iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133377

Ensembl Protein ID

ENSXMAP00000009212.1

UniProt Accession

M4A418; M4A418_XIPMA

Genbank Protein ID

ENSXMAP00000009212

Protein Name

Presenilin

Genbank Nucleotide ID

AGAJ01029365

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000009187.1	ENSXMAT00000009226.1	ENSXMAP00000009212.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.40e-07	31.5	266	292

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLean 28
           +eta+e++++iFP+l+ys+++v+L+++
   Q: 266  VETAQERNEPIFPALIYSSTMVWLVNM 292
           89**********************987 PP

Organism

Xiphophorus maculatus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MDQQQANTSP EAVQQPQEAP ATRARSRGGS GDEGGGDGSG PEANGQPPAA HPAQVVENEE 60
EEDEEMTLKY GAKHVIMLFV PVTLCMVVVV ATIKSVSFYT KNDGQRLIYT PFPEETDTVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGCTCGAT GGGAGCCGAA TCGACTCGAG CAGGAAGCGG ACGGATGTTC TGGGAGGAAG 60
GCAGGAACAA CAAAAAGGAG GAGGAGTGAT TGTCCGGGGT TTAATCCCGT TAAACACAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	30.02	5.00e-23	103.00
IUUC-Aml-001648	Ailuropoda melanoleuca	73.50	8.00e-124	436.00
IUUC-Atr-003039	Amborella trichopoda	30.86	4.00e-37	149.00
IUUC-Apl-003727	Anas platyrhynchos	75.76	2.00e-147	515.00
IUUC-Aca-004582	Anolis carolinensis	77.08	3.00e-149	521.00
IUUC-Aly-005455	Arabidopsis lyrata	43.15	8.00e-18	84.70
IUUC-Ath-006730	Arabidopsis thaliana	31.63	4.00e-18	85.90
IUUC-Ame-011500	Astyanax mexicanus	82.55	8.00e-164	570.00
IUUC-Bta-013026	Bos taurus	74.69	4.00e-145	508.00
IUUC-Bdi-014196	Brachypodium distachyon	33.70	6.00e-30	125.00
IUUC-Bol-015841	Brassica oleracea	36.16	8.00e-31	127.00
IUUC-Bra-017580	Brassica rapa	48.00	8.00e-18	84.70
IUUC-Cel-018553	Caenorhabditis elegans	52.88	2.00e-99	356.00
IUUC-Cja-019994	Callithrix jacchus	75.06	1.00e-144	506.00
IUUC-Cfa-020074	Canis familiaris	75.65	7.00e-146	510.00
IUUC-Cpo-022237	Cavia porcellus	74.18	7.00e-144	503.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.64	9.00e-29	121.00
IUUC-Csa-023537	Chlorocebus sabaeus	74.88	1.00e-143	502.00
IUUC-Cho-024735	Choloepus hoffmanni	68.17	6.00e-133	467.00
IUUC-Cin-025780	Ciona intestinalis	62.66	2.00e-121	429.00
IUUC-Csv-025967	Ciona savignyi	62.32	1.00e-119	422.00
IUUC-Dre-028689	Danio rerio	81.06	1.00e-154	539.00
IUUC-Dno-029758	Dasypus novemcinctus	76.94	6.00e-146	510.00
IUUC-Dor-030609	Dipodomys ordii	56.81	5.00e-104	371.00
IUUC-Dme-031929	Drosophila melanogaster	55.18	2.00e-109	389.00
IUUC-Ete-033081	Echinops telfairi	53.29	1.00e-55	210.00
IUUC-Eca-034387	Equus caballus	65.74	5.00e-118	417.00
IUUC-Eeu-035134	Erinaceus europaeus	74.43	9.00e-108	383.00
IUUC-Fca-036243	Felis catus	75.65	7.00e-146	510.00
IUUC-Fal-036600	Ficedula albicollis	77.62	4.00e-151	528.00
IUUC-Gmo-039665	Gadus morhua	79.38	3.00e-127	448.00
IUUC-Gga-040993	Gallus gallus	77.36	9.00e-152	530.00
IUUC-Gac-042342	Gasterosteus aculeatus	80.84	4.00e-151	528.00
IUUC-Gma-043822	Glycine max	36.50	3.00e-21	96.30
IUUC-Ggo-045338	Gorilla gorilla	64.72	7.00e-119	420.00
IUUC-Hsa-046822	Homo sapiens	74.88	1.00e-143	502.00
IUUC-Hvu-047141	Hordeum vulgare	31.80	6.00e-25	108.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	64.72	9.00e-119	420.00
IUUC-Lch-049946	Latimeria chalumnae	70.38	6.00e-128	450.00
IUUC-Lpe-051132	Leersia perrieri	52.48	1.00e-15	77.80
IUUC-Loc-052469	Lepisosteus oculatus	67.70	3.00e-139	488.00
IUUC-Laf-053979	Loxodonta africana	74.06	5.00e-133	467.00
IUUC-Mcc-055682	Macaca mulatta	74.88	1.00e-143	502.00
IUUC-Meu-056004	Macropus eugenii	62.88	4.00e-118	418.00
IUUC-Mtr-058392	Medicago truncatula	34.47	4.00e-29	122.00
IUUC-Mga-059466	Meleagris gallopavo	76.89	1.00e-151	529.00
IUUC-Mmr-060890	Microcebus murinus	66.24	2.00e-119	422.00
IUUC-Mdo-062122	Monodelphis domestica	75.41	1.00e-149	522.00
IUUC-Mmu-063176	Mus musculus	74.64	9.00e-137	479.00
IUUC-Mac-064858	Musa acuminata	37.76	8.00e-18	84.30
IUUC-Mpu-065927	Mustela putorius furo	76.36	7.00e-146	510.00
IUUC-Mlu-067079	Myotis lucifugus	76.88	1.00e-151	529.00
IUUC-Nle-070180	Nomascus leucogenys	74.88	1.00e-143	502.00
IUUC-Opr-070847	Ochotona princeps	72.58	1.00e-138	486.00
IUUC-Ont-071846	Oreochromis niloticus	81.48	1.00e-179	622.00
IUUC-Oan-072783	Ornithorhynchus anatinus	74.47	8.00e-114	403.00
IUUC-Ocu-074527	Oryctolagus cuniculus	75.53	7.00e-147	514.00
IUUC-Oba-075256	Oryza barthii	46.55	3.00e-15	76.30
IUUC-Obr-076302	Oryza brachyantha	45.59	4.00e-15	76.30
IUUC-Ogl-077097	Oryza glaberrima	46.55	4.00e-15	76.30
IUUC-Ogu-078570	Oryza glumaepatula	46.55	4.00e-15	75.90
IUUC-Oin-079244	Oryza indica	46.55	4.00e-15	76.30
IUUC-Olo-080484	Oryza longistaminata	59.26	1.00e-15	76.60
IUUC-Ome-081814	Oryza meridionalis	46.55	3.00e-15	76.30
IUUC-Oni-082057	Oryza nivara	46.55	5.00e-15	75.90
IUUC-Opu-084176	Oryza punctata	46.55	3.00e-15	76.30
IUUC-Oru-084618	Oryza rufipogon	31.03	1.00e-20	94.00
IUUC-Osa-085602	Oryza sativa	31.08	8.00e-21	94.70
IUUC-Ola-086707	Oryzias latipes	77.98	1.00e-88	319.00
IUUC-Olu-087811	Ostreococcus lucimarinus	32.05	9.00e-41	160.00
IUUC-Oga-088560	Otolemur garnettii	65.99	2.00e-119	422.00
IUUC-Oar-090348	Ovis aries	76.13	1.00e-146	512.00
IUUC-Ptr-091060	Pan troglodytes	74.88	1.00e-143	502.00
IUUC-Pan-091855	Papio anubis	68.72	1.00e-128	453.00
IUUC-Psi-093505	Pelodiscus sinensis	77.20	2.00e-150	525.00
IUUC-Pma-094612	Petromyzon marinus	69.64	3.00e-118	418.00
IUUC-Ppa-095431	Physcomitrella patens	31.65	2.00e-24	106.00
IUUC-Pfo-097396	Poecilia formosa	94.40	0.00e+00	691.00
IUUC-Pab-098591	Pongo abelii	74.88	2.00e-143	502.00
IUUC-Pop-099661	Populus trichocarpa	31.76	4.00e-31	129.00
IUUC-Pca-101029	Procavia capensis	73.46	6.00e-136	477.00
IUUC-Ppe-101495	Prunus persica	31.99	1.00e-36	147.00
IUUC-Pva-102244	Pteropus vampyrus	73.62	3.00e-140	491.00
IUUC-Rno-105861	Rattus norvegicus	70.97	4.00e-139	488.00
IUUC-Sha-107045	Sarcophilus harrisii	75.65	8.00e-150	523.00
IUUC-Smo-109325	Selaginella moellendorffii	36.98	7.00e-36	144.00
IUUC-Sit-110624	Setaria italica	54.35	2.00e-15	77.40
IUUC-Sly-110865	Solanum lycopersicum	57.41	3.00e-07	46.60
IUUC-Stu-112433	Solanum tuberosum	32.85	5.00e-30	125.00
IUUC-Sar-113169	Sorex araneus	72.52	6.00e-111	394.00
IUUC-Sbi-114305	Sorghum bicolor	32.80	7.00e-23	101.00
IUUC-Ssc-115766	Sus scrofa	76.52	1.00e-145	509.00
IUUC-Tgu-117280	Taeniopygia guttata	68.91	1.00e-125	442.00
IUUC-Tru-117732	Takifugu rubripes	81.33	2.00e-175	608.00
IUUC-Tsy-119624	Tarsius syrichta	68.48	2.00e-130	459.00
IUUC-Tni-119852	Tetraodon nigroviridis	77.80	2.00e-172	598.00
IUUC-Tca-121865	Theobroma cacao	33.25	7.00e-34	138.00
IUUC-Tae-123984	Triticum aestivum	35.41	8.00e-25	108.00
IUUC-Tur-126237	Triticum urartu	33.66	1.00e-24	107.00
IUUC-Tbe-128148	Tupaia belangeri	64.24	2.00e-101	362.00
IUUC-Ttr-128793	Tursiops truncatus	75.88	4.00e-140	491.00
IUUC-Vpa-130625	Vicugna pacos	63.82	2.00e-113	402.00
IUUC-Vvi-131312	Vitis vinifera	35.56	4.00e-19	89.40
IUUC-Xtr-131790	Xenopus tropicalis	77.02	3.00e-139	488.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence