iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000016130.2	ENSNLET00000020567.1	ENSNLEP00000019577.1
ENSNLEG00000016130.2	ENSNLET00000032296.1	ENSNLEP00000023925.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.00e-30	102.5	535	567
UBD/Beta-Prp	8.00e-46	156.5	531	745

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlr 31
           gHtd v++la+   +  +l+s+s Dgt+++W+++
   Q: 535  GHTDAVWGLAYsaaH-QRLLSCSADGTLRLWNTT 567
           8**********9853.89**************76 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk......ghedsvlslsfspsgdklvsGshdrtirvwdletgqc 128
             l gh+++v+ + +s   + l+++s D+t+++w+     +  ++       g  +sv ++s++p  +++v+  +  +  ++++et+q 
   Q: 531  GPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFndtkelGIPASVDLVSSDP--SHMVASFSKGYTSIFNMETQQR 617
           5689******************************7775555444442666667777777788888..888888889************* PP
   S: 129  lee......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqt 211
           + +      t ++ +  +n v +hp+  + ++++ Dr ++++d +tgkl++ +   h ++v+sl++d+ng +l+sgs+d +++lw+l++
   Q: 618  ILTlesnvdTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVA-HLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLES 705
           ***9999998888888999999***99**************************98.********************************* PP
   S: 212  gecvrtlnght....dnvksvrfspnderlvsgssDgsir 247
           ++c++++++h+    + + +v+f+p + +++s+++D   +
   Q: 706  KTCIQEFTAHRkkfeESIHDVAFHPSKCYIASAGADALAK 745
           ***********999999******************97655 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MLKLLQDLLQ VDCKGKETST EQFFRWAVNK PQFGNSSRKL RHCLRKAQIA FLQGERKGQE 60
NLKKDLVRRI KMLEYALKQE RAKYHKLKYG TELNQGDMKP PSYDSDEGNE TEVQPQQNSQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTAAAAC TTTTACAGGA TTTACTGCAG GTGGACTGCA AAGGGAAAGA AACTTCAACG 60
GAGCAGTTTT TCAGATGGGC TGTCAACAAA CCACAATTTG GAAACAGCAG CAGAAAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013258--Striatin_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08232--Striatin
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005923--C:bicellular tight junction
GO:0000159--C:protein phosphatase type 2A complex
GO:0008285--P:negative regulation of cell proliferation
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001899	Ailuropoda melanoleuca	97.87	0.00e+00	1295.00
IUUC-Apl-003927	Anas platyrhynchos	88.35	0.00e+00	1125.00
IUUC-Aca-004933	Anolis carolinensis	81.15	0.00e+00	1133.00
IUUC-Ate-010457	Aspergillus terreus	26.49	2.00e-29	124.00
IUUC-Ame-010997	Astyanax mexicanus	75.00	0.00e+00	985.00
IUUC-Bta-013077	Bos taurus	97.58	0.00e+00	1288.00
IUUC-Cja-018973	Callithrix jacchus	99.29	0.00e+00	1309.00
IUUC-Cfa-020988	Canis familiaris	94.17	0.00e+00	1234.00
IUUC-Cpo-022496	Cavia porcellus	96.73	0.00e+00	1291.00
IUUC-Csa-023829	Chlorocebus sabaeus	98.86	0.00e+00	1302.00
IUUC-Dre-028560	Danio rerio	69.54	0.00e+00	887.00
IUUC-Dno-029742	Dasypus novemcinctus	91.18	0.00e+00	1224.00
IUUC-Dor-030721	Dipodomys ordii	88.34	0.00e+00	1160.00
IUUC-Eca-033760	Equus caballus	97.87	0.00e+00	1290.00
IUUC-Eeu-034953	Erinaceus europaeus	97.14	0.00e+00	755.00
IUUC-Fca-036530	Felis catus	97.30	0.00e+00	1291.00
IUUC-Fal-037353	Ficedula albicollis	82.31	0.00e+00	898.00
IUUC-Gga-040132	Gallus gallus	88.34	0.00e+00	1118.00
IUUC-Gac-041713	Gasterosteus aculeatus	74.79	0.00e+00	978.00
IUUC-Ggo-045455	Gorilla gorilla	88.54	0.00e+00	1108.00
IUUC-Hsa-046415	Homo sapiens	99.43	0.00e+00	1310.00
IUUC-Lch-050475	Latimeria chalumnae	84.26	0.00e+00	1110.00
IUUC-Loc-051859	Lepisosteus oculatus	79.38	0.00e+00	1053.00
IUUC-Laf-053537	Loxodonta africana	96.73	0.00e+00	1301.00
IUUC-Mcc-055817	Macaca mulatta	98.86	0.00e+00	1302.00
IUUC-Meu-055946	Macropus eugenii	67.81	0.00e+00	798.00
IUUC-Mga-059694	Meleagris gallopavo	88.19	0.00e+00	1116.00
IUUC-Mmr-060768	Microcebus murinus	98.29	0.00e+00	1294.00
IUUC-Mdo-061901	Monodelphis domestica	87.98	0.00e+00	1207.00
IUUC-Mmu-064154	Mus musculus	96.16	0.00e+00	1278.00
IUUC-Mpu-065827	Mustela putorius furo	92.21	0.00e+00	1282.00
IUUC-Mlu-067102	Myotis lucifugus	97.01	0.00e+00	1285.00
IUUC-Ncr-068831	Neurospora crassa	39.60	5.00e-22	99.80
IUUC-Opr-071067	Ochotona princeps	63.40	5.00e-167	581.00
IUUC-Ont-072025	Oreochromis niloticus	74.33	0.00e+00	966.00
IUUC-Oan-072950	Ornithorhynchus anatinus	92.07	0.00e+00	1171.00
IUUC-Ocu-074316	Oryctolagus cuniculus	97.44	0.00e+00	1279.00
IUUC-Ola-087279	Oryzias latipes	72.01	0.00e+00	943.00
IUUC-Oga-088284	Otolemur garnettii	97.58	0.00e+00	1292.00
IUUC-Oar-090304	Ovis aries	98.01	0.00e+00	1295.00
IUUC-Ptr-091052	Pan troglodytes	99.57	0.00e+00	1311.00
IUUC-Pan-092270	Papio anubis	94.61	0.00e+00	1262.00
IUUC-Psi-093907	Pelodiscus sinensis	88.63	0.00e+00	1053.00
IUUC-Pfo-097042	Poecilia formosa	73.25	0.00e+00	1039.00
IUUC-Pab-098110	Pongo abelii	99.57	0.00e+00	1311.00
IUUC-Pca-100266	Procavia capensis	83.33	0.00e+00	892.00
IUUC-Pva-102824	Pteropus vampyrus	95.31	0.00e+00	1241.00
IUUC-Pgr-103483	Puccinia graminis	36.99	2.00e-56	214.00
IUUC-Rno-105638	Rattus norvegicus	96.16	0.00e+00	1283.00
IUUC-Sha-107004	Sarcophilus harrisii	87.99	0.00e+00	1124.00
IUUC-Ssc-115280	Sus scrofa	98.15	0.00e+00	1295.00
IUUC-Tgu-116759	Taeniopygia guttata	88.76	0.00e+00	1145.00
IUUC-Tru-117944	Takifugu rubripes	74.19	0.00e+00	966.00
IUUC-Tsy-119405	Tarsius syrichta	86.75	0.00e+00	1089.00
IUUC-Tni-120571	Tetraodon nigroviridis	73.57	0.00e+00	972.00
IUUC-Vpa-130294	Vicugna pacos	97.29	0.00e+00	1277.00
IUUC-Xma-134233	Xiphophorus maculatus	67.28	0.00e+00	879.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence