iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074666

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Guanine nucleotide-binding protein subunit beta-5; Gbeta5; Transducin beta chain 5

Genbank Nucleotide ID

AY591252

Gene Name

GNB5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000011893.3	ENSOCUT00000011891.3	ENSOCUP00000010220.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-43	144.9	141	181
UBD/Beta-Prp	6.70e-55	186.4	95	300

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf....sdtllvsGsdDgtikvWDlrtgvllk 37
           gH ++v cl++    +++++vsG+ D++ +vWD+r+g +++
   Q: 141  GHGADVLCLDLapseTGNTFVSGGCDKKAMVWDMRSGQCVQ 181
           8***********9644499********************98 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp..sgdklvsGshdrtirvwdletgqcleet 132
           +s+  h++  +a++f +++  ++t+s D+t  +wd+++g+ +++++gh ++vl+l++ p  +g+++vsG+ d+ ++vwd+++gqc++  
   Q: 95   KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPseTGNTFVSGGCDKKAMVWDMRSGQCVQ-A 182
           567889999*********99***************************************9778************************.* PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng 220
           ++ h++ +n+v++ p+g+ ++sGs+D t+rl+dl+ ++ +    ++       s++f+ +g+ l +g +d t+++wd+ +g  v +l g
   Q: 183  FETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYsKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGARVSILFG 271
           *******************************************5333556778999********************************* PP
   S: 221  htdnvksvrfspnderlvsgssDgsiriW 249
           h++ v+ +r+sp+++ + sgs D ++r+W
   Q: 272  HENRVSTLRVSPDGTAFCSGSWDHTLRVW 300
           ***************************** PP

Organism

Oryctolagus cuniculus

Functional Description
(View)

Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Protein Sequence
(Fasta)

MKTRRTLKGH GNKVLCMDWC KDKRRIVSSS QDGKVIVWDS FTTNKEHAVT MPCTWVMACA 60
YAPSGCAIAC GGLDNKCSVY PLTFDKNENM AAKKKSVAMH TNYLSACSFT NSDMQILTAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCACCAGGT GGCGGAGCGG GTGGAGGCCT TGGGCCAGTT TGTCATGAAG ACGAGGAGGA 60
CACTCAAGGG CCATGGAAAC AAGGTCCTGT GCATGGACTG GTGCAAGGAC AAACGGAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0051087--F:chaperone binding
GO:0031682--F:G-protein gamma-subunit binding
GO:0004871--F:signal transducer activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:1901386--P:negative regulation of voltage-gated calcium channel activity

KEGG

ocu:100008941

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001811	Ailuropoda melanoleuca	99.67	0.00e+00	629.00
IUUC-Apl-003399	Anas platyrhynchos	98.66	5.00e-178	616.00
IUUC-Aca-004861	Anolis carolinensis	98.01	3.00e-180	624.00
IUUC-Ame-011851	Astyanax mexicanus	95.65	1.00e-175	608.00
IUUC-Bta-012438	Bos taurus	99.34	0.00e+00	629.00
IUUC-Cel-018408	Caenorhabditis elegans	68.44	4.00e-127	447.00
IUUC-Cja-019086	Callithrix jacchus	99.67	2.00e-180	625.00
IUUC-Cfa-021255	Canis familiaris	99.67	6.00e-180	623.00
IUUC-Cpo-021398	Cavia porcellus	99.01	7.00e-180	622.00
IUUC-Csa-023776	Chlorocebus sabaeus	99.67	0.00e+00	631.00
IUUC-Cin-025305	Ciona intestinalis	61.30	9.00e-123	433.00
IUUC-Csv-026058	Ciona savignyi	64.55	8.00e-122	429.00
IUUC-Dre-028572	Danio rerio	94.68	3.00e-175	607.00
IUUC-Dno-029776	Dasypus novemcinctus	98.93	6.00e-108	382.00
IUUC-Dor-031013	Dipodomys ordii	98.83	1.00e-151	529.00
IUUC-Dme-031889	Drosophila melanogaster	70.43	7.00e-135	473.00
IUUC-Ete-033033	Echinops telfairi	73.49	2.00e-121	428.00
IUUC-Eca-033977	Equus caballus	99.67	0.00e+00	627.00
IUUC-Eeu-035079	Erinaceus europaeus	99.34	0.00e+00	629.00
IUUC-Fca-035693	Felis catus	99.67	0.00e+00	625.00
IUUC-Fal-037345	Ficedula albicollis	98.01	2.00e-180	624.00
IUUC-Gmo-039222	Gadus morhua	95.02	5.00e-175	606.00
IUUC-Gga-040320	Gallus gallus	98.34	0.00e+00	626.00
IUUC-Gac-042644	Gasterosteus aculeatus	95.35	4.00e-176	610.00
IUUC-Ggo-044489	Gorilla gorilla	99.33	0.00e+00	626.00
IUUC-Hsa-046434	Homo sapiens	99.67	0.00e+00	630.00
IUUC-Itr-048771	Ictidomys tridecemlineatus	94.31	9.00e-167	578.00
IUUC-Loc-052790	Lepisosteus oculatus	96.98	3.00e-176	611.00
IUUC-Laf-054255	Loxodonta africana	98.33	8.00e-178	616.00
IUUC-Mcc-055610	Macaca mulatta	99.67	2.00e-180	625.00
IUUC-Meu-056819	Macropus eugenii	96.31	6.00e-171	593.00
IUUC-Mga-059740	Meleagris gallopavo	98.34	3.00e-180	624.00
IUUC-Mmr-061221	Microcebus murinus	100.00	0.00e+00	630.00
IUUC-Mdo-062619	Monodelphis domestica	99.00	0.00e+00	629.00
IUUC-Mmu-064266	Mus musculus	99.34	0.00e+00	629.00
IUUC-Mpu-065766	Mustela putorius furo	99.00	6.00e-180	622.00
IUUC-Mlu-067221	Myotis lucifugus	98.68	3.00e-179	620.00
IUUC-Nle-069515	Nomascus leucogenys	99.67	0.00e+00	626.00
IUUC-Opr-070195	Ochotona princeps	88.37	1.00e-155	542.00
IUUC-Ont-071535	Oreochromis niloticus	85.71	2.00e-150	525.00
IUUC-Oan-072899	Ornithorhynchus anatinus	98.38	5.00e-107	379.00
IUUC-Ola-086578	Oryzias latipes	95.33	3.00e-175	607.00
IUUC-Oga-089090	Otolemur garnettii	99.01	3.00e-180	624.00
IUUC-Oar-090017	Ovis aries	99.01	2.00e-179	621.00
IUUC-Ptr-091280	Pan troglodytes	99.67	0.00e+00	626.00
IUUC-Pan-092198	Papio anubis	99.67	0.00e+00	626.00
IUUC-Psi-093030	Pelodiscus sinensis	97.67	1.00e-179	622.00
IUUC-Pfo-097182	Poecilia formosa	95.02	7.00e-176	609.00
IUUC-Pab-098157	Pongo abelii	99.67	0.00e+00	631.00
IUUC-Pca-100988	Procavia capensis	72.09	5.00e-116	410.00
IUUC-Pva-102232	Pteropus vampyrus	99.63	2.00e-160	557.00
IUUC-Rno-105526	Rattus norvegicus	95.05	2.00e-170	591.00
IUUC-Sha-106754	Sarcophilus harrisii	99.00	1.00e-180	625.00
IUUC-Ssc-115390	Sus scrofa	99.01	3.00e-180	624.00
IUUC-Tgu-117377	Taeniopygia guttata	98.34	7.00e-179	619.00
IUUC-Tru-117938	Takifugu rubripes	95.02	2.00e-175	607.00
IUUC-Tsy-119392	Tarsius syrichta	84.72	9.00e-145	506.00
IUUC-Tni-119834	Tetraodon nigroviridis	78.41	7.00e-143	499.00
IUUC-Tbe-127469	Tupaia belangeri	97.01	1.00e-171	595.00
IUUC-Ttr-128252	Tursiops truncatus	98.67	3.00e-178	617.00
IUUC-Vpa-130173	Vicugna pacos	90.91	2.00e-128	451.00
IUUC-Xtr-131803	Xenopus tropicalis	97.67	2.00e-179	621.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence