iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-092971

Ensembl Protein ID

ENSPSIP00000012638.1

UniProt Accession

K7FX78; K7FX78_PELSI

Genbank Protein ID

ENSPSIP00000012638

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGCU01130517

Gene Name

USP33

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000011185.1	ENSPSIT00000012699.1	ENSPSIP00000012638.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.00e-114	381.3	154	684

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++l+     + + +++++k +++ks+ kl++elw ks+ ++v p++l++ +k+++++f+gy+
   Q: 154  TGLKNIGNTCYMNAALQALSNCPPLTQFFLD-----CGALARTDKKPAICKSYLKLMTELWhKSRPGSVVPTNLFQGIKTINPMFRGYS 237
           7******************************.....9999999******************99************************** PP
   S: 89   qqDaqEflaflldqleeelkk.......eknkpkeeeeeedkselsde......................................... 129
           qqDaqEfl++l+d l+eelk+                   ++++ +++                                         
   Q: 238  QQDAQEFLRCLMDLLHEELKEpvmeiedT-----------QSTSIEENveedkslsdvdfqscescgssdkaenetgsrpfsedhaeat 315
           *******************7765555533...........3333333333444455557****************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 316  mliqddenhsltskdwqkektlynklnlassmedlkkdtniasetaeflhnpgtvkvqihsrisdyindvhmtdlsapqsppsnegvna 404
           ***************************************************************************************** PP
   S: 130  ............................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..... 185
                                        ++kk+kk+ks+isd+F+g++ s+++cl+cd+vs++ e+f+dlslp+pgke+ +k+     
   Q: 405  hlsttppksaslwsglatahkkvptvssPKKKKHKKYKSVISDIFDGTIVSSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLhsssh 493
           ***************************98899999********************************************99888***** PP
   S: 186  ............................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                       +lqdcL++f++++el+g+n+y+cekckk+++ +k +k++k+Pe+L
   Q: 494  qtsliktgscgeayapqgwiaffveyfkrfviscvpswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEIL 582
           ***************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtev 317
           ++hLkRf  ++e ++++ki ++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G++ssGHY+ay++n+ ++ W++fdD++Vtev
   Q: 583  CIHLKRF--RHELMFSTKIGTHVSFPLEgLDLQPFVAKDSPAQ--IVTYDLLSVICHHGTASSGHYIAYCRNNLNNlWYEFDDQSVTEV 667
           *******..9999*************************88777..9**************************88889************ PP
   S: 318  keeevleetgstaYvlfYkr 337
           +e++v++   ++aYvlfY++
   Q: 668  PESTVQN---AEAYVLFYRK 684
           *******...********98 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

KMSALSCDCP HLESVGEITK EELIQKSHGT CQDCKVRGPN LWACLENRCS YVGCGESHVD 60
HSTIHSQDTK HCLTVNLTTL RVWCYACSKE VFLDRKLGSH SPLPNARLSH QTQGNSLQDF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGGCGGAT CAGGCAGTAG GAAGCGGAAG GAGCTGCCGC TGCGGGCAGC AGGGACAAGC 60
GAACACCGGC TACCGCCAAG CAGGTGAGGC TGCCGCGCAG CGAGTATGGA GCCCGGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005776--C:autophagosome
GO:0044297--C:cell body
GO:0005813--C:centrosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0009267--P:cellular response to starvation
GO:0051298--P:centrosome duplication
GO:0032091--P:negative regulation of protein binding
GO:0032092--P:positive regulation of protein binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	82.92	0.00e+00	1530.00
IUUC-Apl-003987	Anas platyrhynchos	86.42	0.00e+00	1574.00
IUUC-Aca-004713	Anolis carolinensis	80.39	0.00e+00	1459.00
IUUC-Bta-013132	Bos taurus	83.06	0.00e+00	1529.00
IUUC-Cel-018627	Caenorhabditis elegans	34.16	1.00e-37	151.00
IUUC-Cja-018811	Callithrix jacchus	83.17	0.00e+00	1541.00
IUUC-Cfa-021158	Canis familiaris	83.13	0.00e+00	1539.00
IUUC-Cpo-021910	Cavia porcellus	76.61	0.00e+00	1354.00
IUUC-Csa-023130	Chlorocebus sabaeus	83.15	0.00e+00	1536.00
IUUC-Cho-024383	Choloepus hoffmanni	63.81	6.00e-147	514.00
IUUC-Csv-025889	Ciona savignyi	43.71	3.00e-35	140.00
IUUC-Dre-028639	Danio rerio	71.00	0.00e+00	1265.00
IUUC-Dno-029416	Dasypus novemcinctus	82.73	0.00e+00	1507.00
IUUC-Ete-032994	Echinops telfairi	67.72	0.00e+00	708.00
IUUC-Eca-034248	Equus caballus	83.30	0.00e+00	1535.00
IUUC-Eeu-035357	Erinaceus europaeus	66.52	0.00e+00	1123.00
IUUC-Fca-036013	Felis catus	80.81	0.00e+00	1480.00
IUUC-Fal-037509	Ficedula albicollis	85.40	0.00e+00	1571.00
IUUC-Gmo-038944	Gadus morhua	67.18	0.00e+00	1193.00
IUUC-Gga-040647	Gallus gallus	84.54	0.00e+00	1538.00
IUUC-Gac-041752	Gasterosteus aculeatus	69.77	0.00e+00	1263.00
IUUC-Hsa-045694	Homo sapiens	82.51	0.00e+00	1521.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	82.62	0.00e+00	1507.00
IUUC-Kpa-049198	Komagataella pastoris	33.20	5.00e-29	122.00
IUUC-Lch-050400	Latimeria chalumnae	71.58	0.00e+00	1300.00
IUUC-Loc-052616	Lepisosteus oculatus	72.32	0.00e+00	1329.00
IUUC-Laf-053493	Loxodonta africana	83.08	0.00e+00	1531.00
IUUC-Mcc-055542	Macaca mulatta	83.39	0.00e+00	1541.00
IUUC-Meu-056645	Macropus eugenii	69.98	0.00e+00	1204.00
IUUC-Mga-060019	Meleagris gallopavo	84.69	0.00e+00	1301.00
IUUC-Mmr-061241	Microcebus murinus	80.22	0.00e+00	1489.00
IUUC-Mmu-063786	Mus musculus	80.74	0.00e+00	1462.00
IUUC-Mpu-065772	Mustela putorius furo	83.49	0.00e+00	1272.00
IUUC-Mlu-067732	Myotis lucifugus	81.74	0.00e+00	1510.00
IUUC-Nle-069528	Nomascus leucogenys	82.37	0.00e+00	1538.00
IUUC-Opr-070606	Ochotona princeps	79.02	0.00e+00	1359.00
IUUC-Ont-071495	Oreochromis niloticus	71.41	0.00e+00	1270.00
IUUC-Oan-073695	Ornithorhynchus anatinus	83.18	0.00e+00	1030.00
IUUC-Ocu-074457	Oryctolagus cuniculus	81.22	0.00e+00	1495.00
IUUC-Ola-086739	Oryzias latipes	69.34	0.00e+00	1281.00
IUUC-Oga-088720	Otolemur garnettii	83.15	0.00e+00	1543.00
IUUC-Oar-089921	Ovis aries	82.97	0.00e+00	1533.00
IUUC-Ptr-090526	Pan troglodytes	82.62	0.00e+00	1525.00
IUUC-Pan-092396	Papio anubis	83.22	0.00e+00	1533.00
IUUC-Pfo-097415	Poecilia formosa	70.03	0.00e+00	1275.00
IUUC-Pab-098740	Pongo abelii	83.02	0.00e+00	1559.00
IUUC-Pva-102820	Pteropus vampyrus	79.63	0.00e+00	1285.00
IUUC-Rno-104894	Rattus norvegicus	80.44	0.00e+00	1465.00
IUUC-Sha-107244	Sarcophilus harrisii	74.57	0.00e+00	1329.00
IUUC-Sar-113665	Sorex araneus	81.09	0.00e+00	1522.00
IUUC-Ssc-115793	Sus scrofa	80.90	0.00e+00	1467.00
IUUC-Tgu-117487	Taeniopygia guttata	85.96	0.00e+00	1533.00
IUUC-Tru-117694	Takifugu rubripes	68.89	0.00e+00	1275.00
IUUC-Tsy-119598	Tarsius syrichta	73.03	0.00e+00	1253.00
IUUC-Tni-120189	Tetraodon nigroviridis	66.99	0.00e+00	1198.00
IUUC-Tbe-128125	Tupaia belangeri	73.75	1.00e-96	347.00
IUUC-Ttr-128269	Tursiops truncatus	80.66	0.00e+00	1427.00
IUUC-Vpa-130598	Vicugna pacos	81.35	0.00e+00	1489.00
IUUC-Xtr-132044	Xenopus tropicalis	74.62	0.00e+00	1315.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence