iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001965

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01195641

Gene Name

TRIM6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000013410.1	ENSAMET00000014709.1	ENSAMEP00000014117.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.40e-07	30.0	9	77
E3 activity/RING/RING	2.10e-08	34.6	15	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk......tcPvtrqplteedlvPnltlrrl 64
           + +e  CpI lel ++P  + +G+++ +++I +  a++ +      +cPv++++ ++ dl Pn  l ++
   Q: 9    IRDEVTCPICLELLTEPLSIDCGHSFCQACISRNSAESVTgqegegSCPVCQTSYQPGDLRPNRHLANI 77
           668999***************************7644444777888*****************998766 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw.pglknssskefrCPlCr 46
           C+iCle + + pl+ +CgH f++ C+ +    +   + +e +CP+C+
   Q: 15   CPICLELLTE-PLSIDCGHSFCQACISRNsAESVTGQEGEGSCPVCQ 60
           ********99.***************444457778999999*****7 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MTSAVLVDIR DEVTCPICLE LLTEPLSIDC GHSFCQACIS RNSAESVTGQ EGEGSCPVCQ 60
TSYQPGDLRP NRHLANIAER LREVVLGPGM QLKAVLCAHH GEKLRLFCKE DGQLICWLCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCTCAG CGGTCCTGGT GGACATACGA GATGAAGTGA CCTGCCCCAT CTGCCTGGAG 60
CTCCTGACAG AGCCCCTGAG CATAGACTGT GGCCACAGCT TCTGCCAGGC TTGCATCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035458--P:cellular response to interferon-beta
GO:0098586--P:cellular response to virus
GO:0010994--P:free ubiquitin chain polymerization
GO:2000737--P:negative regulation of stem cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045071--P:negative regulation of viral genome replication
GO:0002741--P:positive regulation of cytokine secretion involved in immune response
GO:0002230--P:positive regulation of defense response to virus by host
GO:0010628--P:positive regulation of gene expression
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0032496--P:response to lipopolysaccharide

KEGG

aml:100476251

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013110	Bos taurus	54.62	1.00e-151	529.00
IUUC-Cja-019944	Callithrix jacchus	53.06	8.00e-134	470.00
IUUC-Cho-024416	Choloepus hoffmanni	59.14	1.00e-84	306.00
IUUC-Dno-029492	Dasypus novemcinctus	53.66	6.00e-143	501.00
IUUC-Dor-030480	Dipodomys ordii	78.33	3.00e-131	462.00
IUUC-Ete-033021	Echinops telfairi	47.37	2.00e-104	372.00
IUUC-Eca-034235	Equus caballus	55.73	2.00e-148	519.00
IUUC-Fca-035533	Felis catus	93.43	0.00e+00	901.00
IUUC-Hsa-046006	Homo sapiens	83.40	0.00e+00	830.00
IUUC-Itr-048069	Ictidomys tridecemlineatus	76.97	0.00e+00	729.00
IUUC-Laf-053805	Loxodonta africana	77.25	0.00e+00	705.00
IUUC-Mmr-061023	Microcebus murinus	79.59	0.00e+00	754.00
IUUC-Mmu-063682	Mus musculus	77.66	0.00e+00	768.00
IUUC-Mpu-065842	Mustela putorius furo	92.18	0.00e+00	885.00
IUUC-Opr-071057	Ochotona princeps	49.17	2.00e-116	412.00
IUUC-Ocu-073956	Oryctolagus cuniculus	51.75	7.00e-130	457.00
IUUC-Oga-088267	Otolemur garnettii	82.30	0.00e+00	791.00
IUUC-Ptr-090573	Pan troglodytes	83.81	0.00e+00	834.00
IUUC-Pan-092745	Papio anubis	83.20	0.00e+00	815.00
IUUC-Rno-105401	Rattus norvegicus	79.92	0.00e+00	788.00
IUUC-Sar-113094	Sorex araneus	47.76	4.00e-103	368.00
IUUC-Ssc-115715	Sus scrofa	52.83	1.00e-140	493.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence