iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-101	339.4	485	822

Active Site

Position(s)	Description	Evidence
790	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++ +lf ++s+n+++ ++pnp++  +   +lk++ef+Grl+gk+l+++     
   Q: 485  SDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTSQLFtRFSDNNQALVHPNPNRPAH--LRLKMYEFAGRLVGKCLYESslgga 571
           7999**************************************888999***********975..9******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ +++ +  k +eL++gG+++pVtn+Nk 
   Q: 572  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DMSEMELVFAEEKYNKSGQLDKIVELMTGGAQTPVTNANKT 657
           99***********************************99****99...9****999**99999999999******************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl +++ke+ve+f +G+ne++p++ll++F+e+elell+cG+ +i+v+d+k+++    g ++ ++++++wFw v++++++e
   Q: 658  FYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAvVVGGSWHFREKVMRWFWTVVSSLTQE 746
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 747  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGcEGFGM 822
           ************************99555555.**************************************9***97 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MFYVIGGIIV SVVAFFFTIK FLFELAARVV SFLQNEDRER RGDRTIYDYV RGNYLDPRSC 60
KVSWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLRV HISHVELAVE IPVTQEVLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCAACCCG GAGGCGGAAG CTACTTTGGG AAACGGAAAA GCTCGGAGCC GGCTCTTAAC 60
GCTGGCGAAG ATCTACACTG GGGGTTTTTC TGGGGGGCGG GTGGAGGGTA GGTTTTGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

rno:299197

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	97.08	0.00e+00	1623.00
IUUC-Apl-004071	Anas platyrhynchos	91.37	0.00e+00	1485.00
IUUC-Aca-005218	Anolis carolinensis	91.26	0.00e+00	1504.00
IUUC-Ame-011871	Astyanax mexicanus	79.71	0.00e+00	1384.00
IUUC-Bta-012978	Bos taurus	96.48	0.00e+00	1614.00
IUUC-Cja-019081	Callithrix jacchus	97.69	0.00e+00	1632.00
IUUC-Cfa-020736	Canis familiaris	94.88	0.00e+00	1529.00
IUUC-Cpo-021581	Cavia porcellus	96.72	0.00e+00	1618.00
IUUC-Csa-024189	Chlorocebus sabaeus	95.82	0.00e+00	909.00
IUUC-Cho-024751	Choloepus hoffmanni	95.75	0.00e+00	1548.00
IUUC-Cin-025773	Ciona intestinalis	41.95	2.00e-147	516.00
IUUC-Csv-026090	Ciona savignyi	39.07	6.00e-173	601.00
IUUC-Dre-027788	Danio rerio	80.80	0.00e+00	1395.00
IUUC-Dno-030022	Dasypus novemcinctus	96.60	0.00e+00	1613.00
IUUC-Dme-031577	Drosophila melanogaster	47.56	0.00e+00	733.00
IUUC-Ete-032402	Echinops telfairi	94.14	0.00e+00	1531.00
IUUC-Eca-033908	Equus caballus	97.81	0.00e+00	1634.00
IUUC-Eeu-034869	Erinaceus europaeus	97.84	0.00e+00	924.00
IUUC-Fca-036023	Felis catus	97.21	0.00e+00	1625.00
IUUC-Fal-037477	Ficedula albicollis	91.62	0.00e+00	1535.00
IUUC-Gmo-039197	Gadus morhua	80.56	0.00e+00	1363.00
IUUC-Gga-040704	Gallus gallus	91.86	0.00e+00	1533.00
IUUC-Gac-041511	Gasterosteus aculeatus	79.34	0.00e+00	1372.00
IUUC-Ggo-044527	Gorilla gorilla	94.17	0.00e+00	1555.00
IUUC-Hsa-046082	Homo sapiens	97.69	0.00e+00	1634.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	97.08	0.00e+00	1625.00
IUUC-Lch-049772	Latimeria chalumnae	76.91	0.00e+00	1247.00
IUUC-Loc-052541	Lepisosteus oculatus	81.82	0.00e+00	1406.00
IUUC-Laf-053852	Loxodonta africana	96.48	0.00e+00	1608.00
IUUC-Mcc-054759	Macaca mulatta	96.30	0.00e+00	822.00
IUUC-Meu-056247	Macropus eugenii	77.68	0.00e+00	835.00
IUUC-Mga-060161	Meleagris gallopavo	90.78	0.00e+00	1511.00
IUUC-Mmr-061447	Microcebus murinus	97.45	0.00e+00	1628.00
IUUC-Mdo-062110	Monodelphis domestica	94.05	0.00e+00	1535.00
IUUC-Mmu-064349	Mus musculus	97.81	0.00e+00	1638.00
IUUC-Mpu-065824	Mustela putorius furo	97.08	0.00e+00	1622.00
IUUC-Mlu-067729	Myotis lucifugus	97.08	0.00e+00	1602.00
IUUC-Nle-069721	Nomascus leucogenys	97.69	0.00e+00	1629.00
IUUC-Opr-070189	Ochotona princeps	97.43	0.00e+00	1617.00
IUUC-Ont-072122	Oreochromis niloticus	81.04	0.00e+00	1367.00
IUUC-Oan-072700	Ornithorhynchus anatinus	84.16	0.00e+00	1219.00
IUUC-Ocu-074057	Oryctolagus cuniculus	97.08	0.00e+00	1625.00
IUUC-Ola-087492	Oryzias latipes	79.10	0.00e+00	1370.00
IUUC-Oga-088084	Otolemur garnettii	97.57	0.00e+00	1624.00
IUUC-Oar-090354	Ovis aries	96.93	0.00e+00	1599.00
IUUC-Ptr-091456	Pan troglodytes	97.45	0.00e+00	1627.00
IUUC-Pan-092596	Papio anubis	96.24	0.00e+00	1601.00
IUUC-Psi-092942	Pelodiscus sinensis	92.35	0.00e+00	1535.00
IUUC-Pma-094662	Petromyzon marinus	62.37	0.00e+00	758.00
IUUC-Pfo-096838	Poecilia formosa	80.68	0.00e+00	1348.00
IUUC-Pab-097849	Pongo abelii	97.21	0.00e+00	1625.00
IUUC-Pca-100498	Procavia capensis	95.39	0.00e+00	927.00
IUUC-Pva-102599	Pteropus vampyrus	97.21	0.00e+00	1615.00
IUUC-Sha-106699	Sarcophilus harrisii	94.17	0.00e+00	1540.00
IUUC-Sar-113621	Sorex araneus	95.57	0.00e+00	1580.00
IUUC-Ssc-115742	Sus scrofa	97.33	0.00e+00	1627.00
IUUC-Tgu-116490	Taeniopygia guttata	91.37	0.00e+00	1536.00
IUUC-Tru-117679	Takifugu rubripes	79.95	0.00e+00	1356.00
IUUC-Tsy-119607	Tarsius syrichta	92.90	0.00e+00	1121.00
IUUC-Tni-120376	Tetraodon nigroviridis	76.66	0.00e+00	1278.00
IUUC-Tbe-127348	Tupaia belangeri	66.79	0.00e+00	629.00
IUUC-Ttr-128786	Tursiops truncatus	93.56	0.00e+00	1553.00
IUUC-Vpa-130180	Vicugna pacos	96.39	0.00e+00	1293.00
IUUC-Xtr-132631	Xenopus tropicalis	67.52	0.00e+00	1134.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence