iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049706

Ensembl Protein ID

ENSLACP00000010045.1

UniProt Accession

H3AK74; H3AK74_LATCH

Genbank Protein ID

ENSLACP00000010045

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

AFYH01124724

Gene Name

COPA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000008855.1	ENSLACT00000010122.1	ENSLACP00000010045.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-34	116.9	50	80
UBD/Beta-Prp	3.70e-74	249.8	3	324

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDl 30
           H ++v++++f  + +l+vsG+dD +ikvW++
   Q: 50   HDGPVRGIDFhkQQPLFVSGGDDYKIKVWNY 80
           99********97449**************96 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           t +++++++++ + f+p++++++++  +g i++wd+++ +l+ ++ +h+++v+ ++f+++++++v+g++D+ ikvw+++ + c+ tl g
   Q: 3    TKFETKSARVKGLSFHPKRPWILASLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLG 91
           67889999********************************************************************************* PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl............... 166
           h d+++++ f+ +  +++s s+d+tirvw++++++c+  +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+               
   Q: 92   HLDYIRTTFFHHEYPWILSSSDDQTIRVWNWQSRTCVC-VLTGHNHYVMCAQFHPSEDLVVSASLDQTVRIWDIsglrkknlspgavet 179
           **************************************.************************************************** PP
   S: 167  ............ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgs 241
                        t+ ++++  +gh++ v++ +f+++++ +vsg++d++vk+w + +++   v+t++gh +nv++  f+p++e+++s s
   Q: 180  dvrgitgvdlfgTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAweVDTCRGHYNNVSCAVFHPRQELILSNS 268
           ************888888888777********************************888888*************************** PP
   S: 242  sDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +D+sir+Wd+ +++ ++t+ + +++++  ++   ++ +l++++ ds   ++kl++++p
   Q: 269  EDKSIRVWDMSKRTGVQTFRRDHDRFWVLTA--HTNLNLFAAGHDSGMIVFKLERERP 324
           *****************************99..667777777789*******998775 PP

Organism

Latimeria chalumnae

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLTKFETKSA RVKGLSFHPK RPWILASLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH 60
KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS SSDDQTIRVW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGAATAAAC TTTATCGATT GAGGTGGGAC AGTTCGAACA AAGGAGCGGC GGTGACGTGG 60
AGGAATAGCC GTACTTCCGC AGAGACGTGG CCGGAGGAGA GGAGAGGAGG CTGGAAGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0030903--P:notochord development
GO:0061053--P:somite development
GO:0016192--P:vesicle-mediated transport

KEGG

lcm:102354339

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	53.97	0.00e+00	1335.00
IUUC-Aml-001758	Ailuropoda melanoleuca	92.46	0.00e+00	2377.00
IUUC-Atr-002493	Amborella trichopoda	54.38	0.00e+00	1324.00
IUUC-Apl-003385	Anas platyrhynchos	92.28	0.00e+00	1996.00
IUUC-Aca-005154	Anolis carolinensis	95.17	4.00e-120	423.00
IUUC-Aly-006020	Arabidopsis lyrata	62.10	0.00e+00	1096.00
IUUC-Ath-007058	Arabidopsis thaliana	62.23	0.00e+00	1091.00
IUUC-Ago-007992	Ashbya gossypii	45.04	0.00e+00	1033.00
IUUC-Acl-008027	Aspergillus clavatus	57.04	0.00e+00	1004.00
IUUC-Afl-008644	Aspergillus flavus	57.11	0.00e+00	999.00
IUUC-Afu-008964	Aspergillus fumigatus	49.31	0.00e+00	1193.00
IUUC-Ani-009379	Aspergillus nidulans	56.72	0.00e+00	1014.00
IUUC-Ang-009756	Aspergillus niger	50.00	0.00e+00	1209.00
IUUC-Aor-010174	Aspergillus oryzae	57.11	0.00e+00	999.00
IUUC-Ate-010302	Aspergillus terreus	49.15	0.00e+00	1215.00
IUUC-Ame-011229	Astyanax mexicanus	86.68	0.00e+00	2203.00
IUUC-Bgr-012300	Blumeria graminis	48.56	0.00e+00	1144.00
IUUC-Bta-012524	Bos taurus	93.22	0.00e+00	2363.00
IUUC-Bci-013781	Botrytis cinerea	49.07	0.00e+00	1199.00
IUUC-Bdi-014549	Brachypodium distachyon	54.36	0.00e+00	1350.00
IUUC-Bol-015967	Brassica oleracea	54.49	0.00e+00	1229.00
IUUC-Bra-016978	Brassica rapa	60.93	0.00e+00	1077.00
IUUC-Cel-018115	Caenorhabditis elegans	64.23	0.00e+00	1125.00
IUUC-Cja-019107	Callithrix jacchus	90.59	0.00e+00	2317.00
IUUC-Cfa-020675	Canis familiaris	92.42	0.00e+00	2345.00
IUUC-Cpo-021813	Cavia porcellus	93.30	0.00e+00	2391.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	64.72	0.00e+00	1112.00
IUUC-Csa-023523	Chlorocebus sabaeus	93.46	0.00e+00	2399.00
IUUC-Cho-024704	Choloepus hoffmanni	79.08	0.00e+00	1802.00
IUUC-Cin-025572	Ciona intestinalis	72.53	0.00e+00	1871.00
IUUC-Csv-025864	Ciona savignyi	75.42	0.00e+00	1298.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	57.21	0.00e+00	1022.00
IUUC-Cne-027053	Cryptococcus neoformans	52.26	0.00e+00	1247.00
IUUC-Cme-027222	Cyanidioschyzon merolae	40.33	2.00e-141	497.00
IUUC-Dre-027421	Danio rerio	87.02	0.00e+00	2238.00
IUUC-Dno-029303	Dasypus novemcinctus	92.67	0.00e+00	2375.00
IUUC-Dor-030290	Dipodomys ordii	89.73	0.00e+00	1040.00
IUUC-Dse-031543	Dothistroma septosporum	47.03	0.00e+00	1128.00
IUUC-Dme-031945	Drosophila melanogaster	75.81	0.00e+00	1290.00
IUUC-Ete-032873	Echinops telfairi	87.47	0.00e+00	2060.00
IUUC-Eca-033773	Equus caballus	90.95	0.00e+00	2305.00
IUUC-Eeu-034874	Erinaceus europaeus	79.63	0.00e+00	1420.00
IUUC-Fca-035739	Felis catus	91.71	0.00e+00	2299.00
IUUC-Fal-037263	Ficedula albicollis	85.64	0.00e+00	2090.00
IUUC-Fox-037738	Fusarium oxysporum	47.98	0.00e+00	1194.00
IUUC-Fso-038153	Fusarium solani	48.42	0.00e+00	1189.00
IUUC-Gmo-039602	Gadus morhua	82.48	0.00e+00	2070.00
IUUC-Ggr-039931	Gaeumannomyces graminis	56.12	0.00e+00	1012.00
IUUC-Gga-040590	Gallus gallus	93.30	0.00e+00	2352.00
IUUC-Gac-041318	Gasterosteus aculeatus	86.76	0.00e+00	2227.00
IUUC-Gma-043894	Glycine max	54.58	0.00e+00	1351.00
IUUC-Ggo-045029	Gorilla gorilla	92.70	0.00e+00	2390.00
IUUC-Hsa-046078	Homo sapiens	92.62	0.00e+00	2388.00
IUUC-Hvu-047556	Hordeum vulgare	54.77	0.00e+00	1362.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	90.67	0.00e+00	1647.00
IUUC-Kpa-049256	Komagataella pastoris	45.37	0.00e+00	1082.00
IUUC-Lpe-051316	Leersia perrieri	62.87	0.00e+00	1112.00
IUUC-Loc-051867	Lepisosteus oculatus	70.16	0.00e+00	1221.00
IUUC-Lma-053138	Leptosphaeria maculans	56.96	0.00e+00	1018.00
IUUC-Laf-053510	Loxodonta africana	92.32	0.00e+00	2369.00
IUUC-Mcc-055836	Macaca mulatta	92.05	0.00e+00	2374.00
IUUC-Meu-056238	Macropus eugenii	84.58	0.00e+00	1155.00
IUUC-Mor-057172	Magnaporthe oryzae	48.00	0.00e+00	1187.00
IUUC-Mpo-057300	Magnaporthe poae	47.80	0.00e+00	1170.00
IUUC-Mtr-058248	Medicago truncatula	55.39	0.00e+00	1369.00
IUUC-Mla-059019	Melampsora laricipopulina	52.42	0.00e+00	1283.00
IUUC-Mga-059499	Meleagris gallopavo	93.15	0.00e+00	2345.00
IUUC-Mvi-060336	Microbotryum violaceum	52.76	0.00e+00	1269.00
IUUC-Mmr-061102	Microcebus murinus	92.54	0.00e+00	2346.00
IUUC-Mdo-062594	Monodelphis domestica	92.97	0.00e+00	2419.00
IUUC-Mmu-063736	Mus musculus	92.38	0.00e+00	2374.00
IUUC-Mac-065398	Musa acuminata	52.67	0.00e+00	1243.00
IUUC-Mpu-066701	Mustela putorius furo	92.75	0.00e+00	2337.00
IUUC-Mlu-067392	Myotis lucifugus	92.90	0.00e+00	2346.00
IUUC-Nfi-068270	Neosartorya fischeri	57.45	0.00e+00	1008.00
IUUC-Ncr-068892	Neurospora crassa	49.36	0.00e+00	1184.00
IUUC-Nle-069634	Nomascus leucogenys	96.06	0.00e+00	1345.00
IUUC-Opr-070952	Ochotona princeps	80.69	0.00e+00	1714.00
IUUC-Ont-072488	Oreochromis niloticus	88.48	0.00e+00	2231.00
IUUC-Ocu-074211	Oryctolagus cuniculus	93.22	0.00e+00	2389.00
IUUC-Oba-075761	Oryza barthii	62.63	0.00e+00	1107.00
IUUC-Obr-076429	Oryza brachyantha	62.51	0.00e+00	1105.00
IUUC-Ogl-077364	Oryza glaberrima	62.63	0.00e+00	1108.00
IUUC-Ogu-078257	Oryza glumaepatula	62.63	0.00e+00	1108.00
IUUC-Oin-080029	Oryza indica	62.63	0.00e+00	1105.00
IUUC-Olo-080466	Oryza longistaminata	62.79	0.00e+00	1096.00
IUUC-Ome-081993	Oryza meridionalis	64.79	0.00e+00	1033.00
IUUC-Oni-082874	Oryza nivara	62.63	0.00e+00	1109.00
IUUC-Opu-083370	Oryza punctata	54.21	0.00e+00	1344.00
IUUC-Oru-084274	Oryza rufipogon	62.63	0.00e+00	1108.00
IUUC-Osa-085565	Oryza sativa	62.63	0.00e+00	1108.00
IUUC-Ola-086921	Oryzias latipes	86.88	0.00e+00	2197.00
IUUC-Olu-087639	Ostreococcus lucimarinus	55.67	0.00e+00	1361.00
IUUC-Oga-087991	Otolemur garnettii	88.44	0.00e+00	2251.00
IUUC-Oar-089590	Ovis aries	93.22	0.00e+00	2386.00
IUUC-Ptr-090808	Pan troglodytes	92.70	0.00e+00	2390.00
IUUC-Pan-092475	Papio anubis	92.98	0.00e+00	2385.00
IUUC-Psi-093044	Pelodiscus sinensis	77.19	0.00e+00	1644.00
IUUC-Pno-094839	Phaeosphaeria nodorum	47.93	0.00e+00	1111.00
IUUC-Ppa-095254	Physcomitrella patens	56.57	0.00e+00	1409.00
IUUC-Pfo-097493	Poecilia formosa	88.32	0.00e+00	2202.00
IUUC-Pab-098497	Pongo abelii	93.46	0.00e+00	2400.00
IUUC-Pop-099992	Populus trichocarpa	56.51	0.00e+00	1348.00
IUUC-Pca-100413	Procavia capensis	86.03	0.00e+00	984.00
IUUC-Ppe-101899	Prunus persica	63.49	0.00e+00	1123.00
IUUC-Pva-102126	Pteropus vampyrus	88.65	0.00e+00	2261.00
IUUC-Pgr-103376	Puccinia graminis	52.24	0.00e+00	1295.00
IUUC-Ptt-103978	Puccinia triticina	46.79	0.00e+00	1074.00
IUUC-Pte-104126	Pyrenophora teres	56.83	0.00e+00	980.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	46.94	8.00e-179	620.00
IUUC-Rno-105428	Rattus norvegicus	93.38	0.00e+00	2389.00
IUUC-Sce-106464	Saccharomyces cerevisiae	43.39	0.00e+00	999.00
IUUC-Sha-107301	Sarcophilus harrisii	92.82	0.00e+00	2358.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	46.22	0.00e+00	1101.00
IUUC-Spo-108217	Schizosaccharomyces pombe	46.74	0.00e+00	1125.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	49.35	0.00e+00	1205.00
IUUC-Smo-109582	Selaginella moellendorffii	65.75	0.00e+00	1159.00
IUUC-Sit-109697	Setaria italica	62.16	0.00e+00	1102.00
IUUC-Sly-111759	Solanum lycopersicum	55.16	0.00e+00	1376.00
IUUC-Stu-112564	Solanum tuberosum	54.76	0.00e+00	1370.00
IUUC-Sar-113313	Sorex araneus	82.28	0.00e+00	1416.00
IUUC-Sbi-114388	Sorghum bicolor	54.46	0.00e+00	1357.00
IUUC-Sre-115209	Sporisorium reilianum	58.00	0.00e+00	1046.00
IUUC-Ssc-115933	Sus scrofa	93.06	0.00e+00	2385.00
IUUC-Tgu-117109	Taeniopygia guttata	79.77	0.00e+00	729.00
IUUC-Tru-117772	Takifugu rubripes	86.36	0.00e+00	2170.00
IUUC-Tsy-119105	Tarsius syrichta	79.64	0.00e+00	2006.00
IUUC-Tni-120556	Tetraodon nigroviridis	70.65	0.00e+00	1524.00
IUUC-Tca-121046	Theobroma cacao	54.89	0.00e+00	1378.00
IUUC-Tre-121951	Trichoderma reesei	56.90	0.00e+00	1011.00
IUUC-Tvi-122359	Trichoderma virens	58.01	0.00e+00	1023.00
IUUC-Tae-123688	Triticum aestivum	54.85	0.00e+00	1362.00
IUUC-Tur-126754	Triticum urartu	62.04	0.00e+00	1103.00
IUUC-Tme-127170	Tuber melanosporum	51.05	0.00e+00	1236.00
IUUC-Tbe-127882	Tupaia belangeri	69.73	0.00e+00	783.00
IUUC-Ttr-128217	Tursiops truncatus	90.27	0.00e+00	2305.00
IUUC-Uma-129337	Ustilago maydis	57.85	0.00e+00	1044.00
IUUC-Vda-129828	Verticillium dahliae	48.19	0.00e+00	1178.00
IUUC-Vpa-130537	Vicugna pacos	91.97	0.00e+00	2343.00
IUUC-Vvi-130958	Vitis vinifera	63.71	0.00e+00	1122.00
IUUC-Xtr-132857	Xenopus tropicalis	89.30	0.00e+00	2253.00
IUUC-Xma-133138	Xiphophorus maculatus	88.07	0.00e+00	2200.00
IUUC-Yli-134399	Yarrowia lipolytica	51.45	0.00e+00	870.00
IUUC-Zma-135612	Zea mays	54.33	0.00e+00	1347.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence