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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046169
UUCD1 version UUC-HoS-00452
Ensembl Protein ID ENSP00000351250.2
UniProt Accession Q9UPN9; O95855; Q5TG72; Q5TG73; Q5TG74; Q9C017; Q9UJ79; TRI33_HUMAN
Genbank Protein ID AAD17259.1; AAG53509.1; AAG53510.1; BAA83065.1; CAI13548.1; CAI13548.1; CAI13550.1; CAI13550.1; CAI13551.1; CAI13551.1; CAI21895.1; CAI21895.1; CAI21896.1; CAI21896.1; CAI21897.1; CAI21897.1; CAB55313.1
Protein Name E3 ubiquitin-protein ligase TRIM33; Ectodermin homolog; RET-fused gene 7 protein; RING-type E3 ubiquitin transferase TRIM33; Transcription intermediary factor 1-gamma; Tripartite motif-containing protein 33
Genbank Nucleotide ID AF119043; AF220136; AF220137; AB029036; AL390241; AL035410; AL390241; AL035410; AL390241; AL035410; AL035410; AL390241; AL035410; AL390241; AL035410; AL390241; AJ132948
Gene Name TRIM33; KIAA1113; RFG7; TIF1G
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000197323.11 ENST00000358465.6 ENSP00000351250.2
ENSG00000197323.11 ENST00000448034.5 ENSP00000402333.1
ENSG00000197323.11 ENST00000369543.6 ENSP00000358556.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbGWAS CentralOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 15820681; 17189380; 20447379; 21726812; 24881051
E3 activity/RING/PHD PHD 15820681; 17189380; 21726812; 24881051
Classification
Family E-value Score Start End
E3 activity/RING/PHD 1.00e-08 36.9 888 933
E3 activity/RING/RING 1.10e-05 27.5 125 185
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C+vC++gg+    l++CekC ++fH +C+ ++   ++p+ + wiC+ Cr+
   Q: 888  DWCAVCQNGGD----LLCCEKCPKVFHLTCHVPT-LLSFPSGD-WICTFCRD 933
           79*********....*******************.*******7.******85 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledf....kdgplvlpCgHvfhadCl...qkw........pglknssskefrCPlCr 46
           Ca+C++++    + +p++lpC H f++ Cl   ++          +   ++ + +rCP+Cr
   Q: 125  CAVCQQSLqsrrEAEPKLLPCLHSFCLRCLpepERQlsvpipggSNGDIQQVGVIRCPVCR 185
           ******999888556***************88844468888666555556667779****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
 Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
Protein Sequence
(Fasta)
MAENKGGGEA ESGGGGSGSA PVTAGAAGPA AQEAEPPLTA VLVEEEEEEG GRAGAEGGAA 60
GPDDGGVAAA SSGSAQAASS PAASVGTGVA GGAVSTPAPA PASAPAPGPS AGPPPGPPAS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046169|E3,RING;E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGCGGCTGG GGCTGGGGGC GGCGGCGGCG GCGACGCGGG CGGCGGGCGG CGCGGGGCGG 60
TCCGGCGGGT TCAAAGAGGA AAACATGGCG GAAAACAAAG GCGGCGGCGA GGCTGAGAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046169|E3,RING;E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003649--Bbox_C
IPR001487--Bromodomain
IPR019786--Zinc_finger_PHD-type_CS
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50014--BROMODOMAIN_2
PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00439--Bromodomain
PF00628--PHD
PF00643--zf-B_box
PF13445--zf-RING_UBOX
PRINTS

PR00503--BROMODOMAIN
SMART

SM00502--BBC
SM00336--BBOX
SM00297--BROMO
SM00249--PHD
SM00184--RING
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0070410--F:co-SMAD binding
GO:0003677--F:DNA binding
GO:0070412--F:R-SMAD binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0016567--P:protein ubiquitination
GO:0017015--P:regulation of transforming growth factor beta receptor signaling pathway
GO:0006351--P:transcription, DNA-templated
KEGG hsa:51592
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002364 Ailuropoda melanoleuca 98.22 0.00e+00 1746.00
IUUC-Apl-003894 Anas platyrhynchos 91.46 0.00e+00 1602.00
IUUC-Aca-004658 Anolis carolinensis 90.25 0.00e+00 1563.00
IUUC-Ame-011619 Astyanax mexicanus 60.34 0.00e+00 1060.00
IUUC-Bta-013341 Bos taurus 96.23 0.00e+00 1702.00
IUUC-Cja-018733 Callithrix jacchus 99.30 0.00e+00 1775.00
IUUC-Cfa-020725 Canis familiaris 99.10 0.00e+00 1720.00
IUUC-Cpo-021833 Cavia porcellus 98.41 0.00e+00 1742.00
IUUC-Csa-023040 Chlorocebus sabaeus 99.80 0.00e+00 1721.00
IUUC-Cho-024934 Choloepus hoffmanni 95.79 0.00e+00 1626.00
IUUC-Cin-025200 Ciona intestinalis 31.97 2.00e-45 178.00
IUUC-Csv-026278 Ciona savignyi 47.25 5.00e-20 91.30
IUUC-Dre-027797 Danio rerio 73.18 2.00e-172 600.00
IUUC-Dno-028955 Dasypus novemcinctus 98.11 0.00e+00 1805.00
IUUC-Dme-032143 Drosophila melanogaster 31.98 4.00e-45 177.00
IUUC-Ete-032728 Echinops telfairi 95.87 0.00e+00 926.00
IUUC-Eca-033573 Equus caballus 98.02 0.00e+00 1723.00
IUUC-Eeu-035138 Erinaceus europaeus 86.42 0.00e+00 828.00
IUUC-Fca-035776 Felis catus 98.95 0.00e+00 1632.00
IUUC-Fal-037583 Ficedula albicollis 91.53 0.00e+00 1632.00
IUUC-Gmo-039353 Gadus morhua 61.97 0.00e+00 663.00
IUUC-Gga-040874 Gallus gallus 92.06 0.00e+00 1707.00
IUUC-Gac-041689 Gasterosteus aculeatus 55.93 0.00e+00 1103.00
IUUC-Ggo-045151 Gorilla gorilla 99.16 0.00e+00 1335.00
IUUC-Itr-048377 Ictidomys tridecemlineatus 97.95 0.00e+00 751.00
IUUC-Lch-050411 Latimeria chalumnae 81.69 0.00e+00 1381.00
IUUC-Loc-051992 Lepisosteus oculatus 71.98 0.00e+00 1295.00
IUUC-Laf-054552 Loxodonta africana 98.32 0.00e+00 1653.00
IUUC-Mcc-055744 Macaca mulatta 99.70 0.00e+00 1716.00
IUUC-Meu-056647 Macropus eugenii 99.15 0.00e+00 707.00
IUUC-Mga-059589 Meleagris gallopavo 92.49 0.00e+00 959.00
IUUC-Mmr-060727 Microcebus murinus 99.60 0.00e+00 1751.00
IUUC-Mdo-063029 Monodelphis domestica 96.43 0.00e+00 1751.00
IUUC-Mmu-064033 Mus musculus 96.92 0.00e+00 1762.00
IUUC-Mpu-066679 Mustela putorius furo 98.61 0.00e+00 1736.00
IUUC-Mlu-067286 Myotis lucifugus 97.79 0.00e+00 1633.00
IUUC-Nle-069156 Nomascus leucogenys 99.50 0.00e+00 1714.00
IUUC-Opr-070309 Ochotona princeps 87.85 0.00e+00 1279.00
IUUC-Ont-071586 Oreochromis niloticus 54.27 0.00e+00 1048.00
IUUC-Oan-073205 Ornithorhynchus anatinus 94.85 0.00e+00 1460.00
IUUC-Ocu-074667 Oryctolagus cuniculus 96.03 0.00e+00 1622.00
IUUC-Ola-086481 Oryzias latipes 67.23 3.00e-165 576.00
IUUC-Oga-089101 Otolemur garnettii 98.41 0.00e+00 1732.00
IUUC-Oar-090167 Ovis aries 98.21 0.00e+00 1748.00
IUUC-Ptr-090901 Pan troglodytes 99.90 0.00e+00 1724.00
IUUC-Pan-092448 Papio anubis 97.62 0.00e+00 1717.00
IUUC-Psi-093657 Pelodiscus sinensis 91.76 0.00e+00 1483.00
IUUC-Pma-094506 Petromyzon marinus 65.91 1.00e-50 191.00
IUUC-Pfo-097104 Poecilia formosa 69.15 7.00e-160 558.00
IUUC-Pab-097704 Pongo abelii 99.80 0.00e+00 1758.00
IUUC-Pca-101001 Procavia capensis 88.16 0.00e+00 652.00
IUUC-Pva-102733 Pteropus vampyrus 94.18 0.00e+00 1566.00
IUUC-Rno-105512 Rattus norvegicus 97.91 0.00e+00 1757.00
IUUC-Sha-107423 Sarcophilus harrisii 95.41 0.00e+00 1625.00
IUUC-Sar-113181 Sorex araneus 89.25 9.00e-146 511.00
IUUC-Ssc-116330 Sus scrofa 93.28 0.00e+00 1525.00
IUUC-Tgu-117388 Taeniopygia guttata 75.97 0.00e+00 1267.00
IUUC-Tru-118728 Takifugu rubripes 57.48 0.00e+00 978.00
IUUC-Tsy-119053 Tarsius syrichta 98.73 0.00e+00 1052.00
IUUC-Tni-120279 Tetraodon nigroviridis 47.81 3.00e-162 565.00
IUUC-Tbe-127573 Tupaia belangeri 90.04 0.00e+00 840.00
IUUC-Ttr-128594 Tursiops truncatus 98.31 0.00e+00 1743.00
IUUC-Vpa-130619 Vicugna pacos 92.32 0.00e+00 1097.00
IUUC-Xtr-132837 Xenopus tropicalis 85.02 0.00e+00 1499.00
Created Date 25-Jun-2017

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