iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.70e-30	101.9	169	203
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.40e-16	59.3	375	420
UBD/Beta-Prp	1.50e-45	156.0	135	379

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           H + v++l f +d   llvs+s+D+t++vWDl+++
   Q: 169  HIEVVRDLTFaPDgsLLLVSASRDKTLRVWDLKDD 203
           8889*******7766779*************9887 PP

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           +++w +++++ SLqhLCR++Irr +++q++   +kLP P+++ ++L+y+
   Q: 375  VYFWATPRQVSSLQHLCRMSIRRVMPTQEV---QKLPVPSKMLEFLSYR 420
           689************************999...**************96 PP

UBD/Beta-Prp

   S: 17   kfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfs 103
            f +d+ llatg  +g+ik+wdv tgkll  l +h + v++++f pdg+ +lv++s+D+t++vwdl+ +g +v +l+gh++ v+s++fs
   Q: 135  RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHIEVVRDLTFAPDGSlLLVSASRDKTLRVWDLKdDGNMVKVLRGHQNWVYSCAFS 223
           5678999******************************************999**************989******************** PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tgght 180
           p+ + l s ++ + + +w++++++ ++  l+gh++ v    ++pdg ll+++s+D+ v +Wd   g+ l ++             g+++
   Q: 224  PDCSMLCSVGASKAVFLWNMDKYTMIR-RLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHIGDTLMEFghlfppptpifaGGAND 311
           *99************************.*******************************************************98889* PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
           + v+ +sf+++g +++s ++d+ v++w++        + +  +n ++ +fs ++  l+ g++Dgs+++W 
   Q: 312  RWVRAVSFSHDGLHVASLADDKMVRFWSIGDD--CPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWA 379
           *****************************655..78899******************************2 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MASFPPRVNE KEIVRSRTIG ELLAPAAPFD KKCGGENWTV AFAPDGSYFA WSQGYRIVKL 60
VPWSQCLKNF LLHGSKNVTN SSCLKLARQN SNGGQKNKPR EHIIDCGDIV WSLAFGSSVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAAAAAGAC CGAGCTCGCG TCACGCCCCT CAGCCCCCAT CGAGTCCCTT CTCTGTCGTC 60
GCGCCTGAAT CGAGTTCCCG GAATCAGACG GTGCCCCATA GATGGCCAGC TTTCCCCCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

rno:303336

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001635	Ailuropoda melanoleuca	93.11	0.00e+00	804.00
IUUC-Apl-003903	Anas platyrhynchos	86.73	0.00e+00	751.00
IUUC-Aca-005214	Anolis carolinensis	75.59	0.00e+00	674.00
IUUC-Ame-011740	Astyanax mexicanus	74.11	0.00e+00	669.00
IUUC-Bta-013475	Bos taurus	93.82	0.00e+00	806.00
IUUC-Cja-019053	Callithrix jacchus	93.56	0.00e+00	823.00
IUUC-Cfa-020103	Canis familiaris	93.59	0.00e+00	807.00
IUUC-Cpo-022438	Cavia porcellus	91.45	0.00e+00	813.00
IUUC-Csa-024062	Chlorocebus sabaeus	93.59	0.00e+00	828.00
IUUC-Cho-024334	Choloepus hoffmanni	82.19	0.00e+00	687.00
IUUC-Cin-025590	Ciona intestinalis	39.14	1.00e-75	276.00
IUUC-Csv-026023	Ciona savignyi	38.85	7.00e-76	277.00
IUUC-Dre-028089	Danio rerio	73.70	0.00e+00	669.00
IUUC-Dno-029436	Dasypus novemcinctus	88.15	0.00e+00	655.00
IUUC-Dor-031107	Dipodomys ordii	86.22	0.00e+00	731.00
IUUC-Ete-032326	Echinops telfairi	91.60	0.00e+00	761.00
IUUC-Eca-033401	Equus caballus	92.40	0.00e+00	798.00
IUUC-Eeu-034520	Erinaceus europaeus	90.26	0.00e+00	806.00
IUUC-Fca-036386	Felis catus	93.59	0.00e+00	806.00
IUUC-Fal-036616	Ficedula albicollis	83.29	0.00e+00	721.00
IUUC-Gmo-039335	Gadus morhua	70.76	1.00e-174	605.00
IUUC-Gga-040856	Gallus gallus	85.51	0.00e+00	765.00
IUUC-Gac-042140	Gasterosteus aculeatus	73.24	0.00e+00	659.00
IUUC-Ggo-044619	Gorilla gorilla	93.82	0.00e+00	828.00
IUUC-Hsa-046300	Homo sapiens	93.35	0.00e+00	825.00
IUUC-Itr-048830	Ictidomys tridecemlineatus	92.40	0.00e+00	819.00
IUUC-Lch-049550	Latimeria chalumnae	78.03	7.00e-166	576.00
IUUC-Loc-051769	Lepisosteus oculatus	75.77	0.00e+00	679.00
IUUC-Laf-054576	Loxodonta africana	92.64	0.00e+00	800.00
IUUC-Mcc-054666	Macaca mulatta	93.13	4.00e-147	513.00
IUUC-Meu-055989	Macropus eugenii	86.86	0.00e+00	635.00
IUUC-Mga-059722	Meleagris gallopavo	84.34	0.00e+00	754.00
IUUC-Mmr-060970	Microcebus murinus	92.64	0.00e+00	800.00
IUUC-Mdo-062249	Monodelphis domestica	76.96	0.00e+00	630.00
IUUC-Mmu-063742	Mus musculus	95.95	0.00e+00	838.00
IUUC-Mpu-066518	Mustela putorius furo	93.11	0.00e+00	825.00
IUUC-Mlu-068063	Myotis lucifugus	91.69	0.00e+00	793.00
IUUC-Nle-069561	Nomascus leucogenys	93.11	0.00e+00	825.00
IUUC-Opr-071158	Ochotona princeps	88.10	0.00e+00	782.00
IUUC-Ont-072542	Oreochromis niloticus	71.83	0.00e+00	648.00
IUUC-Oan-073217	Ornithorhynchus anatinus	89.07	0.00e+00	783.00
IUUC-Ocu-074251	Oryctolagus cuniculus	91.20	0.00e+00	775.00
IUUC-Ola-086549	Oryzias latipes	70.66	0.00e+00	649.00
IUUC-Oga-088382	Otolemur garnettii	92.64	0.00e+00	802.00
IUUC-Oar-090263	Ovis aries	92.40	0.00e+00	812.00
IUUC-Ptr-090922	Pan troglodytes	93.11	0.00e+00	826.00
IUUC-Pan-092518	Papio anubis	93.59	0.00e+00	828.00
IUUC-Psi-093512	Pelodiscus sinensis	87.41	0.00e+00	777.00
IUUC-Pma-094324	Petromyzon marinus	59.49	3.00e-138	484.00
IUUC-Pfo-096264	Poecilia formosa	71.60	0.00e+00	652.00
IUUC-Pab-098018	Pongo abelii	91.69	0.00e+00	809.00
IUUC-Pca-101034	Procavia capensis	90.42	0.00e+00	745.00
IUUC-Pva-102862	Pteropus vampyrus	87.89	0.00e+00	733.00
IUUC-Sha-106952	Sarcophilus harrisii	88.51	0.00e+00	738.00
IUUC-Sar-113211	Sorex araneus	81.45	5.00e-146	510.00
IUUC-Ssc-116440	Sus scrofa	93.35	0.00e+00	806.00
IUUC-Tgu-116675	Taeniopygia guttata	83.78	0.00e+00	724.00
IUUC-Tru-118295	Takifugu rubripes	71.60	0.00e+00	632.00
IUUC-Tsy-118916	Tarsius syrichta	81.47	0.00e+00	681.00
IUUC-Tni-120302	Tetraodon nigroviridis	71.13	0.00e+00	630.00
IUUC-Tbe-127416	Tupaia belangeri	80.34	0.00e+00	646.00
IUUC-Ttr-128185	Tursiops truncatus	93.82	0.00e+00	808.00
IUUC-Xtr-132465	Xenopus tropicalis	80.52	0.00e+00	721.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence