iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107635

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AEFK01193356

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000016035.1	ENSSHAT00000019047.1	ENSSHAP00000018891.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-62	212.0	325	832
UBD/Alpha-Helix/UBA	2.70e-23	81.5	700	738

Active Site

Position(s)	Description	Evidence
334	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
794	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel...........wkskkk............ 66
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                +            
   Q: 325  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPSDPTQDFSTQVAKLGHGLlsgeyskpapeS----Gdgeqvpeqkgiq 408
           7******************************.99999999********************555555555550....0555555555555 PP
   S: 67   .avsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqi 154
             ++pr++++ ++k ++efs+++qqDaqEf+ ++++ +e+++                             ++++  +++F++ ++++i
   Q: 409  dGIAPRMFKSLIGKGHPEFSTNRQQDAQEFFLHFINMVERNC-----------------------------RSSENPNEVFRFLVEEKI 468
           5*****************************************.............................6788899*********** PP
   S: 155  kclecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqe 216
           kcl+ ++v+ ++   + ++lpvp++   +ke                            +++cLe+f  +e++++   ++++  ++k+ 
   Q: 469  KCLATEKVKYTQRVDYIMQLPVPMDAALNKEelleyeekkrqaeeekqplpelvraqvPFSSCLEAFGVPEQVDD---FWSTALQAKSV 554
           **************************999989*****************************************97...*********** PP
   S: 217  aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts...................................... 267
           a+k++++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+                                          
   Q: 555  AVKTTRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGLglqpgeeelpdiapplvtpdepkapmldesviiqlvem 642
           ***********************997.*******************8766677788888888888888877777777777777777777 PP
   S: 268  .............................................................peekqke..................... 274
                                                                                                    
   Q: 643  gfpmdacrkavyytgnsgaeaamnwvmshmddpdfanplvlpgssgpgststvadppsedcV-----Ativsmgfsrdqamkalratnn 726
           77777777777777776666666666666666666666666666666655555555555550.....0555555555555555666666 PP
   S: 275  ...............................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVt 315
                                                          + kY+L+a ++H+G s+ +GHYv+++k+ +g+W+ ++D+kV 
   Q: 727  nleravdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYVCHIKK-EGRWVIYNDQKVC 814
           66667777777777777777777777777778888888888888888****************************.9***********9 PP
   S: 316  evkeeevleetgstaYvlfYkrr 338
           ++  e+  +   + +Y++fY+r+
   Q: 815  AS--EKPPK---DLGYIYFYQRM 832
           99..78888...89*******96 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +ed ++ +v+MGF+r++a +aLra+nnnle+Av++++++
   Q: 700  SEDCVATIVSMGFSRDQAMKALRATNNNLERAVDWIFSH 738
           699**********************************97 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVEK 60
HYCRTGQRVY LHLQRTRRPK EDETTSGTGD PPRKKPTRLA IGVEGGFDLT EKFEYDEDVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAAT TGAGTGAGGA GGCGCTGCTA TCTGTATTAC CGACTATCCG GGTCCCCAAG 60
GCCGGAGATC GGGTTCACAA AGACGAATGC GCCTTCTCTT TCGACACGCC GGTAAGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

shr:100915007

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	45.76	0.00e+00	654.00
IUUC-Aml-002104	Ailuropoda melanoleuca	92.23	0.00e+00	1543.00
IUUC-Atr-002580	Amborella trichopoda	46.40	0.00e+00	726.00
IUUC-Apl-003774	Anas platyrhynchos	88.62	0.00e+00	1465.00
IUUC-Aca-005368	Anolis carolinensis	89.58	0.00e+00	1525.00
IUUC-Aly-005727	Arabidopsis lyrata	48.75	0.00e+00	739.00
IUUC-Ath-006974	Arabidopsis thaliana	48.62	0.00e+00	739.00
IUUC-Ago-007890	Ashbya gossypii	29.51	6.00e-84	305.00
IUUC-Acl-008057	Aspergillus clavatus	34.50	3.00e-124	439.00
IUUC-Afl-008547	Aspergillus flavus	36.22	5.00e-118	418.00
IUUC-Afu-008805	Aspergillus fumigatus	34.64	2.00e-116	412.00
IUUC-Ani-009441	Aspergillus nidulans	33.73	5.00e-102	365.00
IUUC-Ang-009720	Aspergillus niger	34.29	1.00e-121	431.00
IUUC-Aor-010111	Aspergillus oryzae	33.77	1.00e-127	450.00
IUUC-Ate-010531	Aspergillus terreus	31.78	1.00e-103	370.00
IUUC-Ame-011893	Astyanax mexicanus	68.10	0.00e+00	1019.00
IUUC-Bgr-012183	Blumeria graminis	34.17	1.00e-124	440.00
IUUC-Bta-013179	Bos taurus	92.33	0.00e+00	1549.00
IUUC-Bci-013858	Botrytis cinerea	34.76	4.00e-131	462.00
IUUC-Bdi-014904	Brachypodium distachyon	48.80	0.00e+00	719.00
IUUC-Bol-015296	Brassica oleracea	48.92	0.00e+00	748.00
IUUC-Bra-017939	Brassica rapa	49.04	0.00e+00	753.00
IUUC-Cel-018625	Caenorhabditis elegans	35.34	2.00e-136	479.00
IUUC-Cja-019063	Callithrix jacchus	90.59	0.00e+00	1513.00
IUUC-Cfa-020976	Canis familiaris	95.27	0.00e+00	1571.00
IUUC-Cpo-022265	Cavia porcellus	94.91	0.00e+00	1560.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.94	2.00e-114	405.00
IUUC-Csa-024177	Chlorocebus sabaeus	94.12	0.00e+00	1424.00
IUUC-Cho-024702	Choloepus hoffmanni	84.53	0.00e+00	925.00
IUUC-Cin-025411	Ciona intestinalis	51.64	0.00e+00	838.00
IUUC-Csv-026347	Ciona savignyi	46.67	0.00e+00	793.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.32	5.00e-113	401.00
IUUC-Cne-026831	Cryptococcus neoformans	35.67	1.00e-130	460.00
IUUC-Cme-027335	Cyanidioschyzon merolae	30.18	4.00e-47	183.00
IUUC-Dre-027982	Danio rerio	65.20	0.00e+00	1083.00
IUUC-Dno-029034	Dasypus novemcinctus	92.44	0.00e+00	1558.00
IUUC-Dor-030479	Dipodomys ordii	90.64	0.00e+00	652.00
IUUC-Dse-031467	Dothistroma septosporum	36.83	3.00e-133	468.00
IUUC-Dme-032075	Drosophila melanogaster	50.65	0.00e+00	817.00
IUUC-Ete-032865	Echinops telfairi	82.03	0.00e+00	1377.00
IUUC-Eca-034059	Equus caballus	92.29	0.00e+00	1559.00
IUUC-Eeu-035304	Erinaceus europaeus	87.01	0.00e+00	1408.00
IUUC-Fca-035515	Felis catus	92.56	0.00e+00	1554.00
IUUC-Fal-037271	Ficedula albicollis	91.63	0.00e+00	1452.00
IUUC-Fox-037745	Fusarium oxysporum	35.57	4.00e-131	462.00
IUUC-Fso-038158	Fusarium solani	36.12	2.00e-131	462.00
IUUC-Gmo-039071	Gadus morhua	64.91	0.00e+00	1085.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.24	2.00e-122	433.00
IUUC-Gga-040635	Gallus gallus	88.93	0.00e+00	1540.00
IUUC-Gac-042528	Gasterosteus aculeatus	64.85	0.00e+00	1100.00
IUUC-Gma-043614	Glycine max	47.72	0.00e+00	708.00
IUUC-Ggo-044602	Gorilla gorilla	91.74	0.00e+00	1538.00
IUUC-Hsa-045959	Homo sapiens	91.74	0.00e+00	1538.00
IUUC-Hvu-047563	Hordeum vulgare	49.17	3.00e-171	595.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	91.16	0.00e+00	1545.00
IUUC-Kpa-049156	Komagataella pastoris	33.81	2.00e-117	416.00
IUUC-Lch-049648	Latimeria chalumnae	84.43	0.00e+00	1384.00
IUUC-Lpe-051523	Leersia perrieri	48.22	0.00e+00	723.00
IUUC-Loc-052520	Lepisosteus oculatus	60.34	0.00e+00	1000.00
IUUC-Lma-053216	Leptosphaeria maculans	34.72	1.00e-114	408.00
IUUC-Laf-054327	Loxodonta africana	91.62	0.00e+00	1536.00
IUUC-Mcc-055443	Macaca mulatta	91.62	0.00e+00	1536.00
IUUC-Meu-056298	Macropus eugenii	98.61	0.00e+00	1121.00
IUUC-Mor-057106	Magnaporthe oryzae	36.41	6.00e-133	468.00
IUUC-Mpo-057589	Magnaporthe poae	34.93	2.00e-125	443.00
IUUC-Mtr-058680	Medicago truncatula	49.16	0.00e+00	740.00
IUUC-Mla-058903	Melampsora laricipopulina	32.63	5.00e-119	421.00
IUUC-Mga-059669	Meleagris gallopavo	88.36	0.00e+00	1462.00
IUUC-Mvi-060476	Microbotryum violaceum	34.92	3.00e-121	429.00
IUUC-Mmr-060575	Microcebus murinus	92.33	0.00e+00	1551.00
IUUC-Mdo-062183	Monodelphis domestica	96.29	0.00e+00	1588.00
IUUC-Mmu-063592	Mus musculus	92.09	0.00e+00	1545.00
IUUC-Mac-065634	Musa acuminata	43.83	0.00e+00	693.00
IUUC-Mpu-066082	Mustela putorius furo	94.54	0.00e+00	1556.00
IUUC-Mlu-067345	Myotis lucifugus	89.53	0.00e+00	1514.00
IUUC-Nfi-068558	Neosartorya fischeri	35.40	2.00e-124	439.00
IUUC-Ncr-068960	Neurospora crassa	35.31	7.00e-117	414.00
IUUC-Nle-070173	Nomascus leucogenys	94.54	0.00e+00	1556.00
IUUC-Opr-070556	Ochotona princeps	91.15	0.00e+00	1535.00
IUUC-Ont-071502	Oreochromis niloticus	66.87	0.00e+00	1105.00
IUUC-Ocu-074861	Oryctolagus cuniculus	94.66	0.00e+00	1563.00
IUUC-Oba-075109	Oryza barthii	48.31	0.00e+00	723.00
IUUC-Obr-076292	Oryza brachyantha	49.52	0.00e+00	719.00
IUUC-Ogl-077065	Oryza glaberrima	49.64	0.00e+00	752.00
IUUC-Ogu-078776	Oryza glumaepatula	48.31	0.00e+00	736.00
IUUC-Oin-080048	Oryza indica	49.16	0.00e+00	747.00
IUUC-Olo-080711	Oryza longistaminata	46.48	0.00e+00	665.00
IUUC-Ome-081506	Oryza meridionalis	47.47	0.00e+00	677.00
IUUC-Oni-082320	Oryza nivara	47.59	0.00e+00	721.00
IUUC-Opu-083801	Oryza punctata	48.43	0.00e+00	713.00
IUUC-Oru-085139	Oryza rufipogon	47.59	0.00e+00	722.00
IUUC-Osa-085713	Oryza sativa	49.76	0.00e+00	756.00
IUUC-Ola-086951	Oryzias latipes	64.33	0.00e+00	1059.00
IUUC-Olu-087822	Ostreococcus lucimarinus	42.29	8.00e-180	624.00
IUUC-Oga-088625	Otolemur garnettii	91.75	0.00e+00	1535.00
IUUC-Oar-089995	Ovis aries	89.41	0.00e+00	1513.00
IUUC-Ptr-090640	Pan troglodytes	89.14	0.00e+00	1518.00
IUUC-Pan-091974	Papio anubis	90.71	0.00e+00	1518.00
IUUC-Psi-093957	Pelodiscus sinensis	87.79	0.00e+00	1541.00
IUUC-Pma-094242	Petromyzon marinus	72.18	5.00e-166	576.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.94	1.00e-107	383.00
IUUC-Ppa-095901	Physcomitrella patens	50.35	0.00e+00	794.00
IUUC-Pfo-097148	Poecilia formosa	68.27	0.00e+00	1115.00
IUUC-Pab-098068	Pongo abelii	84.43	0.00e+00	1361.00
IUUC-Pop-098943	Populus trichocarpa	47.84	0.00e+00	720.00
IUUC-Pca-100738	Procavia capensis	84.89	0.00e+00	1380.00
IUUC-Ppe-101315	Prunus persica	48.56	0.00e+00	726.00
IUUC-Pva-102154	Pteropus vampyrus	90.91	0.00e+00	1521.00
IUUC-Pgr-103343	Puccinia graminis	34.67	5.00e-112	398.00
IUUC-Ptt-103928	Puccinia triticina	31.53	1.00e-111	397.00
IUUC-Pte-104306	Pyrenophora teres	33.25	3.00e-105	375.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	34.04	2.00e-108	387.00
IUUC-Rno-105801	Rattus norvegicus	91.97	0.00e+00	1545.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.49	2.00e-74	273.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	33.13	2.00e-109	389.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.81	4.00e-115	409.00
IUUC-Smo-108848	Selaginella moellendorffii	48.85	0.00e+00	740.00
IUUC-Sit-110728	Setaria italica	49.52	0.00e+00	773.00
IUUC-Sly-111523	Solanum lycopersicum	48.21	0.00e+00	763.00
IUUC-Sbi-114419	Sorghum bicolor	49.04	0.00e+00	756.00
IUUC-Sre-115225	Sporisorium reilianum	34.65	3.00e-127	449.00
IUUC-Ssc-115686	Sus scrofa	90.57	0.00e+00	1537.00
IUUC-Tgu-117346	Taeniopygia guttata	88.94	0.00e+00	1514.00
IUUC-Tru-118350	Takifugu rubripes	62.79	0.00e+00	1088.00
IUUC-Tsy-119278	Tarsius syrichta	53.48	0.00e+00	852.00
IUUC-Tni-120658	Tetraodon nigroviridis	64.24	0.00e+00	1078.00
IUUC-Tca-121585	Theobroma cacao	48.63	0.00e+00	728.00
IUUC-Tre-122043	Trichoderma reesei	34.77	5.00e-120	425.00
IUUC-Tvi-122303	Trichoderma virens	34.69	4.00e-126	445.00
IUUC-Tae-125686	Triticum aestivum	48.67	0.00e+00	736.00
IUUC-Tur-126732	Triticum urartu	46.14	0.00e+00	692.00
IUUC-Tme-126909	Tuber melanosporum	35.01	6.00e-119	421.00
IUUC-Tbe-127261	Tupaia belangeri	85.36	0.00e+00	961.00
IUUC-Ttr-128295	Tursiops truncatus	54.25	0.00e+00	885.00
IUUC-Uma-129599	Ustilago maydis	34.11	2.00e-129	456.00
IUUC-Vda-129688	Verticillium dahliae	33.97	5.00e-123	435.00
IUUC-Vpa-130170	Vicugna pacos	50.79	0.00e+00	787.00
IUUC-Vvi-131116	Vitis vinifera	47.86	0.00e+00	702.00
IUUC-Xtr-131953	Xenopus tropicalis	78.10	0.00e+00	1308.00
IUUC-Xma-133837	Xiphophorus maculatus	68.51	0.00e+00	1119.00
IUUC-Yli-134510	Yarrowia lipolytica	35.91	2.00e-130	459.00
IUUC-Zma-135786	Zea mays	48.09	0.00e+00	721.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence