iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054109

UUCD1 version

UUC-LoA-01113

Ensembl Protein ID

ENSLAFP00000004108.3

UniProt Accession

G3SV61; G3SV61_LOXAF

Protein Name

Uncharacterized protein

Gene Name

USP18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000004907.3	ENSLAFT00000004909.3	ENSLAFP00000004108.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.20e-56	191.8	57	371

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl+Nlg tC +NS++Q  ++  ++++ l++   ++ ++     e+k ++  +l  l+e++++s++kav+p el  +l+k+ +    + 
   Q: 57   VGLHNLGQTCCLNSLIQLFIMNVNFTKILKRiTVPRGVE-----EQKRSVPFQLLLLLEKMQDSRWKAVQPLELAYCLQKYRVP--LFV 138
           6******************************55555554.....5678*********************************998..79* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvp 177
           q+Da  +  ++ + +++++                          ++    + ++ l+ +q+k++++cl+c  +ssr++++l+l+l++ 
   Q: 139  QHDAAQLYLIVWNLIKDQI--------------------------TDVDLVERLQALYTIQMKETLVCLDCSMESSRNSKMLTLPLSLF 201
           *******************..........................66778899************************************ PP
   S: 178  gkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
           + +++ +++l+d+L+ f++++el  + k++c++c kk+  ++ lkl++lP++L++hL Rfs ++  ++ eki  ++ fp++Ld s+++ 
   Q: 202  DIDSKPLKKLEDALQCFFQPKELSAQSKCFCQNCGKKTCGKQVLKLNHLPQTLTIHLLRFSIRN--SKTEKICHSLCFPQSLDFSQVVP 288
           9999999*****************************************************7655..6889***************7443 PP
   S: 267  s.peekqke....kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYkr 337
             ++  +      + +YeL+av+ H G ++ GHY+ay++n  +gkW++f+Ds+V  v+++++  + g       +taY+l+Y++
   Q: 289  IeQDLCN-AedrpEGQYELFAVIAHVGMADFGHYCAYIRNsVDGKWFCFNDSSVCLVSWDDIRCTYGnrnyrwnETAYILVYMK 371
           3122222.2355599*************************45677*******************8889**************97 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MGKAFGFLRT TCQSVLAASQ PFAAEPVEKK EEDGSMKRDR EQPKEHPSAW NRPHGLVGLH 60
NLGQTCCLNS LIQLFIMNVN FTKILKRITV PRGVEEQKRS VPFQLLLLLE KMQDSRWKAV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCAAAG CATTTGGGTT CCTGAGGACA ACCTGCCAGT CAGTCCTGGC TGCGTCTCAG 60
CCTTTCGCAG CAGAACCTGT TGAGAAGAAG GAAGAGGACG GCAGCATGAA GAGGGACAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

lav:100661628

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	78.71	1.00e-161	561.00
IUUC-Apl-004006	Anas platyrhynchos	56.56	3.00e-106	377.00
IUUC-Aca-005088	Anolis carolinensis	55.49	5.00e-94	337.00
IUUC-Ame-010606	Astyanax mexicanus	33.44	6.00e-40	157.00
IUUC-Bta-013036	Bos taurus	72.50	2.00e-142	498.00
IUUC-Cja-019052	Callithrix jacchus	72.98	7.00e-141	493.00
IUUC-Cfa-020554	Canis familiaris	80.53	7.00e-166	576.00
IUUC-Cpo-022421	Cavia porcellus	73.21	1.00e-161	562.00
IUUC-Csa-023737	Chlorocebus sabaeus	77.23	7.00e-97	345.00
IUUC-Cho-024807	Choloepus hoffmanni	69.04	3.00e-70	258.00
IUUC-Dre-027408	Danio rerio	33.74	2.00e-47	182.00
IUUC-Dno-029813	Dasypus novemcinctus	65.96	1.00e-127	449.00
IUUC-Dor-030532	Dipodomys ordii	69.44	2.00e-155	541.00
IUUC-Ete-032254	Echinops telfairi	74.60	7.00e-166	576.00
IUUC-Eca-033482	Equus caballus	82.81	9.00e-163	565.00
IUUC-Eeu-034451	Erinaceus europaeus	73.58	2.00e-93	334.00
IUUC-Fca-036313	Felis catus	77.21	9.00e-168	582.00
IUUC-Fal-037216	Ficedula albicollis	52.13	4.00e-105	374.00
IUUC-Gmo-038649	Gadus morhua	33.33	1.00e-39	156.00
IUUC-Gga-041082	Gallus gallus	55.97	1.00e-94	339.00
IUUC-Gac-042439	Gasterosteus aculeatus	36.48	9.00e-49	187.00
IUUC-Ggo-044957	Gorilla gorilla	80.88	4.00e-135	473.00
IUUC-Hsa-046381	Homo sapiens	77.75	5.00e-179	619.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	75.13	9.00e-169	585.00
IUUC-Loc-052688	Lepisosteus oculatus	33.85	1.00e-48	187.00
IUUC-Mcc-054814	Macaca mulatta	77.75	0.00e+00	627.00
IUUC-Meu-056253	Macropus eugenii	67.13	7.00e-108	383.00
IUUC-Mmr-061613	Microcebus murinus	79.06	5.00e-161	560.00
IUUC-Mdo-061890	Monodelphis domestica	64.12	8.00e-124	436.00
IUUC-Mmu-064329	Mus musculus	69.52	2.00e-148	518.00
IUUC-Mpu-066342	Mustela putorius furo	79.13	5.00e-170	590.00
IUUC-Mlu-067010	Myotis lucifugus	75.60	2.00e-170	591.00
IUUC-Nle-069148	Nomascus leucogenys	77.48	1.00e-176	612.00
IUUC-Opr-070988	Ochotona princeps	68.15	3.00e-63	235.00
IUUC-Ont-072039	Oreochromis niloticus	33.64	2.00e-47	182.00
IUUC-Oan-073740	Ornithorhynchus anatinus	56.63	3.00e-74	271.00
IUUC-Ocu-074498	Oryctolagus cuniculus	76.41	1.00e-153	535.00
IUUC-Ola-086753	Oryzias latipes	33.76	1.00e-46	180.00
IUUC-Oga-088497	Otolemur garnettii	77.99	2.00e-169	587.00
IUUC-Oar-089505	Ovis aries	73.75	5.00e-144	503.00
IUUC-Ptr-091656	Pan troglodytes	77.48	3.00e-179	620.00
IUUC-Pan-092498	Papio anubis	77.48	2.00e-180	624.00
IUUC-Psi-093409	Pelodiscus sinensis	52.37	2.00e-106	379.00
IUUC-Pfo-096507	Poecilia formosa	33.86	4.00e-46	178.00
IUUC-Pab-097828	Pongo abelii	80.12	2.00e-158	551.00
IUUC-Pca-100299	Procavia capensis	85.60	5.00e-121	427.00
IUUC-Pva-102972	Pteropus vampyrus	75.07	3.00e-159	554.00
IUUC-Rno-105738	Rattus norvegicus	68.98	1.00e-152	532.00
IUUC-Sha-107309	Sarcophilus harrisii	62.62	6.00e-116	410.00
IUUC-Sar-112983	Sorex araneus	77.70	3.00e-125	441.00
IUUC-Ssc-116049	Sus scrofa	75.94	4.00e-151	526.00
IUUC-Tgu-117115	Taeniopygia guttata	56.92	4.00e-104	370.00
IUUC-Tru-118022	Takifugu rubripes	32.70	1.00e-40	159.00
IUUC-Tsy-118986	Tarsius syrichta	63.51	9.00e-65	240.00
IUUC-Tni-120306	Tetraodon nigroviridis	32.59	1.00e-38	153.00
IUUC-Tbe-127768	Tupaia belangeri	67.89	6.00e-116	410.00
IUUC-Ttr-128686	Tursiops truncatus	72.14	2.00e-152	531.00
IUUC-Xtr-132032	Xenopus tropicalis	44.34	1.00e-70	259.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence