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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046935
UUCD1 version UUC-HoS-01243
Ensembl Protein ID ENSP00000393183.2
UniProt Accession Q9Y4B6; Q2YD74; Q8TBD9; Q9HCA1; Q9UG37; VPRBP_HUMAN
Genbank Protein ID BAA34520.2; AAH22792.1; AAI10372.1; CAB45738.1; AAG27134.1
Protein Name Protein VPRBP; DDB1- and CUL4-associated factor 1; HIV-1 Vpr-binding protein; Serine/threonine-protein kinase VPRBP; Vpr-interacting protein
Genbank Nucleotide ID AB018343; AC092037; BC110371; AL080145; AF061935
Gene Name VPRBP; DCAF1; KIAA0800; RIP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000145041.15 ENST00000423656.5 ENSP00000393183.2
ENSG00000145041.15 ENST00000504652.5 ENSP00000421724.2
ENSG00000145041.15 ENST00000335891.5 ENSP00000338857.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbCircNetmiRTarBasemicroRNA
TRANSFACRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
KPID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 19595719; 19287380; 17360488; 17620334; 20178741; 20870715
Organism Homo sapiens
Functional Description
(View)

Functional Description


     (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT (PubMed:17314515, PubMed:17620334, PubMed:17626091, PubMed:17630831, PubMed:17609381, PubMed:17559673, PubMed:18524771, PubMed:24116224). In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage (PubMed:18464893, PubMed:19264781, PubMed:19923175, PubMed:24336198).
 (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT (PubMed:17314515, PubMed:17620334, PubMed:17626091, PubMed:17630831, PubMed:17609381, PubMed:17559673, PubMed:18524771, PubMed:24116224). In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage (PubMed:18464893, PubMed:19264781, PubMed:19923175, PubMed:24336198).
Protein Sequence
(Fasta)
MTTVVVHVDS KAELTTLLEQ WEKEHGSGQD MVPILTRMSQ LIEKETEEYR KGDPDPFDDR 60
HPGRADPECM LGHLLRILFK NDDFMNALVN AYVMTSREPP LNTAACRLLL DIMPGLETAV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046935|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCTGTGGAG CCGTGGTCGC GCTGTGTGTG TGTGTGAGTG GAGAGTGAGT GCGGGACCTG 60
AGGCTGTGTG TGTGTGAACT GTGGCCACTG GCGGGGTCGG GGGGGGGCAG CGGCGGAGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046935|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0945--Host-virus interaction
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR006594--LisH
IPR033270--VPRBP/DCAF1
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
PROSITE

PS50896--LISH
SMART

SM00667--LisH
Gene Ontology

GO:0005737--C:cytoplasm
GO:0001650--C:fibrillar center
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0030331--F:estrogen receptor binding
GO:1990244--F:histone kinase activity (H2A-T120 specific)
GO:0030183--P:B cell differentiation
GO:0035212--P:cell competition in a multicellular organism
GO:1990245--P:histone H2A-T120 phosphorylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0006351--P:transcription, DNA-templated
GO:0033151--P:V(D)J recombination
GO:0016032--P:viral process
KEGG hsa:9730
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000876 Aegilops tauschii 34.49 7.00e-63 236.00
IUUC-Aml-001487 Ailuropoda melanoleuca 99.07 0.00e+00 2745.00
IUUC-Apl-004137 Anas platyrhynchos 93.98 0.00e+00 2669.00
IUUC-Aca-004721 Anolis carolinensis 90.68 0.00e+00 2558.00
IUUC-Ath-007548 Arabidopsis thaliana 37.86 5.00e-66 247.00
IUUC-Ame-011378 Astyanax mexicanus 77.67 0.00e+00 2207.00
IUUC-Bta-012499 Bos taurus 98.21 0.00e+00 2728.00
IUUC-Bdi-014023 Brachypodium distachyon 34.24 4.00e-53 204.00
IUUC-Bra-017818 Brassica rapa 35.27 2.00e-61 232.00
IUUC-Cel-018657 Caenorhabditis elegans 33.17 0.00e+00 688.00
IUUC-Cja-019341 Callithrix jacchus 96.99 0.00e+00 2706.00
IUUC-Cfa-020745 Canis familiaris 98.56 0.00e+00 2725.00
IUUC-Cpo-021525 Cavia porcellus 98.95 0.00e+00 2657.00
IUUC-Csa-023213 Chlorocebus sabaeus 100.00 0.00e+00 2806.00
IUUC-Cin-025759 Ciona intestinalis 37.76 0.00e+00 867.00
IUUC-Dno-029592 Dasypus novemcinctus 98.42 0.00e+00 2739.00
IUUC-Dme-031706 Drosophila melanogaster 38.31 0.00e+00 900.00
IUUC-Ete-033014 Echinops telfairi 90.24 0.00e+00 2249.00
IUUC-Eca-034424 Equus caballus 98.92 0.00e+00 2742.00
IUUC-Eeu-034747 Erinaceus europaeus 95.85 0.00e+00 1889.00
IUUC-Fca-035608 Felis catus 98.92 0.00e+00 2744.00
IUUC-Fal-037661 Ficedula albicollis 93.62 0.00e+00 2694.00
IUUC-Gmo-039173 Gadus morhua 75.25 0.00e+00 1363.00
IUUC-Gga-040754 Gallus gallus 93.70 0.00e+00 2672.00
IUUC-Gac-042394 Gasterosteus aculeatus 74.17 0.00e+00 1347.00
IUUC-Gma-043360 Glycine max 37.53 3.00e-60 228.00
IUUC-Ggo-044876 Gorilla gorilla 97.85 0.00e+00 2737.00
IUUC-Hvu-047505 Hordeum vulgare 34.49 6.00e-62 233.00
IUUC-Lch-050623 Latimeria chalumnae 82.75 0.00e+00 2358.00
IUUC-Lpe-051488 Leersia perrieri 35.52 3.00e-54 208.00
IUUC-Loc-052384 Lepisosteus oculatus 81.88 0.00e+00 2269.00
IUUC-Laf-053421 Loxodonta africana 98.57 0.00e+00 2727.00
IUUC-Mcc-055301 Macaca mulatta 100.00 0.00e+00 2677.00
IUUC-Meu-056281 Macropus eugenii 95.95 0.00e+00 1912.00
IUUC-Mtr-058027 Medicago truncatula 35.84 4.00e-68 254.00
IUUC-Mga-059987 Meleagris gallopavo 93.55 0.00e+00 2635.00
IUUC-Mmr-060718 Microcebus murinus 99.43 0.00e+00 2758.00
IUUC-Mdo-062744 Monodelphis domestica 95.69 0.00e+00 2680.00
IUUC-Mmu-063088 Mus musculus 98.21 0.00e+00 2679.00
IUUC-Mpu-066788 Mustela putorius furo 98.71 0.00e+00 2740.00
IUUC-Mlu-067568 Myotis lucifugus 98.35 0.00e+00 2683.00
IUUC-Nle-069773 Nomascus leucogenys 99.93 0.00e+00 2805.00
IUUC-Opr-070786 Ochotona princeps 88.04 0.00e+00 2376.00
IUUC-Ont-072210 Oreochromis niloticus 74.05 0.00e+00 2179.00
IUUC-Ocu-074945 Oryctolagus cuniculus 98.56 0.00e+00 2742.00
IUUC-Olo-080575 Oryza longistaminata 26.98 5.00e-27 117.00
IUUC-Ome-081217 Oryza meridionalis 35.13 5.00e-54 207.00
IUUC-Opu-083522 Oryza punctata 35.31 3.00e-53 206.00
IUUC-Ola-087313 Oryzias latipes 75.92 0.00e+00 2178.00
IUUC-Olu-087714 Ostreococcus lucimarinus 26.62 7.00e-83 303.00
IUUC-Oga-088943 Otolemur garnettii 94.34 0.00e+00 2576.00
IUUC-Oar-089356 Ovis aries 98.14 0.00e+00 2754.00
IUUC-Psi-093315 Pelodiscus sinensis 94.41 0.00e+00 2654.00
IUUC-Ppa-095994 Physcomitrella patens 37.17 1.00e-61 233.00
IUUC-Pfo-097433 Poecilia formosa 75.64 0.00e+00 2113.00
IUUC-Pab-098284 Pongo abelii 95.35 0.00e+00 2645.00
IUUC-Pop-099939 Populus trichocarpa 35.31 1.00e-54 209.00
IUUC-Pca-100616 Procavia capensis 89.39 0.00e+00 2315.00
IUUC-Ppe-102063 Prunus persica 37.38 2.00e-58 221.00
IUUC-Rno-104955 Rattus norvegicus 98.53 0.00e+00 2626.00
IUUC-Sha-107589 Sarcophilus harrisii 95.99 0.00e+00 2687.00
IUUC-Sar-112949 Sorex araneus 91.96 0.00e+00 2506.00
IUUC-Ssc-116123 Sus scrofa 98.93 0.00e+00 2522.00
IUUC-Tgu-117468 Taeniopygia guttata 90.54 0.00e+00 2601.00
IUUC-Tru-117804 Takifugu rubripes 76.67 0.00e+00 2118.00
IUUC-Tsy-118801 Tarsius syrichta 87.37 0.00e+00 2391.00
IUUC-Tni-120578 Tetraodon nigroviridis 76.53 0.00e+00 2095.00
IUUC-Tur-126857 Triticum urartu 34.49 8.00e-63 236.00
IUUC-Tbe-128066 Tupaia belangeri 87.76 0.00e+00 1780.00
IUUC-Ttr-128293 Tursiops truncatus 93.68 0.00e+00 2546.00
IUUC-Vpa-130272 Vicugna pacos 78.39 0.00e+00 905.00
IUUC-Vvi-131322 Vitis vinifera 36.41 4.00e-56 214.00
IUUC-Xtr-132357 Xenopus tropicalis 82.80 0.00e+00 2273.00
Created Date 25-Jun-2017

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