iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106494

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01221752

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000013890.1	ENSSHAT00000016462.1	ENSSHAP00000016327.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.20e-07	31.0	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIVKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MSLLNCEDSC GGNQPESDCC PAMASACSTG AKEDSINGSP VPGNLSSSLM EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIVKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGCCAGGA GCTGGGAAGG CGGAAGCTGT GGCGGTGGCC GGAGGGCCCT CGCCCGCTCC 60
CTGGCCGCGC TCTCCGCCCT CCTTCTTTGC GGGGCGCCGG AGCGACTGAG CGACGGAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

KEGG

shr:100922331

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	81.89	0.00e+00	874.00
IUUC-Apl-004062	Anas platyrhynchos	74.77	0.00e+00	843.00
IUUC-Aca-004636	Anolis carolinensis	72.26	0.00e+00	776.00
IUUC-Ame-011682	Astyanax mexicanus	53.51	9.00e-165	573.00
IUUC-Bta-012692	Bos taurus	80.81	0.00e+00	882.00
IUUC-Cja-019426	Callithrix jacchus	81.89	0.00e+00	879.00
IUUC-Cfa-020948	Canis familiaris	81.60	0.00e+00	777.00
IUUC-Cpo-021378	Cavia porcellus	80.15	0.00e+00	869.00
IUUC-Csa-024045	Chlorocebus sabaeus	83.05	0.00e+00	899.00
IUUC-Cho-024973	Choloepus hoffmanni	66.53	2.00e-94	339.00
IUUC-Csv-026300	Ciona savignyi	40.16	2.00e-46	178.00
IUUC-Dre-027557	Danio rerio	56.20	6.00e-170	590.00
IUUC-Dno-030032	Dasypus novemcinctus	75.15	1.00e-129	455.00
IUUC-Dor-030790	Dipodomys ordii	82.14	0.00e+00	883.00
IUUC-Dse-031478	Dothistroma septosporum	21.67	3.00e-10	60.10
IUUC-Dme-031921	Drosophila melanogaster	26.36	5.00e-43	168.00
IUUC-Ete-032952	Echinops telfairi	82.01	4.00e-161	560.00
IUUC-Eca-033924	Equus caballus	76.61	0.00e+00	791.00
IUUC-Eeu-034734	Erinaceus europaeus	77.02	0.00e+00	799.00
IUUC-Fca-036222	Felis catus	75.92	0.00e+00	793.00
IUUC-Fal-036834	Ficedula albicollis	75.80	0.00e+00	746.00
IUUC-Fox-037935	Fusarium oxysporum	28.77	5.00e-20	92.40
IUUC-Gmo-039061	Gadus morhua	54.42	6.00e-85	308.00
IUUC-Ggr-040084	Gaeumannomyces graminis	28.38	5.00e-14	72.40
IUUC-Gga-040599	Gallus gallus	76.15	0.00e+00	858.00
IUUC-Gac-041977	Gasterosteus aculeatus	56.05	6.00e-168	583.00
IUUC-Ggo-044508	Gorilla gorilla	78.80	0.00e+00	831.00
IUUC-Hsa-046349	Homo sapiens	83.05	0.00e+00	922.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	82.86	0.00e+00	907.00
IUUC-Lch-049821	Latimeria chalumnae	69.05	0.00e+00	772.00
IUUC-Loc-051995	Lepisosteus oculatus	61.38	0.00e+00	641.00
IUUC-Laf-054115	Loxodonta africana	78.74	0.00e+00	870.00
IUUC-Mcc-055298	Macaca mulatta	82.86	0.00e+00	895.00
IUUC-Mor-057263	Magnaporthe oryzae	28.14	7.00e-16	78.60
IUUC-Mpo-057517	Magnaporthe poae	27.80	4.00e-14	72.80
IUUC-Mga-059340	Meleagris gallopavo	75.23	0.00e+00	823.00
IUUC-Mvi-060553	Microbotryum violaceum	27.23	6.00e-15	75.50
IUUC-Mmr-061063	Microcebus murinus	81.61	0.00e+00	877.00
IUUC-Mdo-062075	Monodelphis domestica	89.50	0.00e+00	1009.00
IUUC-Mmu-063780	Mus musculus	80.94	0.00e+00	847.00
IUUC-Mpu-065748	Mustela putorius furo	81.18	0.00e+00	876.00
IUUC-Mlu-067888	Myotis lucifugus	80.82	0.00e+00	879.00
IUUC-Nle-069234	Nomascus leucogenys	83.05	0.00e+00	902.00
IUUC-Opr-070393	Ochotona princeps	90.61	2.00e-116	412.00
IUUC-Ont-072459	Oreochromis niloticus	56.56	6.00e-172	597.00
IUUC-Oan-073578	Ornithorhynchus anatinus	82.35	0.00e+00	904.00
IUUC-Ocu-074201	Oryctolagus cuniculus	81.89	0.00e+00	886.00
IUUC-Ola-087319	Oryzias latipes	60.31	1.00e-88	320.00
IUUC-Olu-087748	Ostreococcus lucimarinus	23.56	3.00e-09	55.80
IUUC-Oga-087936	Otolemur garnettii	80.41	0.00e+00	874.00
IUUC-Oar-089379	Ovis aries	80.81	0.00e+00	888.00
IUUC-Ptr-090758	Pan troglodytes	83.05	0.00e+00	897.00
IUUC-Pan-092590	Papio anubis	83.05	0.00e+00	896.00
IUUC-Psi-093948	Pelodiscus sinensis	73.31	0.00e+00	811.00
IUUC-Pma-094434	Petromyzon marinus	42.50	2.00e-124	439.00
IUUC-Pfo-096912	Poecilia formosa	55.75	2.00e-167	582.00
IUUC-Pab-097651	Pongo abelii	83.05	0.00e+00	898.00
IUUC-Pca-100958	Procavia capensis	81.41	0.00e+00	654.00
IUUC-Pva-103247	Pteropus vampyrus	80.56	9.00e-114	403.00
IUUC-Rno-104994	Rattus norvegicus	79.62	0.00e+00	861.00
IUUC-Sar-113375	Sorex araneus	83.24	0.00e+00	882.00
IUUC-Sre-115218	Sporisorium reilianum	27.75	9.00e-15	75.10
IUUC-Ssc-115417	Sus scrofa	81.00	0.00e+00	884.00
IUUC-Tgu-117232	Taeniopygia guttata	73.94	0.00e+00	796.00
IUUC-Tru-118321	Takifugu rubripes	55.56	6.00e-168	583.00
IUUC-Tni-120475	Tetraodon nigroviridis	56.51	2.00e-163	568.00
IUUC-Tbe-127719	Tupaia belangeri	72.98	0.00e+00	753.00
IUUC-Ttr-129264	Tursiops truncatus	77.87	1.00e-108	386.00
IUUC-Uma-129620	Ustilago maydis	27.42	7.00e-16	79.00
IUUC-Vpa-130244	Vicugna pacos	80.63	6.00e-115	407.00
IUUC-Xtr-131948	Xenopus tropicalis	66.55	0.00e+00	751.00
IUUC-Xma-133132	Xiphophorus maculatus	55.75	3.00e-167	581.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence