iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011871

Ensembl Protein ID

ENSAMXP00000014652.1

UniProt Accession

W5L490; W5L490_ASTMX

Genbank Protein ID

ENSAMXP00000014652

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01109747

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000014228.1	ENSAMXT00000014652.1	ENSAMXP00000014652.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-100	336.7	682	1019

Active Site

Position(s)	Description	Evidence
987	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++++lf ++s+n++  ++pn ++ ++   + k++ef+Gr++gk+l+++   
   Q: 682  SDWSKNFEVVFQDEEALDWGGPRREWFELVCKALFDTNNQLFtRFSDNNQGLVHPNAERPVH--LRVKMYEFAGRVVGKCLYESalg 766
           7999**************************************77899999*********996..9******************9999 PP
   S: 86   ....rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtn 167
               +l+++++++sf+ +++g +++++ +e+ dpe+yk+ + +i +n   d++e++l ++ ++ +++ +  k++eL++gG++i Vtn
   Q: 767  gaykQLVRARFTRSFLAQIIGLRMNYKYFETDDPEFYKTkVCFIINN---DVSEMDLVFAEEKYSKSGQLEKVVELISGGAQIAVTN 850
           9999***********************************88999988...9************************************ PP
   S: 168  eNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevl 253
           eNk  Y +l+++yrl ++++ +ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v+
   Q: 851  ENKIHYLNLLAQYRLASQVRDEVEHFLKGLNELVPENLLAIFDENELELLMCGTGNINVQDFKAHAvIVGGSWHFREKVMKWFWAVV 937
           ******************************************************************445778999************ PP
   S: 254  eefsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           ++f++ee +++LqF+Tgss+lP+gGf++l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+l++ L +Ai+e+ +gF++
   Q: 938  SSFTQEELARLLQFTTGSSQLPPGGFNTLCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEELHKLLKLAISEGsEGFGM 1019
           ******************************99555555.******************************************97 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MDRRFLLTFI FCSVSWIFFW EVRWKKSKES QIEEWLQGHS LSDYKYLFED VQSLEELSLS 60
VLARLEEVVK EQRRWRDISE AHIHLLRDFA FQEWLSSQSL EHYYHTLKAL GCTNLDDLAQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACACCGAG TCCAGGATTG GATGGTTCTA CATCATCTAC AGTCGACGGC AACGACGGCC 60
TACAGCAGCA GCAGCAGCAG CAGGAGCAGC AGCTTGTACG GTGTGTGTGT GAGTCCTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR013761--SAM/pointed

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc
SM00557--IG_FLMN

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	80.66	0.00e+00	1360.00
IUUC-Apl-004071	Anas platyrhynchos	78.25	0.00e+00	1296.00
IUUC-Aca-005218	Anolis carolinensis	79.61	0.00e+00	1343.00
IUUC-Bta-012978	Bos taurus	80.32	0.00e+00	1356.00
IUUC-Cja-019081	Callithrix jacchus	80.80	0.00e+00	1359.00
IUUC-Cfa-020736	Canis familiaris	78.37	0.00e+00	1279.00
IUUC-Cpo-021581	Cavia porcellus	80.19	0.00e+00	1352.00
IUUC-Csa-024189	Chlorocebus sabaeus	74.89	0.00e+00	695.00
IUUC-Cho-024751	Choloepus hoffmanni	79.95	0.00e+00	1313.00
IUUC-Cin-025773	Ciona intestinalis	43.33	7.00e-152	530.00
IUUC-Csv-026090	Ciona savignyi	41.29	9.00e-176	610.00
IUUC-Dre-027788	Danio rerio	92.55	0.00e+00	1914.00
IUUC-Dno-030022	Dasypus novemcinctus	80.56	0.00e+00	1356.00
IUUC-Dme-031577	Drosophila melanogaster	43.76	0.00e+00	726.00
IUUC-Ete-032402	Echinops telfairi	78.75	0.00e+00	1293.00
IUUC-Eca-033908	Equus caballus	80.80	0.00e+00	1362.00
IUUC-Eeu-034869	Erinaceus europaeus	86.39	0.00e+00	835.00
IUUC-Fca-036023	Felis catus	80.68	0.00e+00	1358.00
IUUC-Fal-037477	Ficedula albicollis	80.02	0.00e+00	1358.00
IUUC-Gmo-039197	Gadus morhua	93.67	0.00e+00	1541.00
IUUC-Gga-040704	Gallus gallus	77.94	0.00e+00	1355.00
IUUC-Gac-041511	Gasterosteus aculeatus	92.70	0.00e+00	1576.00
IUUC-Ggo-044527	Gorilla gorilla	77.91	0.00e+00	1291.00
IUUC-Hsa-046082	Homo sapiens	80.80	0.00e+00	1359.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	80.68	0.00e+00	1359.00
IUUC-Lch-049772	Latimeria chalumnae	68.91	0.00e+00	1353.00
IUUC-Loc-052541	Lepisosteus oculatus	87.77	0.00e+00	1817.00
IUUC-Laf-053852	Loxodonta africana	81.04	0.00e+00	1359.00
IUUC-Mcc-054759	Macaca mulatta	75.29	0.00e+00	629.00
IUUC-Meu-056247	Macropus eugenii	65.94	0.00e+00	722.00
IUUC-Mga-060161	Meleagris gallopavo	78.28	0.00e+00	1329.00
IUUC-Mmr-061447	Microcebus murinus	80.44	0.00e+00	1357.00
IUUC-Mdo-062110	Monodelphis domestica	78.74	0.00e+00	1323.00
IUUC-Mmu-064349	Mus musculus	80.44	0.00e+00	1359.00
IUUC-Mpu-065824	Mustela putorius furo	81.04	0.00e+00	1357.00
IUUC-Mlu-067729	Myotis lucifugus	80.56	0.00e+00	1334.00
IUUC-Nle-069721	Nomascus leucogenys	80.68	0.00e+00	1350.00
IUUC-Opr-070189	Ochotona princeps	80.05	0.00e+00	1342.00
IUUC-Ont-072122	Oreochromis niloticus	94.16	0.00e+00	1544.00
IUUC-Oan-072700	Ornithorhynchus anatinus	71.95	0.00e+00	1085.00
IUUC-Ocu-074057	Oryctolagus cuniculus	80.44	0.00e+00	1358.00
IUUC-Ola-087492	Oryzias latipes	92.34	0.00e+00	1565.00
IUUC-Oga-088084	Otolemur garnettii	80.68	0.00e+00	1352.00
IUUC-Oar-090354	Ovis aries	80.10	0.00e+00	1336.00
IUUC-Ptr-091456	Pan troglodytes	80.68	0.00e+00	1355.00
IUUC-Pan-092596	Papio anubis	79.73	0.00e+00	1332.00
IUUC-Psi-092942	Pelodiscus sinensis	80.92	0.00e+00	1346.00
IUUC-Pma-094662	Petromyzon marinus	61.80	0.00e+00	764.00
IUUC-Pfo-096838	Poecilia formosa	91.86	0.00e+00	1838.00
IUUC-Pab-097849	Pongo abelii	80.56	0.00e+00	1358.00
IUUC-Pca-100498	Procavia capensis	74.95	0.00e+00	721.00
IUUC-Pva-102599	Pteropus vampyrus	80.07	0.00e+00	1337.00
IUUC-Rno-105776	Rattus norvegicus	80.56	0.00e+00	1353.00
IUUC-Sha-106699	Sarcophilus harrisii	79.34	0.00e+00	1335.00
IUUC-Sar-113621	Sorex araneus	79.46	0.00e+00	1318.00
IUUC-Ssc-115742	Sus scrofa	80.44	0.00e+00	1357.00
IUUC-Tgu-116490	Taeniopygia guttata	80.19	0.00e+00	1345.00
IUUC-Tru-117679	Takifugu rubripes	93.67	0.00e+00	1541.00
IUUC-Tsy-119607	Tarsius syrichta	75.74	0.00e+00	922.00
IUUC-Tni-120376	Tetraodon nigroviridis	88.82	0.00e+00	1434.00
IUUC-Tbe-127348	Tupaia belangeri	68.73	3.00e-126	445.00
IUUC-Ttr-128786	Tursiops truncatus	77.16	0.00e+00	1290.00
IUUC-Vpa-130180	Vicugna pacos	78.20	0.00e+00	1046.00
IUUC-Xtr-132631	Xenopus tropicalis	66.63	0.00e+00	1112.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence