iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000011462.9	ENSDART00000005853.8	ENSDARP00000006133.8
ENSDARG00000011462.9	ENSDART00000162871.1	ENSDARP00000132932.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	9.70e-44	150.0	76	267

Active Site

Position(s)	Description	Evidence
83	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
86	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
261		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
            i+kt++DGnC++rA++++                                                          +l +f+d+s+sd
   Q: 76   SIRKTRPDGNCFYRAFGFAhleslledskelqrfkavaakskldlvnqgfteftiedfhntfmdlielcekqqslgeVLSSFNDQSVSD 164
           689************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqkl.vepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeekl 119
           ++v++Lr+lts ylq+e+ ff++fie+++ +kefcq++ vep++k +++ihi+aLaq+L++p+ v+++d++e   gg+++ ++fpe + 
   Q: 165  YIVVYLRLLTSGYLQREHVFFQHFIEGGRSVKEFCQQAtVEPMSKeSDHIHIIALAQALNVPVLVEYMDRGE---GGTVNNHVFPEGS- 249
           ***********************************98537899****************************9...9************. PP
   S: 120  kkpivLlYrsgHYdaLva 137
           +++i LlYr+gHYd+L++
   Q: 250  EPRIFLLYRPGHYDILYK 267
           ****************96 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MADEQQESSQ GEMEGVNCLA YDEAIMAQQD RIQQEIATSN PLVSDRQELS VLKGEYAMED 60
TIYQLKIQDL HKKYSSIRKT RPDGNCFYRA FGFAHLESLL EDSKELQRFK AVAAKSKLDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAAGAGTA CACGGGAGAG GGGGCGGTGG AAAAAGAACT CAATCAAGAT GGCGGATGAG 60
CAGCAGGAAT CATCACAGGG AGAGATGGAG GGTAAGTGCA AAATAACGTT TTCTCGTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003233	Anas platyrhynchos	53.85	5.00e-16	75.50
IUUC-Aca-004648	Anolis carolinensis	79.38	5.00e-119	420.00
IUUC-Ame-010662	Astyanax mexicanus	91.01	1.00e-144	505.00
IUUC-Gmo-038908	Gadus morhua	88.39	6.00e-140	489.00
IUUC-Ggr-040020	Gaeumannomyces graminis	33.45	1.00e-30	128.00
IUUC-Gga-040460	Gallus gallus	73.78	1.00e-114	405.00
IUUC-Gac-042417	Gasterosteus aculeatus	86.45	1.00e-129	456.00
IUUC-Lch-050602	Latimeria chalumnae	73.91	2.00e-109	388.00
IUUC-Mvi-060358	Microbotryum violaceum	33.33	7.00e-17	81.30
IUUC-Mac-065274	Musa acuminata	36.65	2.00e-37	149.00
IUUC-Ont-071901	Oreochromis niloticus	89.29	2.00e-134	471.00
IUUC-Ola-087331	Oryzias latipes	84.90	5.00e-93	333.00
IUUC-Psi-093823	Pelodiscus sinensis	77.48	7.00e-118	416.00
IUUC-Pfo-096734	Poecilia formosa	84.13	4.00e-121	427.00
IUUC-Tru-117664	Takifugu rubripes	85.66	1.00e-136	479.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence