iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093191

Ensembl Protein ID

ENSPSIP00000008691.1

UniProt Accession

K7FKY1; K7FKY1_PELSI

Genbank Protein ID

ENSPSIP00000008691

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AGCU01136409

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000007713.1	ENSPSIT00000008737.1	ENSPSIP00000008691.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.70e-117	393.1	9	516

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 6    rlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahe 94
           rlwG+++qe+l+ a+v++++a ++G+E+lKnLvl G+gs+t+vD+++v+ ++++++F+++++++g+++A++a e l+eln dv++ ++e
   Q: 9    RLWGDHGQEALEAAHVCVINASATGTEILKNLVLPGIGSFTIVDGNQVTGEDVGNNFFLQRSNIGQNRAQSATELLQELNNDVSGNFVE 97
           9**************************************************************************************** PP
   S: 95   esiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlket 179
           es+++l ++++ Ff++f++Vv+++ ++++  +++++++na++pl+ ++t+Gl+G++r+iik++ + +s++d   ++++++ Pf++l+e+
   Q: 98   ESPDKLLDNDPsFFCRFNLVVATQLPESTLVRLAEILWNANIPLLVCRTYGLVGYMRIIIKEHSVVESHPDnalEDLRLDDPFPELREH 186
           ***************************************************************************************** PP
   S: 180  pn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakttins. 252
           ++         +++++++w+v+++k+l++++ e++++ +++++eke++++++++++ +      edeenfeeai+++++a++ t i+s 
   Q: 187  IQsydldhmekKDHSHTPWIVIVAKYLAKWYNEKSEQIPKNYKEKEAFRELIRQGILKnengipEDEENFEEAIKNVNTALNVTKIPSc 275
           88888888888****************************************************************************** PP
   S: 253  ikqllksfecdivtkskspfwv................................................................... 274
           i++++++++c ++t+++++fw+                                                                   
   Q: 276  IEDIFNDDRCINLTQQTPSFWIlaravkefvaqegqgnlpvrgtipdmiadsgkfiklqnvyrerakkdaaavgnhavnllqsigkape 364
           ***************************************************************************************** PP
   S: 275  ........sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvt 337
                    +csn++ l+v             + +kde+++++++p     lyl+lr+++rf k++gr+pg+ +++++dd+  + +++ 
   Q: 365  sisqtelkLLCSNSAFLRVVrcrslseeyglNTFNKDEIISSMDNPdneivLYLMLRTVDRFYKQHGRYPGVYNYQVEDDIgkLKSCLS 453
           ********99********777777777788899999999999999999999*****************************888888888 PP
   S: 338  aaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            ++    +++g++  ++dd+++e++++++++ +t+++++gG+aaqE++K+++g+f+ ++n++++ ++
   Q: 454  GFL----QEYGLSVTVKDDYVHEFCRYGAAEPHTIASFLGGAAAQEIVKIITGQFVIFNNTYIYSGM 516
           888....********************************************************9776 PP

Organism

Pelodiscus sinensis

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MLLYFLFCRL WGDHGQEALE AAHVCVINAS ATGTEILKNL VLPGIGSFTI VDGNQVTGED 60
VGNNFFLQRS NIGQNRAQSA TELLQELNND VSGNFVEESP DKLLDNDPSF FCRFNLVVAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTGCAGTC TAGATGCTCT TTTTCAAAAG AAGCTTTTTC GAAAGTATCT TTCGAAAAAG 60
CCTCTTTCGA AAGAGGCTTT CAGTCTAGAC GTAACCCCAG TGTAAATCAT GTTTTGAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	40.00	3.00e-118	418.00
IUUC-Aml-002333	Ailuropoda melanoleuca	85.93	0.00e+00	956.00
IUUC-Atr-002644	Amborella trichopoda	39.03	6.00e-106	377.00
IUUC-Apl-003446	Anas platyrhynchos	87.24	0.00e+00	960.00
IUUC-Aca-004450	Anolis carolinensis	85.69	0.00e+00	940.00
IUUC-Aly-006187	Arabidopsis lyrata	38.93	2.00e-119	422.00
IUUC-Ath-007600	Arabidopsis thaliana	38.61	2.00e-119	422.00
IUUC-Ago-007900	Ashbya gossypii	24.68	2.00e-31	129.00
IUUC-Acl-008333	Aspergillus clavatus	33.33	3.00e-74	272.00
IUUC-Afl-008529	Aspergillus flavus	34.62	2.00e-79	289.00
IUUC-Afu-009071	Aspergillus fumigatus	32.54	2.00e-72	266.00
IUUC-Ani-009443	Aspergillus nidulans	32.47	5.00e-71	261.00
IUUC-Ang-009669	Aspergillus niger	31.50	3.00e-74	272.00
IUUC-Aor-009914	Aspergillus oryzae	33.94	4.00e-76	278.00
IUUC-Ate-010450	Aspergillus terreus	33.33	2.00e-76	279.00
IUUC-Ame-011183	Astyanax mexicanus	73.89	0.00e+00	828.00
IUUC-Bgr-012111	Blumeria graminis	30.58	5.00e-53	201.00
IUUC-Bta-012583	Bos taurus	86.85	0.00e+00	964.00
IUUC-Bci-013892	Botrytis cinerea	30.89	2.00e-57	216.00
IUUC-Bdi-014592	Brachypodium distachyon	40.54	5.00e-120	424.00
IUUC-Bol-016399	Brassica oleracea	38.80	1.00e-118	420.00
IUUC-Bra-017506	Brassica rapa	36.61	2.00e-112	398.00
IUUC-Cel-018456	Caenorhabditis elegans	34.51	5.00e-87	314.00
IUUC-Cja-020007	Callithrix jacchus	85.96	0.00e+00	958.00
IUUC-Cfa-020324	Canis familiaris	87.04	0.00e+00	966.00
IUUC-Cpo-022248	Cavia porcellus	59.20	2.00e-159	555.00
IUUC-Csa-023149	Chlorocebus sabaeus	83.86	0.00e+00	841.00
IUUC-Cho-024537	Choloepus hoffmanni	76.79	0.00e+00	738.00
IUUC-Cin-025763	Ciona intestinalis	49.62	2.00e-150	525.00
IUUC-Csv-026113	Ciona savignyi	45.57	2.00e-139	488.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	29.57	2.00e-57	216.00
IUUC-Cne-026884	Cryptococcus neoformans	28.95	4.00e-64	238.00
IUUC-Cme-027210	Cyanidioschyzon merolae	26.19	5.00e-16	79.00
IUUC-Dre-028140	Danio rerio	74.66	0.00e+00	844.00
IUUC-Dno-030033	Dasypus novemcinctus	86.59	0.00e+00	844.00
IUUC-Dor-030513	Dipodomys ordii	60.70	2.00e-102	365.00
IUUC-Dse-031536	Dothistroma septosporum	30.98	2.00e-72	266.00
IUUC-Dme-031683	Drosophila melanogaster	43.16	2.00e-121	429.00
IUUC-Ete-032420	Echinops telfairi	75.19	0.00e+00	814.00
IUUC-Eca-033992	Equus caballus	87.61	0.00e+00	831.00
IUUC-Eeu-034713	Erinaceus europaeus	73.62	3.00e-110	391.00
IUUC-Fca-036548	Felis catus	85.69	0.00e+00	951.00
IUUC-Fal-037600	Ficedula albicollis	83.56	0.00e+00	912.00
IUUC-Fox-038037	Fusarium oxysporum	32.03	2.00e-67	249.00
IUUC-Fso-038387	Fusarium solani	32.96	2.00e-69	256.00
IUUC-Gmo-038562	Gadus morhua	69.75	0.00e+00	804.00
IUUC-Ggr-040005	Gaeumannomyces graminis	30.98	3.00e-62	232.00
IUUC-Gga-041129	Gallus gallus	88.59	0.00e+00	954.00
IUUC-Gac-042558	Gasterosteus aculeatus	71.87	0.00e+00	813.00
IUUC-Gma-043610	Glycine max	38.46	2.00e-112	399.00
IUUC-Ggo-045611	Gorilla gorilla	86.54	0.00e+00	961.00
IUUC-Hsa-046563	Homo sapiens	86.65	0.00e+00	963.00
IUUC-Hvu-047790	Hordeum vulgare	35.61	6.00e-74	270.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	86.85	0.00e+00	961.00
IUUC-Kpa-049309	Komagataella pastoris	34.23	7.00e-75	274.00
IUUC-Lch-050038	Latimeria chalumnae	76.88	0.00e+00	852.00
IUUC-Lpe-051535	Leersia perrieri	38.70	2.00e-104	372.00
IUUC-Loc-051917	Lepisosteus oculatus	69.89	0.00e+00	781.00
IUUC-Lma-053112	Leptosphaeria maculans	33.21	3.00e-78	285.00
IUUC-Laf-053690	Loxodonta africana	86.46	0.00e+00	961.00
IUUC-Mcc-055117	Macaca mulatta	84.84	0.00e+00	943.00
IUUC-Meu-056761	Macropus eugenii	73.08	0.00e+00	770.00
IUUC-Mor-057230	Magnaporthe oryzae	30.59	2.00e-66	246.00
IUUC-Mpo-057514	Magnaporthe poae	30.26	4.00e-59	221.00
IUUC-Mtr-058551	Medicago truncatula	39.14	4.00e-113	401.00
IUUC-Mla-059183	Melampsora laricipopulina	34.31	5.00e-88	318.00
IUUC-Mga-060144	Meleagris gallopavo	88.01	0.00e+00	947.00
IUUC-Mvi-060221	Microbotryum violaceum	33.65	2.00e-72	266.00
IUUC-Mmr-061325	Microcebus murinus	85.96	0.00e+00	950.00
IUUC-Mdo-062532	Monodelphis domestica	87.23	0.00e+00	965.00
IUUC-Mmu-063956	Mus musculus	86.27	0.00e+00	960.00
IUUC-Mac-064521	Musa acuminata	38.42	2.00e-113	402.00
IUUC-Mpu-066716	Mustela putorius furo	85.57	0.00e+00	897.00
IUUC-Mlu-067459	Myotis lucifugus	85.52	0.00e+00	953.00
IUUC-Nfi-068245	Neosartorya fischeri	33.09	7.00e-74	271.00
IUUC-Ncr-068910	Neurospora crassa	31.85	5.00e-66	245.00
IUUC-Nle-070034	Nomascus leucogenys	85.71	0.00e+00	949.00
IUUC-Opr-070552	Ochotona princeps	78.72	0.00e+00	783.00
IUUC-Ont-071426	Oreochromis niloticus	72.34	0.00e+00	828.00
IUUC-Oan-073389	Ornithorhynchus anatinus	82.88	0.00e+00	765.00
IUUC-Ocu-074911	Oryctolagus cuniculus	86.27	0.00e+00	962.00
IUUC-Oba-075437	Oryza barthii	40.00	5.00e-110	391.00
IUUC-Obr-076684	Oryza brachyantha	40.54	6.00e-107	381.00
IUUC-Ogl-077170	Oryza glaberrima	40.00	5.00e-110	391.00
IUUC-Ogu-078844	Oryza glumaepatula	40.85	8.00e-104	370.00
IUUC-Oin-079105	Oryza indica	40.00	2.00e-109	389.00
IUUC-Olo-080943	Oryza longistaminata	37.32	2.00e-98	352.00
IUUC-Oni-082891	Oryza nivara	36.92	4.00e-103	368.00
IUUC-Opu-083457	Oryza punctata	40.00	1.00e-109	389.00
IUUC-Oru-084960	Oryza rufipogon	37.32	2.00e-98	352.00
IUUC-Osa-085358	Oryza sativa	40.19	3.00e-110	391.00
IUUC-Ola-086420	Oryzias latipes	70.24	1.00e-168	585.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.50	8.00e-55	207.00
IUUC-Oga-088810	Otolemur garnettii	86.07	0.00e+00	956.00
IUUC-Oar-089196	Ovis aries	86.35	0.00e+00	957.00
IUUC-Ptr-090617	Pan troglodytes	86.85	0.00e+00	965.00
IUUC-Pan-092761	Papio anubis	86.85	0.00e+00	965.00
IUUC-Pma-094380	Petromyzon marinus	61.16	0.00e+00	646.00
IUUC-Pno-095084	Phaeosphaeria nodorum	29.62	1.00e-63	238.00
IUUC-Ppa-095875	Physcomitrella patens	39.77	1.00e-117	416.00
IUUC-Pfo-096467	Poecilia formosa	71.92	0.00e+00	813.00
IUUC-Pab-098255	Pongo abelii	85.48	0.00e+00	790.00
IUUC-Pop-099722	Populus trichocarpa	38.42	8.00e-117	413.00
IUUC-Pca-100807	Procavia capensis	70.19	2.00e-107	382.00
IUUC-Ppe-101280	Prunus persica	38.08	8.00e-116	410.00
IUUC-Pva-102333	Pteropus vampyrus	82.69	0.00e+00	904.00
IUUC-Pgr-103401	Puccinia graminis	30.70	2.00e-75	276.00
IUUC-Ptt-103889	Puccinia triticina	27.15	7.00e-57	214.00
IUUC-Pte-104355	Pyrenophora teres	33.88	2.00e-80	292.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	33.76	2.00e-80	292.00
IUUC-Rno-105810	Rattus norvegicus	86.07	0.00e+00	956.00
IUUC-Sce-106397	Saccharomyces cerevisiae	24.95	3.00e-31	129.00
IUUC-Sha-106770	Sarcophilus harrisii	86.74	3.00e-141	493.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.38	2.00e-68	253.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.65	3.00e-77	281.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.27	4.00e-59	222.00
IUUC-Smo-109296	Selaginella moellendorffii	40.66	2.00e-115	409.00
IUUC-Sit-110157	Setaria italica	41.70	1.00e-125	443.00
IUUC-Sly-111105	Solanum lycopersicum	38.16	8.00e-116	410.00
IUUC-Stu-112469	Solanum tuberosum	38.16	8.00e-117	413.00
IUUC-Sar-113083	Sorex araneus	65.89	0.00e+00	698.00
IUUC-Sbi-113813	Sorghum bicolor	41.31	5.00e-124	437.00
IUUC-Sre-115058	Sporisorium reilianum	36.34	2.00e-75	276.00
IUUC-Tgu-116772	Taeniopygia guttata	82.82	0.00e+00	899.00
IUUC-Tru-118686	Takifugu rubripes	71.95	0.00e+00	826.00
IUUC-Tsy-119111	Tarsius syrichta	77.82	2.00e-123	436.00
IUUC-Tni-120231	Tetraodon nigroviridis	68.74	0.00e+00	747.00
IUUC-Tca-121491	Theobroma cacao	38.65	3.00e-111	395.00
IUUC-Tre-122103	Trichoderma reesei	33.46	4.00e-73	268.00
IUUC-Tvi-122672	Trichoderma virens	33.71	2.00e-65	243.00
IUUC-Tae-125679	Triticum aestivum	40.58	2.00e-120	425.00
IUUC-Tur-126487	Triticum urartu	39.89	7.00e-118	417.00
IUUC-Tme-127097	Tuber melanosporum	35.37	3.00e-85	308.00
IUUC-Ttr-128465	Tursiops truncatus	81.15	0.00e+00	895.00
IUUC-Uma-129645	Ustilago maydis	35.51	2.00e-75	276.00
IUUC-Vda-129989	Verticillium dahliae	28.04	2.00e-48	186.00
IUUC-Vpa-130529	Vicugna pacos	83.08	0.00e+00	919.00
IUUC-Vvi-131059	Vitis vinifera	38.85	3.00e-115	408.00
IUUC-Xtr-132002	Xenopus tropicalis	77.95	0.00e+00	881.00
IUUC-Xma-133930	Xiphophorus maculatus	72.15	0.00e+00	818.00
IUUC-Yli-134505	Yarrowia lipolytica	33.98	6.00e-79	288.00
IUUC-Zma-135895	Zea mays	41.15	3.00e-123	434.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence