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Tag Content
iUUCD ID IUUC-Nle-070178
Ensembl Protein ID ENSNLEP00000007631.1
UniProt Accession G1R359; G1R359_NOMLE
Genbank Protein ID ENSNLEP00000007631
Protein Name Tyrosine-protein kinase
Genbank Nucleotide ID ADFV01003922
Gene Name SRC
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSNLEG00000006271.1 ENSNLET00000008000.1 ENSNLEP00000007631.1
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 9.00e-12 44.8 88 148
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvieke....eqdegWlkgvkelegkrGlfPenFvek 61
    ++ +lydye+ ++ +L++kkG+ +++++++ +++W+ + + +g+ G +P+n+v+
   Q: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTllslLREGDWWLAHSLSTGQTGYIPSNYVAP 148
    5789***********************6652222689*********************975 PP
   

Organism Nomascus leucogenys
Protein Sequence
(Fasta)
MGSNKSKPKD ASQRRRSLEP TENVHGAGGG AFPASQTPSK PASAEGHRGP GAAFAPAAAE 60
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTLLS 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Nle-070178|UBD,SH3|Nomascus leucogenys
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCTCTCTCC AGCCAGGACC ATGGGCAGCA ACAAGAGCAA GCCCAAGGAC GCCAGCCAGC 60
GGCGCCGCAG TCTGGAGCCC ACCGAGAACG TGCACGGCGC TGGCGGGGGC GCTTTCCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Nle-070178|UBD,SH3|Nomascus leucogenys
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005901--C:caveola
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005743--C:mitochondrial inner membrane
GO:0005524--F:ATP binding
GO:0020037--F:heme binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0007229--P:integrin-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:2000811--P:negative regulation of anoikis
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0051902--P:negative regulation of mitochondrial depolarization
GO:0032463--P:negative regulation of protein homooligomerization
GO:0051974--P:negative regulation of telomerase activity
GO:0032211--P:negative regulation of telomere maintenance via telomerase
GO:0010634--P:positive regulation of epithelial cell migration
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0051057--P:positive regulation of small GTPase mediated signal transduction
GO:0046777--P:protein autophosphorylation
GO:2001286--P:regulation of caveolin-mediated endocytosis
GO:0022407--P:regulation of cell-cell adhesion
GO:2000641--P:regulation of early endosome to late endosome transport
GO:0070555--P:response to interleukin-1
GO:0043149--P:stress fiber assembly
GO:0007179--P:transforming growth factor beta receptor signaling pathway

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001713 Ailuropoda melanoleuca 95.76 0.00e+00 1057.00
IUUC-Aca-004237 Anolis carolinensis 89.11 0.00e+00 988.00
IUUC-Ath-007146 Arabidopsis thaliana 34.72 2.00e-22 100.00
IUUC-Ame-011887 Astyanax mexicanus 77.01 0.00e+00 853.00
IUUC-Bta-012982 Bos taurus 93.61 0.00e+00 1024.00
IUUC-Bdi-014324 Brachypodium distachyon 35.11 5.00e-23 103.00
IUUC-Bol-016049 Brassica oleracea 34.68 2.00e-17 84.70
IUUC-Bra-017486 Brassica rapa 33.68 6.00e-21 96.30
IUUC-Cja-019995 Callithrix jacchus 96.31 0.00e+00 1058.00
IUUC-Cfa-020060 Canis familiaris 95.20 0.00e+00 1049.00
IUUC-Cpo-021557 Cavia porcellus 92.62 0.00e+00 1022.00
IUUC-Csa-023711 Chlorocebus sabaeus 96.31 0.00e+00 1055.00
IUUC-Dre-028491 Danio rerio 81.03 0.00e+00 860.00
IUUC-Dno-029651 Dasypus novemcinctus 91.30 0.00e+00 1017.00
IUUC-Ete-033170 Echinops telfairi 94.10 0.00e+00 889.00
IUUC-Eca-033970 Equus caballus 89.71 0.00e+00 955.00
IUUC-Fca-036113 Felis catus 95.20 0.00e+00 1049.00
IUUC-Fal-036785 Ficedula albicollis 91.14 0.00e+00 1008.00
IUUC-Gga-040899 Gallus gallus 90.41 0.00e+00 1000.00
IUUC-Gac-042332 Gasterosteus aculeatus 79.30 0.00e+00 860.00
IUUC-Gma-043938 Glycine max 34.34 7.00e-23 102.00
IUUC-Ggo-044829 Gorilla gorilla 82.47 0.00e+00 865.00
IUUC-Hsa-046192 Homo sapiens 96.49 0.00e+00 1060.00
IUUC-Itr-049014 Ictidomys tridecemlineatus 95.57 0.00e+00 1042.00
IUUC-Lch-049892 Latimeria chalumnae 83.21 0.00e+00 921.00
IUUC-Lpe-051166 Leersia perrieri 33.79 4.00e-23 103.00
IUUC-Loc-052812 Lepisosteus oculatus 80.33 0.00e+00 867.00
IUUC-Laf-053977 Loxodonta africana 95.57 0.00e+00 1056.00
IUUC-Mcc-055159 Macaca mulatta 94.58 0.00e+00 1048.00
IUUC-Mtr-058733 Medicago truncatula 34.09 4.00e-23 103.00
IUUC-Mga-060135 Meleagris gallopavo 91.14 0.00e+00 1010.00
IUUC-Mmr-061168 Microcebus murinus 93.13 0.00e+00 1036.00
IUUC-Mdo-063030 Monodelphis domestica 88.97 0.00e+00 998.00
IUUC-Mmu-063893 Mus musculus 95.57 0.00e+00 1050.00
IUUC-Mpu-066411 Mustela putorius furo 95.20 0.00e+00 1049.00
IUUC-Mlu-068139 Myotis lucifugus 94.48 0.00e+00 1034.00
IUUC-Ont-072130 Oreochromis niloticus 79.53 0.00e+00 883.00
IUUC-Ocu-074403 Oryctolagus cuniculus 94.30 0.00e+00 1027.00
IUUC-Ola-086527 Oryzias latipes 79.17 0.00e+00 886.00
IUUC-Oga-088493 Otolemur garnettii 95.39 0.00e+00 1051.00
IUUC-Oar-090279 Ovis aries 94.15 0.00e+00 1029.00
IUUC-Ptr-091050 Pan troglodytes 96.49 0.00e+00 1060.00
IUUC-Pan-091862 Papio anubis 96.13 0.00e+00 1050.00
IUUC-Psi-093071 Pelodiscus sinensis 90.59 0.00e+00 1001.00
IUUC-Pfo-096578 Poecilia formosa 79.89 0.00e+00 890.00
IUUC-Pab-097902 Pongo abelii 94.94 0.00e+00 1052.00
IUUC-Pop-099554 Populus trichocarpa 32.42 2.00e-23 104.00
IUUC-Ppe-102072 Prunus persica 34.89 3.00e-26 114.00
IUUC-Rno-105847 Rattus norvegicus 95.58 0.00e+00 1046.00
IUUC-Sha-107539 Sarcophilus harrisii 90.77 0.00e+00 1003.00
IUUC-Stu-112331 Solanum tuberosum 32.00 2.00e-22 101.00
IUUC-Sbi-114480 Sorghum bicolor 35.78 9.00e-24 105.00
IUUC-Ssc-115762 Sus scrofa 94.34 0.00e+00 1034.00
IUUC-Tru-117849 Takifugu rubripes 80.04 0.00e+00 852.00
IUUC-Tni-120843 Tetraodon nigroviridis 78.99 0.00e+00 877.00
IUUC-Ttr-128702 Tursiops truncatus 89.67 0.00e+00 969.00
IUUC-Vvi-131181 Vitis vinifera 33.21 4.00e-22 100.00
IUUC-Xtr-132291 Xenopus tropicalis 84.93 0.00e+00 908.00
IUUC-Xma-133134 Xiphophorus maculatus 79.53 0.00e+00 888.00
Created Date 25-Jun-2017

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