iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033872

UUCD1 version

UUC-EqC-01045

Ensembl Protein ID

ENSECAP00000000301.1

UniProt Accession

F7D4G5; F7D4G5_HORSE

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP51

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000000481.1	ENSECAT00000000385.1	ENSECAP00000000301.1
ENSECAG00000000481.1	ENSECAT00000000405.1	ENSECAP00000000314.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.40e-90	302.4	340	681

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L++ip l++++l+ +k+k+  +   +p+ +l++++ +lf+++++++++   p +ll+ ++  ae++ gy+qq
   Q: 340  GLINLGNTCFMNCIVQALTHIPLLKDFFLS-DKHKCIMT---SPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQ 424
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl  +ld l+++ k        +         s  +e ++++  +++i+++F g l+s+++c++c++vs++ +p +d+sl++pg+
   Q: 425  DAHEFLIAILDVLHRHSKD-------D---------SVGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGS 497
           *****************22.......2.........233457899******************************************99 PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
             t  +                    sl+dcL+ ft++e+l ++ k++c++c+++qe++k+l++kklP v ++hLkRf  ++ +k+r+k
   Q: 498  YATFGSqsperadstvsrddhvpgipSLTDCLQWFTRPEHLGSSAKIKCSSCQSYQESTKQLTMKKLPIVACFHLKRF--EHVGKQRRK 584
           977666899999******************************************************************..88889**** PP
   S: 249  inkkvefpleLdlspfctspeekqke..........kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetg 327
           in+ ++fpleLd++pf++s++++  e          ++kY+L+av++H+G+l+sGHY+++++++k++W+ +dD  +t+ + e+ l    
   Q: 585  INTFISFPLELDMTPFLASTKDSRMEgqlptdcapnENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAVITKATIEDLLY--- 670
           *******************66666557888888888**************************************************... PP
   S: 328  staYvlfYkrr 338
           s++Y+lfY+++
   Q: 671  SEGYLLFYHKQ 681
           ********985 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

GGASPEEAAE KAGEMEEEAA AVGAAKACSG HGAEEMKLEP LQERKPAPEE NLTWSGSDSG 60
DDEKVLPSTP PHCQSSSSPL CLRRKPRPRP QRWARSRARP GTSAPPLPPA RPLPPPQSQP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTGGCAAGT TGGGGAGGAG CCTCACCCGA GGAGGCGGCT GAGAAGGCGG GGGAAATGGA 60
GGAGGAGGCG GCGGCGGTGG GGGCTGCGAA GGCGTGTTCA GGCCACGGAG CTGAGGAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033383--USP51
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001480	Ailuropoda melanoleuca	92.41	0.00e+00	980.00
IUUC-Bol-016509	Brassica oleracea	37.34	9.00e-75	275.00
IUUC-Csa-023824	Chlorocebus sabaeus	93.17	0.00e+00	983.00
IUUC-Fca-035534	Felis catus	90.89	0.00e+00	996.00
IUUC-Gma-043933	Glycine max	36.19	2.00e-88	319.00
IUUC-Ggo-045109	Gorilla gorilla	92.53	0.00e+00	962.00
IUUC-Hsa-045765	Homo sapiens	94.19	0.00e+00	1006.00
IUUC-Itr-048281	Ictidomys tridecemlineatus	92.99	0.00e+00	937.00
IUUC-Mcc-055420	Macaca mulatta	93.21	0.00e+00	988.00
IUUC-Mla-059185	Melampsora laricipopulina	33.52	4.00e-43	169.00
IUUC-Mmr-061690	Microcebus murinus	93.40	0.00e+00	1004.00
IUUC-Mmu-063435	Mus musculus	80.00	0.00e+00	830.00
IUUC-Mac-065419	Musa acuminata	33.47	2.00e-73	270.00
IUUC-Mpu-065679	Mustela putorius furo	89.09	0.00e+00	1015.00
IUUC-Mlu-067084	Myotis lucifugus	92.74	0.00e+00	977.00
IUUC-Nle-069859	Nomascus leucogenys	94.50	0.00e+00	1000.00
IUUC-Ocu-074365	Oryctolagus cuniculus	86.15	0.00e+00	970.00
IUUC-Ptr-091479	Pan troglodytes	94.01	0.00e+00	1007.00
IUUC-Pan-091707	Papio anubis	92.98	0.00e+00	980.00
IUUC-Pab-097894	Pongo abelii	94.34	0.00e+00	1004.00
IUUC-Ppe-101583	Prunus persica	36.84	8.00e-81	294.00
IUUC-Pgr-103657	Puccinia graminis	29.29	9.00e-39	154.00
IUUC-Rno-105644	Rattus norvegicus	81.29	0.00e+00	840.00
IUUC-Sar-113426	Sorex araneus	74.66	0.00e+00	836.00
IUUC-Ssc-115500	Sus scrofa	90.94	0.00e+00	970.00
IUUC-Tsy-119413	Tarsius syrichta	93.02	0.00e+00	959.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence