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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045908
Ensembl Protein ID ENSP00000440392.1
UniProt Accession A0A0C4DGG9; A0A0C4DGG9_HUMAN
Genbank Protein ID ENSP00000440392
Protein Name Chromodomain-helicase-DNA-binding protein 4
Genbank Nucleotide ID AC006064
Gene Name CHD4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000111642.14 ENST00000544484.5 ENSP00000440392.1
ENSG00000111642.14 ENST00000544040.5 ENSP00000440542.1
ENSG00000111642.14 ENST00000357008.6 ENSP00000349508.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
HINTInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 8.30e-16 59.6 447 491
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C vC++gge    l++C+ C + +H +Cl+++  +e pn e w Cp+C+
   Q: 447  EFCRVCKDGGE----LLCCDTCPSSYHIHCLNPP-LPEIPNGE-WLCPRCT 491
           58*********....*******************.*******8.******6 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MASGLGSPSP CSAGSEEEDM DALLNNSLPP PHPEDPEEDL SETETPKLKK KKKPKKPRDP 60
KIPKSKRQKK ERMLLCRQLG DSSGEGPEFV EEEEEVALRS DSEGSDYTPG KKKKKKLGPK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045908|E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGCTGTC CGTGGGGGGG CGGGGCCTGT GCGGTGGGAT TTCCCGGCCG GTGTTTCAGG 60
CCCTTTAAGA GGCGACGCTG GAGCCGGAGC CATTTTCCCC CCTTCGGCCG CGGCGAGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045908|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR028725--CHD4
IPR012957--CHD_C2
IPR012958--CHD_N
IPR000953--Chromo/chromo_shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR002464--DNA/RNA_helicase_DEAH_CS
IPR009462--DUF1086
IPR009463--DUF1087
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50013--CHROMO_2
PS00690--DEAH_ATP_HELICASE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF08074--CHDCT2
PF08073--CHDNT
PF00385--Chromo
PF06461--DUF1086
PF06465--DUF1087
PF00271--Helicase_C
PF00628--PHD
PF00176--SNF2_N
SMART

SM00298--CHROMO
SM00487--DEXDc
SM01146--DUF1086
SM01147--DUF1087
SM00490--HELICc
SM00249--PHD
Gene Ontology

GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0005524--F:ATP binding
GO:0008026--F:ATP-dependent helicase activity
GO:0003677--F:DNA binding
GO:0008270--F:zinc ion binding
GO:0006325--P:chromatin organization
GO:0006355--P:regulation of transcription, DNA-templated
GO:0051225--P:spindle assembly
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001361 Ailuropoda melanoleuca 97.73 0.00e+00 3093.00
IUUC-Apl-004175 Anas platyrhynchos 89.69 0.00e+00 2711.00
IUUC-Aca-004774 Anolis carolinensis 87.08 0.00e+00 2789.00
IUUC-Bta-013220 Bos taurus 96.58 0.00e+00 2919.00
IUUC-Cja-019510 Callithrix jacchus 94.13 0.00e+00 2753.00
IUUC-Cfa-020422 Canis familiaris 97.22 0.00e+00 2976.00
IUUC-Cpo-021704 Cavia porcellus 96.86 0.00e+00 2915.00
IUUC-Csa-023625 Chlorocebus sabaeus 96.86 0.00e+00 2977.00
IUUC-Cho-024361 Choloepus hoffmanni 93.04 0.00e+00 1542.00
IUUC-Dre-027692 Danio rerio 83.12 0.00e+00 1974.00
IUUC-Dno-029656 Dasypus novemcinctus 96.60 0.00e+00 2933.00
IUUC-Dor-030354 Dipodomys ordii 96.14 0.00e+00 1883.00
IUUC-Eca-034112 Equus caballus 96.44 0.00e+00 2979.00
IUUC-Fca-036056 Felis catus 97.22 0.00e+00 2976.00
IUUC-Fal-037312 Ficedula albicollis 94.27 0.00e+00 2303.00
IUUC-Gga-040216 Gallus gallus 90.77 0.00e+00 2812.00
IUUC-Gac-042478 Gasterosteus aculeatus 77.62 0.00e+00 2016.00
IUUC-Ggo-044428 Gorilla gorilla 87.85 0.00e+00 2654.00
IUUC-Itr-048002 Ictidomys tridecemlineatus 96.89 0.00e+00 2943.00
IUUC-Lch-049948 Latimeria chalumnae 76.55 0.00e+00 1900.00
IUUC-Mcc-055773 Macaca mulatta 99.74 0.00e+00 3075.00
IUUC-Mga-059633 Meleagris gallopavo 90.90 0.00e+00 2817.00
IUUC-Mmr-060886 Microcebus murinus 99.43 0.00e+00 3085.00
IUUC-Mdo-062872 Monodelphis domestica 96.99 0.00e+00 2708.00
IUUC-Mmu-063672 Mus musculus 96.13 0.00e+00 2880.00
IUUC-Mpu-066692 Mustela putorius furo 97.16 0.00e+00 2976.00
IUUC-Mlu-067785 Myotis lucifugus 96.80 0.00e+00 2961.00
IUUC-Nle-070039 Nomascus leucogenys 99.63 0.00e+00 3024.00
IUUC-Ont-072418 Oreochromis niloticus 80.83 0.00e+00 2109.00
IUUC-Ocu-074177 Oryctolagus cuniculus 94.40 0.00e+00 2935.00
IUUC-Ola-086880 Oryzias latipes 79.67 0.00e+00 2157.00
IUUC-Oga-088970 Otolemur garnettii 98.56 0.00e+00 3073.00
IUUC-Oar-090422 Ovis aries 97.10 0.00e+00 2873.00
IUUC-Pan-092441 Papio anubis 96.86 0.00e+00 2977.00
IUUC-Psi-093530 Pelodiscus sinensis 86.76 0.00e+00 2771.00
IUUC-Ppa-095213 Physcomitrella patens 41.64 0.00e+00 718.00
IUUC-Pfo-097530 Poecilia formosa 78.54 0.00e+00 2106.00
IUUC-Pab-097959 Pongo abelii 97.91 0.00e+00 2937.00
IUUC-Pva-103186 Pteropus vampyrus 98.98 0.00e+00 2989.00
IUUC-Rno-105692 Rattus norvegicus 95.32 0.00e+00 2888.00
IUUC-Ssc-115295 Sus scrofa 96.86 0.00e+00 2944.00
IUUC-Tgu-117484 Taeniopygia guttata 89.02 0.00e+00 2792.00
IUUC-Tru-118745 Takifugu rubripes 76.21 0.00e+00 2503.00
IUUC-Tsy-119261 Tarsius syrichta 88.82 0.00e+00 2097.00
IUUC-Tni-120764 Tetraodon nigroviridis 79.03 0.00e+00 2380.00
Created Date 25-Jun-2017

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