iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.50e-15	56.0	602	632

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWD 29
           H+d v+++af   d  +lv+ sdD tikvW+
   Q: 602  HSDVVNSVAFnpRDsEMLVTTSDDYTIKVWR 632
           ***********9777***************9 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MEVTFKKARL GKERLVEQSE EEERDEGSSG QDLFGWWALP EPALLMIFER LSVPDLLRAS 60
RCCVRWHSIA KDDLLWRHKF QEHFKASPSI PLKPGSESWR AEYKRLSMHI PFVQAQRLEP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTCTTGCA ACAGCTGTTC CGTTGGCCTC CGCAAACAAT AACAATAAGG GGGAAAGTTA 60
TCTTTAATCG CGAAGCCGCG GAAACAAGGC AAGCTAAACC AGTTATTACC CAAGGGCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0045732--P:positive regulation of protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG9144

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001942	Ailuropoda melanoleuca	41.28	3.00e-126	444.00
IUUC-Apl-003274	Anas platyrhynchos	44.63	2.00e-114	405.00
IUUC-Aca-004626	Anolis carolinensis	41.50	3.00e-43	167.00
IUUC-Ame-011823	Astyanax mexicanus	38.01	4.00e-95	341.00
IUUC-Bta-012523	Bos taurus	40.94	6.00e-124	437.00
IUUC-Cja-018729	Callithrix jacchus	41.61	3.00e-128	451.00
IUUC-Cfa-020303	Canis familiaris	40.60	3.00e-124	437.00
IUUC-Cpo-022134	Cavia porcellus	41.83	2.00e-128	451.00
IUUC-Csa-023253	Chlorocebus sabaeus	40.92	2.00e-128	451.00
IUUC-Cin-025742	Ciona intestinalis	32.84	3.00e-81	295.00
IUUC-Dre-027511	Danio rerio	42.19	3.00e-114	404.00
IUUC-Dno-029044	Dasypus novemcinctus	41.43	5.00e-128	450.00
IUUC-Dor-030565	Dipodomys ordii	41.28	3.00e-127	447.00
IUUC-Eca-033709	Equus caballus	40.60	8.00e-126	443.00
IUUC-Eeu-035093	Erinaceus europaeus	64.43	1.00e-58	219.00
IUUC-Fca-035674	Felis catus	51.14	1.00e-62	233.00
IUUC-Fal-037104	Ficedula albicollis	42.95	2.00e-122	432.00
IUUC-Gmo-039041	Gadus morhua	39.61	1.00e-109	389.00
IUUC-Gga-041230	Gallus gallus	43.21	4.00e-125	441.00
IUUC-Gac-042594	Gasterosteus aculeatus	42.05	2.00e-117	415.00
IUUC-Ggo-044486	Gorilla gorilla	40.79	5.00e-119	420.00
IUUC-Hsa-045701	Homo sapiens	40.79	7.00e-119	420.00
IUUC-Itr-048811	Ictidomys tridecemlineatus	41.61	1.00e-127	449.00
IUUC-Lch-050058	Latimeria chalumnae	44.13	1.00e-126	445.00
IUUC-Loc-052525	Lepisosteus oculatus	42.76	1.00e-121	429.00
IUUC-Laf-054120	Loxodonta africana	42.28	4.00e-131	460.00
IUUC-Mcc-054915	Macaca mulatta	41.28	1.00e-127	449.00
IUUC-Meu-056715	Macropus eugenii	38.65	3.00e-68	251.00
IUUC-Mga-059831	Meleagris gallopavo	44.63	8.00e-115	406.00
IUUC-Mmr-060655	Microcebus murinus	41.47	1.00e-128	452.00
IUUC-Mdo-062641	Monodelphis domestica	43.89	7.00e-126	443.00
IUUC-Mmu-063471	Mus musculus	41.81	8.00e-128	449.00
IUUC-Mpu-066586	Mustela putorius furo	41.29	1.00e-124	439.00
IUUC-Nle-069429	Nomascus leucogenys	40.62	3.00e-126	444.00
IUUC-Ont-071780	Oreochromis niloticus	45.04	1.00e-63	236.00
IUUC-Ola-086458	Oryzias latipes	42.23	4.00e-119	421.00
IUUC-Oga-088739	Otolemur garnettii	41.05	5.00e-129	453.00
IUUC-Oar-089275	Ovis aries	38.71	4.00e-18	81.30
IUUC-Ptr-090716	Pan troglodytes	42.39	2.00e-103	368.00
IUUC-Pan-092182	Papio anubis	37.75	9.00e-109	386.00
IUUC-Psi-093449	Pelodiscus sinensis	43.46	1.00e-125	442.00
IUUC-Pma-094289	Petromyzon marinus	45.70	6.00e-65	241.00
IUUC-Pfo-096062	Poecilia formosa	41.92	9.00e-116	409.00
IUUC-Pab-098726	Pongo abelii	39.93	1.00e-121	429.00
IUUC-Pca-100163	Procavia capensis	50.30	9.00e-43	167.00
IUUC-Pva-103051	Pteropus vampyrus	52.73	1.00e-63	236.00
IUUC-Rno-105707	Rattus norvegicus	40.69	2.00e-125	442.00
IUUC-Sha-107074	Sarcophilus harrisii	43.07	6.00e-123	433.00
IUUC-Sja-107879	Schizosaccharomyces japonicus	30.17	9.00e-10	57.80
IUUC-Ssc-116020	Sus scrofa	38.45	4.00e-100	357.00
IUUC-Tgu-116683	Taeniopygia guttata	38.53	4.00e-42	164.00
IUUC-Tru-118143	Takifugu rubripes	41.28	3.00e-114	405.00
IUUC-Tni-120777	Tetraodon nigroviridis	41.85	2.00e-117	415.00
IUUC-Ttr-128439	Tursiops truncatus	41.11	1.00e-125	442.00
IUUC-Xtr-132774	Xenopus tropicalis	36.12	5.00e-88	317.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence