iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-57	194.5	332	825
UBD/Alpha-Helix/UBA	1.40e-18	66.4	697	735

Active Site

Position(s)	Description	Evidence
341	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
788	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel..........w...kskkkavsprellkalkkeaeefs 85
           tG++NlgN+CY+NSv+Q+L+ ip++++ +     e+  +e p++p +++  +++kl + l              +++++ +sp +++++++k ++ fs
   Q: 332  TGMRNLGNSCYINSVMQVLFVIPDFQQRFVGTGAERYFKEFPSDPANDFNIQMAKLGTGLqsgkyssiaeNtldTDHSTGISPAMFKNIVGKNHPDFS 429
           7******************************9999999999*******************4444444433034555556******************* PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetk 183
           + +qqDa++f  +ll  l+++                              +n++   d +++ l++++ cl+ ++v+  + + +++ lpvp ++ t+
   Q: 430  TKQQQDANDFYLHLLTLLDRNS-----------------------------RNQTNPADALKFLLEDRVECLASHKVKYNTREEYSFRLPVPLDKATN 498
           ********************99.............................7899999********************9999999*******999887 PP
   S: 184  ke.............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkk 252
           +                               lq cLe f+ +e +e+   +y++   +k++a+k ++l ++P++L++h  +f+     ++++k++ +
   Q: 499  LDevrefqerkkaaretgqrlpdrdivrhkvPLQACLERFFGPELIEQ---FYSTAIGSKTNARKITRLATMPDCLMIHVGKFTLGD-DWVPKKLDVS 592
           7799******************************************96...********************************7755.6********* PP
   S: 253  vefpleLdlspfcts................................................................................... 267
           v++p+eLdls++ +                                                                                    
   Q: 593  VDMPDELDLSNWRSAgglqpgeealpepateevkfafdeavmselltmgfppeackracyhtknsgleaasnwlmehiadedisepfvvpnnsigdca 690
           **************999999999999988888888888888888888888888888888887777777777777777777777777777777777766 PP
   S: 268  ...................................................peekqke........................kkkYeLiavvvHsG.s 289
                                                              +     +                        + kY+L+a ++H+G s
   Q: 691  anqfvanpeslamlmsmgfderqavaalkatdgnveratdwifshadsigvE-----DaapaanssaaaasstpnktnyrdgRGKYRLVAFISHMGtS 783
           6666666666666666666666666666655555555555555555555550.....0555555555666666666677777**************** PP
   S: 290  lssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           ++ GHYv+++++ kg+W+ f+DskV ++  ++  +   + +Y+++Y+r
   Q: 784  AQVGHYVCHIRK-KGEWVIFNDSKVAKS--QNPPK---DLGYLYLYMR 825
           ************.************999..56677...8999999998 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           + + l+ l++MGFd+ +a+ aL a+++n+e+A+++++++
   Q: 697  NPESLAMLMSMGFDERQAVAALKATDGNVERATDWIFSH 735
           67899********************************97 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MEELRKHLSK VNVPCASGAG SPPIYKDECV YSYDNPETPT GLYVCLHSFL GFGEAYVREY 60
ADKTGNRVFL HIQRVKTIKE GADMEAECAE SEAGPERKIT RLAIGVEGGY NESDMAKKYE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTGAATAAA CAACGATAGC CTGCAGCAGT CAAATTAAAC TAATTGTGCT TATTGGGCGG 60
CCAAATACGT AAATATCACT CAAAAGCCGT TATAAGGTAC AAAAATAAGG GTAAGAATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0001751--P:compound eye photoreceptor cell differentiation
GO:0010995--P:free ubiquitin chain depolymerization
GO:0043066--P:negative regulation of apoptotic process
GO:0046329--P:negative regulation of JNK cascade
GO:0048812--P:neuron projection morphogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0090364--P:regulation of proteasome assembly
GO:0010993--P:regulation of ubiquitin homeostasis
GO:0019233--P:sensory perception of pain

KEGG

dme:Dmel_CG12082

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	42.07	5.00e-170	590.00
IUUC-Aml-002104	Ailuropoda melanoleuca	49.36	0.00e+00	805.00
IUUC-Atr-002580	Amborella trichopoda	40.83	4.00e-173	601.00
IUUC-Apl-003774	Anas platyrhynchos	50.66	0.00e+00	799.00
IUUC-Aca-005368	Anolis carolinensis	50.83	0.00e+00	831.00
IUUC-Aly-005727	Arabidopsis lyrata	44.22	0.00e+00	649.00
IUUC-Ath-006974	Arabidopsis thaliana	44.03	0.00e+00	651.00
IUUC-Ago-007890	Ashbya gossypii	28.19	5.00e-67	248.00
IUUC-Acl-008057	Aspergillus clavatus	35.07	7.00e-117	414.00
IUUC-Afl-008547	Aspergillus flavus	38.41	2.00e-116	412.00
IUUC-Afu-008805	Aspergillus fumigatus	36.75	1.00e-105	376.00
IUUC-Ani-009441	Aspergillus nidulans	35.31	4.00e-95	341.00
IUUC-Ang-009720	Aspergillus niger	32.89	5.00e-109	387.00
IUUC-Aor-010111	Aspergillus oryzae	34.50	4.00e-121	428.00
IUUC-Ate-010531	Aspergillus terreus	32.16	3.00e-100	358.00
IUUC-Ame-011470	Astyanax mexicanus	43.07	0.00e+00	670.00
IUUC-Bgr-012183	Blumeria graminis	32.08	3.00e-108	385.00
IUUC-Bta-013179	Bos taurus	49.71	0.00e+00	811.00
IUUC-Bci-013858	Botrytis cinerea	33.58	1.00e-114	406.00
IUUC-Bdi-014904	Brachypodium distachyon	44.43	0.00e+00	642.00
IUUC-Bol-015296	Brassica oleracea	44.74	0.00e+00	664.00
IUUC-Bra-017939	Brassica rapa	44.86	0.00e+00	664.00
IUUC-Cel-018625	Caenorhabditis elegans	37.39	8.00e-135	473.00
IUUC-Cja-019063	Callithrix jacchus	48.44	0.00e+00	791.00
IUUC-Cfa-020976	Canis familiaris	50.71	0.00e+00	817.00
IUUC-Cpo-022265	Cavia porcellus	50.71	0.00e+00	817.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.46	2.00e-106	379.00
IUUC-Csa-024177	Chlorocebus sabaeus	48.28	0.00e+00	726.00
IUUC-Cho-024702	Choloepus hoffmanni	45.03	6.00e-135	474.00
IUUC-Cin-025411	Ciona intestinalis	45.55	0.00e+00	672.00
IUUC-Csv-026347	Ciona savignyi	43.18	0.00e+00	649.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	33.29	1.00e-97	350.00
IUUC-Cne-026831	Cryptococcus neoformans	34.80	4.00e-112	398.00
IUUC-Cme-027335	Cyanidioschyzon merolae	28.74	8.00e-41	161.00
IUUC-Dre-027982	Danio rerio	46.24	0.00e+00	721.00
IUUC-Dno-029034	Dasypus novemcinctus	49.36	0.00e+00	807.00
IUUC-Dor-030479	Dipodomys ordii	51.78	3.00e-103	369.00
IUUC-Dse-031467	Dothistroma septosporum	33.73	4.00e-114	405.00
IUUC-Ete-032865	Echinops telfairi	44.91	0.00e+00	702.00
IUUC-Eca-034059	Equus caballus	49.37	0.00e+00	806.00
IUUC-Eeu-035304	Erinaceus europaeus	49.16	0.00e+00	724.00
IUUC-Fca-035515	Felis catus	49.59	0.00e+00	809.00
IUUC-Fal-037271	Ficedula albicollis	51.06	0.00e+00	781.00
IUUC-Fox-037745	Fusarium oxysporum	34.39	5.00e-118	417.00
IUUC-Fso-038158	Fusarium solani	33.49	2.00e-110	392.00
IUUC-Gmo-039071	Gadus morhua	45.68	0.00e+00	726.00
IUUC-Ggr-040098	Gaeumannomyces graminis	32.65	7.00e-110	390.00
IUUC-Gga-040635	Gallus gallus	49.89	0.00e+00	821.00
IUUC-Gac-042528	Gasterosteus aculeatus	46.70	0.00e+00	741.00
IUUC-Gma-043614	Glycine max	43.40	0.00e+00	643.00
IUUC-Ggo-044602	Gorilla gorilla	49.36	0.00e+00	806.00
IUUC-Hsa-045959	Homo sapiens	49.36	0.00e+00	806.00
IUUC-Hvu-047563	Hordeum vulgare	47.07	6.00e-161	560.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	49.02	0.00e+00	806.00
IUUC-Kpa-049156	Komagataella pastoris	30.84	5.00e-98	351.00
IUUC-Lch-049648	Latimeria chalumnae	50.73	0.00e+00	813.00
IUUC-Lpe-051523	Leersia perrieri	43.26	0.00e+00	633.00
IUUC-Loc-052072	Lepisosteus oculatus	44.72	0.00e+00	677.00
IUUC-Lma-053216	Leptosphaeria maculans	34.87	2.00e-109	390.00
IUUC-Laf-054327	Loxodonta africana	49.13	0.00e+00	804.00
IUUC-Mcc-055443	Macaca mulatta	49.25	0.00e+00	806.00
IUUC-Meu-056298	Macropus eugenii	49.92	4.00e-167	580.00
IUUC-Mor-057106	Magnaporthe oryzae	34.47	2.00e-119	422.00
IUUC-Mpo-057589	Magnaporthe poae	32.89	2.00e-109	389.00
IUUC-Mtr-058680	Medicago truncatula	43.77	0.00e+00	647.00
IUUC-Mla-058903	Melampsora laricipopulina	30.89	3.00e-101	362.00
IUUC-Mga-059669	Meleagris gallopavo	50.18	0.00e+00	785.00
IUUC-Mvi-060476	Microbotryum violaceum	32.14	6.00e-100	357.00
IUUC-Mmr-060575	Microcebus murinus	49.25	0.00e+00	806.00
IUUC-Mdo-062183	Monodelphis domestica	50.48	0.00e+00	815.00
IUUC-Mmu-063592	Mus musculus	49.59	0.00e+00	808.00
IUUC-Mac-065634	Musa acuminata	41.98	4.00e-175	607.00
IUUC-Mpu-066082	Mustela putorius furo	50.60	0.00e+00	816.00
IUUC-Mlu-067345	Myotis lucifugus	49.07	0.00e+00	806.00
IUUC-Nfi-068558	Neosartorya fischeri	37.54	2.00e-116	412.00
IUUC-Ncr-068960	Neurospora crassa	32.64	1.00e-102	366.00
IUUC-Nle-070173	Nomascus leucogenys	50.60	0.00e+00	816.00
IUUC-Opr-070556	Ochotona princeps	48.44	0.00e+00	809.00
IUUC-Ont-071502	Oreochromis niloticus	46.21	0.00e+00	724.00
IUUC-Oan-072959	Ornithorhynchus anatinus	57.33	1.00e-74	271.00
IUUC-Ocu-074861	Oryctolagus cuniculus	50.48	0.00e+00	822.00
IUUC-Oba-075109	Oryza barthii	43.46	0.00e+00	644.00
IUUC-Obr-076292	Oryza brachyantha	44.18	0.00e+00	637.00
IUUC-Ogl-077065	Oryza glaberrima	44.48	0.00e+00	664.00
IUUC-Ogu-078776	Oryza glumaepatula	43.22	0.00e+00	654.00
IUUC-Oin-080048	Oryza indica	44.36	0.00e+00	662.00
IUUC-Olo-080711	Oryza longistaminata	42.48	9.00e-173	599.00
IUUC-Ome-081506	Oryza meridionalis	43.27	9.00e-176	609.00
IUUC-Oni-082320	Oryza nivara	42.41	0.00e+00	632.00
IUUC-Opu-083801	Oryza punctata	44.06	0.00e+00	631.00
IUUC-Oru-085139	Oryza rufipogon	42.64	0.00e+00	634.00
IUUC-Osa-085713	Oryza sativa	44.60	0.00e+00	667.00
IUUC-Ola-086951	Oryzias latipes	45.79	0.00e+00	707.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.46	7.00e-161	560.00
IUUC-Oga-088625	Otolemur garnettii	48.67	0.00e+00	806.00
IUUC-Oar-089995	Ovis aries	48.55	0.00e+00	798.00
IUUC-Ptr-090640	Pan troglodytes	48.44	0.00e+00	803.00
IUUC-Pan-091974	Papio anubis	48.67	0.00e+00	800.00
IUUC-Psi-093957	Pelodiscus sinensis	49.31	0.00e+00	832.00
IUUC-Pma-094242	Petromyzon marinus	54.69	5.00e-123	433.00
IUUC-Pno-094835	Phaeosphaeria nodorum	36.24	4.00e-102	365.00
IUUC-Ppa-095901	Physcomitrella patens	45.11	0.00e+00	691.00
IUUC-Pfo-097148	Poecilia formosa	46.33	0.00e+00	718.00
IUUC-Pab-098068	Pongo abelii	44.33	0.00e+00	669.00
IUUC-Pop-098943	Populus trichocarpa	43.54	1.00e-180	625.00
IUUC-Pca-100738	Procavia capensis	48.34	2.00e-161	562.00
IUUC-Ppe-101315	Prunus persica	43.64	0.00e+00	644.00
IUUC-Pva-102154	Pteropus vampyrus	49.41	0.00e+00	790.00
IUUC-Pgr-103343	Puccinia graminis	32.01	4.00e-96	344.00
IUUC-Ptt-103928	Puccinia triticina	29.89	1.00e-93	336.00
IUUC-Pte-104306	Pyrenophora teres	33.73	1.00e-99	357.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	37.11	3.00e-100	358.00
IUUC-Rno-105801	Rattus norvegicus	49.71	0.00e+00	810.00
IUUC-Sce-106304	Saccharomyces cerevisiae	27.87	1.00e-68	254.00
IUUC-Sha-107635	Sarcophilus harrisii	50.30	0.00e+00	815.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	30.01	1.00e-89	323.00
IUUC-Spo-108144	Schizosaccharomyces pombe	30.88	7.00e-92	331.00
IUUC-Smo-108848	Selaginella moellendorffii	44.77	0.00e+00	638.00
IUUC-Sit-110728	Setaria italica	45.51	0.00e+00	699.00
IUUC-Sly-111523	Solanum lycopersicum	43.65	0.00e+00	687.00
IUUC-Sar-113733	Sorex araneus	45.05	8.00e-97	347.00
IUUC-Sbi-114419	Sorghum bicolor	44.96	0.00e+00	692.00
IUUC-Sre-115225	Sporisorium reilianum	32.52	3.00e-100	358.00
IUUC-Ssc-115686	Sus scrofa	48.55	0.00e+00	800.00
IUUC-Tgu-117346	Taeniopygia guttata	48.79	0.00e+00	803.00
IUUC-Tru-118350	Takifugu rubripes	45.65	0.00e+00	719.00
IUUC-Tsy-119278	Tarsius syrichta	40.68	1.00e-169	589.00
IUUC-Tni-120658	Tetraodon nigroviridis	45.56	0.00e+00	706.00
IUUC-Tca-121585	Theobroma cacao	42.74	1.00e-179	622.00
IUUC-Tre-122043	Trichoderma reesei	33.57	5.00e-104	371.00
IUUC-Tvi-122303	Trichoderma virens	33.33	2.00e-106	379.00
IUUC-Tae-123798	Triticum aestivum	44.67	0.00e+00	656.00
IUUC-Tur-126732	Triticum urartu	41.97	3.00e-178	617.00
IUUC-Tme-126909	Tuber melanosporum	33.57	2.00e-101	362.00
IUUC-Tbe-127261	Tupaia belangeri	44.35	3.00e-139	488.00
IUUC-Ttr-128295	Tursiops truncatus	39.21	1.00e-168	585.00
IUUC-Uma-129599	Ustilago maydis	31.93	4.00e-102	365.00
IUUC-Vda-129688	Verticillium dahliae	32.66	8.00e-105	374.00
IUUC-Vpa-130170	Vicugna pacos	39.02	2.00e-155	541.00
IUUC-Vvi-131116	Vitis vinifera	43.35	0.00e+00	627.00
IUUC-Xtr-131953	Xenopus tropicalis	47.05	0.00e+00	757.00
IUUC-Xma-133837	Xiphophorus maculatus	46.56	0.00e+00	722.00
IUUC-Yli-134510	Yarrowia lipolytica	33.70	3.00e-112	398.00
IUUC-Zma-135786	Zea mays	44.12	0.00e+00	661.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence