iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004716

UUCD1 version

UUC-AnC-00974

Ensembl Protein ID

ENSACAP00000011795.2

UniProt Accession

G1KLS5; G1KLS5_ANOCA

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Gene Name

UCHL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000011963.3	ENSACAT00000012039.3	ENSACAP00000011795.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.10e-58	197.7	2	222

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvi 95
           +w ++e +P++++++++++g+   +++ ++ + ++++l+ +++p ++llllF+++ ++e++rk+qv+    e +++++ ++++f+kq+ 
   Q: 2    AWQPMEINPEMLNKVLSRLGIAPGWRFVDVLGFEEDSLNAVPNPACALLLLFPLTAQHENFRKQQVE----ELKGQEVSSKVYFLKQTA 86
           7****************************************************************99....99**************** PP
   S: 96   gNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           +NsC+t++l+++++n++dk+ +d G+ l+++++ t   sp+++a+ l+n+++++ +hn++a++++++++          +k +fhf+++
   Q: 87   SNSCGTIGLIHAIANNQDKIlFDEGSALKEFLNATADLSPDERAKRLENNKAIQDAHNAVAEEGQCRAED---------DKVNFHFILF 166
           *****************************************************************99883.........4789****** PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaiva 243
             ++g+lyeldg++pfP+++g++++++ lk  +kv+r+f+er    e++e+rf+++a+++
   Q: 167  ASVDGQLYELDGRMPFPINHGASSDDTLLKASAKVCRQFTER----EQGEVRFSAVALSK 222
           ******************************************....9********99876 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MAWQPMEINP EMLNKVLSRL GIAPGWRFVD VLGFEEDSLN AVPNPACALL LLFPLTAQHE 60
NFRKQQVEEL KGQEVSSKVY FLKQTASNSC GTIGLIHAIA NNQDKILFDE GSALKEFLNA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTTGCCGA TCCCAGCAGC GCTTTCCCTC CCTGCTGAAT GATCAATAAT GCATGGCAGC 60
TGCCTCCTTG GCGTCGAAAG CGAACCGTGT GTTTCGGGCG ATGCCTACTT CGCCTTTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

acs:100561831

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001376	Ailuropoda melanoleuca	62.40	2.00e-86	311.00
IUUC-Apl-003693	Anas platyrhynchos	71.75	1.00e-95	341.00
IUUC-Ame-011806	Astyanax mexicanus	63.23	6.00e-84	303.00
IUUC-Bta-013521	Bos taurus	63.24	4.00e-88	317.00
IUUC-Cja-018752	Callithrix jacchus	76.89	4.00e-92	330.00
IUUC-Cfa-020442	Canis familiaris	74.67	8.00e-90	322.00
IUUC-Cpo-021723	Cavia porcellus	74.25	1.00e-72	265.00
IUUC-Csa-023626	Chlorocebus sabaeus	76.79	1.00e-92	332.00
IUUC-Cho-024548	Choloepus hoffmanni	68.52	2.00e-31	127.00
IUUC-Cgl-026409	Colletotrichum gloeosporioides	33.61	1.00e-28	119.00
IUUC-Dre-027854	Danio rerio	64.73	9.00e-86	308.00
IUUC-Dno-029325	Dasypus novemcinctus	74.11	1.00e-90	325.00
IUUC-Dor-030114	Dipodomys ordii	74.11	2.00e-100	357.00
IUUC-Ete-033092	Echinops telfairi	59.82	7.00e-74	269.00
IUUC-Eeu-034493	Erinaceus europaeus	72.77	4.00e-87	313.00
IUUC-Fal-036693	Ficedula albicollis	78.57	2.00e-100	358.00
IUUC-Gmo-038848	Gadus morhua	58.49	9.00e-75	272.00
IUUC-Gga-041078	Gallus gallus	81.25	4.00e-112	396.00
IUUC-Gac-042064	Gasterosteus aculeatus	65.47	2.00e-86	311.00
IUUC-Ggo-044827	Gorilla gorilla	77.68	5.00e-94	336.00
IUUC-Hsa-045820	Homo sapiens	77.68	5.00e-94	336.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	75.00	4.00e-91	327.00
IUUC-Lch-050121	Latimeria chalumnae	66.67	7.00e-91	326.00
IUUC-Loc-052342	Lepisosteus oculatus	64.60	6.00e-89	319.00
IUUC-Laf-053916	Loxodonta africana	73.33	4.00e-90	323.00
IUUC-Mcc-054838	Macaca mulatta	76.79	1.00e-92	332.00
IUUC-Meu-056478	Macropus eugenii	76.34	2.00e-103	367.00
IUUC-Mpo-057343	Magnaporthe poae	31.65	1.00e-19	89.40
IUUC-Mga-059878	Meleagris gallopavo	78.80	9.00e-104	369.00
IUUC-Mdo-062544	Monodelphis domestica	74.55	2.00e-91	327.00
IUUC-Mmu-063300	Mus musculus	75.00	6.00e-101	359.00
IUUC-Mpu-066128	Mustela putorius furo	73.13	4.00e-78	283.00
IUUC-Mlu-067778	Myotis lucifugus	75.00	5.00e-101	359.00
IUUC-Nle-069686	Nomascus leucogenys	77.23	1.00e-93	335.00
IUUC-Opr-070535	Ochotona princeps	60.71	7.00e-76	276.00
IUUC-Ont-071510	Oreochromis niloticus	61.88	4.00e-84	303.00
IUUC-Ocu-074590	Oryctolagus cuniculus	75.00	1.00e-91	328.00
IUUC-Ola-087552	Oryzias latipes	60.96	5.00e-79	286.00
IUUC-Oga-089013	Otolemur garnettii	62.85	7.00e-87	313.00
IUUC-Oar-089861	Ovis aries	63.24	3.00e-88	317.00
IUUC-Ptr-091536	Pan troglodytes	75.89	2.00e-91	328.00
IUUC-Pan-092909	Papio anubis	76.79	1.00e-92	332.00
IUUC-Psi-093818	Pelodiscus sinensis	85.71	2.00e-117	414.00
IUUC-Pfo-097335	Poecilia formosa	62.67	4.00e-83	300.00
IUUC-Pab-098048	Pongo abelii	77.68	5.00e-94	336.00
IUUC-Pca-100818	Procavia capensis	59.69	1.00e-53	202.00
IUUC-Pva-102954	Pteropus vampyrus	75.45	1.00e-88	318.00
IUUC-Pyt-104587	Pyrenophora triticirepentis	34.58	4.00e-29	120.00
IUUC-Rno-105966	Rattus norvegicus	75.00	6.00e-101	359.00
IUUC-Sha-107111	Sarcophilus harrisii	74.10	2.00e-73	267.00
IUUC-Spo-108322	Schizosaccharomyces pombe	30.53	7.00e-24	103.00
IUUC-Sar-113190	Sorex araneus	56.52	1.00e-26	110.00
IUUC-Ssc-115908	Sus scrofa	61.50	2.00e-75	275.00
IUUC-Tgu-117465	Taeniopygia guttata	74.88	3.00e-94	337.00
IUUC-Tru-118565	Takifugu rubripes	60.99	2.00e-74	271.00
IUUC-Tsy-119561	Tarsius syrichta	59.82	2.00e-73	268.00
IUUC-Tbe-128048	Tupaia belangeri	74.10	2.00e-72	264.00
IUUC-Ttr-128494	Tursiops truncatus	73.99	7.00e-88	316.00
IUUC-Vda-129850	Verticillium dahliae	32.46	1.00e-27	115.00
IUUC-Xtr-132286	Xenopus tropicalis	67.86	2.00e-90	324.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence