iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010791

Ensembl Protein ID

ENSAMXP00000018194.1

UniProt Accession

W5LED2; W5LED2_ASTMX

Genbank Protein ID

ENSAMXP00000018194

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

APWO01020032

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000017664.1	ENSAMXT00000018194.1	ENSAMXP00000018194.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.30e-97	327.5	1	316

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
164	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++ + ew+ +esdPg+ft+l++ fg+k+  qvee++s++pen++ + +pv+gl++lFk+++ +e +          ++v+++ +++if
   Q: 1    MSGSAGEWCLMESDPGVFTELIKGFGCKGA-QVEEIWSMEPENFENL-KPVHGLIFLFKWQPGEEPAG---------SIVQDSRLDQIF 78
           678889************************.****************.*******************9.........8899******** PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc++  ++lG+tl ++ke+++++++ +k+lal+n++v++++hns+ar+++++ + +       ++++af
   Q: 79   FAKQVINNACATQAIVSVLLNCTHSDMHLGETLTEFKEFSNSFDAAMKGLALSNSEVIRQVHNSFARQQMFEFDAKSTS----KDEDAF 163
           *************************************************************************987744....589*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i++ ++  l+ +        
   Q: 164  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWINAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYERKISELQAQlseeepmd 249
           **************************9.78999*********..******************************998888888888888 PP
   S: 260  .keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveet 325
             +  +Ll+ i+se++k++  +++e++k k++ki++irR++ny  fi++++k+la+ ++l  lve+ 
   Q: 250  tDQGGNLLSSIQSEIAKYQLLIEEENQKLKRYKIENIRRKHNYLPFIMELLKTLAEYQQLIPLVEKA 316
           745567**********************************************************984 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MSGSAGEWCL MESDPGVFTE LIKGFGCKGA QVEEIWSMEP ENFENLKPVH GLIFLFKWQP 60
GEEPAGSIVQ DSRLDQIFFA KQVINNACAT QAIVSVLLNC THSDMHLGET LTEFKEFSNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGGACAGA GGGTGGCGGT GTCGGGTCTG AGCGGTTGGG AGAGCGCGCG GCGAGGAGAA 60
GGCTGTGTGT GAATGAGCGC TGGAGAGTCT GTTGGTTGAT TCAGTAGCAG CGCTGCAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0031011--C:Ino80 complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	45.95	5.00e-83	301.00
IUUC-Aml-001866	Ailuropoda melanoleuca	90.73	5.00e-175	606.00
IUUC-Atr-002966	Amborella trichopoda	46.84	9.00e-81	293.00
IUUC-Apl-003306	Anas platyrhynchos	82.12	7.00e-172	596.00
IUUC-Aca-004763	Anolis carolinensis	92.60	6.00e-177	613.00
IUUC-Aly-005581	Arabidopsis lyrata	48.63	2.00e-79	289.00
IUUC-Ath-007283	Arabidopsis thaliana	48.33	2.00e-81	295.00
IUUC-Ago-007999	Ashbya gossypii	33.44	9.00e-33	134.00
IUUC-Acl-008231	Aspergillus clavatus	44.17	3.00e-53	201.00
IUUC-Afl-008557	Aspergillus flavus	38.36	7.00e-56	210.00
IUUC-Afu-008988	Aspergillus fumigatus	45.61	4.00e-55	207.00
IUUC-Ani-009420	Aspergillus nidulans	37.31	8.00e-54	204.00
IUUC-Ang-009859	Aspergillus niger	41.80	3.00e-50	192.00
IUUC-Aor-010145	Aspergillus oryzae	38.36	7.00e-56	210.00
IUUC-Ate-010347	Aspergillus terreus	41.90	4.00e-53	201.00
IUUC-Bgr-012298	Blumeria graminis	38.36	2.00e-50	192.00
IUUC-Bta-013251	Bos taurus	90.42	4.00e-173	600.00
IUUC-Bci-013786	Botrytis cinerea	38.44	2.00e-57	215.00
IUUC-Bdi-014132	Brachypodium distachyon	48.46	3.00e-80	291.00
IUUC-Bol-015611	Brassica oleracea	50.00	7.00e-84	303.00
IUUC-Bra-017769	Brassica rapa	50.00	1.00e-83	302.00
IUUC-Cel-018604	Caenorhabditis elegans	46.89	2.00e-81	295.00
IUUC-Cja-019768	Callithrix jacchus	82.11	7.00e-168	582.00
IUUC-Cfa-020207	Canis familiaris	90.73	5.00e-175	606.00
IUUC-Cpo-021925	Cavia porcellus	86.58	1.00e-165	575.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.96	6.00e-74	270.00
IUUC-Csa-023958	Chlorocebus sabaeus	89.78	2.00e-171	595.00
IUUC-Cho-024928	Choloepus hoffmanni	92.21	7.00e-40	157.00
IUUC-Cin-025771	Ciona intestinalis	54.01	2.00e-99	355.00
IUUC-Csv-026149	Ciona savignyi	57.37	2.00e-103	368.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	38.24	2.00e-52	199.00
IUUC-Cne-026955	Cryptococcus neoformans	35.21	2.00e-52	199.00
IUUC-Cme-027104	Cyanidioschyzon merolae	34.28	3.00e-49	188.00
IUUC-Dre-027409	Danio rerio	95.44	0.00e+00	655.00
IUUC-Dno-028921	Dasypus novemcinctus	90.10	6.00e-174	603.00
IUUC-Dse-031170	Dothistroma septosporum	37.24	2.00e-57	216.00
IUUC-Dme-031677	Drosophila melanogaster	60.94	2.00e-113	402.00
IUUC-Ete-032707	Echinops telfairi	63.95	2.00e-111	395.00
IUUC-Eca-033776	Equus caballus	90.97	6.00e-160	556.00
IUUC-Eeu-035305	Erinaceus europaeus	72.87	6.00e-78	283.00
IUUC-Fca-035846	Felis catus	83.53	8.00e-170	589.00
IUUC-Fal-037597	Ficedula albicollis	90.97	5.00e-155	540.00
IUUC-Fox-037670	Fusarium oxysporum	48.48	4.00e-53	201.00
IUUC-Fso-038243	Fusarium solani	48.05	3.00e-52	198.00
IUUC-Gmo-038499	Gadus morhua	88.18	3.00e-168	584.00
IUUC-Ggr-039975	Gaeumannomyces graminis	40.65	3.00e-47	182.00
IUUC-Gga-040904	Gallus gallus	90.03	0.00e+00	629.00
IUUC-Gac-042058	Gasterosteus aculeatus	93.29	2.00e-178	618.00
IUUC-Gma-043030	Glycine max	49.26	2.00e-85	308.00
IUUC-Ggo-044699	Gorilla gorilla	84.04	7.00e-157	546.00
IUUC-Hsa-046227	Homo sapiens	90.10	5.00e-174	603.00
IUUC-Hvu-047359	Hordeum vulgare	46.20	2.00e-81	295.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	82.27	5.00e-169	586.00
IUUC-Lch-049829	Latimeria chalumnae	91.69	1.00e-174	605.00
IUUC-Lpe-050899	Leersia perrieri	47.32	4.00e-77	281.00
IUUC-Loc-052264	Lepisosteus oculatus	93.63	8.00e-178	615.00
IUUC-Lma-053110	Leptosphaeria maculans	38.03	6.00e-48	184.00
IUUC-Laf-053639	Loxodonta africana	90.73	5.00e-175	606.00
IUUC-Mcc-055506	Macaca mulatta	89.78	2.00e-171	594.00
IUUC-Mor-057001	Magnaporthe oryzae	44.12	5.00e-54	204.00
IUUC-Mpo-057608	Magnaporthe poae	40.11	7.00e-32	130.00
IUUC-Mtr-057731	Medicago truncatula	49.85	1.00e-85	309.00
IUUC-Mla-059016	Melampsora laricipopulina	42.29	1.00e-42	165.00
IUUC-Mga-060178	Meleagris gallopavo	90.46	3.00e-168	583.00
IUUC-Mvi-060353	Microbotryum violaceum	38.81	2.00e-55	209.00
IUUC-Mmr-060738	Microcebus murinus	90.42	2.00e-174	604.00
IUUC-Mdo-062266	Monodelphis domestica	92.65	4.00e-116	410.00
IUUC-Mmu-063619	Mus musculus	89.14	8.00e-172	595.00
IUUC-Mac-065301	Musa acuminata	51.56	4.00e-88	317.00
IUUC-Mpu-066058	Mustela putorius furo	90.73	4.00e-175	607.00
IUUC-Mlu-067292	Myotis lucifugus	89.78	2.00e-171	594.00
IUUC-Nfi-068275	Neosartorya fischeri	38.59	2.00e-56	213.00
IUUC-Ncr-068713	Neurospora crassa	38.36	3.00e-57	215.00
IUUC-Nle-069013	Nomascus leucogenys	89.46	4.00e-171	593.00
IUUC-Opr-070628	Ochotona princeps	78.82	7.00e-158	549.00
IUUC-Ont-072688	Oreochromis niloticus	93.33	8.00e-178	615.00
IUUC-Oan-073004	Ornithorhynchus anatinus	89.43	3.00e-134	470.00
IUUC-Ocu-074303	Oryctolagus cuniculus	90.73	2.00e-175	608.00
IUUC-Oba-075002	Oryza barthii	47.89	5.00e-81	294.00
IUUC-Obr-076392	Oryza brachyantha	48.26	7.00e-79	286.00
IUUC-Ogl-077271	Oryza glaberrima	47.89	5.00e-81	294.00
IUUC-Ogu-078493	Oryza glumaepatula	47.89	1.00e-81	296.00
IUUC-Oin-080084	Oryza indica	47.89	1.00e-81	296.00
IUUC-Olo-080803	Oryza longistaminata	47.59	2.00e-81	295.00
IUUC-Ome-081146	Oryza meridionalis	46.39	3.00e-80	291.00
IUUC-Oni-082146	Oryza nivara	47.89	1.00e-81	296.00
IUUC-Opu-083633	Oryza punctata	47.95	1.00e-77	283.00
IUUC-Oru-084789	Oryza rufipogon	47.89	1.00e-81	296.00
IUUC-Osa-086196	Oryza sativa	47.89	1.00e-81	296.00
IUUC-Ola-087126	Oryzias latipes	93.61	1.00e-174	605.00
IUUC-Olu-087665	Ostreococcus lucimarinus	40.28	2.00e-67	249.00
IUUC-Oga-089140	Otolemur garnettii	82.65	5.00e-169	586.00
IUUC-Oar-090296	Ovis aries	90.10	2.00e-173	601.00
IUUC-Ptr-090566	Pan troglodytes	90.10	5.00e-174	603.00
IUUC-Pan-092052	Papio anubis	89.78	2.00e-171	595.00
IUUC-Psi-093723	Pelodiscus sinensis	91.67	2.00e-161	561.00
IUUC-Pma-094568	Petromyzon marinus	63.19	7.00e-109	386.00
IUUC-Pno-095120	Phaeosphaeria nodorum	39.34	7.00e-50	190.00
IUUC-Ppa-095761	Physcomitrella patens	47.37	1.00e-84	306.00
IUUC-Pfo-096210	Poecilia formosa	93.29	2.00e-178	617.00
IUUC-Pab-098463	Pongo abelii	90.10	1.00e-173	602.00
IUUC-Pop-099423	Populus trichocarpa	48.96	5.00e-85	307.00
IUUC-Pca-100108	Procavia capensis	89.02	2.00e-133	468.00
IUUC-Ppe-101176	Prunus persica	50.60	2.00e-84	305.00
IUUC-Pva-102629	Pteropus vampyrus	88.17	3.00e-139	488.00
IUUC-Pgr-103419	Puccinia graminis	39.51	2.00e-55	209.00
IUUC-Pte-104207	Pyrenophora teres	42.60	2.00e-31	128.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	38.36	5.00e-55	207.00
IUUC-Rno-105579	Rattus norvegicus	79.26	5.00e-151	526.00
IUUC-Sha-106894	Sarcophilus harrisii	88.77	4.00e-149	520.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	40.68	2.00e-58	219.00
IUUC-Spo-108371	Schizosaccharomyces pombe	40.12	3.00e-60	225.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	38.41	7.00e-49	187.00
IUUC-Smo-109396	Selaginella moellendorffii	51.08	1.00e-87	316.00
IUUC-Sit-110630	Setaria italica	50.00	6.00e-86	310.00
IUUC-Sly-110972	Solanum lycopersicum	48.88	6.00e-80	290.00
IUUC-Stu-112185	Solanum tuberosum	49.40	4.00e-88	317.00
IUUC-Sar-113294	Sorex araneus	75.21	2.00e-152	531.00
IUUC-Sbi-113951	Sorghum bicolor	50.31	2.00e-86	311.00
IUUC-Ssc-115501	Sus scrofa	89.56	1.00e-162	565.00
IUUC-Tgu-117152	Taeniopygia guttata	90.62	5.00e-155	540.00
IUUC-Tru-118388	Takifugu rubripes	92.33	2.00e-177	614.00
IUUC-Tsy-119109	Tarsius syrichta	90.42	2.00e-174	604.00
IUUC-Tni-120048	Tetraodon nigroviridis	92.33	7.00e-178	615.00
IUUC-Tca-121750	Theobroma cacao	49.41	1.00e-88	319.00
IUUC-Tre-122130	Trichoderma reesei	38.67	3.00e-54	205.00
IUUC-Tvi-122284	Trichoderma virens	38.87	5.00e-52	197.00
IUUC-Tae-124082	Triticum aestivum	47.11	5.00e-82	297.00
IUUC-Tur-126366	Triticum urartu	43.67	2.00e-66	246.00
IUUC-Tme-127187	Tuber melanosporum	38.92	4.00e-59	221.00
IUUC-Tbe-127619	Tupaia belangeri	81.88	2.00e-133	468.00
IUUC-Ttr-128867	Tursiops truncatus	80.41	7.00e-116	410.00
IUUC-Vda-129912	Verticillium dahliae	36.49	1.00e-52	200.00
IUUC-Vpa-130552	Vicugna pacos	91.87	4.00e-119	421.00
IUUC-Vvi-130881	Vitis vinifera	49.85	3.00e-83	301.00
IUUC-Xtr-131934	Xenopus tropicalis	85.11	9.00e-174	602.00
IUUC-Xma-133312	Xiphophorus maculatus	92.97	3.00e-177	613.00
IUUC-Yli-134487	Yarrowia lipolytica	40.00	5.00e-47	181.00
IUUC-Zma-135462	Zea mays	44.00	3.00e-71	261.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence