iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115501

Ensembl Protein ID

ENSSSCP00000011515.2

UniProt Accession

F1SAA9; F1SAA9_PIG

Genbank Protein ID

ENSSSCP00000011515

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

CU896682

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000010802.2	ENSSSCT00000011818.2	ENSSSCP00000011515.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.50e-92	309.7	1	305

Active Site

Position(s)	Description	Evidence
72	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
148	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 17   lftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAll 105
           +f ++++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tiffakqvi+N+Cat+A++
   Q: 1    VFSEIISCFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIFFAKQVINNACATQAIV 78
           68999*********.****************.********************.........899************************* PP
   S: 106  svllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeld 194
           svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + +++++    +++afhfvsyv++ngrlyeld
   Q: 79   SVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDAKTSAK----EEDAFHFVSYVPVNGRLYELD 163
           ************************************************************9887....79******************* PP
   S: 195  glkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid.........keLlkLlkdieseee 274
           gl++ P+dlg+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +          +  ++l++i+se++
   Q: 164  GLREGPIDLGA-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeeepmdtDQGSNMLSAIQSEVA 249
           **********9.78999*********..******************************976665567777777755568********** PP
   S: 275  kieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
           k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+    + +++
   Q: 250  KNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 305
           ************************************************993...33344 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

VFSEIISCFG CRGAQVEEIW SLEPENFEKL KPVHGLIFLF KWQPGEEPAG SVVQDSRLDT 60
IFFAKQVINN ACATQAIVSV LLNCTHQDVH LGETLSEFKE FSQSFDAAMK GLALSNSDVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTCTCAA GAAATAATTT CTTGTTTCAG GTTGCCGAGG AGCCCAAGTA GAAGAAATAT 60
GGAGTTTAGA GCCTGAGAAT TTTGAAAAAT TAAAGTAAGT GTATTTTTAG TTATGTTAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031011--C:Ino80 complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	44.71	2.00e-77	282.00
IUUC-Aml-001866	Ailuropoda melanoleuca	98.32	2.00e-175	607.00
IUUC-Atr-002966	Amborella trichopoda	47.29	3.00e-78	285.00
IUUC-Apl-003306	Anas platyrhynchos	87.10	9.00e-172	595.00
IUUC-Aca-004763	Anolis carolinensis	94.61	8.00e-169	585.00
IUUC-Aly-005581	Arabidopsis lyrata	46.88	1.00e-72	265.00
IUUC-Ath-007283	Arabidopsis thaliana	46.88	3.00e-75	274.00
IUUC-Ago-007999	Ashbya gossypii	32.01	3.00e-29	121.00
IUUC-Acl-008231	Aspergillus clavatus	42.11	3.00e-47	181.00
IUUC-Afl-008557	Aspergillus flavus	36.18	5.00e-49	187.00
IUUC-Afu-008988	Aspergillus fumigatus	44.05	4.00e-49	187.00
IUUC-Ani-009420	Aspergillus nidulans	36.04	5.00e-48	184.00
IUUC-Ang-009859	Aspergillus niger	39.66	6.00e-44	170.00
IUUC-Aor-010145	Aspergillus oryzae	36.18	5.00e-49	187.00
IUUC-Ate-010347	Aspergillus terreus	40.66	9.00e-48	183.00
IUUC-Ame-010791	Astyanax mexicanus	89.14	4.00e-170	589.00
IUUC-Bgr-012298	Blumeria graminis	36.30	6.00e-44	171.00
IUUC-Bta-013251	Bos taurus	97.98	2.00e-173	601.00
IUUC-Bci-013786	Botrytis cinerea	36.70	9.00e-53	200.00
IUUC-Bdi-014132	Brachypodium distachyon	47.32	1.00e-74	273.00
IUUC-Bol-015611	Brassica oleracea	48.28	6.00e-78	283.00
IUUC-Bra-017769	Brassica rapa	48.28	8.00e-78	283.00
IUUC-Cel-018604	Caenorhabditis elegans	45.18	2.00e-72	265.00
IUUC-Cja-019768	Callithrix jacchus	88.62	4.00e-168	583.00
IUUC-Cfa-020207	Canis familiaris	98.32	2.00e-175	607.00
IUUC-Cpo-021925	Cavia porcellus	93.94	6.00e-166	576.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	43.83	3.00e-68	251.00
IUUC-Csa-023958	Chlorocebus sabaeus	97.31	4.00e-172	597.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	1.00e-42	166.00
IUUC-Cin-025771	Ciona intestinalis	52.75	2.00e-90	325.00
IUUC-Csv-026149	Ciona savignyi	56.21	2.00e-93	335.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.23	2.00e-51	196.00
IUUC-Cne-026955	Cryptococcus neoformans	36.65	4.00e-49	187.00
IUUC-Cme-027104	Cyanidioschyzon merolae	31.52	2.00e-41	162.00
IUUC-Dre-027409	Danio rerio	88.18	5.00e-167	579.00
IUUC-Dno-028921	Dasypus novemcinctus	97.64	5.00e-174	603.00
IUUC-Dse-031170	Dothistroma septosporum	38.16	1.00e-53	202.00
IUUC-Dme-031677	Drosophila melanogaster	58.36	1.00e-105	375.00
IUUC-Ete-032707	Echinops telfairi	66.67	2.00e-107	381.00
IUUC-Eca-033776	Equus caballus	99.31	4.00e-172	596.00
IUUC-Eeu-035305	Erinaceus europaeus	75.58	7.00e-71	260.00
IUUC-Fca-035846	Felis catus	90.12	4.00e-170	590.00
IUUC-Fal-037597	Ficedula albicollis	96.18	3.00e-160	556.00
IUUC-Fox-037670	Fusarium oxysporum	41.89	3.00e-50	191.00
IUUC-Fso-038243	Fusarium solani	41.89	1.00e-49	189.00
IUUC-Gmo-038499	Gadus morhua	82.83	7.00e-150	522.00
IUUC-Ggr-039975	Gaeumannomyces graminis	40.93	6.00e-43	167.00
IUUC-Gga-040904	Gallus gallus	94.25	5.00e-177	612.00
IUUC-Gac-042058	Gasterosteus aculeatus	87.88	4.00e-159	553.00
IUUC-Gma-043763	Glycine max	46.95	3.00e-78	285.00
IUUC-Ggo-044699	Gorilla gorilla	91.41	3.00e-157	547.00
IUUC-Hsa-046227	Homo sapiens	97.64	2.00e-174	603.00
IUUC-Hvu-047359	Hordeum vulgare	45.94	5.00e-76	277.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	89.02	5.00e-170	590.00
IUUC-Lch-049829	Latimeria chalumnae	91.92	9.00e-164	568.00
IUUC-Lpe-050899	Leersia perrieri	46.75	4.00e-71	261.00
IUUC-Loc-052264	Lepisosteus oculatus	89.93	6.00e-162	562.00
IUUC-Lma-053110	Leptosphaeria maculans	37.24	1.00e-43	169.00
IUUC-Laf-053639	Loxodonta africana	98.32	2.00e-175	607.00
IUUC-Mcc-055506	Macaca mulatta	97.31	5.00e-172	596.00
IUUC-Mor-057001	Magnaporthe oryzae	44.25	4.00e-50	191.00
IUUC-Mpo-057608	Magnaporthe poae	38.86	8.00e-28	116.00
IUUC-Mtr-057731	Medicago truncatula	47.85	8.00e-79	286.00
IUUC-Mla-059016	Melampsora laricipopulina	41.67	4.00e-39	153.00
IUUC-Mga-060178	Meleagris gallopavo	95.72	8.00e-175	605.00
IUUC-Mvi-060353	Microbotryum violaceum	36.99	2.00e-48	186.00
IUUC-Mmr-060738	Microcebus murinus	97.64	2.00e-174	603.00
IUUC-Mdo-062266	Monodelphis domestica	95.88	3.00e-111	393.00
IUUC-Mmu-063619	Mus musculus	95.96	1.00e-171	595.00
IUUC-Mac-065301	Musa acuminata	48.70	2.00e-81	295.00
IUUC-Mpu-066058	Mustela putorius furo	98.65	7.00e-176	608.00
IUUC-Mlu-067292	Myotis lucifugus	96.97	1.00e-171	595.00
IUUC-Nfi-068275	Neosartorya fischeri	36.45	3.00e-50	191.00
IUUC-Ncr-068713	Neurospora crassa	37.70	2.00e-53	202.00
IUUC-Nle-069013	Nomascus leucogenys	96.97	1.00e-171	595.00
IUUC-Opr-070628	Ochotona princeps	87.65	6.00e-166	576.00
IUUC-Ont-072688	Oreochromis niloticus	88.63	3.00e-159	553.00
IUUC-Oan-073004	Ornithorhynchus anatinus	97.94	3.00e-143	500.00
IUUC-Ocu-074303	Oryctolagus cuniculus	98.65	5.00e-176	610.00
IUUC-Oba-075002	Oryza barthii	46.75	4.00e-75	274.00
IUUC-Obr-076392	Oryza brachyantha	48.08	4.00e-73	267.00
IUUC-Ogl-077271	Oryza glaberrima	46.75	4.00e-75	274.00
IUUC-Ogu-078493	Oryza glumaepatula	46.75	8.00e-76	276.00
IUUC-Oin-080084	Oryza indica	46.75	8.00e-76	276.00
IUUC-Olo-080803	Oryza longistaminata	46.44	2.00e-75	275.00
IUUC-Ome-081146	Oryza meridionalis	45.82	2.00e-74	271.00
IUUC-Oni-082146	Oryza nivara	46.75	8.00e-76	276.00
IUUC-Opu-083633	Oryza punctata	47.40	5.00e-72	263.00
IUUC-Oru-084789	Oryza rufipogon	46.75	8.00e-76	276.00
IUUC-Osa-086196	Oryza sativa	46.75	8.00e-76	276.00
IUUC-Ola-087126	Oryzias latipes	88.55	1.00e-155	541.00
IUUC-Olu-087665	Ostreococcus lucimarinus	39.93	3.00e-62	231.00
IUUC-Oga-089140	Otolemur garnettii	88.89	1.00e-168	585.00
IUUC-Oar-090296	Ovis aries	98.32	1.00e-175	608.00
IUUC-Ptr-090566	Pan troglodytes	97.64	2.00e-174	603.00
IUUC-Pan-092052	Papio anubis	97.31	5.00e-172	596.00
IUUC-Psi-093723	Pelodiscus sinensis	95.83	1.00e-166	578.00
IUUC-Pma-094568	Petromyzon marinus	61.11	3.00e-107	380.00
IUUC-Pno-095120	Phaeosphaeria nodorum	37.88	4.00e-45	174.00
IUUC-Ppa-095761	Physcomitrella patens	46.25	1.00e-77	283.00
IUUC-Pfo-096210	Poecilia formosa	87.88	3.00e-159	553.00
IUUC-Pab-098463	Pongo abelii	97.64	3.00e-174	603.00
IUUC-Pop-099423	Populus trichocarpa	47.56	8.00e-78	283.00
IUUC-Pca-100108	Procavia capensis	96.09	2.00e-130	458.00
IUUC-Ppe-101176	Prunus persica	49.54	3.00e-79	288.00
IUUC-Pva-102629	Pteropus vampyrus	94.31	6.00e-136	476.00
IUUC-Pgr-103419	Puccinia graminis	38.41	3.00e-51	194.00
IUUC-Pte-104207	Pyrenophora teres	42.68	6.00e-28	116.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	38.23	3.00e-52	198.00
IUUC-Rno-105579	Rattus norvegicus	87.00	1.00e-163	568.00
IUUC-Sha-106894	Sarcophilus harrisii	94.57	1.00e-156	545.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	37.67	2.00e-54	205.00
IUUC-Spo-108371	Schizosaccharomyces pombe	40.48	2.00e-54	205.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	38.41	1.00e-47	182.00
IUUC-Smo-109396	Selaginella moellendorffii	49.68	2.00e-81	295.00
IUUC-Sit-110630	Setaria italica	47.80	8.00e-79	286.00
IUUC-Sly-110972	Solanum lycopersicum	50.16	1.00e-80	292.00
IUUC-Stu-112185	Solanum tuberosum	48.00	5.00e-82	297.00
IUUC-Sar-113294	Sorex araneus	81.07	2.00e-155	541.00
IUUC-Sbi-113951	Sorghum bicolor	48.11	3.00e-79	288.00
IUUC-Tgu-117152	Taeniopygia guttata	95.83	3.00e-160	556.00
IUUC-Tru-118388	Takifugu rubripes	87.54	2.00e-159	554.00
IUUC-Tsy-119109	Tarsius syrichta	97.98	1.00e-174	605.00
IUUC-Tni-120048	Tetraodon nigroviridis	87.54	8.00e-160	555.00
IUUC-Tca-121750	Theobroma cacao	47.42	1.00e-81	295.00
IUUC-Tre-122130	Trichoderma reesei	38.19	1.00e-50	193.00
IUUC-Tvi-122284	Trichoderma virens	38.41	7.00e-48	183.00
IUUC-Tae-125344	Triticum aestivum	46.37	3.00e-75	275.00
IUUC-Tur-126366	Triticum urartu	41.93	6.00e-65	241.00
IUUC-Tme-127187	Tuber melanosporum	39.52	5.00e-53	201.00
IUUC-Tbe-127619	Tupaia belangeri	90.24	1.00e-145	508.00
IUUC-Ttr-128867	Tursiops truncatus	88.16	1.00e-124	438.00
IUUC-Vda-129912	Verticillium dahliae	36.14	1.00e-47	183.00
IUUC-Vpa-130552	Vicugna pacos	97.93	2.00e-113	402.00
IUUC-Vvi-130881	Vitis vinifera	49.39	4.00e-78	284.00
IUUC-Xtr-131934	Xenopus tropicalis	84.66	3.00e-162	563.00
IUUC-Xma-133312	Xiphophorus maculatus	87.88	5.00e-159	553.00
IUUC-Zma-135462	Zea mays	42.72	2.00e-66	245.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence