iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046306

UUCD1 version

UUC-HoS-00106

Ensembl Protein ID

ENSP00000264122.4

UniProt Accession

Q13191; A8K9S7; B7WNM4; Q13192; Q13193; Q3LIC0; Q63Z43; Q8IVC5; CBLB_HUMAN

Genbank Protein ID

AAB09291.1; AAB09292.1; AAB09293.1; ABC86700.1; BAF85481.1; EAW79752.1; EAW79753.1; EAW79754.1; AAH32851.1; BAE45748.1; CAH56175.1

Protein Name

E3 ubiquitin-protein ligase CBL-B; Casitas B-lineage lymphoma proto-oncogene b; RING finger protein 56; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; Signal transduction protein CBL-B

Genbank Nucleotide ID

U26710; U26711; U26712; DQ349203; AK292792; AC016138; CH471052; CH471052; BC032851; AB075490; BX537484

Gene Name

CBLB; RNF56; Nbla00127

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000114423.18	ENST00000394030.6	ENSP00000377598.2
ENSG00000114423.18	ENST00000264122.8	ENSP00000264122.4
ENSG00000114423.18	ENST00000403724.5	ENSP00000384816.1
ENSG00000114423.18	ENST00000438603.5	ENSP00000409750.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19546233; 15308098; 11526404; 19815501; 19007436; 12218189
UBD/Alpha-Helix/UBA	UBA	15273720; 17679095; 24651487

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.70e-07	32.7	373	412
UBD/Alpha-Helix/UBA	0.00054	21.7	935	967

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl +w    ++s ++  CP Cr
   Q: 373  CKICAENDKD-VKIEPCGHLMCTSCLTAW----QESDGQ-GCPFCR 412
           99********.******************....555555.5****8 PP

UBD/Alpha-Helix/UBA

   S: 6    kleqlveMGFdreealqaLraannnleaAveyL 38
           k+++l+  G+ +ee+++aL+ a nn+e+A   L
   Q: 935  KIAKLMGEGYAFEEVKRALEIAQNNVEVARSIL 967
           89***************************7766 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.

Protein Sequence
(Fasta)

MANSMNGRNP GGRGGNPRKG RILGIIDAIQ DAVGPPKQAA ADRRTVEKTW KLMDKVVRLC 60
QNPKLQLKNS PPYILDILPD TYQHLRLILS KYDDNQKLAQ LSENEYFKIY IDSLMKKSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGTCCTGG GTAGAAGGGT TTGGCAGCCC TAGGGAGATG AATTTCTCCA GCGTTGGACC 60
CGCCCAGAGC GGAGAAGCAA CACCCTTCCA GCCACTACTC TGTTGCTATG AAACAAAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0045121--C:membrane raft
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0006508--P:proteolysis
GO:0007165--P:signal transduction

KEGG

hsa:868

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001412	Ailuropoda melanoleuca	96.85	0.00e+00	1654.00
IUUC-Apl-004148	Anas platyrhynchos	86.36	0.00e+00	1475.00
IUUC-Aca-005204	Anolis carolinensis	82.67	0.00e+00	1412.00
IUUC-Ame-011919	Astyanax mexicanus	64.91	0.00e+00	1050.00
IUUC-Bta-013044	Bos taurus	97.15	0.00e+00	1659.00
IUUC-Cel-018674	Caenorhabditis elegans	56.92	2.00e-133	469.00
IUUC-Cja-018813	Callithrix jacchus	89.85	0.00e+00	1563.00
IUUC-Cfa-021054	Canis familiaris	97.05	0.00e+00	1695.00
IUUC-Cpo-022514	Cavia porcellus	90.74	0.00e+00	1626.00
IUUC-Csa-024110	Chlorocebus sabaeus	99.69	0.00e+00	1737.00
IUUC-Cho-024886	Choloepus hoffmanni	80.50	0.00e+00	1120.00
IUUC-Dre-027480	Danio rerio	64.61	0.00e+00	1027.00
IUUC-Dno-028923	Dasypus novemcinctus	97.05	0.00e+00	1656.00
IUUC-Dor-031040	Dipodomys ordii	89.98	0.00e+00	811.00
IUUC-Ete-032406	Echinops telfairi	91.37	0.00e+00	1504.00
IUUC-Eca-033849	Equus caballus	96.24	0.00e+00	1679.00
IUUC-Fca-036224	Felis catus	97.36	0.00e+00	1670.00
IUUC-Fal-036860	Ficedula albicollis	96.89	0.00e+00	1006.00
IUUC-Gga-040159	Gallus gallus	83.33	0.00e+00	1436.00
IUUC-Gac-042312	Gasterosteus aculeatus	84.92	0.00e+00	889.00
IUUC-Ggo-045175	Gorilla gorilla	90.65	0.00e+00	1575.00
IUUC-Lch-049931	Latimeria chalumnae	61.45	0.00e+00	856.00
IUUC-Loc-052524	Lepisosteus oculatus	69.68	0.00e+00	1101.00
IUUC-Laf-053635	Loxodonta africana	93.09	0.00e+00	1601.00
IUUC-Mcc-055536	Macaca mulatta	99.59	0.00e+00	1736.00
IUUC-Meu-056045	Macropus eugenii	79.00	0.00e+00	1287.00
IUUC-Mga-060177	Meleagris gallopavo	93.29	0.00e+00	1117.00
IUUC-Mmr-061088	Microcebus murinus	97.97	0.00e+00	1696.00
IUUC-Mdo-062020	Monodelphis domestica	91.68	0.00e+00	1576.00
IUUC-Mmu-063114	Mus musculus	90.44	0.00e+00	1587.00
IUUC-Mpu-066632	Mustela putorius furo	97.76	0.00e+00	1704.00
IUUC-Mlu-067145	Myotis lucifugus	96.95	0.00e+00	1688.00
IUUC-Ont-072323	Oreochromis niloticus	84.44	0.00e+00	891.00
IUUC-Oan-073165	Ornithorhynchus anatinus	89.64	0.00e+00	1589.00
IUUC-Ocu-074723	Oryctolagus cuniculus	97.25	0.00e+00	1694.00
IUUC-Oga-088021	Otolemur garnettii	96.44	0.00e+00	1664.00
IUUC-Oar-089809	Ovis aries	96.95	0.00e+00	1660.00
IUUC-Ptr-090834	Pan troglodytes	99.90	0.00e+00	1739.00
IUUC-Pan-092225	Papio anubis	99.59	0.00e+00	1737.00
IUUC-Psi-093317	Pelodiscus sinensis	86.83	0.00e+00	1520.00
IUUC-Pma-094249	Petromyzon marinus	77.61	7.00e-127	446.00
IUUC-Pab-097595	Pongo abelii	99.80	0.00e+00	1738.00
IUUC-Pca-100844	Procavia capensis	79.96	0.00e+00	1308.00
IUUC-Pva-103216	Pteropus vampyrus	89.92	0.00e+00	1588.00
IUUC-Rno-105381	Rattus norvegicus	94.71	0.00e+00	1670.00
IUUC-Sha-107574	Sarcophilus harrisii	91.50	0.00e+00	1568.00
IUUC-Sar-113500	Sorex araneus	84.86	0.00e+00	1354.00
IUUC-Ssc-115856	Sus scrofa	96.60	0.00e+00	1440.00
IUUC-Tgu-116866	Taeniopygia guttata	86.13	0.00e+00	1459.00
IUUC-Tru-118579	Takifugu rubripes	86.15	0.00e+00	887.00
IUUC-Tsy-119167	Tarsius syrichta	85.14	0.00e+00	1409.00
IUUC-Tni-120788	Tetraodon nigroviridis	85.03	0.00e+00	897.00
IUUC-Tbe-127830	Tupaia belangeri	94.38	0.00e+00	1165.00
IUUC-Ttr-128631	Tursiops truncatus	97.56	0.00e+00	1696.00
IUUC-Vpa-130713	Vicugna pacos	96.39	0.00e+00	1460.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence