iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tvi-122285

Ensembl Protein ID

EHK27258

UniProt Accession

G9MDW1; G9MDW1_HYPVG

Genbank Protein ID

EHK27258.1

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

ABDF02000001

Gene Name

URM1; TRIVIDRAFT_63022

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIVIDRAFT_63022	EHK27258	EHK27258

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	45.10	3.00e-15	74.70	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Trichoderma virens

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MASTPDDAAA HLSLDVEFSG GLEMLFSDQR QHSLTLPAED KDGNPSTIAF LIHHLCENVM 60
KDTRKELFVL QDHLRPGILV LINDADWELE GEEEYELKNG DNILFVSTLH GG 112

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Nucleotide Sequence
(Fasta)

ATGGCTTCTA CCCCCGACGA TGCTGCCGCG CATCTCTCCC TAGACGTGGA GTTTTCGTAA 60
GCCTCCACCT CCCTTTTATG CGCCTAAAGC ACTCTTGTCA CATATCCTTT TCCCTCCCTC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	50.96	5.00e-21	90.90
IUUC-Atr-003089	Amborella trichopoda	44.55	1.00e-17	79.70
IUUC-Apl-003382	Anas platyrhynchos	50.53	6.00e-18	80.10
IUUC-Aca-004981	Anolis carolinensis	50.96	9.00e-21	89.70
IUUC-Aly-005517	Arabidopsis lyrata	41.49	2.00e-12	62.00
IUUC-Ath-006718	Arabidopsis thaliana	45.07	4.00e-10	54.30
IUUC-Ago-007917	Ashbya gossypii	44.12	1.00e-15	72.80
IUUC-Acl-008054	Aspergillus clavatus	79.25	5.00e-16	73.60
IUUC-Afl-008704	Aspergillus flavus	69.66	3.00e-28	114.00
IUUC-Aor-009890	Aspergillus oryzae	66.36	8.00e-34	133.00
IUUC-Bta-012448	Bos taurus	50.96	3.00e-21	91.70
IUUC-Bci-013865	Botrytis cinerea	65.71	2.00e-34	135.00
IUUC-Bdi-014980	Brachypodium distachyon	46.48	2.00e-11	58.90
IUUC-Bol-016055	Brassica oleracea	48.48	7.00e-11	57.00
IUUC-Bra-016845	Brassica rapa	48.48	7.00e-11	57.00
IUUC-Cel-018485	Caenorhabditis elegans	32.69	8.00e-08	47.00
IUUC-Cja-019587	Callithrix jacchus	51.92	3.00e-21	91.70
IUUC-Cfa-020653	Canis familiaris	51.92	2.00e-21	92.00
IUUC-Cpo-021622	Cavia porcellus	51.92	3.00e-21	91.70
IUUC-Cre-023015	Chlamydomonas reinhardtii	46.53	2.00e-19	85.10
IUUC-Csa-023756	Chlorocebus sabaeus	49.37	3.00e-16	75.90
IUUC-Cgl-026518	Colletotrichum gloeosporioides	73.68	4.00e-40	154.00
IUUC-Cne-026953	Cryptococcus neoformans	48.08	2.00e-16	76.30
IUUC-Cme-027314	Cyanidioschyzon merolae	41.58	9.00e-11	56.60
IUUC-Dre-027884	Danio rerio	50.96	3.00e-19	84.70
IUUC-Dno-029262	Dasypus novemcinctus	48.10	1.00e-14	70.90
IUUC-Dor-030601	Dipodomys ordii	48.39	6.00e-05	37.00
IUUC-Dme-031893	Drosophila melanogaster	47.62	1.00e-16	76.30
IUUC-Ete-032773	Echinops telfairi	48.48	1.00e-17	79.30
IUUC-Eca-034187	Equus caballus	52.88	2.00e-21	92.00
IUUC-Eeu-034808	Erinaceus europaeus	51.92	7.00e-21	90.10
IUUC-Fca-036107	Felis catus	52.88	8.00e-22	93.20
IUUC-Fal-036607	Ficedula albicollis	49.47	1.00e-17	79.30
IUUC-Fox-037698	Fusarium oxysporum	75.24	2.00e-39	152.00
IUUC-Gmo-039492	Gadus morhua	49.04	1.00e-19	85.90
IUUC-Ggr-039965	Gaeumannomyces graminis	71.15	4.00e-33	131.00
IUUC-Gga-041268	Gallus gallus	51.92	3.00e-21	91.70
IUUC-Gac-042111	Gasterosteus aculeatus	47.12	7.00e-19	83.60
IUUC-Gma-043240	Glycine max	50.91	1.00e-09	52.80
IUUC-Ggo-045176	Gorilla gorilla	49.37	2.00e-13	66.20
IUUC-Hsa-046077	Homo sapiens	51.92	3.00e-18	81.60
IUUC-Itr-048111	Ictidomys tridecemlineatus	50.54	3.00e-14	67.80
IUUC-Kpa-049157	Komagataella pastoris	50.00	1.00e-15	72.40
IUUC-Lch-049889	Latimeria chalumnae	50.96	2.00e-20	88.60
IUUC-Lpe-050783	Leersia perrieri	53.70	8.00e-09	50.10
IUUC-Loc-052400	Lepisosteus oculatus	50.00	2.00e-19	85.50
IUUC-Lma-053259	Leptosphaeria maculans	64.36	2.00e-31	125.00
IUUC-Laf-053596	Loxodonta africana	50.94	5.00e-20	87.40
IUUC-Mcc-054845	Macaca mulatta	49.50	2.00e-17	79.00
IUUC-Meu-055968	Macropus eugenii	52.88	1.00e-21	92.80
IUUC-Mor-057126	Magnaporthe oryzae	69.23	1.00e-32	129.00
IUUC-Mpo-057311	Magnaporthe poae	72.28	5.00e-33	131.00
IUUC-Mtr-058266	Medicago truncatula	45.45	4.00e-10	54.30
IUUC-Mla-058847	Melampsora laricipopulina	40.19	2.00e-11	59.30
IUUC-Mga-059468	Meleagris gallopavo	50.53	3.00e-18	81.30
IUUC-Mvi-060235	Microbotryum violaceum	35.76	8.00e-14	67.80
IUUC-Mdo-061948	Monodelphis domestica	51.92	2.00e-21	91.70
IUUC-Mmu-063946	Mus musculus	50.96	4.00e-20	87.80
IUUC-Mac-064812	Musa acuminata	48.68	3.00e-11	58.20
IUUC-Mpu-066763	Mustela putorius furo	52.88	1.00e-21	92.80
IUUC-Mlu-066970	Myotis lucifugus	49.37	2.00e-16	75.10
IUUC-Ncr-068824	Neurospora crassa	59.41	3.00e-30	121.00
IUUC-Nle-069849	Nomascus leucogenys	49.37	2.00e-16	76.30
IUUC-Opr-070227	Ochotona princeps	51.92	3.00e-21	91.70
IUUC-Ont-072530	Oreochromis niloticus	49.04	4.00e-20	87.40
IUUC-Oan-073191	Ornithorhynchus anatinus	50.50	5.00e-18	80.50
IUUC-Ocu-074460	Oryctolagus cuniculus	52.48	5.00e-21	90.50
IUUC-Oba-075499	Oryza barthii	43.37	3.00e-10	56.20
IUUC-Obr-076896	Oryza brachyantha	48.39	1.00e-08	51.60
IUUC-Ogl-077834	Oryza glaberrima	43.37	1.00e-10	56.20
IUUC-Ogu-078622	Oryza glumaepatula	43.37	1.00e-10	56.20
IUUC-Oin-079358	Oryza indica	43.37	3.00e-10	56.60
IUUC-Olo-081035	Oryza longistaminata	40.95	7.00e-12	61.60
IUUC-Oni-082425	Oryza nivara	43.37	1.00e-10	56.20
IUUC-Opu-083461	Oryza punctata	41.46	2.00e-09	53.10
IUUC-Oru-084875	Oryza rufipogon	44.93	1.00e-07	45.80
IUUC-Oga-089128	Otolemur garnettii	52.88	2.00e-21	92.00
IUUC-Oar-089896	Ovis aries	50.96	3.00e-21	91.70
IUUC-Ptr-091618	Pan troglodytes	49.37	3.00e-13	65.90
IUUC-Pan-092238	Papio anubis	49.37	2.00e-16	76.30
IUUC-Psi-093879	Pelodiscus sinensis	52.88	1.00e-21	92.80
IUUC-Pma-094484	Petromyzon marinus	48.08	3.00e-12	61.20
IUUC-Ppa-095801	Physcomitrella patens	42.86	1.00e-12	62.80
IUUC-Pfo-097192	Poecilia formosa	50.00	5.00e-19	84.00
IUUC-Pab-098203	Pongo abelii	52.88	1.00e-18	82.80
IUUC-Pop-099614	Populus trichocarpa	45.45	1.00e-09	52.80
IUUC-Pca-100507	Procavia capensis	48.10	2.00e-16	74.70
IUUC-Ppe-101174	Prunus persica	38.61	2.00e-13	65.90
IUUC-Pva-102735	Pteropus vampyrus	52.88	9.00e-19	83.20
IUUC-Pgr-103510	Puccinia graminis	42.45	1.00e-13	66.60
IUUC-Ptt-103918	Puccinia triticina	38.74	3.00e-13	65.10
IUUC-Pte-104173	Pyrenophora teres	60.19	2.00e-32	128.00
IUUC-Pyt-104806	Pyrenophora triticirepentis	60.19	2.00e-32	129.00
IUUC-Rno-105820	Rattus norvegicus	51.92	1.00e-20	89.40
IUUC-Sce-106366	Saccharomyces cerevisiae	45.10	3.00e-16	74.70
IUUC-Sja-107727	Schizosaccharomyces japonicus	42.42	7.00e-16	73.90
IUUC-Spo-108074	Schizosaccharomyces pombe	43.56	4.00e-15	70.90
IUUC-Smo-108944	Selaginella moellendorffii	45.16	4.00e-15	70.90
IUUC-Sit-110277	Setaria italica	43.37	3.00e-11	58.20
IUUC-Sly-111505	Solanum lycopersicum	42.17	1.00e-11	59.70
IUUC-Stu-112076	Solanum tuberosum	42.17	1.00e-11	59.70
IUUC-Sbi-114274	Sorghum bicolor	42.86	1.00e-12	62.80
IUUC-Sre-114953	Sporisorium reilianum	50.49	2.00e-22	95.90
IUUC-Ssc-115418	Sus scrofa	52.88	1.00e-21	93.20
IUUC-Tgu-117311	Taeniopygia guttata	49.47	1.00e-17	79.30
IUUC-Tru-118598	Takifugu rubripes	50.00	1.00e-17	79.30
IUUC-Tni-120109	Tetraodon nigroviridis	47.62	2.00e-16	75.90
IUUC-Tca-120942	Theobroma cacao	40.28	6.00e-10	53.90
IUUC-Tre-122099	Trichoderma reesei	90.43	6.00e-41	156.00
IUUC-Tae-125193	Triticum aestivum	46.58	7.00e-11	57.00
IUUC-Tur-126677	Triticum urartu	40.00	3.00e-08	48.50
IUUC-Tme-127120	Tuber melanosporum	69.31	4.00e-34	134.00
IUUC-Tbe-128050	Tupaia belangeri	42.31	8.00e-14	66.60
IUUC-Ttr-129019	Tursiops truncatus	50.96	1.00e-19	86.30
IUUC-Uma-129483	Ustilago maydis	50.49	6.00e-22	94.00
IUUC-Vda-129690	Verticillium dahliae	61.61	7.00e-29	117.00
IUUC-Vpa-130822	Vicugna pacos	33.33	1.80e+00	25.00
IUUC-Vvi-131174	Vitis vinifera	46.97	4.00e-10	54.70
IUUC-Xma-133862	Xiphophorus maculatus	50.00	5.00e-19	84.00
IUUC-Yli-134398	Yarrowia lipolytica	45.71	1.00e-17	79.30
IUUC-Zma-134964	Zea mays	50.68	3.00e-12	61.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence