iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-017823

Ensembl Protein ID

Bra010674.1-P

UniProt Accession

M4D2H4; M4D2H4_BRARP

Protein Name

Coatomer subunit alpha

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra010674	Bra010674.1	Bra010674.1-P

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.40e-39	130.9	50	86
UBD/Beta-Prp	1.10e-77	262.1	3	322

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           H+++v++++f ++ +l+vsG+dD +ikvW+ +t+++l
   Q: 50   HEGPVRGVHFhNSqPLFVSGGDDYKIKVWNHKTHRCL 86
           9*********9777****************9999997 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvls 99
           t +++++++++ ++f+p++++++++  +g i++wd+++g+l+ ++ +he++v+ v f+++++++v+g++D+ ikvw+ +t  c+ tl gh d++++
   Q: 3    TKFETKSNRVKGLTFHPKRPWILASLHSGVIQLWDYRMGTLIDRFDEHEGPVRGVHFHNSQPLFVSGGDDYKIKVWNHKTHRCLFTLLGHLDYIRT 98
           67889999**************************************************************************************** PP
   S: 100  lsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl......................ktgkllr 173
           ++f+ ++ ++vs+s+d+tir+w++++++c++ +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+                             
   Q: 99   VQFHHENPWIVSASDDQTIRIWNWQSRTCIS-VLTGHNHYVMCASFHPKEDLVVSASLDQTVRVWDIgslkkksvspaddlmrftqmnsD------ 187
           *******************************.*******************************************999999955555550...... PP
   S: 174  tl...........tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdl 256
            l            +gh++ v++ sf+++ + +vsg++d++vklw + +++   v+tl+gh +nv+sv f+ +++++vs s+D+sir+Wd ++++ 
   Q: 188  -LfggvdaivkyvLEGHDRGVNWASFHPTLPLIVSGADDRQVKLWRMNETKAweVDTLRGHMNNVSSVMFHAKQDIIVSNSEDKSIRVWDATKRTG 282
           .455555555555555********************************887778****************************************** PP
   S: 257  lktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkne 298
           ++t+ +++++++  av +++ n l++g + +   ++kl++++
   Q: 283  IQTFRREHDRFWILAV-HPEINLLAAGHD-NGMIVFKLERER 322
           ****************.888777777755.566677887766 PP

Organism

Brassica rapa

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLTKFETKSN RVKGLTFHPK RPWILASLHS GVIQLWDYRM GTLIDRFDEH EGPVRGVHFH 60
NSQPLFVSGG DDYKIKVWNH KTHRCLFTLL GHLDYIRTVQ FHHENPWIVS ASDDQTIRIW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTGACGA AGTTCGAGAC GAAGAGTAAC AGAGTCAAGG GACTCACCTT CCACCCTAAA 60
CGGCCATGGA TCCTCGCCAG TTTGCACAGT GGCGTGATCC AGCTCTGGGA TTATCGTATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011048--Haem_d1
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cne-027053	Cryptococcus neoformans	56.89	0.00e+00	1013.00
IUUC-Cme-027222	Cyanidioschyzon merolae	40.76	4.00e-146	512.00
IUUC-Dor-030290	Dipodomys ordii	52.72	1.00e-162	567.00
IUUC-Loc-051867	Lepisosteus oculatus	49.88	0.00e+00	808.00
IUUC-Meu-056238	Macropus eugenii	56.72	0.00e+00	765.00
IUUC-Nle-069634	Nomascus leucogenys	65.92	0.00e+00	939.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence