iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027651

UUCD1 version

UUC-DaR-01483

Ensembl Protein ID

ENSDARP00000065292.5

UniProt Accession

F1QFS9; A5D8T1; UBP13_DANRE

Genbank Protein ID

AAI41801.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinating enzyme 13; Ubiquitin thioesterase 13; Ubiquitin-specific-processing protease 13

Genbank Nucleotide ID

AL928701

Gene Name

usp13; wu:fc61g08

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000079198.3	ENSDART00000065293.6	ENSDARP00000065292.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.40e-56	191.4	318	856
UBD/Alpha-Helix/UBA	4.50e-20	72.0	713	750

Active Site

Position(s)	Description	Evidence
327	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10093}
819	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel.......................wkskkk 66
           tG+kNlgN+CY+  ++Q+L++ipe+++++   + +++ + +p +p++++ ++++kl + l                        +++++
   Q: 318  TGIKNLGNSCYLSTTMQVLFSIPEFQRAYAG-NLQRIFDYSPLDPTQDFNTQMAKLGHGLlsgqyskppmkselieqvmkeehKQQQQR 405
           7******************************.7777778889******************99999999999988888766543388888 PP
   S: 67   avsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqik 155
            +sp+++++ ++k ++efs+++qqDa+Efl +l++ +e++                              ++++  sd+F++ ++++++
   Q: 406  GISPKMFKALVSKGHPEFSSNRQQDAHEFLLHLINLVERNN-----------------------------SGSENPSDVFRFIVEERTQ 465
           ***********************************999977.............................788999************* PP
   S: 156  clecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqea 217
           c + ++v  ++   + ++lpvp +  ++ e                            ++ cL++ft++e++ +   ++++  ++k+  
   Q: 466  CCQSQKVRYTQRVDYLMQLPVPLEAASNREeliayegkrkeaeenmrplpevvrarvPFTACLQAFTEPENVPD---FWSSALQAKSAG 551
           *******9888888888888887776666678****************************************97...************ PP
   S: 218  ekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts....................................... 267
           +k+ ++ ++Pe++i++Lk+f+f  + ++++k++ +v++p+ Ldl++  ++                                       
   Q: 552  VKTSRFATFPEYMIVQLKKFTFGVD-WVPKKLDMSVDVPDFLDLNRLRATglqageeelpdltppivipedtrdsstnnslespeides 639
           **********************776.*******************98888899999999999999999988888888888887777777 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 640  svmqlaemgfpleacrkavyytgnmgaemafnwiiahmeepdfaeplavptymesdlpspslpttsaldnqppeesisiltsmgfprhh 728
           77777777777777777777777777777777777777777777777777777777777777666666666666666666666666666 PP
   S: 268  ...........peekqke.........................................................kkkYeLiavvvHsG 288
                            e                                                         + +YeL+a ++H+G
   Q: 729  tiqalkasnnnL-----EraldwifthpdcedeseamsdtadtepndnsfsnanahtdsslspdqdlssprvrdgPGRYELFAFISHMG 812
           665555555550.....0555555555555555556666666677777777888888888889999999999999************** PP
   S: 289  .slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            s+ sGHYv+++k+ +g+Wl ++D+kV  +  e+  +   + +Y++fY+r
   Q: 813  tSTMSGHYVCHIKK-EGRWLIYNDHKVCLS--ERPPK---DLGYMYFYRR 856
           **************.9***********988..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+ +  l++MGF+r++ +qaL a+nnnle+A+++++++
   Q: 713  EESISILTSMGFPRHHTIQALKASNNNLERALDWIFTH 750
           789999******************************98 PP

Organism

Danio rerio

Functional Description
(View)

Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).

Protein Sequence
(Fasta)

MATDLGELLV PYMPTIRVPR TGDRVFKSEC AFSYDSPESE GGLYVCMNSF LGFGREHVER 60
HYRKTGQSVY MHLKRHVKEK ATGAAGGAIP RRRNGKVFLD LELNRDFNGD DYEYEDEAKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACGCATCA AACGCAGTGT GTGCAGTTCT GAAAACGCCA CCGTTTGGCG TCAGGGTGAA 60
TAATGTCAAA TACCGAATAT TTCTCGAAGG GGACACCCAT TGTTTTCCCA CTCCTGCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0008283--P:cell proliferation
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dre:558011

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	40.96	1.00e-177	616.00
IUUC-Aml-001356	Ailuropoda melanoleuca	75.00	0.00e+00	1296.00
IUUC-Atr-002580	Amborella trichopoda	41.47	0.00e+00	665.00
IUUC-Apl-003712	Anas platyrhynchos	75.46	0.00e+00	1281.00
IUUC-Aca-004634	Anolis carolinensis	76.72	0.00e+00	1337.00
IUUC-Aly-005727	Arabidopsis lyrata	42.99	0.00e+00	671.00
IUUC-Ago-007890	Ashbya gossypii	26.00	2.00e-65	244.00
IUUC-Ani-009441	Aspergillus nidulans	31.42	3.00e-91	329.00
IUUC-Ame-011470	Astyanax mexicanus	89.42	0.00e+00	1558.00
IUUC-Bta-013349	Bos taurus	75.17	0.00e+00	1315.00
IUUC-Bdi-014904	Brachypodium distachyon	41.90	0.00e+00	641.00
IUUC-Bol-015296	Brassica oleracea	43.04	0.00e+00	682.00
IUUC-Bra-017939	Brassica rapa	42.92	0.00e+00	685.00
IUUC-Cja-019021	Callithrix jacchus	74.94	0.00e+00	1295.00
IUUC-Cfa-020614	Canis familiaris	75.12	0.00e+00	1294.00
IUUC-Cpo-022484	Cavia porcellus	74.07	0.00e+00	1233.00
IUUC-Csa-024078	Chlorocebus sabaeus	75.06	0.00e+00	1298.00
IUUC-Cho-024522	Choloepus hoffmanni	61.75	0.00e+00	953.00
IUUC-Cne-026831	Cryptococcus neoformans	33.64	1.00e-114	407.00
IUUC-Cme-027335	Cyanidioschyzon merolae	25.58	1.00e-56	215.00
IUUC-Dno-028975	Dasypus novemcinctus	74.77	0.00e+00	1288.00
IUUC-Dor-030130	Dipodomys ordii	54.99	0.00e+00	845.00
IUUC-Ete-032251	Echinops telfairi	62.97	0.00e+00	1020.00
IUUC-Eca-033568	Equus caballus	75.15	0.00e+00	1236.00
IUUC-Eeu-034612	Erinaceus europaeus	70.75	0.00e+00	830.00
IUUC-Fca-036280	Felis catus	74.85	0.00e+00	1230.00
IUUC-Fal-036610	Ficedula albicollis	76.14	0.00e+00	1266.00
IUUC-Gmo-038906	Gadus morhua	79.98	0.00e+00	1426.00
IUUC-Gga-041215	Gallus gallus	75.64	0.00e+00	1337.00
IUUC-Gac-042441	Gasterosteus aculeatus	81.27	0.00e+00	1471.00
IUUC-Ggo-044446	Gorilla gorilla	75.41	0.00e+00	1307.00
IUUC-Hsa-046546	Homo sapiens	75.17	0.00e+00	1301.00
IUUC-Hvu-047563	Hordeum vulgare	45.10	3.00e-165	575.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	69.86	0.00e+00	1190.00
IUUC-Kpa-049156	Komagataella pastoris	30.44	2.00e-103	370.00
IUUC-Lch-050425	Latimeria chalumnae	75.28	0.00e+00	1357.00
IUUC-Loc-052072	Lepisosteus oculatus	79.77	0.00e+00	1389.00
IUUC-Laf-053909	Loxodonta africana	73.37	0.00e+00	1277.00
IUUC-Mcc-054686	Macaca mulatta	74.94	0.00e+00	1298.00
IUUC-Meu-056361	Macropus eugenii	68.41	0.00e+00	1185.00
IUUC-Mga-059972	Meleagris gallopavo	71.09	0.00e+00	1219.00
IUUC-Mmr-060916	Microcebus murinus	75.29	0.00e+00	1295.00
IUUC-Mdo-062302	Monodelphis domestica	76.81	0.00e+00	1368.00
IUUC-Mmu-063639	Mus musculus	74.33	0.00e+00	1294.00
IUUC-Mac-065634	Musa acuminata	38.62	1.00e-174	606.00
IUUC-Mpu-066533	Mustela putorius furo	75.00	0.00e+00	1295.00
IUUC-Mlu-067786	Myotis lucifugus	70.93	0.00e+00	1220.00
IUUC-Nle-069997	Nomascus leucogenys	74.54	0.00e+00	1222.00
IUUC-Ont-071859	Oreochromis niloticus	83.77	0.00e+00	1516.00
IUUC-Oan-072959	Ornithorhynchus anatinus	80.42	4.00e-118	417.00
IUUC-Ocu-074265	Oryctolagus cuniculus	74.59	0.00e+00	1291.00
IUUC-Oba-075109	Oryza barthii	42.67	0.00e+00	658.00
IUUC-Obr-076292	Oryza brachyantha	41.82	0.00e+00	645.00
IUUC-Ogl-077065	Oryza glaberrima	43.62	0.00e+00	682.00
IUUC-Ogu-078776	Oryza glumaepatula	41.98	0.00e+00	671.00
IUUC-Oin-080048	Oryza indica	42.81	0.00e+00	673.00
IUUC-Olo-080711	Oryza longistaminata	40.86	4.00e-174	605.00
IUUC-Ome-081506	Oryza meridionalis	41.83	2.00e-177	615.00
IUUC-Oni-082320	Oryza nivara	41.79	0.00e+00	652.00
IUUC-Opu-083801	Oryza punctata	42.09	0.00e+00	644.00
IUUC-Oru-085139	Oryza rufipogon	41.62	0.00e+00	650.00
IUUC-Osa-085713	Oryza sativa	43.62	0.00e+00	684.00
IUUC-Ola-087344	Oryzias latipes	81.16	0.00e+00	1494.00
IUUC-Oga-088734	Otolemur garnettii	74.73	0.00e+00	1279.00
IUUC-Oar-089636	Ovis aries	74.79	0.00e+00	1280.00
IUUC-Ptr-090982	Pan troglodytes	75.29	0.00e+00	1304.00
IUUC-Pan-091991	Papio anubis	75.06	0.00e+00	1300.00
IUUC-Psi-093509	Pelodiscus sinensis	76.92	0.00e+00	1355.00
IUUC-Pfo-096029	Poecilia formosa	85.43	0.00e+00	1563.00
IUUC-Pab-098672	Pongo abelii	71.45	0.00e+00	1214.00
IUUC-Pca-100860	Procavia capensis	60.06	0.00e+00	753.00
IUUC-Pva-102545	Pteropus vampyrus	74.42	0.00e+00	1093.00
IUUC-Pte-104306	Pyrenophora teres	31.54	2.00e-94	340.00
IUUC-Rno-105210	Rattus norvegicus	74.21	0.00e+00	1283.00
IUUC-Spo-108144	Schizosaccharomyces pombe	31.09	3.00e-105	376.00
IUUC-Sly-111523	Solanum lycopersicum	41.78	0.00e+00	692.00
IUUC-Sar-113733	Sorex araneus	78.52	0.00e+00	647.00
IUUC-Tgu-116591	Taeniopygia guttata	75.99	0.00e+00	1343.00
IUUC-Tru-118627	Takifugu rubripes	82.99	0.00e+00	1529.00
IUUC-Tsy-119278	Tarsius syrichta	66.87	0.00e+00	1100.00
IUUC-Tni-120804	Tetraodon nigroviridis	84.86	0.00e+00	1549.00
IUUC-Tae-125686	Triticum aestivum	43.27	0.00e+00	679.00
IUUC-Tur-126732	Triticum urartu	40.80	0.00e+00	637.00
IUUC-Tbe-127699	Tupaia belangeri	60.43	0.00e+00	709.00
IUUC-Ttr-128295	Tursiops truncatus	68.92	0.00e+00	1176.00
IUUC-Vpa-130170	Vicugna pacos	65.90	0.00e+00	1056.00
IUUC-Xtr-132809	Xenopus tropicalis	69.19	0.00e+00	1238.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence