iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-041511

UUCD1 version

UUC-GaA-00285

Ensembl Protein ID

ENSGACP00000007671.1

UniProt Accession

G3NQQ5; G3NQQ5_GASAC

Protein Name

Uncharacterized protein

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000005788.1	ENSGACT00000007690.1	ENSGACP00000007671.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.50e-100	335.0	483	820

Active Site

Position(s)	Description	Evidence
788	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++e+ f++Ee+ld+gG+ re+++l++k l++++++lf ++s+n++  ++pn ++   ++ + k++ef+Gr++gk+l+++     
   Q: 483  SDWSKNFEIAFQDEEALDWGGPRREWFELVCKTLFDTSNQLFtRFSDNNQGLVHPNAERP--PHLRVKMYEFAGRVVGKCLYESavgga 569
           7999**************************************778888999999999998..459******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ d+e+yk+ + +i++n   d++e++l ++ ++ +++ +  k++eL++gG++i V+neNk 
   Q: 570  ykQLVRARFTRSFLAQIIGLRMNYKYFETDDQEFYKTkVCFILNN---DVSEMDLVFAEEKYSKSGQLEKVVELISGGSQIAVNNENKM 655
           99***********************************99****99...9**************************************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl ++++ ++e+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v+++f++e
   Q: 656  HYLNLLAQYRLASQVRDELEHFLKGLNELVPENLLAIFDENELELLMCGTGDINVQDFKAHAvIVGGSWHFREKVMKWFWAVVSSFTQE 744
           **************************************************************445778999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGf++l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+l+++L +Ai+e+ +gF++
   Q: 745  ELARLLQFTTGSSQLPPGGFNTLCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEELHKMLKLAISEGsEGFGM 820
           ************************99555555.******************************************97 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

MFYVIGGITV SIIAFVFTIK FLCELAARVV SFLQNEDPGR RGDRSIYDYV RGNYLDPRSC 60
KVSWDWTEPQ EVGQTMSFRV QLFYKNGQPF PAHRPVGLRV NITHIELALD IPVTQEVLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTTACG TGATTGGTGA GTCGAGTGTG AGCGCTTTGG GGTGTGGTCT CTTCGGGCTG 60
GTCCAGGCAT CGCTGGCGCG TAACTTCTTC TTTCTGTCAG GCACTTCTAC CTGCTTTACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	80.29	0.00e+00	1361.00
IUUC-Apl-004071	Anas platyrhynchos	77.64	0.00e+00	1289.00
IUUC-Aca-005218	Anolis carolinensis	79.25	0.00e+00	1341.00
IUUC-Ame-011871	Astyanax mexicanus	92.70	0.00e+00	1590.00
IUUC-Bta-012978	Bos taurus	79.95	0.00e+00	1357.00
IUUC-Cja-019081	Callithrix jacchus	79.95	0.00e+00	1353.00
IUUC-Cfa-020736	Canis familiaris	77.89	0.00e+00	1285.00
IUUC-Cpo-021581	Cavia porcellus	79.95	0.00e+00	1355.00
IUUC-Csa-024189	Chlorocebus sabaeus	72.73	0.00e+00	701.00
IUUC-Cho-024751	Choloepus hoffmanni	79.56	0.00e+00	1315.00
IUUC-Cin-025773	Ciona intestinalis	42.38	1.00e-149	523.00
IUUC-Csv-026090	Ciona savignyi	40.67	1.00e-174	606.00
IUUC-Dre-027788	Danio rerio	90.51	0.00e+00	1553.00
IUUC-Dno-030022	Dasypus novemcinctus	80.19	0.00e+00	1357.00
IUUC-Dme-031577	Drosophila melanogaster	47.49	0.00e+00	709.00
IUUC-Ete-032402	Echinops telfairi	78.32	0.00e+00	1293.00
IUUC-Eca-033908	Equus caballus	80.44	0.00e+00	1363.00
IUUC-Eeu-034869	Erinaceus europaeus	84.45	0.00e+00	823.00
IUUC-Fca-036023	Felis catus	80.19	0.00e+00	1359.00
IUUC-Fal-037477	Ficedula albicollis	80.07	0.00e+00	1343.00
IUUC-Gmo-039197	Gadus morhua	92.82	0.00e+00	1551.00
IUUC-Gga-040704	Gallus gallus	77.89	0.00e+00	1333.00
IUUC-Ggo-044527	Gorilla gorilla	76.94	0.00e+00	1281.00
IUUC-Hsa-046082	Homo sapiens	79.95	0.00e+00	1354.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	80.80	0.00e+00	1368.00
IUUC-Lch-049772	Latimeria chalumnae	74.12	0.00e+00	1198.00
IUUC-Loc-052541	Lepisosteus oculatus	89.20	0.00e+00	1520.00
IUUC-Laf-053852	Loxodonta africana	80.19	0.00e+00	1350.00
IUUC-Mcc-054759	Macaca mulatta	75.52	0.00e+00	634.00
IUUC-Meu-056247	Macropus eugenii	65.94	0.00e+00	715.00
IUUC-Mga-060161	Meleagris gallopavo	77.43	0.00e+00	1318.00
IUUC-Mmr-061447	Microcebus murinus	80.07	0.00e+00	1358.00
IUUC-Mdo-062110	Monodelphis domestica	78.37	0.00e+00	1324.00
IUUC-Mmu-064349	Mus musculus	80.07	0.00e+00	1358.00
IUUC-Mpu-065824	Mustela putorius furo	80.68	0.00e+00	1357.00
IUUC-Mlu-067729	Myotis lucifugus	80.19	0.00e+00	1338.00
IUUC-Nle-069721	Nomascus leucogenys	80.07	0.00e+00	1347.00
IUUC-Opr-070189	Ochotona princeps	79.80	0.00e+00	1344.00
IUUC-Ont-072122	Oreochromis niloticus	94.28	0.00e+00	1576.00
IUUC-Oan-072700	Ornithorhynchus anatinus	71.30	0.00e+00	1070.00
IUUC-Ocu-074057	Oryctolagus cuniculus	80.07	0.00e+00	1358.00
IUUC-Ola-087492	Oryzias latipes	93.19	0.00e+00	1587.00
IUUC-Oga-088084	Otolemur garnettii	80.17	0.00e+00	1355.00
IUUC-Oar-090354	Ovis aries	79.73	0.00e+00	1336.00
IUUC-Ptr-091456	Pan troglodytes	79.83	0.00e+00	1349.00
IUUC-Pan-092596	Papio anubis	78.88	0.00e+00	1327.00
IUUC-Psi-092942	Pelodiscus sinensis	79.95	0.00e+00	1340.00
IUUC-Pma-094662	Petromyzon marinus	61.48	0.00e+00	763.00
IUUC-Pfo-096838	Poecilia formosa	92.70	0.00e+00	1531.00
IUUC-Pab-097849	Pongo abelii	79.71	0.00e+00	1351.00
IUUC-Pca-100498	Procavia capensis	74.95	0.00e+00	725.00
IUUC-Pva-102599	Pteropus vampyrus	79.71	0.00e+00	1336.00
IUUC-Rno-105776	Rattus norvegicus	80.19	0.00e+00	1352.00
IUUC-Sha-106699	Sarcophilus harrisii	78.86	0.00e+00	1333.00
IUUC-Sar-113621	Sorex araneus	78.72	0.00e+00	1313.00
IUUC-Ssc-115742	Sus scrofa	79.95	0.00e+00	1358.00
IUUC-Tgu-116490	Taeniopygia guttata	79.47	0.00e+00	1337.00
IUUC-Tru-117679	Takifugu rubripes	92.82	0.00e+00	1560.00
IUUC-Tsy-119607	Tarsius syrichta	75.91	0.00e+00	925.00
IUUC-Tni-120376	Tetraodon nigroviridis	88.58	0.00e+00	1461.00
IUUC-Tbe-127348	Tupaia belangeri	55.78	6.00e-149	520.00
IUUC-Ttr-128786	Tursiops truncatus	76.79	0.00e+00	1291.00
IUUC-Vpa-130180	Vicugna pacos	77.89	0.00e+00	1046.00
IUUC-Xtr-132631	Xenopus tropicalis	65.86	0.00e+00	1114.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence