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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106463
UUCD1 version UUC-SaC-00224
Ensembl Protein ID YBR082C
UniProt Accession P15731; D6VQ81; UBC4_YEAST
Genbank Protein ID CAA35528.1; CAA53942.1; CAA85027.1; DAA07201.1
Protein Name Ubiquitin-conjugating enzyme E2 4; E2 ubiquitin-conjugating enzyme 4; Ubiquitin carrier protein 4; Ubiquitin-protein ligase 4
Genbank Nucleotide ID X17493; X76294; Z35951; BK006936
Gene Name UBC4; YBR082C; YBR0745
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YBR082C YBR082C YBR082C
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UBC E2_UBC 20613989; 16275324; 19578373; 20660159; 19204001
Classification
Family E-value Score Start End
E2/UBC 1.80e-55 185.0 6 140
UBD/UBC-like/UBD_UBC 1.40e-76 253.6 6 143
Active Site
Position(s) Description Evidence
86 Glycyl thioester intermediate N/A
Domain Profile

   E2/UBC
   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsvesvl 102
           R++kel++le+dpp+++sa+pv + dl++w++ i+Gp+d+pY+ggvF l+i+fp+dYPfkPPk++f+tki+hPn+++nG++Cl+ilk  ++Wspal++++vl
   Q: 6    RIAKELSDLERDPPTSCSAGPVGD-DLYHWQASIMGPADSPYAGGVFFLSIHFPTDYPFKPPKISFTTKIYHPNINANGNICLDILK--DQWSPALTLSKVL 104
           89**********************.9************************************************************9..************* PP
   S: 103  lsiqsllaepnpesplneeaaellkknreeykkkvr 138
           lsi+sll+++np++pl  e+a+++k++r +y+ ++r
   Q: 105  LSICSLLTDANPDDPLVPEIAHIYKTDRPKYEATAR 140
           ********************************9987 PP
   

   UBD/UBC-like/UBD_UBC
   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsaaltlskvllsl 102
           ri kel+dl rd+++ +sa++v+ddl++++a i+gp dspy ggvffl i++ptdypfkppk++f+tkiyhpnin+ng icldil++qws+altlskvlls+
   Q: 6    RIAKELSDLERDPPTSCSAGPVGDDLYHWQASIMGPADSPYAGGVFFLSIHFPTDYPFKPPKISFTTKIYHPNINANGNICLDILKDQWSPALTLSKVLLSI 107
           89**************************************************************************************************** PP
   S: 103  cslladaepddplvaeiariyktdkekykriarewt 138
           csll+da+pddplv+eia+iyktd+ ky+ +arewt
   Q: 108  CSLLTDANPDDPLVPEIAHIYKTDRPKYEATAREWT 143
           ***********************************8 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Mediates ubiquitination of PEX5.
 Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Mediates ubiquitination of PEX5.
Protein Sequence
(Fasta)
MSSSKRIAKE LSDLERDPPT SCSAGPVGDD LYHWQASIMG PADSPYAGGV FFLSIHFPTD 60
YPFKPPKISF TTKIYHPNIN ANGNICLDIL KDQWSPALTL SKVLLSICSL LTDANPDDPL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106463|E2,E2/UBC;UBD,UBD_UBC|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCTTCTT CTAAACGTAT TGCTAAAGAA CTAAGTGATC TAGAAAGGTA TGTCTAAAGT 60
TATGGCCACG TTTCAAATGC GTGCTTTTTT TTTAAAACTT ATGCTCTTAT TTACTAACAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106463|E2,E2/UBC;UBD,UBD_UBC|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0346--Stress response
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0000502--C:proteasome complex
GO:0005524--F:ATP binding
GO:0030674--F:protein binding, bridging
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0034605--P:cellular response to heat
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
KEGG sce:YBR082C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000292 Aegilops tauschii 79.45 2.00e-71 259.00
IUUC-Atr-002894 Amborella trichopoda 80.14 5.00e-72 260.00
IUUC-Aly-006221 Arabidopsis lyrata 79.45 3.00e-71 258.00
IUUC-Ath-007700 Arabidopsis thaliana 79.45 3.00e-71 258.00
IUUC-Ago-007967 Ashbya gossypii 94.52 8.00e-80 286.00
IUUC-Acl-008266 Aspergillus clavatus 84.03 2.00e-75 272.00
IUUC-Afl-008709 Aspergillus flavus 78.17 5.00e-72 263.00
IUUC-Afu-008956 Aspergillus fumigatus 84.72 7.00e-76 273.00
IUUC-Ani-009401 Aspergillus nidulans 82.64 2.00e-74 268.00
IUUC-Ang-009725 Aspergillus niger 85.60 4.00e-66 241.00
IUUC-Ate-010438 Aspergillus terreus 84.72 2.00e-75 272.00
IUUC-Ame-011566 Astyanax mexicanus 80.56 5.00e-71 257.00
IUUC-Bci-013661 Botrytis cinerea 83.33 7.00e-75 270.00
IUUC-Bdi-014561 Brachypodium distachyon 78.77 5.00e-72 260.00
IUUC-Bol-016512 Brassica oleracea 81.51 1.00e-72 262.00
IUUC-Bra-017985 Brassica rapa 81.51 1.00e-72 262.00
IUUC-Cre-022765 Chlamydomonas reinhardtii 80.82 1.00e-72 262.00
IUUC-Csa-023377 Chlorocebus sabaeus 79.72 6.00e-70 254.00
IUUC-Cne-026957 Cryptococcus neoformans 81.94 3.00e-71 258.00
IUUC-Dre-028568 Danio rerio 80.56 5.00e-71 257.00
IUUC-Dor-030323 Dipodomys ordii 80.56 1.00e-70 256.00
IUUC-Fca-035917 Felis catus 80.56 2.00e-70 255.00
IUUC-Fal-036904 Ficedula albicollis 80.71 1.00e-68 249.00
IUUC-Fox-038021 Fusarium oxysporum 84.03 2.00e-75 272.00
IUUC-Fso-038297 Fusarium solani 83.33 4.00e-75 271.00
IUUC-Gmo-038775 Gadus morhua 81.25 1.00e-71 259.00
IUUC-Ggr-039912 Gaeumannomyces graminis 79.19 2.00e-69 252.00
IUUC-Gac-041509 Gasterosteus aculeatus 79.17 4.00e-69 251.00
IUUC-Gma-043068 Glycine max 80.82 2.00e-72 262.00
IUUC-Ggo-045361 Gorilla gorilla 81.25 4.00e-71 257.00
IUUC-Hsa-045934 Homo sapiens 81.25 4.00e-71 257.00
IUUC-Hvu-047546 Hordeum vulgare 77.40 8.00e-71 256.00
IUUC-Lpe-051194 Leersia perrieri 80.14 2.00e-72 263.00
IUUC-Loc-052838 Lepisosteus oculatus 81.25 4.00e-71 257.00
IUUC-Mcc-055421 Macaca mulatta 81.25 4.00e-71 257.00
IUUC-Meu-056462 Macropus eugenii 80.58 1.00e-67 246.00
IUUC-Mtr-058257 Medicago truncatula 80.82 2.00e-72 262.00
IUUC-Mla-059189 Melampsora laricipopulina 80.56 8.00e-69 249.00
IUUC-Mga-059237 Meleagris gallopavo 79.58 1.00e-68 249.00
IUUC-Mvi-060397 Microbotryum violaceum 80.56 2.00e-71 258.00
IUUC-Mdo-062596 Monodelphis domestica 81.25 1.00e-70 256.00
IUUC-Mac-065337 Musa acuminata 80.14 4.00e-72 261.00
IUUC-Nfi-068599 Neosartorya fischeri 84.72 7.00e-76 273.00
IUUC-Ncr-068677 Neurospora crassa 83.33 6.00e-74 267.00
IUUC-Nle-069715 Nomascus leucogenys 81.25 4.00e-71 257.00
IUUC-Ont-072562 Oreochromis niloticus 80.56 1.00e-70 256.00
IUUC-Oan-073026 Ornithorhynchus anatinus 80.14 6.00e-69 251.00
IUUC-Oba-075411 Oryza barthii 80.82 1.00e-72 262.00
IUUC-Obr-076481 Oryza brachyantha 80.14 3.00e-72 261.00
IUUC-Ogl-077772 Oryza glaberrima 80.82 1.00e-72 262.00
IUUC-Ogu-078981 Oryza glumaepatula 80.82 1.00e-72 262.00
IUUC-Oin-079652 Oryza indica 80.82 1.00e-72 262.00
IUUC-Olo-080786 Oryza longistaminata 80.82 1.00e-72 262.00
IUUC-Ome-081967 Oryza meridionalis 80.14 3.00e-72 261.00
IUUC-Oni-082720 Oryza nivara 80.82 1.00e-72 262.00
IUUC-Opu-083205 Oryza punctata 80.14 7.00e-72 261.00
IUUC-Oru-084481 Oryza rufipogon 80.82 1.00e-72 262.00
IUUC-Osa-085585 Oryza sativa 80.14 2.00e-72 262.00
IUUC-Ola-087515 Oryzias latipes 81.25 5.00e-71 257.00
IUUC-Oga-088477 Otolemur garnettii 80.42 5.00e-70 254.00
IUUC-Oar-090038 Ovis aries 80.56 2.00e-70 255.00
IUUC-Psi-094076 Pelodiscus sinensis 80.56 2.00e-70 255.00
IUUC-Ppa-095177 Physcomitrella patens 79.45 2.00e-71 258.00
IUUC-Pfo-096867 Poecilia formosa 81.25 5.00e-71 257.00
IUUC-Pab-098760 Pongo abelii 81.25 2.00e-71 258.00
IUUC-Pop-098986 Populus trichocarpa 80.82 2.00e-72 262.00
IUUC-Ppe-101538 Prunus persica 80.82 2.00e-72 262.00
IUUC-Rno-105498 Rattus norvegicus 80.56 2.00e-70 255.00
IUUC-Spo-108032 Schizosaccharomyces pombe 84.03 1.00e-74 269.00
IUUC-Ssl-108443 Sclerotinia sclerotiorum 84.03 3.00e-75 271.00
IUUC-Smo-108911 Selaginella moellendorffii 79.45 6.00e-72 260.00
IUUC-Sit-110205 Setaria italica 80.82 1.00e-72 263.00
IUUC-Sly-110857 Solanum lycopersicum 79.45 5.00e-72 260.00
IUUC-Stu-112825 Solanum tuberosum 79.45 1.00e-71 259.00
IUUC-Sbi-113792 Sorghum bicolor 80.82 1.00e-72 263.00
IUUC-Sre-115037 Sporisorium reilianum 80.85 3.00e-70 254.00
IUUC-Ssc-115391 Sus scrofa 81.25 4.00e-71 257.00
IUUC-Tgu-116727 Taeniopygia guttata 80.56 2.00e-70 255.00
IUUC-Tsy-118832 Tarsius syrichta 80.56 4.00e-69 250.00
IUUC-Tca-121542 Theobroma cacao 79.45 2.00e-72 263.00
IUUC-Tre-122125 Trichoderma reesei 82.64 3.00e-73 265.00
IUUC-Tvi-122296 Trichoderma virens 82.64 3.00e-73 265.00
IUUC-Tae-125784 Triticum aestivum 79.45 4.00e-71 258.00
IUUC-Tur-126518 Triticum urartu 79.45 4.00e-72 261.00
IUUC-Tme-126912 Tuber melanosporum 84.03 4.00e-74 267.00
IUUC-Tbe-128122 Tupaia belangeri 82.11 1.00e-52 196.00
IUUC-Uma-129648 Ustilago maydis 80.14 7.00e-72 260.00
IUUC-Vvi-131016 Vitis vinifera 80.82 1.00e-72 262.00
Created Date 25-Jun-2017

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