iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
AREsite	microRNA	TRANSFAC	TargetScan
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	21449984

Classification

Family	E-value	Score	Start	End
DUB/USP	6.30e-84	283.7	295	885

Active Site

Position(s)	Description	Evidence
304	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
841	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqkl..feelwkskkkavsprellkalkkeaeefsgyeqq 90
           +Gl NlgNtCYmN+vLQ+L++ip+++++ll+   +++++   k p ++l+++l++l  f+  ++ + k +   +l+ka++++ae f+g++q+
   Q: 295  HGLPNLGNTCYMNAVLQSLLSIPSFADDLLN---QSFPWG--KIPLNALTMCLARLlfFKDTYNIEIKEMLLLNLKKAISAAAEIFHGNAQN 381
           59*****************************...9****9..5788999999988733577779**************************** PP
   S: 91   DaqEflaflldqleeelkk.eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkee 181
           Da+Efla++ldql+++++k ++ ++ ++e++ed+  ++  a++ +++  ++++ ++F+ +l ++i c++c++v  ++e +++ls+++p++ +
   Q: 382  DAHEFLAHCLDQLKDNMEKlNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPVITNFELELLHSIACKACGQVILKTELNNYLSINLPQRIK 473
           *****************8889999999***************************************************************** PP
   S: 182  tkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts...... 267
            +++s+q+ ++ f+ +eele    y+c kc++k+ ++  +++++lP++Li+hLkR+s +e  +  +k++++v + + L++s++c++      
   Q: 474  AHPSSIQSTFDLFFGAEELE----YKCAKCEHKT-SVGVHSFSRLPRILIVHLKRYSLNEF-CALKKNDQEVIISKYLKVSSHCNEgtrppl 559
           *******************9....*******999.7999*****************99887.8899************************** PP
   S: 268  ............................................................................................ 267
                                                                                                       
   Q: 560  plsedgeitdfqllkvirkmtsgnisvswpatkeskdilaphigsdkeseqkkgqtvfkgasrrqqqkylgknskpnelesvysgdrafiek 651
           ******************************************99999999988888888888888888888888888888888888888888 PP
   S: 268  ............................................................................................ 267
                                                                                                       
   Q: 652  eplahlmtyledtslcqfhkaggkpasspgtplskvdfqtvpenpkrkkyvktskfvafdriinptkdlyedkniriperfqkvseqtqqcd 743
           88888888888888888888888888888888888888888777777777777777777777777777777777777777777666666666 PP
   S: 268  .................................................peekqke..........................kkkYeLiavv 284
                                                            +     +                          +++Y+Li+vv
   Q: 744  gmriceqapqqalpqsfpkpgtqghtknllrptklnlqksnrnsllalgS-----NknprnkdildkikskaketkrnddkgDHTYRLISVV 830
           66666666666666666666666666666665555555555555555550.....055555555555555556666666667********** PP
   S: 285  vHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           +H G +l+sGHY++++++ +++ W+++dD +V  ++e++++e++++t+Y++fY++
   Q: 831  SHLGkTLKSGHYICDAYDFEKQiWFTYDDMRVLGIQEAQMQEDRRCTGYIFFYMH 885
           ******************9999*******************************98 PP

Organism

Homo sapiens

Functional Description
(View)

Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.

Protein Sequence
(Fasta)

MAALFLRGFV QIGNCKTGIS KSKEAFIEAV ERKKKDRLVL YFKSGKYSTF RLSDNIQNVV 60
LKSYRGNQNH LHLTLQNNNG LFIEGLSSTD AEQLKIFLDR VHQNEVQPPV RPGKGGSVFS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCATTTTGTT TTCGATCGTT AAGTGGGCAC GTGGTGGAGC GTTGGTGTGT CAGGGGTGTC 60
GACTTCTTCC ACAAACTATT GTAAGATCAA TTTGCTTTTC ATTTGTAATA GTTATTGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR032069--USP37-like_PH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF16674--UCH_N

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:83844

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002281	Ailuropoda melanoleuca	57.53	0.00e+00	942.00
IUUC-Bta-012832	Bos taurus	46.30	0.00e+00	680.00
IUUC-Cja-019801	Callithrix jacchus	74.43	0.00e+00	1350.00
IUUC-Cfa-020088	Canis familiaris	57.56	0.00e+00	962.00
IUUC-Cpo-022049	Cavia porcellus	40.96	2.00e-173	603.00
IUUC-Csa-023990	Chlorocebus sabaeus	91.48	0.00e+00	1655.00
IUUC-Dor-030370	Dipodomys ordii	43.29	0.00e+00	667.00
IUUC-Eca-034060	Equus caballus	58.77	0.00e+00	937.00
IUUC-Fca-035628	Felis catus	55.84	0.00e+00	916.00
IUUC-Ggr-039843	Gaeumannomyces graminis	46.30	2.00e-08	55.80
IUUC-Ggo-045311	Gorilla gorilla	97.92	0.00e+00	1775.00
IUUC-Itr-047983	Ictidomys tridecemlineatus	54.42	0.00e+00	906.00
IUUC-Laf-054311	Loxodonta africana	51.44	0.00e+00	790.00
IUUC-Mmr-061542	Microcebus murinus	62.36	0.00e+00	1048.00
IUUC-Mpu-066846	Mustela putorius furo	54.77	0.00e+00	914.00
IUUC-Mlu-068224	Myotis lucifugus	56.62	0.00e+00	915.00
IUUC-Ocu-073860	Oryctolagus cuniculus	51.19	0.00e+00	832.00
IUUC-Oga-088020	Otolemur garnettii	46.95	0.00e+00	730.00
IUUC-Oar-089263	Ovis aries	47.24	0.00e+00	711.00
IUUC-Ptr-090973	Pan troglodytes	95.18	0.00e+00	762.00
IUUC-Pan-092928	Papio anubis	90.38	0.00e+00	1624.00
IUUC-Pab-098555	Pongo abelii	95.30	0.00e+00	1760.00
IUUC-Sar-113624	Sorex araneus	43.97	1.00e-174	607.00
IUUC-Ssc-116225	Sus scrofa	58.43	0.00e+00	975.00
IUUC-Tbe-127615	Tupaia belangeri	54.34	1.00e-125	444.00
IUUC-Ttr-129071	Tursiops truncatus	51.20	0.00e+00	833.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence