iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bol-015296

Ensembl Protein ID

Bo3g076130.1

UniProt Accession

A0A0D3BCF7; A0A0D3BCF7_BRAOL

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bo3g076130	Bo3g076130.1	Bo3g076130.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-52	180.6	308	794
UBD/Alpha-Helix/UBA	5.70e-17	62.8	613	653

Active Site

Position(s)	Description	Evidence
317	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
757	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklnee.npkepkgellkslqklfeel...............w.kskkkavsprellkalkke 80
           tGl NlgN+CY+ +++Q L++++++ + ++++++ kl+ e +p +p+ ++ ++l+kl + l               + + +++ + pr++++++++ 
   Q: 308  TGLVNLGNSCYLAATMQILFSTHSFISRYFSHQSLKLAFEmAPADPTLDINMQLTKLGHGLlsgkysipvaekdvaTgDVRQEGIPPRMFKSVVAAG 404
           7*************************9999977777765515689999*************6666666665555432577777************** PP
   S: 81   aeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvs.sreepfldlslpv 176
           + efs+++qqDa +f+ +lld++e+                             +++ +   s+ F++ ++++i c + + ++ +r++  l+l++p+
   Q: 405  HAEFSSMRQQDALDFFLHLLDKVERGN---------------------------NMRPDLDPSRSFKFGVEEKILCSSGKVSYnKRDDCILSLNIPL 474
           ************************988...........................5678888999************776555544445555555555 PP
   S: 177  pgkeetkke.............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqk 244
           ++ +  +k                               l+ cL+ f+++e++++   yy++  k+k++a k+++l+++P++L+lh+ +f + e+++
   Q: 475  QEAT--NKDeleafnnqkadkgleednmstdeivrprvPLEACLATFSSPEQIRD---YYSTALKGKTTAIKTTSLTSFPDYLVLHMRKF-VMEAGW 565
           5555..444569*****************************************97...********************************.77889* PP
   S: 245  srekinkkvefpleLdlspfcts.......................................................................... 267
           +++k++ ++++p+ +d+s++ ++                                                                          
   Q: 566  VPKKLDVYIDVPDVIDISHMRSKglqpgeelladdvpeeamesaqpvaneeivaqlvsmgfsqlhcqkaaintsntgveeamtwllshmddpdidap 662
           ******************9999999999999999998888888888777777777777777777777777776666666666666666666666665 PP
   S: 268  ....peekqke....................................................................kkkYeLiavvvHsG.sls 291
               +     +                                                                      +Y+L+++v+H+G s++
   Q: 663  ishqK-----SdvdqssvdtlisfgfaeevarkalkasggdiekatdwifnnpnaslsdmdvsssssaltpaesalpdgGGRYKLFGIVSHMGtSTH 754
           55550.....0555556666666666666666666677777777777777777777777888888888888999999999***************** PP
   S: 292  sGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +GHYva++ + +g+W+ f+DskV  +  ++  +   + +Y++f++r
   Q: 755  CGHYVAHILK-EGRWVIFNDSKVGIS--TNPPK---DMGYLYFFQR 794
           **********.9***********998..56777...8999999987 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           ++e++++qlv+MGF++ ++++a  ++ n  +e+A+++Ll++
   Q: 613  ANEEIVAQLVSMGFSQLHCQKAAINTsNTGVEEAMTWLLSH 653
           589************************************97 PP

Organism

Brassica oleracea

Protein Sequence
(Fasta)

MELLRSNLSR VQIPEPTHRI YKHECCLSFD TPRSEGGLFV DMNSFLAFGK DYVSWNYEKT 60
RNPVYLHIKE TPKSVPEDRP LKKPTLLAIG VDGGFDNNEP EYKESYSIVI LPDFVSLPFP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCTCC TCCGATCAAA CTTGTCTAGG GTTCAGATCC CCGAGCCCAC CCACCGCATC 60
TACAAGCACG AGTGCTGCCT CTCCTTCGAC ACTCCGGTAA AACCTCTCCT CGTTTATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002104	Ailuropoda melanoleuca	47.78	0.00e+00	745.00
IUUC-Atr-002580	Amborella trichopoda	65.89	0.00e+00	1145.00
IUUC-Apl-003774	Anas platyrhynchos	48.36	0.00e+00	739.00
IUUC-Afu-008805	Aspergillus fumigatus	33.51	6.00e-108	384.00
IUUC-Ani-009441	Aspergillus nidulans	34.44	1.00e-95	344.00
IUUC-Ate-010531	Aspergillus terreus	32.26	4.00e-100	358.00
IUUC-Ame-011470	Astyanax mexicanus	42.49	0.00e+00	669.00
IUUC-Bgr-012183	Blumeria graminis	32.80	1.00e-110	394.00
IUUC-Bta-013179	Bos taurus	47.89	0.00e+00	749.00
IUUC-Bci-013858	Botrytis cinerea	33.77	3.00e-123	436.00
IUUC-Bdi-014904	Brachypodium distachyon	69.98	0.00e+00	1116.00
IUUC-Bra-017619	Brassica rapa	95.12	0.00e+00	1555.00
IUUC-Cja-019063	Callithrix jacchus	47.54	0.00e+00	745.00
IUUC-Cfa-020976	Canis familiaris	49.22	0.00e+00	762.00
IUUC-Cpo-022265	Cavia porcellus	48.98	0.00e+00	762.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	40.51	2.00e-117	416.00
IUUC-Cho-024522	Choloepus hoffmanni	35.17	6.00e-123	434.00
IUUC-Cin-025411	Ciona intestinalis	43.00	4.00e-179	621.00
IUUC-Csv-026347	Ciona savignyi	41.68	9.00e-176	610.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.16	2.00e-109	389.00
IUUC-Cne-026831	Cryptococcus neoformans	36.10	6.00e-124	437.00
IUUC-Cme-027335	Cyanidioschyzon merolae	28.80	1.00e-38	154.00
IUUC-Dre-027651	Danio rerio	42.92	0.00e+00	703.00
IUUC-Dno-029034	Dasypus novemcinctus	48.47	0.00e+00	756.00
IUUC-Dor-030130	Dipodomys ordii	38.38	4.00e-107	382.00
IUUC-Dse-031467	Dothistroma septosporum	36.03	5.00e-119	421.00
IUUC-Dme-032075	Drosophila melanogaster	44.74	0.00e+00	665.00
IUUC-Ete-032865	Echinops telfairi	44.56	0.00e+00	666.00
IUUC-Eca-034059	Equus caballus	48.02	0.00e+00	752.00
IUUC-Eeu-035304	Erinaceus europaeus	46.01	0.00e+00	680.00
IUUC-Fca-035515	Felis catus	48.12	0.00e+00	754.00
IUUC-Fal-037271	Ficedula albicollis	49.56	0.00e+00	727.00
IUUC-Fox-037745	Fusarium oxysporum	35.66	1.00e-124	440.00
IUUC-Fso-038158	Fusarium solani	35.32	3.00e-119	422.00
IUUC-Gmo-039071	Gadus morhua	44.79	0.00e+00	669.00
IUUC-Gga-040635	Gallus gallus	47.78	0.00e+00	769.00
IUUC-Gac-042528	Gasterosteus aculeatus	44.95	0.00e+00	677.00
IUUC-Ggo-044602	Gorilla gorilla	48.12	0.00e+00	755.00
IUUC-Hsa-045959	Homo sapiens	48.12	0.00e+00	755.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	47.65	0.00e+00	751.00
IUUC-Loc-052072	Lepisosteus oculatus	43.24	0.00e+00	677.00
IUUC-Lma-053216	Leptosphaeria maculans	34.16	4.00e-108	386.00
IUUC-Laf-054327	Loxodonta africana	48.12	0.00e+00	754.00
IUUC-Mcc-055443	Macaca mulatta	48.12	0.00e+00	753.00
IUUC-Meu-056298	Macropus eugenii	51.55	3.00e-156	545.00
IUUC-Mtr-058680	Medicago truncatula	75.47	0.00e+00	1228.00
IUUC-Mga-059669	Meleagris gallopavo	48.01	0.00e+00	728.00
IUUC-Mmr-060575	Microcebus murinus	48.00	0.00e+00	749.00
IUUC-Mdo-062183	Monodelphis domestica	48.39	0.00e+00	751.00
IUUC-Mmu-063592	Mus musculus	48.00	0.00e+00	751.00
IUUC-Mac-065634	Musa acuminata	66.16	0.00e+00	1149.00
IUUC-Mpu-066082	Mustela putorius furo	49.10	0.00e+00	759.00
IUUC-Mlu-067345	Myotis lucifugus	47.66	0.00e+00	746.00
IUUC-Nfi-068558	Neosartorya fischeri	35.20	6.00e-121	427.00
IUUC-Ncr-068960	Neurospora crassa	32.85	8.00e-108	384.00
IUUC-Nle-070173	Nomascus leucogenys	49.34	0.00e+00	764.00
IUUC-Opr-070556	Ochotona princeps	47.90	0.00e+00	759.00
IUUC-Ont-071502	Oreochromis niloticus	46.35	0.00e+00	684.00
IUUC-Oan-072959	Ornithorhynchus anatinus	54.62	1.00e-72	265.00
IUUC-Obr-076292	Oryza brachyantha	68.62	0.00e+00	1092.00
IUUC-Ola-086951	Oryzias latipes	43.02	0.00e+00	647.00
IUUC-Olu-087822	Ostreococcus lucimarinus	39.49	3.00e-163	568.00
IUUC-Oga-088625	Otolemur garnettii	47.59	0.00e+00	749.00
IUUC-Oar-089995	Ovis aries	47.48	0.00e+00	743.00
IUUC-Ptr-090640	Pan troglodytes	47.18	0.00e+00	753.00
IUUC-Pan-091974	Papio anubis	47.66	0.00e+00	749.00
IUUC-Psi-093957	Pelodiscus sinensis	47.92	0.00e+00	777.00
IUUC-Pma-094242	Petromyzon marinus	49.35	8.00e-106	376.00
IUUC-Pfo-097148	Poecilia formosa	46.18	0.00e+00	681.00
IUUC-Pop-098855	Populus trichocarpa	76.83	0.00e+00	1222.00
IUUC-Pca-100738	Procavia capensis	46.12	3.00e-146	512.00
IUUC-Ppe-101315	Prunus persica	77.27	0.00e+00	1244.00
IUUC-Pva-102154	Pteropus vampyrus	47.42	0.00e+00	743.00
IUUC-Pte-104306	Pyrenophora teres	32.97	2.00e-100	360.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.89	1.00e-106	380.00
IUUC-Rno-105801	Rattus norvegicus	48.12	0.00e+00	753.00
IUUC-Sce-106304	Saccharomyces cerevisiae	30.05	1.00e-67	251.00
IUUC-Sha-107635	Sarcophilus harrisii	49.28	0.00e+00	754.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	33.66	3.00e-98	352.00
IUUC-Sly-111523	Solanum lycopersicum	71.45	0.00e+00	1219.00
IUUC-Sar-113733	Sorex araneus	45.26	4.00e-93	335.00
IUUC-Sbi-114419	Sorghum bicolor	70.90	0.00e+00	1164.00
IUUC-Sre-115225	Sporisorium reilianum	33.18	6.00e-109	388.00
IUUC-Ssc-115686	Sus scrofa	47.30	0.00e+00	748.00
IUUC-Tgu-117346	Taeniopygia guttata	47.96	0.00e+00	753.00
IUUC-Tru-118350	Takifugu rubripes	44.25	0.00e+00	674.00
IUUC-Tsy-119278	Tarsius syrichta	38.94	1.00e-158	553.00
IUUC-Tca-121585	Theobroma cacao	78.51	0.00e+00	1264.00
IUUC-Tme-126909	Tuber melanosporum	34.22	1.00e-106	380.00
IUUC-Ttr-128295	Tursiops truncatus	37.99	1.00e-162	566.00
IUUC-Uma-129599	Ustilago maydis	33.56	8.00e-118	417.00
IUUC-Vda-129688	Verticillium dahliae	33.92	1.00e-113	403.00
IUUC-Vpa-130170	Vicugna pacos	36.90	4.00e-143	501.00
IUUC-Xtr-131953	Xenopus tropicalis	46.67	0.00e+00	725.00
IUUC-Xma-133837	Xiphophorus maculatus	46.18	0.00e+00	682.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence