iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-036754

Ensembl Protein ID

ENSFALP00000012878.1

UniProt Accession

U3KCX4; U3KCX4_FICAL

Genbank Protein ID

ENSFALP00000012878

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

AGTO01000025

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000012305.1	ENSFALT00000012929.1	ENSFALP00000012878.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	77.35	0.00e+00	880.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ficedula albicollis

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

LTMTLHTKTS GVTLLHQIQG TELETLSRPQ LKIPLERPLS DMYVETNKTG VFNYPEGATY 60
DFGTTAPVYS STTLSYAPTS ESFGSSSLAG FHSLNSVPPS PVVFLQTAPQ LSPFIHHHSQ 120

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Nucleotide Sequence
(Fasta)

TGTTTAAACC AGCGTCGGCA CAAGGCAAGG GCTGCTGGCT GGCAGCCAGC ACCTTGTAAT 60
GCATATTAGT GCAGATGAGG AGTTCCTAAA AGTTAGAGAG AGGCAGAGGG AGGGAAGAAG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0008584--P:male gonad development
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0010628--P:positive regulation of gene expression
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	84.44	0.00e+00	729.00
IUUC-Apl-003688	Anas platyrhynchos	97.37	0.00e+00	992.00
IUUC-Aca-005222	Anolis carolinensis	83.70	0.00e+00	965.00
IUUC-Ame-010731	Astyanax mexicanus	51.74	1.00e-139	489.00
IUUC-Bta-013112	Bos taurus	73.53	0.00e+00	830.00
IUUC-Cja-019408	Callithrix jacchus	78.69	0.00e+00	872.00
IUUC-Cfa-020694	Canis familiaris	75.71	0.00e+00	848.00
IUUC-Cpo-021426	Cavia porcellus	73.87	0.00e+00	812.00
IUUC-Csa-023736	Chlorocebus sabaeus	83.16	0.00e+00	782.00
IUUC-Dre-027698	Danio rerio	51.98	9.00e-139	486.00
IUUC-Dno-029477	Dasypus novemcinctus	81.10	0.00e+00	726.00
IUUC-Dor-030572	Dipodomys ordii	83.60	0.00e+00	696.00
IUUC-Ete-032849	Echinops telfairi	61.74	3.00e-169	588.00
IUUC-Eca-033605	Equus caballus	74.83	0.00e+00	831.00
IUUC-Eeu-034683	Erinaceus europaeus	83.18	4.00e-99	354.00
IUUC-Fca-035928	Felis catus	87.16	0.00e+00	729.00
IUUC-Gmo-038872	Gadus morhua	60.21	1.00e-113	403.00
IUUC-Gga-040988	Gallus gallus	97.28	0.00e+00	1106.00
IUUC-Gac-042015	Gasterosteus aculeatus	64.08	1.00e-129	456.00
IUUC-Ggo-044749	Gorilla gorilla	78.36	0.00e+00	867.00
IUUC-Hsa-046944	Homo sapiens	77.35	0.00e+00	855.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	77.68	0.00e+00	865.00
IUUC-Loc-052414	Lepisosteus oculatus	61.31	0.00e+00	691.00
IUUC-Mcc-054781	Macaca mulatta	78.95	0.00e+00	867.00
IUUC-Meu-056232	Macropus eugenii	81.86	0.00e+00	922.00
IUUC-Mga-059319	Meleagris gallopavo	96.77	0.00e+00	1102.00
IUUC-Mmr-061636	Microcebus murinus	73.10	2.00e-141	495.00
IUUC-Mdo-062661	Monodelphis domestica	83.39	0.00e+00	942.00
IUUC-Mmu-063330	Mus musculus	76.29	0.00e+00	834.00
IUUC-Mpu-065757	Mustela putorius furo	75.59	0.00e+00	862.00
IUUC-Mlu-067712	Myotis lucifugus	78.58	0.00e+00	776.00
IUUC-Nle-069283	Nomascus leucogenys	77.35	0.00e+00	840.00
IUUC-Opr-070391	Ochotona princeps	77.52	0.00e+00	888.00
IUUC-Ont-071369	Oreochromis niloticus	52.28	1.00e-125	443.00
IUUC-Oan-073734	Ornithorhynchus anatinus	72.30	7.00e-130	456.00
IUUC-Ocu-074292	Oryctolagus cuniculus	79.47	0.00e+00	883.00
IUUC-Oba-075103	Oryza barthii	26.92	1.10e-02	34.70
IUUC-Ogu-079042	Oryza glumaepatula	26.92	3.00e-03	36.60
IUUC-Olo-080944	Oryza longistaminata	26.92	4.00e-03	34.30
IUUC-Oni-082560	Oryza nivara	26.92	9.00e-03	35.00
IUUC-Ola-087052	Oryzias latipes	53.60	1.00e-134	473.00
IUUC-Oga-088586	Otolemur garnettii	77.63	0.00e+00	848.00
IUUC-Oar-090156	Ovis aries	78.22	0.00e+00	747.00
IUUC-Ptr-091321	Pan troglodytes	78.19	0.00e+00	866.00
IUUC-Pan-092851	Papio anubis	78.78	0.00e+00	865.00
IUUC-Psi-093434	Pelodiscus sinensis	87.95	0.00e+00	1029.00
IUUC-Pfo-097379	Poecilia formosa	57.97	3.00e-140	491.00
IUUC-Pab-097735	Pongo abelii	78.02	0.00e+00	864.00
IUUC-Pva-102125	Pteropus vampyrus	76.64	0.00e+00	853.00
IUUC-Rno-106121	Rattus norvegicus	76.17	0.00e+00	834.00
IUUC-Sha-107547	Sarcophilus harrisii	83.56	0.00e+00	941.00
IUUC-Sar-113650	Sorex araneus	68.03	4.00e-159	553.00
IUUC-Tgu-117175	Taeniopygia guttata	98.47	0.00e+00	1135.00
IUUC-Tru-117545	Takifugu rubripes	53.12	4.00e-143	502.00
IUUC-Tsy-119586	Tarsius syrichta	68.01	0.00e+00	731.00
IUUC-Tni-120121	Tetraodon nigroviridis	52.42	4.00e-145	508.00
IUUC-Tbe-127548	Tupaia belangeri	72.97	8.00e-168	583.00
IUUC-Ttr-128374	Tursiops truncatus	70.13	0.00e+00	750.00
IUUC-Vpa-130464	Vicugna pacos	74.59	3.00e-140	491.00
IUUC-Xtr-132171	Xenopus tropicalis	76.99	0.00e+00	823.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence