iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-055421

UUCD1 version

UUC-MaM-00985

Ensembl Protein ID

ENSMMUP00000041610.1

UniProt Accession

F6PPG7; F6PPG7_MACMU

Genbank Protein ID

AFE63995.1; AFH32749.1; AFI37407.1; EHH17351.1

Protein Name

Ubiquitin-conjugating enzyme E2 D4

Genbank Nucleotide ID

JSUE03028352; JU475945; JV047336; CM001255

Gene Name

UBE2D4; EGK_13741

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000043293.1	ENSMMUT00000076972.1	ENSMMUP00000041610.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	5.50e-57	192.5	5	139
UBD/UBC-like/UBD_UBC	2.10e-83	278.4	5	142

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++kel++l++dpp+++sa+pv + dl++w+++i+Gp+d+pY+ggvF l+i+fp+dYPfkPPkv f+tki+hPn+++nG++Cl+il+  
   Q: 5    RIQKELTDLQRDPPAQCSAGPVGD-DLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTKIYHPNINSNGSICLDILR-- 90
           9***********************.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++Wspal+v++vllsi+sll++pnp++pl  e+a+++k++re+y++ +r
   Q: 91   SQWSPALTVSKVLLSICSLLCDPNPDDPLVPEIAHTYKADREKYNRLAR 139
           *********************************************9987 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqw 89
           ri+kel dl+rd++aq+sa++v+ddlf+++ati+gp+dspy+ggvfflti++ptdypfkppkvaf+tkiyhpninsngsicldilrsqw
   Q: 5    RIQKELTDLQRDPPAQCSAGPVGDDLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTKIYHPNINSNGSICLDILRSQW 93
           8**************************************************************************************** PP
   S: 90   saaltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           s+alt+skvlls+csll+d++pddplv+eia+ yk+d+eky+r arewt
   Q: 94   SPALTVSKVLLSICSLLCDPNPDDPLVPEIAHTYKADREKYNRLAREWT 142
           ************************************************8 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MALKRIQKEL TDLQRDPPAQ CSAGPVGDDL FHWQATIMGP NDSPYQGGVF FLTIHFPTDY 60
PFKPPKVAFT TKIYHPNINS NGSICLDILR SQWSPALTVS KVLLSICSLL CDPNPDDPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGGTGGCG GCTGACCCGG CAGCGGGCCG CCTCAGGCAG CCCTGGCCGG GCCGCCTCAG 60
GCAGCCCTGG CCGGGCCGCC CGGGTCCCCG GCAGCGGGGT AGGATGGCGC TAAAGCGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0070979--P:protein K11-linked ubiquitination
GO:0044314--P:protein K27-linked ubiquitination
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000292	Aegilops tauschii	79.59	7.00e-70	255.00
IUUC-Atr-002861	Amborella trichopoda	80.95	1.00e-70	258.00
IUUC-Aly-006221	Arabidopsis lyrata	81.63	2.00e-71	260.00
IUUC-Ath-007700	Arabidopsis thaliana	81.63	2.00e-70	257.00
IUUC-Ago-007967	Ashbya gossypii	80.27	8.00e-71	258.00
IUUC-Acl-008266	Aspergillus clavatus	85.03	3.00e-74	270.00
IUUC-Afl-008709	Aspergillus flavus	79.58	3.00e-69	256.00
IUUC-Afu-008956	Aspergillus fumigatus	85.71	1.00e-74	271.00
IUUC-Ani-009401	Aspergillus nidulans	83.67	4.00e-73	266.00
IUUC-Aor-010157	Aspergillus oryzae	83.67	2.00e-73	267.00
IUUC-Ate-010438	Aspergillus terreus	84.35	2.00e-73	267.00
IUUC-Ame-011566	Astyanax mexicanus	95.92	4.00e-83	299.00
IUUC-Bgr-012238	Blumeria graminis	78.91	2.00e-69	253.00
IUUC-Bci-013661	Botrytis cinerea	83.67	3.00e-74	270.00
IUUC-Bdi-014561	Brachypodium distachyon	80.95	1.00e-71	261.00
IUUC-Bol-015722	Brassica oleracea	82.31	3.00e-72	263.00
IUUC-Bra-017985	Brassica rapa	82.31	1.00e-71	261.00
IUUC-Cel-018362	Caenorhabditis elegans	92.52	5.00e-80	289.00
IUUC-Cja-019014	Callithrix jacchus	97.18	1.00e-81	295.00
IUUC-Cpo-021897	Cavia porcellus	97.90	3.00e-82	296.00
IUUC-Cre-022765	Chlamydomonas reinhardtii	80.27	2.00e-70	257.00
IUUC-Csa-023377	Chlorocebus sabaeus	97.20	1.00e-81	294.00
IUUC-Cin-025379	Ciona intestinalis	88.36	2.00e-76	277.00
IUUC-Cgl-026490	Colletotrichum gloeosporioides	84.35	6.00e-74	269.00
IUUC-Cne-026957	Cryptococcus neoformans	80.82	4.00e-70	256.00
IUUC-Cme-027220	Cyanidioschyzon merolae	83.67	2.00e-72	263.00
IUUC-Dre-028686	Danio rerio	99.32	1.00e-85	308.00
IUUC-Dor-030323	Dipodomys ordii	99.32	1.00e-85	308.00
IUUC-Dse-031397	Dothistroma septosporum	84.35	3.00e-74	270.00
IUUC-Dme-031594	Drosophila melanogaster	92.52	2.00e-79	287.00
IUUC-Eca-033231	Equus caballus	100.00	3.00e-81	293.00
IUUC-Fca-035917	Felis catus	91.84	8.00e-81	291.00
IUUC-Fox-038021	Fusarium oxysporum	84.35	8.00e-74	268.00
IUUC-Fso-038297	Fusarium solani	83.67	2.00e-73	267.00
IUUC-Gmo-038775	Gadus morhua	91.84	2.00e-80	290.00
IUUC-Ggr-039912	Gaeumannomyces graminis	78.95	5.00e-69	252.00
IUUC-Gac-042231	Gasterosteus aculeatus	90.48	2.00e-79	287.00
IUUC-Gma-043733	Glycine max	81.63	2.00e-71	261.00
IUUC-Ggo-045361	Gorilla gorilla	100.00	5.00e-86	309.00
IUUC-Hsa-045934	Homo sapiens	100.00	5.00e-86	309.00
IUUC-Hvu-047546	Hordeum vulgare	78.23	2.00e-69	254.00
IUUC-Kpa-049290	Komagataella pastoris	78.91	2.00e-69	254.00
IUUC-Lch-050109	Latimeria chalumnae	87.76	1.00e-77	281.00
IUUC-Lpe-051289	Leersia perrieri	81.63	5.00e-71	259.00
IUUC-Loc-052838	Lepisosteus oculatus	100.00	5.00e-86	309.00
IUUC-Lma-053121	Leptosphaeria maculans	84.35	2.00e-74	270.00
IUUC-Mor-057235	Magnaporthe oryzae	83.67	4.00e-73	266.00
IUUC-Mpo-057596	Magnaporthe poae	78.95	1.00e-68	251.00
IUUC-Mtr-058257	Medicago truncatula	80.27	2.00e-70	257.00
IUUC-Mla-059189	Melampsora laricipopulina	79.59	1.00e-67	248.00
IUUC-Mvi-060397	Microbotryum violaceum	81.63	1.00e-71	261.00
IUUC-Mac-064668	Musa acuminata	80.27	2.00e-70	258.00
IUUC-Nfi-068599	Neosartorya fischeri	85.71	1.00e-74	271.00
IUUC-Ncr-068677	Neurospora crassa	82.31	6.00e-72	262.00
IUUC-Nle-069715	Nomascus leucogenys	100.00	5.00e-86	309.00
IUUC-Ont-072562	Oreochromis niloticus	96.60	8.00e-84	301.00
IUUC-Oan-073026	Ornithorhynchus anatinus	99.29	2.00e-81	294.00
IUUC-Oba-075411	Oryza barthii	81.63	6.00e-71	259.00
IUUC-Obr-076691	Oryza brachyantha	80.95	2.00e-70	258.00
IUUC-Ogl-076968	Oryza glaberrima	81.63	7.00e-72	262.00
IUUC-Ogu-078091	Oryza glumaepatula	80.69	9.00e-71	260.00
IUUC-Oin-079659	Oryza indica	81.63	7.00e-72	262.00
IUUC-Olo-080786	Oryza longistaminata	81.63	6.00e-71	259.00
IUUC-Ome-081920	Oryza meridionalis	80.95	3.00e-70	256.00
IUUC-Oni-082391	Oryza nivara	81.63	6.00e-72	264.00
IUUC-Opu-083833	Oryza punctata	80.27	8.00e-71	258.00
IUUC-Oru-085167	Oryza rufipogon	81.63	5.00e-72	264.00
IUUC-Osa-086003	Oryza sativa	81.63	7.00e-72	262.00
IUUC-Ola-087515	Oryzias latipes	97.28	4.00e-84	303.00
IUUC-Olu-087615	Ostreococcus lucimarinus	77.55	8.00e-67	245.00
IUUC-Oar-090038	Ovis aries	91.84	8.00e-81	291.00
IUUC-Pan-092614	Papio anubis	97.24	2.00e-82	297.00
IUUC-Psi-094076	Pelodiscus sinensis	91.84	8.00e-81	291.00
IUUC-Pno-094765	Phaeosphaeria nodorum	84.35	2.00e-74	270.00
IUUC-Ppa-095177	Physcomitrella patens	80.95	1.00e-70	258.00
IUUC-Pfo-096867	Poecilia formosa	97.28	4.00e-84	303.00
IUUC-Pab-098760	Pongo abelii	99.32	2.00e-85	307.00
IUUC-Pop-098799	Populus trichocarpa	80.95	9.00e-71	258.00
IUUC-Ppe-101431	Prunus persica	81.63	3.00e-71	259.00
IUUC-Pgr-103381	Puccinia graminis	80.95	3.00e-68	251.00
IUUC-Pte-104015	Pyrenophora teres	84.35	3.00e-74	270.00
IUUC-Pyt-104701	Pyrenophora triticirepentis	84.35	3.00e-74	270.00
IUUC-Rno-105498	Rattus norvegicus	91.84	8.00e-81	291.00
IUUC-Sce-106463	Saccharomyces cerevisiae	81.25	2.00e-70	257.00
IUUC-Sja-107729	Schizosaccharomyces japonicus	83.67	7.00e-73	265.00
IUUC-Spo-108032	Schizosaccharomyces pombe	83.67	4.00e-73	266.00
IUUC-Ssl-108443	Sclerotinia sclerotiorum	84.35	1.00e-74	271.00
IUUC-Smo-108911	Selaginella moellendorffii	80.95	3.00e-70	256.00
IUUC-Sit-109936	Setaria italica	81.63	8.00e-72	263.00
IUUC-Sly-110857	Solanum lycopersicum	81.63	2.00e-71	261.00
IUUC-Stu-112436	Solanum tuberosum	81.63	3.00e-72	263.00
IUUC-Sbi-114840	Sorghum bicolor	81.63	5.00e-72	262.00
IUUC-Sre-115037	Sporisorium reilianum	79.17	9.00e-69	251.00
IUUC-Ssc-115391	Sus scrofa	100.00	5.00e-86	309.00
IUUC-Tgu-116727	Taeniopygia guttata	91.84	8.00e-81	291.00
IUUC-Tsy-118832	Tarsius syrichta	97.28	4.00e-83	299.00
IUUC-Tca-121542	Theobroma cacao	81.63	2.00e-72	265.00
IUUC-Tre-122125	Trichoderma reesei	81.63	5.00e-71	259.00
IUUC-Tvi-122296	Trichoderma virens	81.63	5.00e-71	259.00
IUUC-Tae-123340	Triticum aestivum	82.31	6.00e-73	265.00
IUUC-Tur-126518	Triticum urartu	79.59	2.00e-70	258.00
IUUC-Tme-126912	Tuber melanosporum	80.95	2.00e-71	260.00
IUUC-Tbe-128122	Tupaia belangeri	96.77	4.00e-61	226.00
IUUC-Uma-129648	Ustilago maydis	80.27	7.00e-71	258.00
IUUC-Vda-129695	Verticillium dahliae	84.35	6.00e-74	269.00
IUUC-Vvi-131016	Vitis vinifera	80.27	5.00e-71	259.00
IUUC-Xtr-132238	Xenopus tropicalis	97.96	1.00e-84	305.00
IUUC-Yli-134353	Yarrowia lipolytica	78.91	7.00e-71	258.00
IUUC-Zma-135267	Zea mays	80.27	3.00e-62	230.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence