iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048168

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01020515

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000008036.2	ENSSTOT00000008068.2	ENSSTOP00000007223.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.20e-102	342.0	485	822

Active Site

Position(s)	Description	Evidence
790	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++++lf ++s+n+++ ++pnp++   ++ +lk++ef+Grl+gk+l+++     
   Q: 485  SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFtRFSDNNQALVHPNPNRP--PHLRLKMYEFAGRLVGKCLYESslgga 571
           7999**************************************888999***********8..459******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ +++ +  k++eL++gG+++pVtn+Nk 
   Q: 572  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKI 657
           99***********************************99****99...9****9****9999999************************ PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl +++ke+ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v++++++e
   Q: 658  FYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAvVVGGSWHFREKVMKWFWTVVSSLTQE 746
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 747  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHKMLQLAISEGcEGFGM 822
           ************************99555555.**************************************9***97 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MFYVIGGITV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC 60
KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HISHVELAVE IPVTQEVLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTTACG TTATTGGTAT GTTATAGAAA GAGCTTTCTT AATTATCTTT TTTTTTTAAT 60
TGTTACCAAG TTGCTTTTTG TTTCCATGAC TATTCCCTTC TCTCTTGAAA ACAGAGCTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	98.05	0.00e+00	1625.00
IUUC-Apl-004071	Anas platyrhynchos	91.62	0.00e+00	1478.00
IUUC-Aca-005218	Anolis carolinensis	91.38	0.00e+00	1503.00
IUUC-Ame-011871	Astyanax mexicanus	79.83	0.00e+00	1372.00
IUUC-Bta-012978	Bos taurus	97.45	0.00e+00	1619.00
IUUC-Cja-019081	Callithrix jacchus	97.81	0.00e+00	1624.00
IUUC-Cfa-020736	Canis familiaris	95.49	0.00e+00	1529.00
IUUC-Cpo-021581	Cavia porcellus	97.33	0.00e+00	1612.00
IUUC-Csa-024189	Chlorocebus sabaeus	96.24	0.00e+00	904.00
IUUC-Cho-024751	Choloepus hoffmanni	96.23	0.00e+00	1550.00
IUUC-Cin-025773	Ciona intestinalis	42.79	9.00e-149	520.00
IUUC-Csv-026090	Ciona savignyi	40.44	2.00e-172	599.00
IUUC-Dre-027788	Danio rerio	80.92	0.00e+00	1382.00
IUUC-Dno-030022	Dasypus novemcinctus	97.57	0.00e+00	1617.00
IUUC-Dme-031577	Drosophila melanogaster	47.37	0.00e+00	729.00
IUUC-Ete-032402	Echinops telfairi	95.12	0.00e+00	1533.00
IUUC-Eca-033908	Equus caballus	98.54	0.00e+00	1635.00
IUUC-Eeu-034869	Erinaceus europaeus	97.84	0.00e+00	922.00
IUUC-Fca-036023	Felis catus	98.06	0.00e+00	1626.00
IUUC-Fal-037477	Ficedula albicollis	92.35	0.00e+00	1538.00
IUUC-Gmo-039197	Gadus morhua	80.68	0.00e+00	1355.00
IUUC-Gga-040704	Gallus gallus	92.10	0.00e+00	1528.00
IUUC-Gac-041511	Gasterosteus aculeatus	79.95	0.00e+00	1370.00
IUUC-Ggo-044527	Gorilla gorilla	94.54	0.00e+00	1552.00
IUUC-Hsa-046082	Homo sapiens	97.93	0.00e+00	1625.00
IUUC-Lch-049772	Latimeria chalumnae	77.28	0.00e+00	1250.00
IUUC-Loc-052541	Lepisosteus oculatus	81.92	0.00e+00	1399.00
IUUC-Laf-053852	Loxodonta africana	97.57	0.00e+00	1613.00
IUUC-Mcc-054759	Macaca mulatta	97.00	0.00e+00	819.00
IUUC-Meu-056247	Macropus eugenii	78.86	0.00e+00	849.00
IUUC-Mga-060161	Meleagris gallopavo	91.26	0.00e+00	1509.00
IUUC-Mmr-061447	Microcebus murinus	98.18	0.00e+00	1625.00
IUUC-Mdo-062110	Monodelphis domestica	94.90	0.00e+00	1545.00
IUUC-Mmu-064349	Mus musculus	96.96	0.00e+00	1612.00
IUUC-Mpu-065824	Mustela putorius furo	97.93	0.00e+00	1627.00
IUUC-Mlu-067729	Myotis lucifugus	98.18	0.00e+00	1619.00
IUUC-Nle-069721	Nomascus leucogenys	97.45	0.00e+00	1614.00
IUUC-Opr-070189	Ochotona princeps	97.55	0.00e+00	1605.00
IUUC-Ont-072122	Oreochromis niloticus	81.29	0.00e+00	1363.00
IUUC-Oan-072700	Ornithorhynchus anatinus	84.30	0.00e+00	1225.00
IUUC-Ocu-074057	Oryctolagus cuniculus	97.81	0.00e+00	1622.00
IUUC-Ola-087492	Oryzias latipes	80.44	0.00e+00	1371.00
IUUC-Oga-088084	Otolemur garnettii	98.30	0.00e+00	1621.00
IUUC-Oar-090354	Ovis aries	97.54	0.00e+00	1597.00
IUUC-Ptr-091456	Pan troglodytes	97.81	0.00e+00	1622.00
IUUC-Pan-092596	Papio anubis	96.48	0.00e+00	1594.00
IUUC-Psi-092942	Pelodiscus sinensis	92.83	0.00e+00	1536.00
IUUC-Pma-094662	Petromyzon marinus	60.95	0.00e+00	755.00
IUUC-Pfo-096838	Poecilia formosa	80.92	0.00e+00	1344.00
IUUC-Pab-097849	Pongo abelii	97.45	0.00e+00	1619.00
IUUC-Pca-100498	Procavia capensis	95.99	0.00e+00	919.00
IUUC-Pva-102599	Pteropus vampyrus	98.30	0.00e+00	1629.00
IUUC-Rno-105776	Rattus norvegicus	97.08	0.00e+00	1611.00
IUUC-Sha-106699	Sarcophilus harrisii	95.02	0.00e+00	1551.00
IUUC-Sar-113621	Sorex araneus	95.94	0.00e+00	1575.00
IUUC-Ssc-115742	Sus scrofa	97.81	0.00e+00	1623.00
IUUC-Tgu-116490	Taeniopygia guttata	91.86	0.00e+00	1535.00
IUUC-Tru-117679	Takifugu rubripes	80.32	0.00e+00	1353.00
IUUC-Tsy-119607	Tarsius syrichta	93.56	0.00e+00	1116.00
IUUC-Tni-120376	Tetraodon nigroviridis	76.78	0.00e+00	1271.00
IUUC-Tbe-127348	Tupaia belangeri	67.16	9.00e-180	622.00
IUUC-Ttr-128786	Tursiops truncatus	94.41	0.00e+00	1554.00
IUUC-Vpa-130180	Vicugna pacos	97.44	0.00e+00	1299.00
IUUC-Xtr-132631	Xenopus tropicalis	67.75	0.00e+00	1137.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence