iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067090

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAPE02057120

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000014017.2	ENSMLUT00000014019.2	ENSMLUP00000012752.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.90e-98	329.8	247	650

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp............................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+ +++k+++  +                                               
   Q: 247  TGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEQLFNraangkaplagrlasssatelsprshraescerdglfwnggasitks 335
           7******************************6666666665566779999************************************999 PP
   S: 43   .........kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeed 122
                     +++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++
   Q: 336  leliqnkepGSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGTT 415
           99999999889999************************************************************.........668888 PP
   S: 123  kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeele 201
           ++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e le
   Q: 416  RRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKgfvplnqtecLLTEMLAKFTETEALE 504
           8999999***************************************************998879************************* PP
   S: 202  genkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkk 277
           g+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++  ++ +  +  
   Q: 505  GR-VYACDQCNSKRRksnpkplvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQVLTMEPYCCRDMLSSLDkeTFA 591
           95.5*******9999999*******************************997.8889********************876654433999 PP
   S: 278  YeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ e+v++   ++aY+lfY++
   Q: 592  YDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCNVEDVCK---TQAYILFYTQ 650
           *************************9999********************...********98 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWCCRECT TTESVWACLK CSHVACGRYI EDHALKHFEE 60
TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSALL AVRGQKQDLP GRRGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAGAT GCAAACATGT AGGGCGGTTG CGGCTGGCCC AGGACCACTC CATCCTGAAC 60
CCCCAGAAGT GGTGCTGTAG GGAGTGCACC ACCACCGAGT CGGTGTGGGC TTGTCTCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	92.74	0.00e+00	829.00
IUUC-Apl-003658	Anas platyrhynchos	76.76	0.00e+00	1045.00
IUUC-Aca-005278	Anolis carolinensis	77.33	0.00e+00	1071.00
IUUC-Bta-012911	Bos taurus	89.75	0.00e+00	1125.00
IUUC-Cja-019171	Callithrix jacchus	89.08	0.00e+00	1187.00
IUUC-Cfa-020408	Canis familiaris	91.78	0.00e+00	1164.00
IUUC-Cpo-022233	Cavia porcellus	82.70	0.00e+00	1056.00
IUUC-Csa-024272	Chlorocebus sabaeus	88.73	0.00e+00	959.00
IUUC-Cho-025051	Choloepus hoffmanni	89.43	0.00e+00	644.00
IUUC-Cin-025587	Ciona intestinalis	47.56	3.00e-107	383.00
IUUC-Dre-027577	Danio rerio	59.59	0.00e+00	717.00
IUUC-Dno-029856	Dasypus novemcinctus	88.23	0.00e+00	1153.00
IUUC-Ete-032761	Echinops telfairi	73.28	0.00e+00	831.00
IUUC-Eca-033851	Equus caballus	83.61	0.00e+00	1013.00
IUUC-Fca-035919	Felis catus	92.52	0.00e+00	776.00
IUUC-Fal-037290	Ficedula albicollis	75.11	0.00e+00	920.00
IUUC-Gmo-039249	Gadus morhua	76.73	1.00e-144	506.00
IUUC-Gac-042595	Gasterosteus aculeatus	61.09	0.00e+00	766.00
IUUC-Ggo-044979	Gorilla gorilla	89.23	0.00e+00	1178.00
IUUC-Hsa-046743	Homo sapiens	88.94	0.00e+00	1173.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	89.78	0.00e+00	1192.00
IUUC-Lch-050294	Latimeria chalumnae	74.06	0.00e+00	927.00
IUUC-Loc-051961	Lepisosteus oculatus	69.57	0.00e+00	805.00
IUUC-Laf-053819	Loxodonta africana	91.59	0.00e+00	826.00
IUUC-Mcc-055048	Macaca mulatta	89.23	0.00e+00	1177.00
IUUC-Meu-055971	Macropus eugenii	66.14	1.00e-150	526.00
IUUC-Mmr-061253	Microcebus murinus	83.49	6.00e-151	527.00
IUUC-Mdo-062073	Monodelphis domestica	79.91	0.00e+00	1095.00
IUUC-Mmu-064095	Mus musculus	88.18	0.00e+00	1160.00
IUUC-Mpu-066318	Mustela putorius furo	91.80	0.00e+00	846.00
IUUC-Nle-069486	Nomascus leucogenys	89.52	0.00e+00	1181.00
IUUC-Opr-070563	Ochotona princeps	87.34	0.00e+00	1158.00
IUUC-Ont-072103	Oreochromis niloticus	61.43	0.00e+00	773.00
IUUC-Oan-073245	Ornithorhynchus anatinus	88.29	8.00e-179	619.00
IUUC-Ocu-074851	Oryctolagus cuniculus	87.80	0.00e+00	933.00
IUUC-Ola-086413	Oryzias latipes	58.64	0.00e+00	732.00
IUUC-Oga-088862	Otolemur garnettii	88.37	0.00e+00	1153.00
IUUC-Oar-089462	Ovis aries	88.13	0.00e+00	791.00
IUUC-Ptr-091525	Pan troglodytes	89.62	0.00e+00	1064.00
IUUC-Pan-092363	Papio anubis	87.98	0.00e+00	1137.00
IUUC-Psi-093353	Pelodiscus sinensis	78.37	0.00e+00	1065.00
IUUC-Pma-094155	Petromyzon marinus	59.04	3.00e-82	298.00
IUUC-Pfo-096413	Poecilia formosa	62.27	0.00e+00	781.00
IUUC-Pab-098592	Pongo abelii	88.56	0.00e+00	957.00
IUUC-Pca-100449	Procavia capensis	86.69	0.00e+00	1134.00
IUUC-Pva-102868	Pteropus vampyrus	93.40	0.00e+00	1190.00
IUUC-Rno-105190	Rattus norvegicus	86.86	0.00e+00	1147.00
IUUC-Sha-107337	Sarcophilus harrisii	80.53	0.00e+00	1084.00
IUUC-Sar-113561	Sorex araneus	91.62	1.00e-91	329.00
IUUC-Ssc-115735	Sus scrofa	92.52	0.00e+00	1169.00
IUUC-Tgu-117025	Taeniopygia guttata	69.97	0.00e+00	852.00
IUUC-Tru-117585	Takifugu rubripes	61.82	0.00e+00	769.00
IUUC-Tsy-118814	Tarsius syrichta	89.24	0.00e+00	1151.00
IUUC-Tni-120600	Tetraodon nigroviridis	61.83	0.00e+00	731.00
IUUC-Vpa-130263	Vicugna pacos	93.09	0.00e+00	763.00
IUUC-Xtr-132090	Xenopus tropicalis	70.88	0.00e+00	935.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence