iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067292

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AAPE02046924

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000001431.2	ENSMLUT00000001432.2	ENSMLUP00000001313.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	5.70e-101	338.3	1	320

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
164	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m+s++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 1    MTSNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 78
           88999*************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + ++  +    +++af
   Q: 79   FAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDAKTPTK----EEDAF 163
           **************************************************************************999666....89*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg+ + ++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +        
   Q: 164  HFVSYVPVNGRLYELDGLREGPIDLGA-CSQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeeepmd 249
           ***************************.66789*********..******************************976554445555555 PP
   S: 260  keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
            +  ++l++i+se +k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+    + +++
   Q: 250  TDQGSMLSAIQSELAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 320
           88889**********************************************************993...33344 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MTSNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP 60
GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACGAGCA ATGCCGGGGA GTGGTGCCTC ATGGAGAGCG ACCCCGGCGT CTTCACCGAG 60
CTCATTAAAG GATTCGGTGA GAGCCAGGGG CACCGTCCTG GGCCGGGGGT CATGTGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	47.73	6.00e-85	307.00
IUUC-Aml-001866	Ailuropoda melanoleuca	97.76	0.00e+00	635.00
IUUC-Atr-002966	Amborella trichopoda	48.21	2.00e-80	292.00
IUUC-Apl-003306	Anas platyrhynchos	84.92	1.00e-173	602.00
IUUC-Aca-004763	Anolis carolinensis	94.21	1.00e-175	608.00
IUUC-Aly-005581	Arabidopsis lyrata	48.63	4.00e-80	291.00
IUUC-Ath-007283	Arabidopsis thaliana	48.94	4.00e-83	301.00
IUUC-Ago-007999	Ashbya gossypii	33.12	1.00e-32	133.00
IUUC-Acl-008231	Aspergillus clavatus	43.39	4.00e-52	197.00
IUUC-Afl-008557	Aspergillus flavus	37.91	9.00e-54	203.00
IUUC-Afu-008988	Aspergillus fumigatus	44.40	2.00e-53	202.00
IUUC-Ani-009420	Aspergillus nidulans	38.05	3.00e-53	202.00
IUUC-Ang-009859	Aspergillus niger	40.65	3.00e-49	188.00
IUUC-Aor-010145	Aspergillus oryzae	37.91	9.00e-54	203.00
IUUC-Ate-010347	Aspergillus terreus	41.57	2.00e-53	202.00
IUUC-Ame-010791	Astyanax mexicanus	89.36	1.00e-178	618.00
IUUC-Bgr-012298	Blumeria graminis	37.95	1.00e-49	190.00
IUUC-Bta-013251	Bos taurus	97.76	0.00e+00	631.00
IUUC-Bci-013786	Botrytis cinerea	37.57	2.00e-57	216.00
IUUC-Bdi-014132	Brachypodium distachyon	48.46	6.00e-81	294.00
IUUC-Bol-015611	Brassica oleracea	50.30	5.00e-84	304.00
IUUC-Bra-017769	Brassica rapa	50.30	5.00e-84	304.00
IUUC-Cel-018604	Caenorhabditis elegans	47.13	1.00e-81	296.00
IUUC-Cja-019768	Callithrix jacchus	89.15	2.00e-177	614.00
IUUC-Cfa-020207	Canis familiaris	97.76	0.00e+00	635.00
IUUC-Cpo-021925	Cavia porcellus	93.93	3.00e-175	607.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.37	2.00e-74	272.00
IUUC-Csa-023958	Chlorocebus sabaeus	97.44	0.00e+00	628.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	1.00e-42	166.00
IUUC-Cin-025771	Ciona intestinalis	54.88	1.00e-100	358.00
IUUC-Csv-026149	Ciona savignyi	57.81	4.00e-104	370.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.64	1.00e-50	193.00
IUUC-Cne-026955	Cryptococcus neoformans	37.98	2.00e-55	208.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.15	5.00e-48	184.00
IUUC-Dre-027409	Danio rerio	88.45	2.00e-175	608.00
IUUC-Dno-028921	Dasypus novemcinctus	97.44	0.00e+00	632.00
IUUC-Dse-031170	Dothistroma septosporum	39.81	3.00e-59	221.00
IUUC-Dme-031677	Drosophila melanogaster	59.94	3.00e-115	407.00
IUUC-Ete-032707	Echinops telfairi	68.34	6.00e-117	413.00
IUUC-Eca-033776	Equus caballus	97.57	1.00e-167	581.00
IUUC-Eeu-035305	Erinaceus europaeus	79.26	1.00e-83	303.00
IUUC-Fca-035846	Felis catus	90.00	2.00e-178	618.00
IUUC-Fal-037597	Ficedula albicollis	94.79	3.00e-156	543.00
IUUC-Fox-037670	Fusarium oxysporum	50.22	5.00e-55	207.00
IUUC-Fso-038243	Fusarium solani	49.78	4.00e-54	204.00
IUUC-Gmo-038499	Gadus morhua	83.07	4.00e-158	550.00
IUUC-Ggr-039975	Gaeumannomyces graminis	41.06	9.00e-48	184.00
IUUC-Gga-040904	Gallus gallus	93.88	0.00e+00	636.00
IUUC-Gac-042058	Gasterosteus aculeatus	87.86	4.00e-167	580.00
IUUC-Gma-043763	Glycine max	48.66	2.00e-85	308.00
IUUC-Ggo-044699	Gorilla gorilla	91.86	7.00e-167	579.00
IUUC-Hsa-046227	Homo sapiens	97.76	0.00e+00	635.00
IUUC-Hvu-047359	Hordeum vulgare	48.34	2.00e-83	302.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	88.95	4.00e-178	617.00
IUUC-Lch-049829	Latimeria chalumnae	91.69	3.00e-172	597.00
IUUC-Lpe-050899	Leersia perrieri	48.74	8.00e-78	283.00
IUUC-Loc-052264	Lepisosteus oculatus	89.49	3.00e-169	587.00
IUUC-Lma-053110	Leptosphaeria maculans	38.49	8.00e-49	187.00
IUUC-Laf-053639	Loxodonta africana	97.76	0.00e+00	635.00
IUUC-Mcc-055506	Macaca mulatta	97.44	0.00e+00	627.00
IUUC-Mor-057001	Magnaporthe oryzae	44.96	1.00e-54	206.00
IUUC-Mpo-057608	Magnaporthe poae	40.11	1.00e-31	129.00
IUUC-Mtr-057731	Medicago truncatula	48.96	1.00e-85	310.00
IUUC-Mla-059016	Melampsora laricipopulina	42.79	1.00e-42	166.00
IUUC-Mga-060178	Meleagris gallopavo	94.08	2.00e-170	591.00
IUUC-Mvi-060353	Microbotryum violaceum	38.62	5.00e-56	211.00
IUUC-Mmr-060738	Microcebus murinus	97.76	0.00e+00	635.00
IUUC-Mdo-062266	Monodelphis domestica	96.57	6.00e-119	419.00
IUUC-Mmu-063619	Mus musculus	96.49	0.00e+00	632.00
IUUC-Mac-065301	Musa acuminata	50.79	1.00e-87	316.00
IUUC-Mpu-066058	Mustela putorius furo	98.08	0.00e+00	637.00
IUUC-Nfi-068275	Neosartorya fischeri	37.82	2.00e-54	206.00
IUUC-Ncr-068713	Neurospora crassa	39.12	3.00e-58	218.00
IUUC-Nle-069013	Nomascus leucogenys	97.12	0.00e+00	626.00
IUUC-Opr-070628	Ochotona princeps	86.18	2.00e-168	585.00
IUUC-Ont-072688	Oreochromis niloticus	88.57	8.00e-168	582.00
IUUC-Oan-073004	Ornithorhynchus anatinus	95.88	9.00e-139	485.00
IUUC-Ocu-074303	Oryctolagus cuniculus	98.08	0.00e+00	638.00
IUUC-Oba-075002	Oryza barthii	48.19	2.00e-81	295.00
IUUC-Obr-076392	Oryza brachyantha	49.53	1.00e-79	289.00
IUUC-Ogl-077271	Oryza glaberrima	48.19	2.00e-81	295.00
IUUC-Ogu-078493	Oryza glumaepatula	48.19	4.00e-82	298.00
IUUC-Oin-080084	Oryza indica	48.19	4.00e-82	298.00
IUUC-Olo-080803	Oryza longistaminata	47.89	8.00e-82	296.00
IUUC-Ome-081146	Oryza meridionalis	47.29	1.00e-80	293.00
IUUC-Oni-082146	Oryza nivara	48.19	4.00e-82	298.00
IUUC-Opu-083633	Oryza punctata	48.90	1.00e-78	286.00
IUUC-Oru-084789	Oryza rufipogon	48.19	4.00e-82	298.00
IUUC-Osa-086196	Oryza sativa	48.19	4.00e-82	298.00
IUUC-Ola-087126	Oryzias latipes	88.50	2.00e-164	571.00
IUUC-Olu-087665	Ostreococcus lucimarinus	42.16	2.00e-69	255.00
IUUC-Oga-089140	Otolemur garnettii	89.41	3.00e-178	617.00
IUUC-Oar-090296	Ovis aries	97.44	0.00e+00	631.00
IUUC-Ptr-090566	Pan troglodytes	97.76	0.00e+00	635.00
IUUC-Pan-092052	Papio anubis	97.44	0.00e+00	627.00
IUUC-Psi-093723	Pelodiscus sinensis	94.10	6.00e-162	562.00
IUUC-Pma-094568	Petromyzon marinus	61.67	6.00e-106	377.00
IUUC-Pno-095120	Phaeosphaeria nodorum	40.79	2.00e-50	192.00
IUUC-Ppa-095761	Physcomitrella patens	47.66	1.00e-83	303.00
IUUC-Pfo-096210	Poecilia formosa	87.86	1.00e-167	582.00
IUUC-Pab-098463	Pongo abelii	97.76	0.00e+00	635.00
IUUC-Pop-099423	Populus trichocarpa	48.96	2.00e-84	305.00
IUUC-Pca-100108	Procavia capensis	96.75	6.00e-142	496.00
IUUC-Ppe-101176	Prunus persica	50.60	8.00e-86	310.00
IUUC-Pva-102629	Pteropus vampyrus	95.79	7.00e-148	516.00
IUUC-Pgr-103419	Puccinia graminis	39.76	9.00e-57	213.00
IUUC-Pte-104207	Pyrenophora teres	44.97	4.00e-33	133.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	39.80	3.00e-57	215.00
IUUC-Rno-105579	Rattus norvegicus	85.76	1.00e-159	555.00
IUUC-Sha-106894	Sarcophilus harrisii	92.75	3.00e-152	530.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	40.33	4.00e-60	224.00
IUUC-Spo-108371	Schizosaccharomyces pombe	41.06	4.00e-60	224.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	38.18	2.00e-47	182.00
IUUC-Smo-109396	Selaginella moellendorffii	51.08	4.00e-87	314.00
IUUC-Sit-110630	Setaria italica	48.93	2.00e-84	305.00
IUUC-Sly-110972	Solanum lycopersicum	49.20	1.00e-79	289.00
IUUC-Stu-112185	Solanum tuberosum	50.00	3.00e-88	318.00
IUUC-Sar-113294	Sorex araneus	81.82	3.00e-162	564.00
IUUC-Sbi-113951	Sorghum bicolor	49.24	1.00e-84	306.00
IUUC-Ssc-115501	Sus scrofa	96.97	1.00e-171	594.00
IUUC-Tgu-117152	Taeniopygia guttata	94.44	3.00e-156	543.00
IUUC-Tru-118388	Takifugu rubripes	87.54	2.00e-167	581.00
IUUC-Tsy-119109	Tarsius syrichta	98.08	0.00e+00	636.00
IUUC-Tni-120048	Tetraodon nigroviridis	87.54	6.00e-168	582.00
IUUC-Tca-121750	Theobroma cacao	48.82	1.00e-87	316.00
IUUC-Tre-122130	Trichoderma reesei	39.46	2.00e-55	209.00
IUUC-Tvi-122284	Trichoderma virens	40.00	4.00e-53	201.00
IUUC-Tae-124082	Triticum aestivum	47.43	3.00e-83	301.00
IUUC-Tur-126366	Triticum urartu	43.65	6.00e-66	244.00
IUUC-Tme-127187	Tuber melanosporum	41.06	1.00e-58	219.00
IUUC-Tbe-127619	Tupaia belangeri	88.50	4.00e-141	493.00
IUUC-Ttr-128867	Tursiops truncatus	86.94	7.00e-123	433.00
IUUC-Vda-129912	Verticillium dahliae	36.95	2.00e-52	199.00
IUUC-Vpa-130552	Vicugna pacos	98.09	2.00e-124	438.00
IUUC-Vvi-130881	Vitis vinifera	49.85	4.00e-84	304.00
IUUC-Xtr-131934	Xenopus tropicalis	86.02	3.00e-172	597.00
IUUC-Xma-133312	Xiphophorus maculatus	87.86	1.00e-167	581.00
IUUC-Yli-134487	Yarrowia lipolytica	34.55	7.00e-50	190.00
IUUC-Zma-135462	Zea mays	43.87	2.00e-71	262.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence