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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046136
Ensembl Protein ID ENSP00000380308.3
UniProt Accession Q13409; B7ZA04; D3DPD4; D3DPD5; D3DPD6; Q32LY9; Q53S84; Q5BJF8; Q7Z4X1; Q96NG7; Q96S87; Q9BXZ5; Q9NT58; DC1I2_HUMAN
Genbank Protein ID AAP97254.1; AAK37426.1; AAK67638.1; AAP35794.1; BAB70932.1; BAH14490.1; CAB70785.1; CAD97654.1; AAY24133.1; EAX11202.1; EAX11204.1; EAX11206.1; EAX11207.1; EAX11208.1; EAX11209.1; AAH91498.1; AAI09376.1; AAH15038.1; AAA89166.1
Protein Name Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; Dynein intermediate chain 2, cytosolic
Genbank Nucleotide ID AF134477; AF250307; AY037160; BT007130; AK055491; AK316119; AL137519; BX537412; AC064826; CH471058; CH471058; CH471058; CH471058; CH471058; CH471058; BC091498; BC109375; BC015038; U39575
Gene Name DYNC1I2; DNCI2; DNCIC2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000077380.15 ENST00000340296.8 ENSP00000339430.4
ENSG00000077380.15 ENST00000397119.7 ENSP00000380308.3
ENSG00000077380.15 ENST00000410079.7 ENSP00000386522.3
ENSG00000077380.15 ENST00000438879.5 ENSP00000392741.1
ENSG00000077380.15 ENST00000508530.5 ENSP00000423339.1
ENSG00000077380.15 ENST00000409317.5 ENSP00000386591.1
ENSG00000077380.15 ENST00000409453.5 ENSP00000386886.1
ENSG00000077380.15 ENST00000445378.5 ENSP00000415410.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtPHOSIDABioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.50e-14 52.8 474 516
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf......sd..tllvsGsdDgtikvWDlrtgvl 35
           gH++++t+++        d  +l+v++s D t+k+W ++ +++
   Q: 474  GHQGPITGIHChaavgaVDfsHLFVTSSFDWTVKLWTTKNNKP 516
           8********999999**4444899************8776665 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 (By similarity). Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport (PubMed:20006841). Interacts with BICD2 (By similarity).
 Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 (By similarity). Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport (PubMed:20006841). Interacts with BICD2 (By similarity).
Protein Sequence
(Fasta)
MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAVAPVQEE SDLEKKRREA 60
EALLQSMGLT PESPIVFSEY WVPPPMSPSS KSVSTPSEAG SQDSGDGAVG SRTLHWDTDP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046136|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AATTCCCAGA ACGCACTGCT CGTCGCACGC AGGTTTTCCT TGTTGCCGGG GTTTGTAGTT 60
CTTCTCGATC GTGTCAGTTT GTAAGGCGAG GGCGGAAGTT GGATTCCTGG CCTGAGAATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046136|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0243--Dynein
KW-0945--Host-virus interaction
KW-0493--Microtubule
KW-0505--Motor protein
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR025956--DYNC1I1/DYNC1I2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50294--WD_REPEATS_REGION
Pfam

PF11540--Dynein_IC2
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005868--C:cytoplasmic dynein complex
GO:0005829--C:cytosol
GO:0005874--C:microtubule
GO:0031982--C:vesicle
GO:0003777--F:microtubule motor activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0097711--P:ciliary basal body docking
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0007018--P:microtubule-based movement
GO:0016032--P:viral process
KEGG hsa:1781
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002108 Ailuropoda melanoleuca 99.37 0.00e+00 1161.00
IUUC-Apl-003265 Anas platyrhynchos 90.73 0.00e+00 1047.00
IUUC-Aca-004911 Anolis carolinensis 89.50 0.00e+00 1005.00
IUUC-Acl-008245 Aspergillus clavatus 39.45 1.00e-90 327.00
IUUC-Afl-008509 Aspergillus flavus 39.83 1.00e-91 331.00
IUUC-Afu-009032 Aspergillus fumigatus 39.01 7.00e-90 325.00
IUUC-Ani-009498 Aspergillus nidulans 39.62 2.00e-93 337.00
IUUC-Ang-009680 Aspergillus niger 37.94 1.00e-92 333.00
IUUC-Aor-010087 Aspergillus oryzae 39.83 1.00e-91 331.00
IUUC-Ate-010443 Aspergillus terreus 39.49 3.00e-93 336.00
IUUC-Ame-011786 Astyanax mexicanus 81.66 0.00e+00 994.00
IUUC-Bta-013350 Bos taurus 92.63 0.00e+00 1061.00
IUUC-Bci-013835 Botrytis cinerea 39.87 4.00e-99 355.00
IUUC-Cel-018207 Caenorhabditis elegans 43.65 2.00e-104 373.00
IUUC-Cja-019943 Callithrix jacchus 96.88 0.00e+00 1163.00
IUUC-Cfa-020325 Canis familiaris 94.98 0.00e+00 1079.00
IUUC-Cpo-022271 Cavia porcellus 98.87 0.00e+00 1149.00
IUUC-Csa-023526 Chlorocebus sabaeus 97.28 0.00e+00 1122.00
IUUC-Cho-025091 Choloepus hoffmanni 80.12 0.00e+00 717.00
IUUC-Cin-025487 Ciona intestinalis 55.58 8.00e-173 600.00
IUUC-Cne-026971 Cryptococcus neoformans 46.14 4.00e-116 412.00
IUUC-Dre-028011 Danio rerio 80.88 0.00e+00 976.00
IUUC-Dno-029574 Dasypus novemcinctus 97.65 0.00e+00 1124.00
IUUC-Dor-030788 Dipodomys ordii 90.13 0.00e+00 962.00
IUUC-Dse-031518 Dothistroma septosporum 37.39 1.00e-87 317.00
IUUC-Dme-032110 Drosophila melanogaster 63.10 2.00e-170 592.00
IUUC-Ete-032732 Echinops telfairi 98.42 0.00e+00 738.00
IUUC-Eca-033654 Equus caballus 99.51 0.00e+00 1159.00
IUUC-Eeu-035271 Erinaceus europaeus 93.06 0.00e+00 1032.00
IUUC-Fca-035962 Felis catus 99.22 0.00e+00 1159.00
IUUC-Fal-037591 Ficedula albicollis 94.20 0.00e+00 1052.00
IUUC-Fox-037992 Fusarium oxysporum 40.17 3.00e-99 356.00
IUUC-Fso-038209 Fusarium solani 38.23 3.00e-94 339.00
IUUC-Gmo-039036 Gadus morhua 68.12 0.00e+00 799.00
IUUC-Ggr-039785 Gaeumannomyces graminis 36.90 3.00e-82 300.00
IUUC-Gga-040996 Gallus gallus 93.89 0.00e+00 1056.00
IUUC-Gac-041771 Gasterosteus aculeatus 82.34 0.00e+00 1015.00
IUUC-Ggo-044656 Gorilla gorilla 100.00 0.00e+00 1168.00
IUUC-Itr-048711 Ictidomys tridecemlineatus 99.06 0.00e+00 1158.00
IUUC-Lch-050416 Latimeria chalumnae 85.94 0.00e+00 1014.00
IUUC-Loc-051856 Lepisosteus oculatus 82.88 0.00e+00 914.00
IUUC-Lma-052957 Leptosphaeria maculans 33.69 1.00e-72 267.00
IUUC-Laf-054418 Loxodonta africana 99.22 0.00e+00 1161.00
IUUC-Mcc-055539 Macaca mulatta 97.38 0.00e+00 1147.00
IUUC-Meu-056899 Macropus eugenii 92.49 0.00e+00 1084.00
IUUC-Mla-058954 Melampsora laricipopulina 42.98 2.00e-106 379.00
IUUC-Mga-060055 Meleagris gallopavo 92.57 0.00e+00 1047.00
IUUC-Mvi-060541 Microbotryum violaceum 43.45 4.00e-112 399.00
IUUC-Mmr-061254 Microcebus murinus 96.47 0.00e+00 1141.00
IUUC-Mdo-061887 Monodelphis domestica 99.77 0.00e+00 871.00
IUUC-Mmu-064021 Mus musculus 97.96 0.00e+00 1149.00
IUUC-Mpu-065831 Mustela putorius furo 99.37 0.00e+00 1156.00
IUUC-Mlu-066987 Myotis lucifugus 94.51 0.00e+00 1105.00
IUUC-Ncr-068656 Neurospora crassa 40.17 3.00e-102 366.00
IUUC-Nle-069113 Nomascus leucogenys 98.43 0.00e+00 1133.00
IUUC-Opr-070488 Ochotona princeps 86.38 0.00e+00 914.00
IUUC-Ont-071319 Oreochromis niloticus 77.85 0.00e+00 940.00
IUUC-Oan-073420 Ornithorhynchus anatinus 94.83 0.00e+00 1070.00
IUUC-Ocu-074046 Oryctolagus cuniculus 90.44 0.00e+00 1047.00
IUUC-Ola-086484 Oryzias latipes 77.64 0.00e+00 983.00
IUUC-Oga-088759 Otolemur garnettii 96.44 0.00e+00 1108.00
IUUC-Oar-090204 Ovis aries 97.81 0.00e+00 1132.00
IUUC-Ptr-091193 Pan troglodytes 100.00 0.00e+00 1168.00
IUUC-Pan-092842 Papio anubis 100.00 0.00e+00 1168.00
IUUC-Psi-092969 Pelodiscus sinensis 92.25 0.00e+00 1094.00
IUUC-Pma-094729 Petromyzon marinus 72.38 0.00e+00 877.00
IUUC-Pno-095122 Phaeosphaeria nodorum 38.61 5.00e-92 332.00
IUUC-Pfo-097067 Poecilia formosa 77.47 0.00e+00 876.00
IUUC-Pab-098223 Pongo abelii 100.00 0.00e+00 1168.00
IUUC-Pva-102326 Pteropus vampyrus 96.39 0.00e+00 1112.00
IUUC-Pgr-103384 Puccinia graminis 42.79 3.00e-108 386.00
IUUC-Pte-104046 Pyrenophora teres 37.50 2.00e-88 320.00
IUUC-Pyt-104796 Pyrenophora triticirepentis 38.08 6.00e-85 308.00
IUUC-Rno-105916 Rattus norvegicus 97.65 0.00e+00 1182.00
IUUC-Sha-107044 Sarcophilus harrisii 93.42 0.00e+00 1027.00
IUUC-Spo-108374 Schizosaccharomyces pombe 31.37 1.00e-48 187.00
IUUC-Ssl-108411 Sclerotinia sclerotiorum 39.50 6.00e-93 335.00
IUUC-Sar-113334 Sorex araneus 89.09 0.00e+00 1015.00
IUUC-Sre-114966 Sporisorium reilianum 42.89 5.00e-96 345.00
IUUC-Ssc-116396 Sus scrofa 94.51 0.00e+00 1073.00
IUUC-Tgu-116477 Taeniopygia guttata 94.36 0.00e+00 1049.00
IUUC-Tru-117872 Takifugu rubripes 80.43 0.00e+00 974.00
IUUC-Tsy-118912 Tarsius syrichta 98.59 0.00e+00 1147.00
IUUC-Tni-120754 Tetraodon nigroviridis 78.57 0.00e+00 948.00
IUUC-Tre-122022 Trichoderma reesei 42.79 1.00e-100 360.00
IUUC-Tvi-122391 Trichoderma virens 42.20 6.00e-100 358.00
IUUC-Tme-126997 Tuber melanosporum 39.89 4.00e-99 355.00
IUUC-Tbe-127693 Tupaia belangeri 84.30 3.00e-169 588.00
IUUC-Ttr-128834 Tursiops truncatus 98.11 0.00e+00 1096.00
IUUC-Uma-129615 Ustilago maydis 40.83 2.00e-101 363.00
IUUC-Vpa-130062 Vicugna pacos 98.59 0.00e+00 1161.00
IUUC-Xtr-132003 Xenopus tropicalis 81.94 0.00e+00 1003.00
IUUC-Xma-133021 Xiphophorus maculatus 78.69 0.00e+00 915.00
IUUC-Yli-134587 Yarrowia lipolytica 36.45 7.00e-72 265.00
Created Date 25-Jun-2017

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