iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088571

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03029596

Gene Name

USP14

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000000466.2	ENSOGAT00000000468.2	ENSOGAP00000000419.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.40e-65	220.9	105	479
ULD/UDP/UBQ/UBQ_Other	2.30e-09	37.0	5	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.... 85
           +Gl+NlgNtCYmN+++Qc+ ++pel+++l++ +  +l+++ + ++ + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f     
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPELKDALKR-YAGALRASGEMSSAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekge 191
           7******************************.****************************.99999******************999*9 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             +y qqDa+E++ +++  l+++l+          e+++ +e++++a+  +++k+ksli++ F++++++++kc e +++ +++ + ++l
   Q: 192  qgQYLQQDANECWVQMMRVLQQKLEA--------IEDDSVKETDSSASAVTPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQL 272
           999*********************44........44444445566678999**************************999999888888 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+   ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+
   Q: 273  QLSCFINQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDV 354
           8888877754..58999999999999998.....58899999999******************************************** PP
   S: 262  spfcts........................peekqke...........................kkkYeLiavvvHsG.slssGHYvay 298
            + ct                         p     +                           +  Y+L av+ H+G s+ssGHYv++
   Q: 355  YELCTPelqekmvsfrskfkdledkkvnqqP-----DtsdkksspqkevkyepfsfaddigsnnCGYYDLQAVLTHQGrSSSSGHYVSW 438
           ******6666666666666666655555551.....0555556666667777777777777777************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetg....staYvlfY 335
           vk ++++W++fdD+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 439  VKRKQDEWIKFDDDKVSIVTPEDILRLSGggdwHIAYVLLY 479
           **************************988************ PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           +vtvk+ + +  ++++n +++  ++K +++ ++g++p +q+ ++kG  L+dd ++++ ++k+g+t++++ +
   Q: 5    SVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPSRQKVMVKGGTLKDD-DWGNIKIKNGMTVLMMGS 74
           69********99*************************************999.9**************976 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MPLYSVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PSRQKVMVKG GTLKDDDWGN 60
IKIKNGMTVL MMGSAEALPE EPLAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCATCGCCA GTGGCCGGTT TGAATGAGAC TCTCGTCGCA CCGAAGCAGC AGCCAGCTCC 60
GCGTCTCTGC CTTGGCCGCC GCTACACCTT CTTCTGGTAC CCTGCCCTTC ACCACCCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045202--C:synapse
GO:0004866--F:endopeptidase inhibitor activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	42.86	2.00e-37	150.00
IUUC-Aml-002053	Ailuropoda melanoleuca	95.93	0.00e+00	925.00
IUUC-Atr-002725	Amborella trichopoda	41.72	1.00e-101	363.00
IUUC-Apl-004031	Anas platyrhynchos	91.04	0.00e+00	899.00
IUUC-Aca-004361	Anolis carolinensis	89.29	0.00e+00	917.00
IUUC-Aly-006078	Arabidopsis lyrata	41.88	1.00e-111	396.00
IUUC-Ath-007623	Arabidopsis thaliana	41.87	4.00e-112	397.00
IUUC-Ago-007796	Ashbya gossypii	32.02	5.00e-59	221.00
IUUC-Acl-008258	Aspergillus clavatus	37.28	2.00e-66	246.00
IUUC-Afl-008732	Aspergillus flavus	32.87	3.00e-78	285.00
IUUC-Afu-008755	Aspergillus fumigatus	34.95	2.00e-80	292.00
IUUC-Ani-009148	Aspergillus nidulans	39.22	6.00e-71	261.00
IUUC-Ang-009878	Aspergillus niger	37.80	3.00e-66	246.00
IUUC-Aor-010239	Aspergillus oryzae	33.74	5.00e-78	285.00
IUUC-Ate-010243	Aspergillus terreus	33.98	3.00e-72	266.00
IUUC-Ame-011327	Astyanax mexicanus	50.80	2.00e-127	449.00
IUUC-Bgr-012231	Blumeria graminis	34.56	1.00e-79	290.00
IUUC-Bta-012553	Bos taurus	97.37	0.00e+00	952.00
IUUC-Bci-013606	Botrytis cinerea	40.31	4.00e-71	262.00
IUUC-Bdi-014567	Brachypodium distachyon	42.80	2.00e-112	399.00
IUUC-Bol-016127	Brassica oleracea	42.28	2.00e-113	402.00
IUUC-Bra-017501	Brassica rapa	42.08	1.00e-112	399.00
IUUC-Cel-018140	Caenorhabditis elegans	42.66	2.00e-101	362.00
IUUC-Cja-019516	Callithrix jacchus	96.98	0.00e+00	950.00
IUUC-Cfa-020808	Canis familiaris	98.18	0.00e+00	962.00
IUUC-Cpo-021688	Cavia porcellus	96.75	0.00e+00	949.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	37.93	2.00e-83	302.00
IUUC-Csa-023429	Chlorocebus sabaeus	97.77	0.00e+00	931.00
IUUC-Cho-024347	Choloepus hoffmanni	96.96	0.00e+00	951.00
IUUC-Cin-025198	Ciona intestinalis	54.69	1.00e-152	533.00
IUUC-Csv-026007	Ciona savignyi	53.52	7.00e-155	540.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	39.02	7.00e-64	238.00
IUUC-Cne-026963	Cryptococcus neoformans	35.39	1.00e-77	283.00
IUUC-Cme-027240	Cyanidioschyzon merolae	31.07	1.00e-60	227.00
IUUC-Dre-027647	Danio rerio	81.80	0.00e+00	836.00
IUUC-Dno-029967	Dasypus novemcinctus	95.34	0.00e+00	927.00
IUUC-Dor-030886	Dipodomys ordii	90.00	0.00e+00	757.00
IUUC-Dse-031466	Dothistroma septosporum	36.19	2.00e-58	220.00
IUUC-Dme-032079	Drosophila melanogaster	56.08	1.00e-161	562.00
IUUC-Ete-032351	Echinops telfairi	85.80	0.00e+00	857.00
IUUC-Eca-033461	Equus caballus	96.96	0.00e+00	994.00
IUUC-Eeu-035220	Erinaceus europaeus	73.16	0.00e+00	686.00
IUUC-Fca-036210	Felis catus	98.38	0.00e+00	963.00
IUUC-Fal-037528	Ficedula albicollis	90.85	0.00e+00	878.00
IUUC-Fox-037805	Fusarium oxysporum	39.58	5.00e-71	261.00
IUUC-Fso-038177	Fusarium solani	38.44	2.00e-68	253.00
IUUC-Gmo-038953	Gadus morhua	78.37	0.00e+00	775.00
IUUC-Ggr-039972	Gaeumannomyces graminis	34.54	7.00e-75	274.00
IUUC-Gga-040462	Gallus gallus	90.06	0.00e+00	891.00
IUUC-Gac-041312	Gasterosteus aculeatus	81.48	0.00e+00	807.00
IUUC-Gma-043255	Glycine max	42.91	4.00e-109	388.00
IUUC-Ggo-045458	Gorilla gorilla	81.21	0.00e+00	785.00
IUUC-Hsa-045706	Homo sapiens	96.36	0.00e+00	934.00
IUUC-Hvu-047821	Hordeum vulgare	45.83	1.00e-56	213.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	94.94	0.00e+00	950.00
IUUC-Lch-050464	Latimeria chalumnae	82.82	0.00e+00	829.00
IUUC-Lpe-051419	Leersia perrieri	41.98	3.00e-108	385.00
IUUC-Loc-052732	Lepisosteus oculatus	81.05	0.00e+00	844.00
IUUC-Lma-053177	Leptosphaeria maculans	40.36	3.00e-70	259.00
IUUC-Laf-053822	Loxodonta africana	97.36	0.00e+00	950.00
IUUC-Mcc-055893	Macaca mulatta	96.35	0.00e+00	932.00
IUUC-Meu-056307	Macropus eugenii	81.84	0.00e+00	796.00
IUUC-Mor-057171	Magnaporthe oryzae	38.46	3.00e-68	253.00
IUUC-Mpo-057415	Magnaporthe poae	39.39	5.00e-71	261.00
IUUC-Mtr-057901	Medicago truncatula	42.49	5.00e-111	394.00
IUUC-Mla-058897	Melampsora laricipopulina	39.73	4.00e-75	275.00
IUUC-Mga-060016	Meleagris gallopavo	90.63	0.00e+00	895.00
IUUC-Mvi-060562	Microbotryum violaceum	39.68	3.00e-68	252.00
IUUC-Mmr-060624	Microcebus murinus	97.98	0.00e+00	1003.00
IUUC-Mdo-061809	Monodelphis domestica	92.54	0.00e+00	899.00
IUUC-Mmu-063869	Mus musculus	95.95	0.00e+00	940.00
IUUC-Mac-064876	Musa acuminata	39.36	8.00e-96	344.00
IUUC-Mpu-066480	Mustela putorius furo	97.77	0.00e+00	959.00
IUUC-Mlu-067866	Myotis lucifugus	96.76	0.00e+00	959.00
IUUC-Nfi-068393	Neosartorya fischeri	36.56	6.00e-66	245.00
IUUC-Ncr-068815	Neurospora crassa	36.09	3.00e-82	299.00
IUUC-Nle-070121	Nomascus leucogenys	96.84	9.00e-138	482.00
IUUC-Opr-070712	Ochotona princeps	77.10	1.00e-175	609.00
IUUC-Ont-071544	Oreochromis niloticus	81.63	0.00e+00	773.00
IUUC-Oan-073635	Ornithorhynchus anatinus	91.33	0.00e+00	756.00
IUUC-Ocu-074926	Oryctolagus cuniculus	96.75	0.00e+00	931.00
IUUC-Oba-075633	Oryza barthii	41.65	3.00e-108	385.00
IUUC-Obr-076423	Oryza brachyantha	42.11	5.00e-111	394.00
IUUC-Ogl-077913	Oryza glaberrima	41.50	8.00e-111	394.00
IUUC-Ogu-078435	Oryza glumaepatula	41.65	3.00e-108	385.00
IUUC-Oin-080072	Oryza indica	41.61	2.00e-108	385.00
IUUC-Olo-080535	Oryza longistaminata	38.88	3.00e-92	332.00
IUUC-Ome-081309	Oryza meridionalis	41.65	3.00e-108	385.00
IUUC-Oni-083113	Oryza nivara	41.65	3.00e-108	385.00
IUUC-Opu-083168	Oryza punctata	40.70	1.00e-102	366.00
IUUC-Oru-084253	Oryza rufipogon	41.65	3.00e-108	385.00
IUUC-Osa-085554	Oryza sativa	41.50	8.00e-111	394.00
IUUC-Ola-086998	Oryzias latipes	81.10	0.00e+00	799.00
IUUC-Olu-087818	Ostreococcus lucimarinus	36.03	1.00e-71	263.00
IUUC-Oar-089526	Ovis aries	97.15	0.00e+00	946.00
IUUC-Ptr-091433	Pan troglodytes	96.35	0.00e+00	932.00
IUUC-Pan-091966	Papio anubis	97.77	0.00e+00	931.00
IUUC-Psi-093458	Pelodiscus sinensis	89.42	0.00e+00	852.00
IUUC-Pma-094343	Petromyzon marinus	69.20	1.00e-121	428.00
IUUC-Pno-095109	Phaeosphaeria nodorum	39.00	9.00e-66	244.00
IUUC-Ppa-095756	Physcomitrella patens	43.98	2.00e-112	399.00
IUUC-Pfo-096514	Poecilia formosa	82.45	0.00e+00	791.00
IUUC-Pab-098477	Pongo abelii	85.96	0.00e+00	740.00
IUUC-Pop-099221	Populus trichocarpa	41.25	5.00e-103	368.00
IUUC-Pca-100791	Procavia capensis	80.19	4.00e-179	620.00
IUUC-Ppe-101812	Prunus persica	41.45	5.00e-107	381.00
IUUC-Pva-102462	Pteropus vampyrus	92.54	0.00e+00	771.00
IUUC-Pgr-103623	Puccinia graminis	41.09	7.00e-75	274.00
IUUC-Ptt-103767	Puccinia triticina	40.12	2.00e-68	253.00
IUUC-Pte-104109	Pyrenophora teres	40.55	1.00e-70	260.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	40.92	1.00e-70	261.00
IUUC-Rno-105351	Rattus norvegicus	94.74	0.00e+00	897.00
IUUC-Sce-106168	Saccharomyces cerevisiae	33.13	5.00e-62	231.00
IUUC-Sha-107491	Sarcophilus harrisii	92.53	0.00e+00	917.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	33.46	9.00e-80	290.00
IUUC-Spo-108174	Schizosaccharomyces pombe	37.50	7.00e-81	294.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	35.51	2.00e-85	309.00
IUUC-Smo-108805	Selaginella moellendorffii	43.56	1.00e-110	392.00
IUUC-Sit-110361	Setaria italica	43.03	7.00e-114	404.00
IUUC-Sly-110965	Solanum lycopersicum	40.86	8.00e-108	384.00
IUUC-Sar-113355	Sorex araneus	83.88	0.00e+00	663.00
IUUC-Sbi-114778	Sorghum bicolor	43.93	1.00e-114	406.00
IUUC-Sre-115011	Sporisorium reilianum	37.01	1.00e-62	234.00
IUUC-Ssc-116273	Sus scrofa	96.54	0.00e+00	935.00
IUUC-Tgu-117063	Taeniopygia guttata	90.22	0.00e+00	875.00
IUUC-Tru-118381	Takifugu rubripes	79.67	0.00e+00	800.00
IUUC-Tsy-119076	Tarsius syrichta	81.82	4.00e-119	421.00
IUUC-Tni-119941	Tetraodon nigroviridis	80.98	0.00e+00	793.00
IUUC-Tca-121246	Theobroma cacao	41.70	1.00e-108	386.00
IUUC-Tre-121969	Trichoderma reesei	34.55	4.00e-75	275.00
IUUC-Tvi-122543	Trichoderma virens	34.51	1.00e-77	283.00
IUUC-Tae-125484	Triticum aestivum	42.34	2.00e-109	389.00
IUUC-Tur-126128	Triticum urartu	31.75	2.00e-66	246.00
IUUC-Tbe-128030	Tupaia belangeri	90.37	0.00e+00	853.00
IUUC-Ttr-128701	Tursiops truncatus	95.99	0.00e+00	769.00
IUUC-Uma-129657	Ustilago maydis	37.01	1.00e-65	243.00
IUUC-Vda-129723	Verticillium dahliae	32.54	4.00e-72	265.00
IUUC-Vpa-130284	Vicugna pacos	69.47	0.00e+00	632.00
IUUC-Vvi-131037	Vitis vinifera	42.44	4.00e-108	384.00
IUUC-Xtr-132235	Xenopus tropicalis	86.26	0.00e+00	885.00
IUUC-Xma-133840	Xiphophorus maculatus	82.45	0.00e+00	816.00
IUUC-Yli-134453	Yarrowia lipolytica	36.85	2.00e-82	299.00
IUUC-Zma-135669	Zea mays	36.69	4.00e-96	345.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence