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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063927
UUCD1 version UUC-MuM-00269
Ensembl Protein ID ENSMUSP00000107590.1
UniProt Accession E9Q8J9; E9Q8J9_MOUSE
Genbank Protein ID ENSMUSP00000107590
Protein Name WD repeat and SOCS box-containing protein 2
Genbank Nucleotide ID AC110234
Gene Name Wsb2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029364.15 ENSMUST00000031309.15 ENSMUSP00000031309.9
ENSMUSG00000029364.15 ENSMUST00000111959.1 ENSMUSP00000107590.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
CPLMmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.50e-14 54.7 358 405
E3 adaptor/Cullin RING/DCX/DWD 5.10e-33 112.8 153 186
UBD/Beta-Prp 6.10e-46 158.1 127 362
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 358  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 405
           689****************************...***************86 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  s+  +lvs+s+D+t+++WDl 
   Q: 153  GHQDVVRDLSFtpSGsLILVSASRDKTLRIWDLN 186
           8***********6556779*************85 PP
   

   UBD/Beta-Prp
   S: 24   llatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklv 110
           +latg  dg ik+w+v+tg ll  lsgh++ v++++f p+g+ ilv++s+D+t+++wdl+  gk++++l+gh + v+++s+sp+ + l 
   Q: 127  ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSMLC 215
           699***************************************9****************9789********************99**** PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...........tgghtdsvyslsf 188
           s+   + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lr l           +  h +s +s+ f
   Q: 216  SAAGEKSVFLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLhhtqleptmddSDVHMSSLRSVCF 303
           ********************.****************************************999999999997777666777777777* PP
   S: 189  dsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +++g +l+++++d+ +++w l+ +       +  +n ++  f+p++ ++++g+ Dg +++W
   Q: 304  SPEGLYLATVADDRLLRIWALELK--APVAFAPMTNGLCCTFFPHGGIIATGTRDGHVQFW 362
           *********************888..5778999**************************** PP
   
Organism Mus musculus
Protein Sequence
(Fasta)
MISPSPEEPL LLAELKPGRP HQFDWKSSCE TWSVAFSPDG SWFAWSQGHC VVKLVPWPLE 60
EQFIPKGFEA KSRSSKNDPK GRGSLKEKTL DCGQIVWGLA FSPWPSPPSR KLWARHHPQA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063927|E3,SOCS;E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGGAAGCAG CTGATGGCCT CTGCGGGCGG CAGCGGCGGC GGCATTGGCG GCGGTGGTGG 60
CGGCGGCGGG CGCGGCCGCG GCGGGGCGGG CGCGGAATGA AGGCCCACGG CCCTGGGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063927|E3,SOCS;E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF07525--SOCS_box
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40
Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002221 Ailuropoda melanoleuca 95.57 0.00e+00 805.00
IUUC-Apl-004107 Anas platyrhynchos 69.03 2.00e-131 461.00
IUUC-Aca-004354 Anolis carolinensis 73.88 2.00e-169 588.00
IUUC-Bta-012627 Bos taurus 96.42 0.00e+00 763.00
IUUC-Cja-018897 Callithrix jacchus 94.60 0.00e+00 764.00
IUUC-Cfa-020122 Canis familiaris 95.81 0.00e+00 805.00
IUUC-Cpo-022540 Cavia porcellus 96.93 0.00e+00 787.00
IUUC-Csa-023719 Chlorocebus sabaeus 95.88 0.00e+00 776.00
IUUC-Cho-024367 Choloepus hoffmanni 96.64 5.00e-171 593.00
IUUC-Dno-029021 Dasypus novemcinctus 96.68 0.00e+00 785.00
IUUC-Dor-030321 Dipodomys ordii 96.91 0.00e+00 780.00
IUUC-Ete-032955 Echinops telfairi 96.74 0.00e+00 776.00
IUUC-Eca-033485 Equus caballus 96.68 0.00e+00 756.00
IUUC-Fca-035389 Felis catus 96.14 0.00e+00 778.00
IUUC-Fal-037184 Ficedula albicollis 84.81 1.00e-143 501.00
IUUC-Gga-041014 Gallus gallus 77.26 9.00e-178 616.00
IUUC-Ggo-045585 Gorilla gorilla 96.16 0.00e+00 785.00
IUUC-Hsa-046344 Homo sapiens 96.16 0.00e+00 784.00
IUUC-Itr-049085 Ictidomys tridecemlineatus 97.69 0.00e+00 787.00
IUUC-Lch-050131 Latimeria chalumnae 70.05 2.00e-167 581.00
IUUC-Loc-052807 Lepisosteus oculatus 50.93 2.00e-116 412.00
IUUC-Laf-053528 Loxodonta africana 96.93 0.00e+00 767.00
IUUC-Mcc-055665 Macaca mulatta 96.16 0.00e+00 784.00
IUUC-Meu-056054 Macropus eugenii 88.38 0.00e+00 697.00
IUUC-Mga-059326 Meleagris gallopavo 77.44 0.00e+00 630.00
IUUC-Mmr-060815 Microcebus murinus 93.86 0.00e+00 768.00
IUUC-Mdo-062000 Monodelphis domestica 91.52 0.00e+00 750.00
IUUC-Mpu-065726 Mustela putorius furo 94.86 0.00e+00 766.00
IUUC-Mlu-067527 Myotis lucifugus 96.19 2.00e-118 417.00
IUUC-Nle-069680 Nomascus leucogenys 95.65 0.00e+00 776.00
IUUC-Opr-070356 Ochotona princeps 96.49 0.00e+00 796.00
IUUC-Oan-073647 Ornithorhynchus anatinus 83.94 4.00e-136 478.00
IUUC-Ocu-073973 Oryctolagus cuniculus 97.19 0.00e+00 787.00
IUUC-Oga-088797 Otolemur garnettii 95.66 0.00e+00 775.00
IUUC-Oar-089187 Ovis aries 96.42 0.00e+00 763.00
IUUC-Ptr-091317 Pan troglodytes 96.16 0.00e+00 784.00
IUUC-Pan-092694 Papio anubis 88.31 0.00e+00 668.00
IUUC-Psi-093392 Pelodiscus sinensis 79.65 0.00e+00 642.00
IUUC-Pab-098145 Pongo abelii 95.88 0.00e+00 776.00
IUUC-Pca-100454 Procavia capensis 88.22 0.00e+00 714.00
IUUC-Pva-102986 Pteropus vampyrus 87.97 0.00e+00 716.00
IUUC-Rno-104931 Rattus norvegicus 97.16 0.00e+00 777.00
IUUC-Sha-106476 Sarcophilus harrisii 92.52 0.00e+00 748.00
IUUC-Ssc-115643 Sus scrofa 96.91 0.00e+00 779.00
IUUC-Tgu-117522 Taeniopygia guttata 64.04 6.00e-136 477.00
IUUC-Tsy-119301 Tarsius syrichta 96.24 0.00e+00 798.00
IUUC-Tni-120198 Tetraodon nigroviridis 49.88 7.00e-110 390.00
IUUC-Ttr-128683 Tursiops truncatus 96.91 0.00e+00 779.00
Created Date 25-Jun-2017

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