iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-087240

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

BAAF04001041

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000003940.1	ENSORLT00000004922.1	ENSORLP00000004921.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-110	369.9	150	678

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kN+gN+CYmN++LQ+Lsn+p+l++++l+     ++   ++++k +l+ks+qkl++elw k++ ++v p++l + +k ++++f+gy+
   Q: 150  TGMKNIGNSCYMNAALQALSNCPPLTQFFLD-----CSGLVRTDKKPALCKSYQKLISELWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 233
           7******************************.....9999999******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde................................................ 129
           qqD+qEfl++l+dql+eelk+  ++  ++ e++d +++ d                                                 
   Q: 234  QQDTQEFLRCLMDQLHEELKEPLTECNMSGEGSDGEDRRDGdcspsedeflscdsgsssdrgegggvgdgellllddcdglisekerlk 322
           *******************997777777776766666555588999999**************************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 323  ekrvsgsplrgasqemdedadvdtaaeeikekvllqpginktltscflepnneapmtqpqstpcspvrtlqelhhklssspprssplrs 411
           ***************************************************************************************** PP
   S: 130  ...............aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.................. 185
                          +++kk+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+                  
   Q: 412  agpayslkkaqlllsSRKKKQSHYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhssihqnlpvktgvcpds 500
           **************9999************************************************99888****************** PP
   S: 186  ...............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeq 243
                                          +l+dcL++f++++el+g+n+y+ce+ckk+++  k +k+ klPe+L++hLkRf  ++e 
   Q: 501  yssqgwisfimdsirrfvvsciptwfwgpmvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGIKYCKVLKLPEILCIHLKRF--RHEV 587
           ***********************************************************************************..9999 PP
   S: 244  ksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgsta 330
           + + ki+++v+fple Ld++pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+e+ v++   ++a
   Q: 588  MYSFKISSHVSFPLEgLDMRPFLAKESPSQ--VTTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVHETVVQN---AEA 671
           *************************88887..9**************************78999*******************...*** PP
   S: 331  YvlfYkr 337
           YvlfY++
   Q: 672  YVLFYRK 678
           *****98 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

VMAEQDVCPH LDSIGEVTKD DLLKKSKGTC QSCGAGGPNL WACLQSDCPY VGCGESHSDH 60
STLHAQAKKH NLTVNLTTFR IWCYTCEREV FLDQRPALVP VPSAPHHCKA AEQDGAPQSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTATGGCAG AGCAAGACGT TTGTCCTCAC CTGGACTCCA TAGGTGAGGT GACCAAGGAT 60
GATCTACTGA AGAAATCAAA GGTGAGTTTC CATTTTTGTT GCTAAATAAA ATGGATGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	73.10	0.00e+00	1311.00
IUUC-Apl-003351	Anas platyrhynchos	75.27	0.00e+00	1343.00
IUUC-Aca-005077	Anolis carolinensis	70.73	0.00e+00	1010.00
IUUC-Ame-011777	Astyanax mexicanus	80.11	0.00e+00	1442.00
IUUC-Bta-013063	Bos taurus	74.84	0.00e+00	1344.00
IUUC-Cja-019868	Callithrix jacchus	75.08	0.00e+00	1348.00
IUUC-Cfa-020761	Canis familiaris	73.56	0.00e+00	1328.00
IUUC-Cpo-022267	Cavia porcellus	74.24	0.00e+00	1317.00
IUUC-Csa-024251	Chlorocebus sabaeus	75.60	0.00e+00	1354.00
IUUC-Cho-024483	Choloepus hoffmanni	89.62	5.00e-117	415.00
IUUC-Csv-025889	Ciona savignyi	42.35	4.00e-34	137.00
IUUC-Dre-028061	Danio rerio	73.69	0.00e+00	1359.00
IUUC-Dno-029423	Dasypus novemcinctus	74.62	0.00e+00	1351.00
IUUC-Dor-030877	Dipodomys ordii	75.96	0.00e+00	898.00
IUUC-Dme-031837	Drosophila melanogaster	49.15	4.00e-135	475.00
IUUC-Ete-032802	Echinops telfairi	62.75	4.00e-104	372.00
IUUC-Eca-034283	Equus caballus	72.70	0.00e+00	1307.00
IUUC-Eeu-034620	Erinaceus europaeus	69.96	0.00e+00	891.00
IUUC-Fca-036357	Felis catus	74.13	0.00e+00	1331.00
IUUC-Fal-037411	Ficedula albicollis	76.00	0.00e+00	1353.00
IUUC-Gmo-038563	Gadus morhua	84.42	0.00e+00	897.00
IUUC-Gga-041101	Gallus gallus	75.11	0.00e+00	1338.00
IUUC-Gac-041315	Gasterosteus aculeatus	86.81	0.00e+00	1520.00
IUUC-Ggo-045600	Gorilla gorilla	74.87	0.00e+00	1326.00
IUUC-Hsa-045825	Homo sapiens	75.16	0.00e+00	1341.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	64.59	0.00e+00	1108.00
IUUC-Lch-050002	Latimeria chalumnae	73.39	0.00e+00	1258.00
IUUC-Loc-052574	Lepisosteus oculatus	82.68	0.00e+00	1459.00
IUUC-Laf-054428	Loxodonta africana	74.24	0.00e+00	1337.00
IUUC-Mcc-055736	Macaca mulatta	75.49	0.00e+00	1353.00
IUUC-Mga-059781	Meleagris gallopavo	75.30	0.00e+00	1338.00
IUUC-Mmr-061328	Microcebus murinus	83.99	0.00e+00	823.00
IUUC-Mdo-063048	Monodelphis domestica	75.76	0.00e+00	1324.00
IUUC-Mmu-064079	Mus musculus	75.16	0.00e+00	1317.00
IUUC-Mpu-066616	Mustela putorius furo	73.38	0.00e+00	1345.00
IUUC-Mlu-067294	Myotis lucifugus	74.19	0.00e+00	1303.00
IUUC-Nle-070015	Nomascus leucogenys	74.51	0.00e+00	1337.00
IUUC-Opr-070328	Ochotona princeps	72.93	0.00e+00	1323.00
IUUC-Ont-071464	Oreochromis niloticus	90.88	0.00e+00	1508.00
IUUC-Oan-073259	Ornithorhynchus anatinus	69.84	0.00e+00	1157.00
IUUC-Ocu-074630	Oryctolagus cuniculus	72.34	0.00e+00	1293.00
IUUC-Oga-088761	Otolemur garnettii	74.40	0.00e+00	1362.00
IUUC-Oar-089490	Ovis aries	71.48	0.00e+00	1235.00
IUUC-Ptr-091662	Pan troglodytes	75.27	0.00e+00	1341.00
IUUC-Pan-092199	Papio anubis	75.43	0.00e+00	1342.00
IUUC-Psi-093726	Pelodiscus sinensis	77.04	0.00e+00	1351.00
IUUC-Pma-094389	Petromyzon marinus	62.95	6.00e-100	356.00
IUUC-Pfo-096522	Poecilia formosa	88.03	0.00e+00	1143.00
IUUC-Pab-098632	Pongo abelii	75.49	0.00e+00	1341.00
IUUC-Pca-100614	Procavia capensis	68.34	0.00e+00	1044.00
IUUC-Pva-102922	Pteropus vampyrus	66.55	0.00e+00	715.00
IUUC-Rno-105215	Rattus norvegicus	74.19	0.00e+00	1315.00
IUUC-Sce-106176	Saccharomyces cerevisiae	29.08	4.00e-23	103.00
IUUC-Sha-106601	Sarcophilus harrisii	73.83	0.00e+00	1295.00
IUUC-Ssc-115533	Sus scrofa	73.25	0.00e+00	1325.00
IUUC-Tgu-117364	Taeniopygia guttata	75.38	0.00e+00	1342.00
IUUC-Tru-117770	Takifugu rubripes	87.03	0.00e+00	1519.00
IUUC-Tni-120001	Tetraodon nigroviridis	85.56	0.00e+00	1462.00
IUUC-Ttr-128732	Tursiops truncatus	75.95	0.00e+00	1346.00
IUUC-Xtr-132157	Xenopus tropicalis	69.91	0.00e+00	1252.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence