guttata 40.91 3.00e-15 70.90
IUUC-Tru-118598 Takifugu rubripes 44.94 9.00e-17 75.90
IUUC-Tni-120109 Tetraodon nigroviridis 41.24 9.00e-15 69.70
IUUC-Tca-120942 Theobroma cacao 55.10 2.00e-11 58.20
IUUC-Tre-122099 Trichoderma reesei 41.76 9.00e-15 69.30
IUUC-Tvi-122285 Trichoderma virens 42.42 5.00e-16 73.90
IUUC-Tae-125193 Triticum aestivum 43.21 3.00e-13 64.30
IUUC-Tur-126677 Triticum urartu 37.63 2.00e-10 55.10
IUUC-Tme-127120 Tuber melanosporum 36.36 7.00e-19 83.60
IUUC-Tbe-128050 Tupaia belangeri 36.08 6.00e-11 57.00
IUUC-Ttr-129019 Tursiops truncatus 41.24 7.00e-16 73.20
IUUC-Uma-129483 Ustilago maydis 46.53 1.00e-16 75.90
IUUC-Vda-129690 Verticillium dahliae 34.55 2.00e-14 68.60
IUUC-Vvi-131174 Vitis vinifera 44.78 7.00e-12 59.70
IUUC-Xma-133862 Xiphophorus maculatus 40.62 1.00e-16 75.50
IUUC-Yli-134398 Yarrowia lipolytica 37.00 2.00e-16 75.10
IUUC-Zma-134964 Zea mays 53.06 1.00e-10 56.20
Created Date 25-Jun-2017

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